Ignite Creation Date:
2024-05-05 @ 11:30 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00063180
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2003-06-20
Brief Title:
Evaluating the Remote Effects of Stroke With MRI and PET Scans
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Remote Effects of Stroke on Cerebral Metabolism Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy
Status:
COMPLETED
Status Verified Date:
2009-04-20
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with stroke sometimes have a condition called diaschisis a loss of function in a part of the brain located some distance from the original stroke-injury site Doctors do not know why this happens
The purpose of this study is to get a better understanding as to why diaschisis occurs by studying people who have experienced a stroke and people who have aged in good health
Forty-four participants who are older than 40 year of age will be enrolled in this study-18 healthy people and 26 stroke patients They will have 3 to 4 study visits The first visit will involve a medical history and a physical and neurological exam Participants will then have a magnetic resonance imaging MRI scan either on the first visit or on a later day On the next visit they will undergo a position emission tomography PET scan Finally they will return for another MRI scan
The purpose of this study is to get a better understanding as to why diaschisis occurs by studying people who have experienced a stroke and people who have aged in good health
Forty-four participants who are older than 40 year of age will be enrolled in this study-18 healthy people and 26 stroke patients They will have 3 to 4 study visits The first visit will involve a medical history and a physical and neurological exam Participants will then have a magnetic resonance imaging MRI scan either on the first visit or on a later day On the next visit they will undergo a position emission tomography PET scan Finally they will return for another MRI scan
Detailed Description:
Objective Following a stroke not only is there dysfunction of the lesioned area but there is also remote functional depression of non-lesioned areas This functional depression called diaschisis likely contributes to the functional deficit of the patient
The objective of this study is to obtain a better understanding of the pathophysiology of diaschisis with the integrated methods of neuroimaging positron emission tomography PET and proton magnetic resonance spectroscopy H-MRS
Study population We will recruit patients with subcortical stroke in the subacute state and in the chronic state and normal controls
Design The stroke lesion will be the basal ganglia internal capsule thalamus or cerebellum The frontal cortex including the motor cortex is chosen as a remote area Neurochemical changes in the diaschitic area will be investigated by measuring the glucose metabolic rate with PET and concentrations of neurochemically important metabolites such as gamma-aminobutyric acid GABA and glutamate with H-MRS
Outcome measures Metabolic change in the diaschitic areas relative to the contra-lateral unaffected side will be calculated as a laterality index First this index will be compared among patient groups and control group As a second analysis the relationship of glucose metabolism measured by PET and concentrations of the metabolites detected by H-MRS will be evaluated
The objective of this study is to obtain a better understanding of the pathophysiology of diaschisis with the integrated methods of neuroimaging positron emission tomography PET and proton magnetic resonance spectroscopy H-MRS
Study population We will recruit patients with subcortical stroke in the subacute state and in the chronic state and normal controls
Design The stroke lesion will be the basal ganglia internal capsule thalamus or cerebellum The frontal cortex including the motor cortex is chosen as a remote area Neurochemical changes in the diaschitic area will be investigated by measuring the glucose metabolic rate with PET and concentrations of neurochemically important metabolites such as gamma-aminobutyric acid GABA and glutamate with H-MRS
Outcome measures Metabolic change in the diaschitic areas relative to the contra-lateral unaffected side will be calculated as a laterality index First this index will be compared among patient groups and control group As a second analysis the relationship of glucose metabolism measured by PET and concentrations of the metabolites detected by H-MRS will be evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0224 | None | None | None |