Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00065169
Status:
COMPLETED
Last Update Posted:
2020-03-02
First Post:
2003-07-17
Brief Title:
Delaying Alzheimer Disease Symptoms With Anti-Inflammatory Drugs
Sponsor:
University of California Los Angeles
Organization:
University of California Los Angeles
Study Overview
Official Title:
Anti-Inflammation in AD PET Imaging Supplement
Status:
COMPLETED
Status Verified Date:
2020-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether the anti-inflammatory drug celecoxib can delay the onset of Alzheimer Disease AD in people with Age Associated Memory Impairment AAMI This study will also evaluate genetic risk and brain structure as potential predictors of mental decline
Detailed Description:
AD is one of the most common mental disorders of late life Preliminary studies indicate that anti-inflammatory drugs may attenuate or prevent AD symptoms but efficacy trials are needed
Participants in this study will be randomly assigned to receive either celecoxib or placebo for 18 months Participants will undergo positron emission tomography PET and magnetic resonance imaging MRI scans of the brain Routine laboratory blood tests cognitive tests and an electrocardiogram ECG will be performed Participants will also be screened for Parkinson disease Follow-up testing will be conducted at specific intervals following the study
Participants in this study will be randomly assigned to receive either celecoxib or placebo for 18 months Participants will undergo positron emission tomography PET and magnetic resonance imaging MRI scans of the brain Routine laboratory blood tests cognitive tests and an electrocardiogram ECG will be performed Participants will also be screened for Parkinson disease Follow-up testing will be conducted at specific intervals following the study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DSIR AT-GP | US NIH GrantContract | None | httpsreporternihgovquickSearchR01MH058156 |
| R01MH058156 | NIH | None | None |