Ignite Creation Date:
2025-12-25 @ 1:26 AM
Ignite Modification Date:
2025-12-27 @ 11:17 PM
Study NCT ID:
NCT03193593
Status:
COMPLETED
Last Update Posted:
2019-01-25
First Post:
2017-06-19
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Study to Evaluate EB-001 in Reducing Musculoskeletal Pain
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D059352', 'term': 'Musculoskeletal Pain'}], 'ancestors': [{'id': 'D009135', 'term': 'Muscular Diseases'}, {'id': 'D009140', 'term': 'Musculoskeletal Diseases'}, {'id': 'D010146', 'term': 'Pain'}, {'id': 'D009461', 'term': 'Neurologic Manifestations'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'wajdie@bonti.com', 'phone': '9493796569', 'title': 'Wajdie Ahmad', 'organization': 'Bonti'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'timeFrame': '30 Days', 'eventGroups': [{'id': 'EG000', 'title': 'Placebo Injections', 'description': 'Placebo Injection into the Pectoralis Muscle', 'otherNumAtRisk': 18, 'deathsNumAtRisk': 18, 'otherNumAffected': 15, 'seriousNumAtRisk': 18, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'EB-001 Dose 1 (1X)', 'description': '1st Dose in escalation paradigm.\n\nInjection of active drug into the pectoralis muscle', 'otherNumAtRisk': 4, 'deathsNumAtRisk': 4, 'otherNumAffected': 3, 'seriousNumAtRisk': 4, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'EB-001 Dose 2 (1.6X)', 'description': '2nd Dose in escalation paradigm, 1.6X Dose 1.\n\nInjection of active drug into the pectoralis muscle.', 'otherNumAtRisk': 4, 'deathsNumAtRisk': 4, 'otherNumAffected': 4, 'seriousNumAtRisk': 4, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG003', 'title': 'EB-001 Dose 3 (3.3X)', 'description': '3rd Dose in escalation paradigm, 3.3X Dose 1.\n\nInjection of active drug into the pectoralis muscle.', 'otherNumAtRisk': 4, 'deathsNumAtRisk': 4, 'otherNumAffected': 4, 'seriousNumAtRisk': 4, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG004', 'title': 'EB-001 Dose 4 (6.7X)', 'description': '4th Dose in escalation paradigm, 6.7X Dose 1.\n\nInjection of active drug into the pectoralis muscle.', 'otherNumAtRisk': 8, 'deathsNumAtRisk': 8, 'otherNumAffected': 7, 'seriousNumAtRisk': 8, 'deathsNumAffected': 0, 'seriousNumAffected': 1}, {'id': 'EG005', 'title': 'EB-001 Dose 5 (10X)', 'description': '5th Dose in escalation paradigm, 10X Dose 1.\n\nInjection of active drug into the pectoralis muscle.', 'otherNumAtRisk': 16, 'deathsNumAtRisk': 16, 'otherNumAffected': 14, 'seriousNumAtRisk': 16, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG006', 'title': 'EB-001 Dose 6 (13.3X)', 'description': '6th Dose in escalation paradigm, 13.3X Dose 1.\n\nInjection of active drug into the pectoralis muscle.', 'otherNumAtRisk': 12, 'deathsNumAtRisk': 12, 'otherNumAffected': 8, 'seriousNumAtRisk': 12, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Nausea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 18, 'numEvents': 13, 'numAffected': 13}, {'groupId': 'EG001', 'numAtRisk': 4, 'numEvents': 3, 'numAffected': 3}, {'groupId': 'EG002', 'numAtRisk': 4, 'numEvents': 3, 'numAffected': 3}, {'groupId': 'EG003', 'numAtRisk': 4, 'numEvents': 4, 'numAffected': 4}, {'groupId': 'EG004', 'numAtRisk': 8, 'numEvents': 6, 'numAffected': 6}, {'groupId': 'EG005', 'numAtRisk': 16, 'numEvents': 14, 'numAffected': 14}, {'groupId': 'EG006', 'numAtRisk': 12, 'numEvents': 6, 'numAffected': 6}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Vomiting', 'stats': [{'groupId': 'EG000', 'numAtRisk': 18, 'numEvents': 5, 'numAffected': 5}, {'groupId': 'EG001', 'numAtRisk': 4, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 4, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 8, 'numEvents': 5, 'numAffected': 5}, {'groupId': 'EG005', 'numAtRisk': 16, 'numEvents': 6, 'numAffected': 6}, {'groupId': 'EG006', 'numAtRisk': 12, 'numEvents': 3, 'numAffected': 3}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Constipation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 18, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 8, 'numEvents': 3, 'numAffected': 3}, {'groupId': 'EG005', 'numAtRisk': 16, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG006', 'numAtRisk': 12, 'numEvents': 5, 'numAffected': 5}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Headache', 'stats': [{'groupId': 'EG000', 'numAtRisk': 18, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 4, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 8, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 16, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG006', 'numAtRisk': 12, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Back Pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 18, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG001', 'numAtRisk': 4, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 4, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 8, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 16, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 12, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Musculoskeletal and connective tissue disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Pruritis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 18, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 4, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG003', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 8, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 16, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 12, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Skin and subcutaneous tissue disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'seriousEvents': [{'term': 'Breast Hematoma', 'stats': [{'groupId': 'EG000', 'numAtRisk': 18, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 8, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 16, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 12, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Reproductive system and breast disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': "Subject's Assessment of Pain Using the Numeric Pain Rating Scale (AUC16h-96h)", 'denoms': [{'units': 'Participants', 'counts': [{'value': '18', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '4', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '16', 'groupId': 'OG005'}, {'value': '12', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo Injections', 'description': 'Placebo Injection into the Pectoralis Muscle'}, {'id': 'OG001', 'title': 'EB-001 Dose 1 (1X)', 'description': '1st Dose in escalation paradigm.\n\nInjection of active drug into the pectoralis muscle'}, {'id': 'OG002', 'title': 'EB-001 Dose 2 (1.6X)', 'description': '2nd Dose in escalation paradigm, 1.6X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}, {'id': 'OG003', 'title': 'EB-001 Dose 3 (3.3X)', 'description': '3rd Dose in escalation paradigm, 3.3X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}, {'id': 'OG004', 'title': 'EB-001 Dose 4 (6.7X)', 'description': '4th Dose in escalation paradigm, 6.7X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}, {'id': 'OG005', 'title': 'EB-001 Dose 5 (10X)', 'description': '5th Dose in escalation paradigm, 10X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}, {'id': 'OG006', 'title': 'EB-001 Dose 6 (13.3X)', 'description': '6th Dose in escalation paradigm, 13.3X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}], 'classes': [{'categories': [{'measurements': [{'value': '289.18', 'spread': '211.552', 'groupId': 'OG000'}, {'value': '341.78', 'spread': '124.655', 'groupId': 'OG001'}, {'value': '401.75', 'spread': '310.509', 'groupId': 'OG002'}, {'value': '290.55', 'spread': '224.966', 'groupId': 'OG003'}, {'value': '333.44', 'spread': '217.742', 'groupId': 'OG004'}, {'value': '381.82', 'spread': '199.401', 'groupId': 'OG005'}, {'value': '340.89', 'spread': '155.328', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': '16 hours to 96 hours following dosing', 'description': "Subject's assessment of pain using the Numeric Pain Rating Scale (1= No Pain, 10= Maximum Pain) for the first 96 hours following injection, expressed as AUC over the 16h to 96h period following dosing.", 'unitOfMeasure': 'units on a Scale*hours', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'mITT'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Placebo Injections', 'description': 'Placebo Injection into the Pectoralis Muscle'}, {'id': 'FG001', 'title': 'EB-001 Dose 1 (1X)', 'description': '1st Dose in escalation paradigm.\n\nInjection of active drug into the pectoralis muscle'}, {'id': 'FG002', 'title': 'EB-001 Dose 2 (1.6X)', 'description': '2nd Dose in escalation paradigm, 1.6X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}, {'id': 'FG003', 'title': 'EB-001 Dose 3 (3.3X)', 'description': '3rd Dose in escalation paradigm, 3.3X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}, {'id': 'FG004', 'title': 'EB-001 Dose 4 (6.7X)', 'description': '4th Dose in escalation paradigm, 6.7X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}, {'id': 'FG005', 'title': 'EB-001 Dose 5 (10X)', 'description': '5th Dose in escalation paradigm, 10X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}, {'id': 'FG006', 'title': 'EB-001 Dose 6 (13.3X)', 'description': '6th Dose in escalation paradigm, 13.3X Dose 1.\n\nInjection of active drug into the pectoralis muscle.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '18'}, {'groupId': 'FG001', 'numSubjects': '4'}, {'groupId': 'FG002', 'numSubjects': '4'}, {'groupId': 'FG003', 'numSubjects': '4'}, {'groupId': 'FG004', 'numSubjects': '8'}, {'groupId': 'FG005', 'numSubjects': '16'}, {'groupId': 'FG006', 'numSubjects': '12'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '14'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '3'}, {'groupId': 'FG003', 'numSubjects': '4'}, {'groupId': 'FG004', 'numSubjects': '7'}, {'groupId': 'FG005', 'numSubjects': '13'}, {'groupId': 'FG006', 'numSubjects': '8'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '4'}, {'groupId': 'FG001', 'numSubjects': '1'}, {'groupId': 'FG002', 'numSubjects': '1'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '1'}, {'groupId': 'FG005', 'numSubjects': '3'}, {'groupId': 'FG006', 'numSubjects': '4'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '18', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '4', 'groupId': 'BG002'}, {'value': '4', 'groupId': 'BG003'}, {'value': '8', 'groupId': 'BG004'}, {'value': '16', 'groupId': 'BG005'}, {'value': '12', 'groupId': 'BG006'}, {'value': '66', 'groupId': 'BG007'}]}], 'groups': [{'id': 'BG000', 'title': 'Placebo Injections', 'description': 'Placebo Injection into the Pectoralis Muscle'}, {'id': 'BG001', 'title': 'EB-001 Dose 1 (1X)', 'description': '1st Dose in escalation paradigm.\n\nSingle Injection of active drug into the pectoralis muscle'}, {'id': 'BG002', 'title': 'EB-001 Dose 2 (1.6X)', 'description': '2nd Dose in escalation paradigm, 1.6X Dose 1.\n\nSingle Injection of active drug into the pectoralis muscle.'}, {'id': 'BG003', 'title': 'EB-001 Dose 3 (3.3X)', 'description': '3rd Dose in escalation paradigm, 3.3X Dose 1.\n\nSingle Injection of active drug into the pectoralis muscle.'}, {'id': 'BG004', 'title': 'EB-001 Dose 4 (6.7X)', 'description': '4th Dose in escalation paradigm, 6.7X Dose 1.\n\nSingle Injection of active drug into the pectoralis muscle.'}, {'id': 'BG005', 'title': 'EB-001 Dose 5 (10X)', 'description': '5th Dose in escalation paradigm, 10X Dose 1.\n\nSingle Injection of active drug into the pectoralis muscle.'}, {'id': 'BG006', 'title': 'EB-001 Dose 6 (13.3X)', 'description': '6th Dose in escalation paradigm, 13.3X Dose 1.\n\nSingle Injection of active drug into the pectoralis muscle.'}, {'id': 'BG007', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '26.1', 'spread': '4.66', 'groupId': 'BG000'}, {'value': '29.5', 'spread': '4.36', 'groupId': 'BG001'}, {'value': '28.8', 'spread': '6.08', 'groupId': 'BG002'}, {'value': '27.0', 'spread': '3.37', 'groupId': 'BG003'}, {'value': '27.3', 'spread': '4.30', 'groupId': 'BG004'}, {'value': '27.3', 'spread': '3.14', 'groupId': 'BG005'}, {'value': '27.3', 'spread': '3.14', 'groupId': 'BG006'}, {'value': '27.6', 'spread': '3.61', 'groupId': 'BG007'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '18', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '4', 'groupId': 'BG002'}, {'value': '4', 'groupId': 'BG003'}, {'value': '8', 'groupId': 'BG004'}, {'value': '16', 'groupId': 'BG005'}, {'value': '12', 'groupId': 'BG006'}, {'value': '66', 'groupId': 'BG007'}]}, {'title': 'Male', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '0', 'groupId': 'BG007'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '0', 'groupId': 'BG007'}]}, {'title': 'Asian', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '1', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '2', 'groupId': 'BG007'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '0', 'groupId': 'BG007'}]}, {'title': 'Black or African American', 'measurements': [{'value': '7', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '1', 'groupId': 'BG003'}, {'value': '3', 'groupId': 'BG004'}, {'value': '1', 'groupId': 'BG005'}, {'value': '6', 'groupId': 'BG006'}, {'value': '21', 'groupId': 'BG007'}]}, {'title': 'White', 'measurements': [{'value': '10', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '3', 'groupId': 'BG003'}, {'value': '5', 'groupId': 'BG004'}, {'value': '14', 'groupId': 'BG005'}, {'value': '5', 'groupId': 'BG006'}, {'value': '42', 'groupId': 'BG007'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '1', 'groupId': 'BG006'}, {'value': '1', 'groupId': 'BG007'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '0', 'groupId': 'BG007'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'United States', 'categories': [{'measurements': [{'value': '18', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '4', 'groupId': 'BG002'}, {'value': '4', 'groupId': 'BG003'}, {'value': '8', 'groupId': 'BG004'}, {'value': '16', 'groupId': 'BG005'}, {'value': '12', 'groupId': 'BG006'}, {'value': '66', 'groupId': 'BG007'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}, {'title': 'BMI', 'classes': [{'categories': [{'measurements': [{'value': '22.57', 'spread': '2.596', 'groupId': 'BG000'}, {'value': '23.95', 'spread': '2.958', 'groupId': 'BG001'}, {'value': '23.00', 'spread': '3.614', 'groupId': 'BG002'}, {'value': '22.40', 'spread': '2.848', 'groupId': 'BG003'}, {'value': '22.66', 'spread': '2.630', 'groupId': 'BG004'}, {'value': '22.94', 'spread': '2.117', 'groupId': 'BG005'}, {'value': '23.18', 'spread': '2.474', 'groupId': 'BG006'}, {'value': '23.00', 'spread': '2.437', 'groupId': 'BG007'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'Kg/m^2', 'dispersionType': 'STANDARD_DEVIATION'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2018-01-04', 'size': 394470, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2018-10-12T10:24', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SEQUENTIAL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 66}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2017-08-29', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2019-01', 'completionDateStruct': {'date': '2018-08-07', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2019-01-23', 'studyFirstSubmitDate': '2017-06-19', 'resultsFirstSubmitDate': '2018-10-17', 'studyFirstSubmitQcDate': '2017-06-20', 'lastUpdatePostDateStruct': {'date': '2019-01-25', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2019-01-23', 'studyFirstPostDateStruct': {'date': '2017-06-21', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2019-01-25', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2018-04-26', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': "Subject's Assessment of Pain Using the Numeric Pain Rating Scale (AUC16h-96h)", 'timeFrame': '16 hours to 96 hours following dosing', 'description': "Subject's assessment of pain using the Numeric Pain Rating Scale (1= No Pain, 10= Maximum Pain) for the first 96 hours following injection, expressed as AUC over the 16h to 96h period following dosing."}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Musculoskeletal Pain']}, 'descriptionModule': {'briefSummary': 'To determine the safety and efficacy of single intra-operative treatment of EB-001 IM injections into the Pectoralis Major (PM) in subjects undergoing breast augmentation with subpectoral implants', 'detailedDescription': 'This study will evaluate the safety and efficacy of EB-001 in decreasing post-surgical pain in patients undergoing surgical breast augmentation with subpectoral placement of the implants. Intramuscular (IM) injection of EB-001 into the PM bilaterally during surgery may decrease pain related to stretching of the PM by the implants.\n\nThe safety objective is to determine the safety and tolerability of single intraoperative treatment of EB-001 IM injections into the PM in subjects undergoing breast augmentation with subpectoral implants.\n\nThe efficacy objective is to evaluate the efficacy of intraoperative administration of EB-001 IM into the PM in reducing the pain and use of rescue pain medications in subjects undergoing breast augmentation with subpectoral implants.'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['ADULT'], 'maximumAge': '55 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Women 18 to 55 years of age, inclusive\n2. Women who are in good health as determined by medical history, physical examination, clinical laboratory studies, ECGs, vital signs, and Investigator judgment\n3. Scheduled to undergo primary breast augmentation under general anesthesia (endotracheal or otherwise) with:\n\n 1. Sub-pectoral implants placement,\n 2. Infra-mammary surgical approach,\n 3. Implant size between 250 and 400cc and\n 4. Non-textured saline breast implants\n4. American Society of Anesthesiologist (ASA) Physical Class 1-2\n5. Women of non-childbearing potential or postmenopausal (at least 12 consecutive months of amenorrhea)\n6. Women of childbearing potential must not be pregnant, lactating, or planning to become pregnant during the study\n7. Women of childbearing potential agreeing to use either:\n\n 1. a highly effective method of contraception with failures rates less than 1% per year such as implant, intrauterine device (IUD), or confirmed sterilization and sterilization procedure at least 3 months prior to the day of dosing\n 2. dual methods of contraception with overall failures rate less than 1% per year such as injectable, pill, patch, ring, and diaphragm from the day of dosing for 3 months (subjects using oral contraception must have initiated treatment at least 2 months prior to the day of dosing)\n8. Willing and able to complete protocol requirements and instructions, which includes completion of all required visits, procedures and in-clinic stays until the end of the study\n9. Willing and able to sign and date IRB-approved informed consent\n10. Able to speak, read, and understand the language of the informed consent form (ICF) and study questionnaires\n\nExclusion Criteria:\n\n1. History of surgical procedure involving the breast, including, but not limited to, breast augmentation. History of minor localized breast biopsy is not exclusionary if it occurred at least 1 year prior to the screening visit, and if considered not clinically significant in the opinion of the investigator.\n2. Pre-existing lung disease that could impact subject safety in the opinion of the investigator\n3. History of smoking within the past two years\n4. Slow vital capacity that is below 80% of normal value for respective race, age, height, and gender\n5. Pulse oximetry below 95%\n6. Body weight less than 50 kg (110 pounds) or a Body Mass Index (BMI) of ≥ 32\n7. Documented diagnosis of chronic pain condition, or other painful pre-operative condition that, in the opinion of the investigator, may require analgesic treatment in the post-operative period (e.g. significant joint pain, neuropathic pain)\n8. Known hypersensitivity to any botulinum toxin serotype or to any component of the formulation\n9. Reported use of any botulinum toxin within 3 months prior to the date of surgery\n10. Anticipated use of any botulinum toxin of any serotype during the study\n11. Use of long acting opioids within 3 days or any opioid medication within 24 hours prior to surgery\n12. Aminoglycoside intake within 48 hours prior to or during surgery\n13. Pre-existing disorders of the neuromuscular junction (myasthenia gravis, Eaton- Lambert syndrome, or amyotrophic lateral Sclerosis)\n14. Any past or current medical condition that in opinion of investigator, puts subject at undue safety risk for surgical complications or for use of the investigational product.