Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00066066
Status:
COMPLETED
Last Update Posted:
2013-04-22
First Post:
2003-08-01
Brief Title:
Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers
Sponsor:
The Forsyth Institute
Organization:
The Forsyth Institute
Study Overview
Official Title:
Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers
Status:
COMPLETED
Status Verified Date:
2013-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine in current and non-smokers the clinical and microbiological effects of 3 therapies scaling and root planing SRP alone SRP in combination with the orally administered antibiotic metronidazole and SRP with the orally administered antibiotics metronidazole and amoxicillin along with the locally delivered antibiotic doxycycline at periodontal pockets 4 mm
Detailed Description:
Cigarette smokers have more severe periodontal disease and more widespread colonization by periodontal pathogens than non smokers In addition smokers respond less well to periodontal therapies particularly mechanical therapies such as scaling and root planing SRP and surgery Recent data from our laboratory have indicated that treatment that included antibiotics produced a better clinical effect in smokers than mechanical therapy alone Thus the purpose of the present investigation is to compare the immediate and long-term effects of 3 periodontal therapies on clinical microbiological and host parameters in current and non smokers In this double blind placebo-controlled randomized study 108 current smokers and 108 non smokers will be randomly assigned to 1 of 3 treatment groups SRP alone SRP systemically administered metronidazole SRP systemically administered amoxicillin and metronidazole and local delivery of doxycycline at pockets 4 mm Plaque Index Gingival Index of sites with bleeding on probing suppuration pocket depth and attachment level will be measured at 6 sites per tooth at all teeth excluding 3rd molars at baseline 3 6 12 18 and 24 months Subgingival plaque samples taken from the mesial aspect of each tooth at the same time points will be analyzed individually for their content of 40 subgingival species using checkerboard DNA-DNA hybridization Antibody levels to 20 subgingival species will be measured in serum samples taken at baseline 6 and 24 months Levels of IL-1b IL-10 and IFNg will be measured in GCF samples taken from the 4 deepest pockets at baseline 3 6 and 24 months The major hypothesis to be tested is whether smokers respond better to periodontal therapies that include 1 or more antibiotics Other hypotheses will test whether host and microbiological parameters differ between smokers and non smokers and if such parameters are comparably altered after therapy in both groups The results will be of immediate clinical benefit to the large segment of periodontal patients who smoke cigarettes Smokers make up 26 - 30 of the adult population and form a disproportionately high segment of the population requiring periodontal treatment They may have special needs in terms of periodontal therapy which should be clarified by the proposed investigation In addition the cigarette smoker is an example of a periodontal patient who is compromised in terms of hisher ability to cope with infectious diseases The proposed investigation should provide a model to examine methods that could be useful in treating compromised patients whether compromised by harmful habits such as smoking systemic disease or genetic background
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DE014242 | NIH | None | httpsreporternihgovquickSearchR01DE014242 |