Ignite Creation Date:
2024-05-06 @ 8:34 AM
Last Modification Date:
2024-10-26 @ 12:02 PM
Study NCT ID:
NCT02766959
Status:
COMPLETED
Last Update Posted:
2018-09-18
First Post:
2016-05-05
Brief Title:
Allele-specific Expression of a Bitter Taste Receptor
Sponsor:
Organization:
Monell Chemical Senses Center
Study Design
Study Type:
OBSERVATIONAL
Expanded Access Type Individual:
None
Expanded Access Type Intermediate:
None
Expanded Access Type Treatment:
None
Patient Registry:
False
Target Duration:
None
Design Allocation:
Design Intervention Model:
Design Intervention Model Description:
Design Masking Description:
Bio Spec Retention:
SAMPLES_WITH_DNA
Bio Spec Description:
In part one of the study each subject will provide a saliva sample DNA will be isolated purified and quantitated for alleles of TAS2R38 a bitter taste receptor gene Based on the results of the genetic screen 25 individuals with the heterozygous genotype will be invited to return for part two of the study In part two of the study subject will provide nasal epithelium and taste tissue in the form of fungiform papillae One half of each set of tissue will be placed in saline on ice in preparation for cell culture and assessment of AHL-induced defensive responses while the second half will be placed in RNA preservative for mRNA isolation
Enrollment Count:
57
Enrollment Type:
ACTUAL
Design Primary Purpose:
Design Masking:
Phases:
Observational Models:
| Name |
|---|
| Cohort |
Time Perspective List:
Clinical Trial Statuses
| Name |
|---|
| 34799 |
Who Masked List: