Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00062777
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2003-06-13
Brief Title:
The Framingham Study Examining DNA Markers and Links to Diseases
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Genome-Wide Scan for Quantitative Trait Loci of Hematocrit - A Framingham Study
Status:
COMPLETED
Status Verified Date:
2011-06-16
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Since 1948 residents of Framingham Massachusetts have participated in a program that collects blood samples and clinical data to provide a rare and valuable database for scientific research
The purpose of this study is to support this national resource by aiding in its research capacity Specifically researchers in this study will 1 investigate heart lung and blood diseases stroke memory loss joint disease bone loss deafness cancer blood vessel diseases and other health conditions and 2 examine DNA and its relationship to risk of developing these disease and health conditions
Approximately 330 families have participated in the Framingham Study Participants will be required to undergo a four-hour exam and to take that exam every two years thereafter During the exam the Framingham investigators will 1 interview participants about medical status health issues and lifestyles 2 perform a regular physical exam 3 obtain blood and urine samples and administer a glucose-tolerance test 4 supervise a brisk six-minute treadmill walk 5 administer an ultrasound procedure and 6 review and obtain copies of medical and hospital records Participants will also be asked to complete a questionnaire at home regarding dietary and health habits
The purpose of this study is to support this national resource by aiding in its research capacity Specifically researchers in this study will 1 investigate heart lung and blood diseases stroke memory loss joint disease bone loss deafness cancer blood vessel diseases and other health conditions and 2 examine DNA and its relationship to risk of developing these disease and health conditions
Approximately 330 families have participated in the Framingham Study Participants will be required to undergo a four-hour exam and to take that exam every two years thereafter During the exam the Framingham investigators will 1 interview participants about medical status health issues and lifestyles 2 perform a regular physical exam 3 obtain blood and urine samples and administer a glucose-tolerance test 4 supervise a brisk six-minute treadmill walk 5 administer an ultrasound procedure and 6 review and obtain copies of medical and hospital records Participants will also be asked to complete a questionnaire at home regarding dietary and health habits
Detailed Description:
Many studies have shown that hematocrit HCT levels are associated with cerebrovascular disease cardiovascular disease CVD peripheral vascular disease as well as all-cause mortality Twin studies have shown that HCT variation is largely determined by genetic factors with heritability estimated as 40 - 65 So far no linkage analysis in humans between HCT and DNA markers have been reported The purpose of this protocol is to identify chromosome regions that contain quantitative trait loci QTL involved in controlling HCT levels In the Framingham Study a 10cM genome scan about 400 markers has been conducted in 330 families HCT was measured in the original cohort and Framingham offspring These data provide us the opportunity to undertake linkage analyses using variance component method to map quantitative trait loci QTL of HCT
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-H-0219 | None | None | None |