Ignite Creation Date:
2024-05-05 @ 11:30 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00063115
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2003-06-19
Brief Title:
Using fMRI to Understand the Roles of Brain Areas for Fine Hand Movements
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Event-Related fMRI Analysis of Patients With Ideomotor Apraxia During Transitive and Intransitive Hand Gesturing
Status:
COMPLETED
Status Verified Date:
2008-07-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Ideomotor apraxia a disorder that affects patients with stroke and a variety of other brain lesions features disturbed timing sequence and spatial organization of skilled movements This study will look at how different areas of the human brain control fine hand movements
Thirty-five participants 21 years and older will be enrolled in this study-25 healthy right-handed people and 10 stroke patients They will undergo two outpatient sessions each lasting up to 3 hours The first visit for the stroke patients will occur between 2 weeks and 3 months after the stroke the second visit will be at least 6 months after the stroke
Participants will have a physical exam give a medical history and complete a questionnaire Then they will undergo magnetic resonance imaging MRI scans They will lie in the MRI scanner and will be asked to do a number of skilled hand movements using the right hand such as pretending to use a hammer or waving goodbye in response to directions that will appear on a screen mounted over their head Their movements will be recorded on videotape during the procedures
Thirty-five participants 21 years and older will be enrolled in this study-25 healthy right-handed people and 10 stroke patients They will undergo two outpatient sessions each lasting up to 3 hours The first visit for the stroke patients will occur between 2 weeks and 3 months after the stroke the second visit will be at least 6 months after the stroke
Participants will have a physical exam give a medical history and complete a questionnaire Then they will undergo magnetic resonance imaging MRI scans They will lie in the MRI scanner and will be asked to do a number of skilled hand movements using the right hand such as pretending to use a hammer or waving goodbye in response to directions that will appear on a screen mounted over their head Their movements will be recorded on videotape during the procedures
Detailed Description:
OBJECTIVE The present study focuses on evaluating neural activation patterns underlying praxis movements in normal controls and in patients with ideomotor apraxia using event-related functional magnetic resonance imaging fMRI Ideomotor apraxia is a disorder affecting patients with stroke and a variety of other brain lesions The disorder involves disturbed timing sequence and spatial organization of skilled movements during the execution and probably also preparatory phases As a consequence patients suffer from incorrect temporal and spatial components to movements as evidenced during pantomime of transitive objecttool related and intransitive independent of objecttool use gestures Thus far damage to posterior parietal regions and parietofrontal circuits has been implicated in significantly contributing to this disorder However little is known about the mechanism of cortical reorganization following damage notably during recovery process We hypothesize that recruitment of parallel and contralateral motor pathways compensates for reduced communication within parietofrontal circuits which prevents accurate motor performance
STUDY POPULATION We will study two groups of participants one group of patients with ideomotor apraxia and one group of healthy subjects
DESIGN We will measure fMRI activation on transitive and intransitive gestures in 10 patients with ideomotor apraxia during subacute and chronic stage compared to 25 normal controls The design of the behavioral paradigm incorporates a distinct period of planning prior to each movement
OUTCOME MEASURES The design of this study allows evaluating any differences in the planning and execution phases between patients and controls Further analysis will examine patterns of functional connectivity between activated brain areas notably their altered interactions in ideomotor apraxia Of special interest is the putative engagement of perilesional or even remote brain areas in a neuronal network during attempted recovery from motor deficit
It is expected from the study that a better understanding of cortical plasticity compensating for motor deficits in ideomotor apraxia can be therapeutically exploited notably in the rehabilitation process
STUDY POPULATION We will study two groups of participants one group of patients with ideomotor apraxia and one group of healthy subjects
DESIGN We will measure fMRI activation on transitive and intransitive gestures in 10 patients with ideomotor apraxia during subacute and chronic stage compared to 25 normal controls The design of the behavioral paradigm incorporates a distinct period of planning prior to each movement
OUTCOME MEASURES The design of this study allows evaluating any differences in the planning and execution phases between patients and controls Further analysis will examine patterns of functional connectivity between activated brain areas notably their altered interactions in ideomotor apraxia Of special interest is the putative engagement of perilesional or even remote brain areas in a neuronal network during attempted recovery from motor deficit
It is expected from the study that a better understanding of cortical plasticity compensating for motor deficits in ideomotor apraxia can be therapeutically exploited notably in the rehabilitation process
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0230 | None | None | None |