Ignite Creation Date:
2025-12-25 @ 12:43 AM
Ignite Modification Date:
2026-01-05 @ 11:48 PM
Study NCT ID:
NCT01896167
Status:
COMPLETED
Last Update Posted:
2015-02-12
First Post:
2013-06-21
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow by Hypoxia
Sponsor:
Danish Headache Center
Organization:
Study Overview
Official Title:
Study of Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries by Hypoxia in a Humane Experimental Migraine Model
Status:
COMPLETED
Status Verified Date:
2015-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study the investigators will investigate the following hypothesis
* that hypoxia induce migraine headache and migraine aura
* the aura phase is associated with a spreading reduction in cerebral blood flow
* the migraine headache is associated with dilatation of intra- and extracerebral arteries
* the migraine headache is associated with changes in brain metabolism
* the pre-ictal stage of a migraine attack with aura is associated with specific patterns in neural activity.
* that hypoxia induce migraine headache and migraine aura
* the aura phase is associated with a spreading reduction in cerebral blood flow
* the migraine headache is associated with dilatation of intra- and extracerebral arteries
* the migraine headache is associated with changes in brain metabolism
* the pre-ictal stage of a migraine attack with aura is associated with specific patterns in neural activity.
Detailed Description:
To investigate migraine with aura symptoms during and after hypoxia.
With magnetic resonance imaging the investigators will investigate changes in
* regional cerebral blood flow (rCBF)
* resting state functional connectivity
* circumference of the middle cerebral artery(MCA), internal carotic artery, superficial temporal artery, medial meningeal artery, external carotic artery
* brain metabolism
And compare these changes with a aged match healthy control group.
With magnetic resonance imaging the investigators will investigate changes in
* regional cerebral blood flow (rCBF)
* resting state functional connectivity
* circumference of the middle cerebral artery(MCA), internal carotic artery, superficial temporal artery, medial meningeal artery, external carotic artery
* brain metabolism
And compare these changes with a aged match healthy control group.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: