Ignite Creation Date:
2024-05-05 @ 11:30 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00063661
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2003-07-02
Brief Title:
Studying Automatic Movements in Patients With Parkinsons Disease
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Neuroimaging Study of Automatic Movements in Patients With Parkinsons Disease
Status:
COMPLETED
Status Verified Date:
2005-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Parkinsons disease patients usually have difficulty making automatic movements Automatic movements are movements people often make without conscious thought
The purpose of this study is to investigate regions of the brain that affect automatic movements and to understand the movements of Parkinsons patients Investigators hope this knowledge will lead to better treatment for the disease
Thirty participants will be enrolled in this study Each will give a medical history and undergo a brief physical exam Participants will have two MRI scans each lasting approximately 15 hours During these scans they may be asked to move their right or left hands or to remember some letters that they have been shown Before undergoing the second scan participants will be asked to practice the tasks until they can perform them correctly
The purpose of this study is to investigate regions of the brain that affect automatic movements and to understand the movements of Parkinsons patients Investigators hope this knowledge will lead to better treatment for the disease
Thirty participants will be enrolled in this study Each will give a medical history and undergo a brief physical exam Participants will have two MRI scans each lasting approximately 15 hours During these scans they may be asked to move their right or left hands or to remember some letters that they have been shown Before undergoing the second scan participants will be asked to practice the tasks until they can perform them correctly
Detailed Description:
Patients with Parkinsons Disease PD are deficient in making automatic movements The underlying neural correlates of the problem are not understood In the present study to investigate the brain activity contributing to this disorder we will use specially designed dual-task paradigm and the functional magnetic resonance imaging fMRI technique Thirty patients with PD will be asked to perform sequential finger-tapping movement with the right hand results will be analyzed from 20 patients who achieve automaticity as defined in the study In addition we will use a dual-task paradigm to evaluate automaticity by having subjects perform either a distraction task involving visual memory or an interference task tapping with the left hand simultaneously with the sequential movements Patients will practice to achieve automaticity fMRI will be obtained before and after achieving automaticity By analyzing fMRI results we will explore the brain regions associated with deficiency of automatic movements in PD patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0236 | None | None | None |