Ignite Creation Date:
2025-12-17 @ 4:38 PM
Ignite Modification Date:
2025-12-24 @ 2:54 AM
Study NCT ID:
NCT00745693
Status:
COMPLETED
Last Update Posted:
2024-05-17
First Post:
2008-09-02
Is Possible Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
Sponsor:
University of Edinburgh
Organization:
Study Overview
Official Title:
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
Status:
COMPLETED
Status Verified Date:
2008-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution
Detailed Description:
Air pollution is a major problem, and can be linked to around 5% of all deaths worldwide each year. There are strong associations between air pollution exposure and heart disease but we do not yet understand how these harmful effects are mediated. Understanding this mechanism is likely to have a major impact on the way we treat patients with heart disease and have the potential to shape future environmental health policy. The upregulation of Endothelin-1 provides a plausible mechanism for these harmful effects, and we plan to investigate this in more depth in the human forearm following exposure to diesel exhaust.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: