Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00062517
Status:
COMPLETED
Last Update Posted:
2017-10-06
First Post:
2003-06-06
Brief Title:
Generalized Anxiety Disorder and Social Anxiety Disorder Their Impact on the Processing of Information and Learning
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Generalized Anxiety Disorder and Social Anxiety Disorder Their Impact on the Processing of Social Emotional Information and Instrumental Learning
Status:
COMPLETED
Status Verified Date:
2016-09-21
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to increase researchers understanding of the biological basis of generalized anxiety disorder and social anxiety disorder They will investigate how the brain activity associated with specific thoughts and feelings may play a role in these anxiety disorders This knowledge will be used to design interventions to help those with these illnesses
To qualify for this study participants must be evaluated via an initial telephone screening interview and material sent through the mail
Participants will then be required to make three visits to NIH During the first visit they will be asked questions about their general mood degree of nervousness thinking skills and behavior They will undergo a thorough physical exam including an EKG blood work urinalysis and a pregnancy test for women of childbearing potential During the second visit participants will spend about 25 hours doing various tasks while sitting and looking at a computer screen These tasks will guide them to experience specific kinds of thoughts and emotions Researchers will attach electrodes to the participants hands to monitor the amount of electricity conducted by the skin The third visit will be similar to the second visit but participants will perform the tasks while lying in a MRI scanner
Participants will be compensated up to 400 for their involvement in this study
To qualify for this study participants must be evaluated via an initial telephone screening interview and material sent through the mail
Participants will then be required to make three visits to NIH During the first visit they will be asked questions about their general mood degree of nervousness thinking skills and behavior They will undergo a thorough physical exam including an EKG blood work urinalysis and a pregnancy test for women of childbearing potential During the second visit participants will spend about 25 hours doing various tasks while sitting and looking at a computer screen These tasks will guide them to experience specific kinds of thoughts and emotions Researchers will attach electrodes to the participants hands to monitor the amount of electricity conducted by the skin The third visit will be similar to the second visit but participants will perform the tasks while lying in a MRI scanner
Participants will be compensated up to 400 for their involvement in this study
Detailed Description:
There have been suggestions that the threshold for amygdala activity is lower in individuals with anxiety disorders than in healthy individuals However despite its immediate plausibility there have been relatively few tests of this hypothesis Specifically there have been very few explorations of the performance of patients with anxiety disorders on measures known to implicate the amygdala
Although the high co-morbidity of Generalized Anxiety Disorder GAD and Social Anxiety Disorder SAD complicates the issue the fact that the disorders doubly dissociate suggests that they are due to dysfunctional activity in separable neurocognitive systems We would suggest that the hyper-responsive amygdala hypothesis is more likely to be linked to the explanation of GAD In contrast SAD may be due to reduced activation thresholds for units in a system that responds to social threat and which recruits lateral orbital frontal cortex Thus the current project will determine the performance of patients with GAD and SAD on measures in which the amygdala is known to play a role and also measures that recruit lateral orbital frontal cortex and the system for social response reversal In addition two proposed neuro-imaging studies will directly assess neural responses in these two systems in both patient populations The project should provide clear data that will constrain future theorizing on the pathology implicated in these two disorders
Although the high co-morbidity of Generalized Anxiety Disorder GAD and Social Anxiety Disorder SAD complicates the issue the fact that the disorders doubly dissociate suggests that they are due to dysfunctional activity in separable neurocognitive systems We would suggest that the hyper-responsive amygdala hypothesis is more likely to be linked to the explanation of GAD In contrast SAD may be due to reduced activation thresholds for units in a system that responds to social threat and which recruits lateral orbital frontal cortex Thus the current project will determine the performance of patients with GAD and SAD on measures in which the amygdala is known to play a role and also measures that recruit lateral orbital frontal cortex and the system for social response reversal In addition two proposed neuro-imaging studies will directly assess neural responses in these two systems in both patient populations The project should provide clear data that will constrain future theorizing on the pathology implicated in these two disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-M-0185 | None | None | None |