Ignite Creation Date:
2024-05-05 @ 11:32 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00071123
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2003-10-10
Brief Title:
Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Functional Neuroanatomy of Emotion Regulation in Major Depressive Disorder MDD
Status:
COMPLETED
Status Verified Date:
2010-11-15
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will evaluate emotional processing biases in the brain while viewing facial expressions in adults with current or remitted major depressive disorder and healthy volunteers
Detailed Description:
The goal of this research is to elucidate the neurophysiological abnormalities associated with processing emotionally valenced stimuli in MDD Neuroimaging technology has led to the identification of specific abnormalities in the amygdala ventral striatum and medial prefrontal cortex in response to affective pictures Much of the knowledge involving these structures in emotion processing has been elucidated through animal models including classical fear conditioning and reversal-learning paradigms Functional magnetic resonance imaging fMRI studies have applied similar techniques in humans to study emotional processing The amygdala has been shown to play a role in the learning of fear aversive conditioning to emotional stimuli the ventral striatum has been shown to play a role in appetitive conditioning and areas of the prefrontal cortex are recruited for extinction of conditioned responses These areas have also been implicated as key structures in the abnormal expression of emotion in MDD Dysregulation of connections between the amygdala and prefrontal cortex has been hypothesized to influence depressed subjects tendency to ruminate on emotional events and memories which may be associated with an inability to properly regulate emotional processing through habituation and extinction mechanisms Research suggests that depressed individuals have an impaired ability to disengage from or habituate to emotional stimuli perceived as sad
In addition to studying emotional processing at a conscious cortical level significant evidence suggests that many aspects of emotional processing occur below conscious awareness at a preconscious level The technique of backward masking assesses the automaticity of emotional processing and responses to affective stimuli In MDD backward masking serves to avoid confounding interpretation by the presence of other cognitive processing which may result from depressed subjects perseverating on emotional stimuli The proposed study builds on previous fMRI research to investigate neurophysiological differences in the processing of aversively conditioned emotional stimuli in depressed compared to healthy individuals Using fMRI technology and a variation of the paradigm developed by Morris et al subjects with MDD will be classically conditioned to the presence of an unmasked specific target face angry or sad and the subsequent neural responses to the stimuli will be assessed utilizing the backward masking technique The BOLD hemodynamic response and rates of habituation and extinction to the faces will be compared between depressed subjects with MDD and healthy controls currently depressed versus currently remitted subjects with MDD and MDD subjects pre- and post-antidepressant therapy
The present amendment proposes to include an additional paradigm in the testing battery This new paradigm has been extensively examined under different pharmacological manipulations and in healthy individuals undergoing fMRI but has yet to be examined in patient populations The task complements the paradigms presently included by extending the research to encompass appetitive as well as aversive emotional processing
This research will be used to evaluate neural processes involved in emotional dysregulation in MDD and may direct future research to potential therapeutic approaches for the treatment of mood and anxiety disorders with abnormalities in emotional processing
In addition to studying emotional processing at a conscious cortical level significant evidence suggests that many aspects of emotional processing occur below conscious awareness at a preconscious level The technique of backward masking assesses the automaticity of emotional processing and responses to affective stimuli In MDD backward masking serves to avoid confounding interpretation by the presence of other cognitive processing which may result from depressed subjects perseverating on emotional stimuli The proposed study builds on previous fMRI research to investigate neurophysiological differences in the processing of aversively conditioned emotional stimuli in depressed compared to healthy individuals Using fMRI technology and a variation of the paradigm developed by Morris et al subjects with MDD will be classically conditioned to the presence of an unmasked specific target face angry or sad and the subsequent neural responses to the stimuli will be assessed utilizing the backward masking technique The BOLD hemodynamic response and rates of habituation and extinction to the faces will be compared between depressed subjects with MDD and healthy controls currently depressed versus currently remitted subjects with MDD and MDD subjects pre- and post-antidepressant therapy
The present amendment proposes to include an additional paradigm in the testing battery This new paradigm has been extensively examined under different pharmacological manipulations and in healthy individuals undergoing fMRI but has yet to be examined in patient populations The task complements the paradigms presently included by extending the research to encompass appetitive as well as aversive emotional processing
This research will be used to evaluate neural processes involved in emotional dysregulation in MDD and may direct future research to potential therapeutic approaches for the treatment of mood and anxiety disorders with abnormalities in emotional processing
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-M-0002 | None | None | None |