\n15. Any clinically significant psychiatric condition that, in opinion of investigator, may interfere with study assessments or protocol compliance\n16. History of alcohol or drug abuse in the last 3 years, based on investigator judgement\n17. Current enrollment in an investigational drug or device study or participation in such a study within 30 days or 5 half-lives of the drug, whichever is longer, of entry into this study\n18. Subject plans to donate blood or plasma from 30 days prior to screening until last follow-up visit (Day 29)\n19. Reported pain score of 2 or more at screening on the 11-point scale NPRS-A following strength testing with PM activation'}, 'identificationModule': {'nctId': 'NCT03193593', 'briefTitle': 'Study to Evaluate EB-001 in Reducing Musculoskeletal Pain', 'organization': {'class': 'INDUSTRY', 'fullName': 'Bonti, Inc.'}, 'officialTitle': 'Phase 2 Placebo-Controlled, Double Blind, Ascending Dose Cohort Study to Evaluate Safety and Efficacy of EB-001 IM Injections in Reducing Musculoskeletal Pain in Subjects Undergoing Elective Augmentation Mammoplasty (Breast Augmentation)', 'orgStudyIdInfo': {'id': 'EB001-MA201'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo Injections', 'description': 'Intervention: Drug: Placebo\n\nSingle Saline Injection into the Pectoralis Muscle', 'interventionNames': ['Drug: Placebo']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'EB-001 Dose 1', 'description': 'Intervention: Drug: EB-001\n\n1st Dose in escalation paradigm. Single Injection of active drug into the pectoralis muscle', 'interventionNames': ['Drug: EB-001']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'EB-001 Dose 2 (1.6X)', 'description': 'Intervention: Drug: EB-001\n\n2nd Dose in escalation paradigm, 1.6X Dose 1. Single Injection of active drug into the pectoralis muscle', 'interventionNames': ['Drug: EB-001']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'EB-001 Dose 3 (3.3X)', 'description': 'Intervention: Drug: EB-001\n\n3rd Dose in escalation paradigm, 3.3X Dose 1. Single Injection of active drug into the pectoralis muscle', 'interventionNames': ['Drug: EB-001']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'EB-001 Dose 4 (6.7X)', 'description': 'Intervention: Drug: EB-001\n\n4th Dose in escalation paradigm, 6.7X Dose 1. Single Injection of active drug into the pectoralis muscle', 'interventionNames': ['Drug: EB-001']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'EB-001 Dose 5 (10X)', 'description': 'Intervention: Drug: EB-001\n\n5th Dose in escalation paradigm, 10X Dose 1. Single Injection of active drug into the pectoralis muscle', 'interventionNames': ['Drug: EB-001']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'EB-001 Dose 6 (13.3X)', 'description': 'Intervention: Drug: EB-001\n\n6th Dose in escalation paradigm, 13.3X Dose 1. Single Injection of active drug into the pectoralis muscle', 'interventionNames': ['Drug: EB-001']}], 'interventions': [{'name': 'Placebo', 'type': 'DRUG', 'description': 'Placebo- Single injection of saline into Pectoralis Muscle', 'armGroupLabels': ['Placebo Injections']}, {'name': 'EB-001', 'type': 'DRUG', 'description': 'Single injection of EB-001 into Pectoralis Muscle', 'armGroupLabels': ['EB-001 Dose 1', 'EB-001 Dose 2 (1.6X)', 'EB-001 Dose 3 (3.3X)', 'EB-001 Dose 4 (6.7X)', 'EB-001 Dose 5 (10X)', 'EB-001 Dose 6 (13.3X)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '91105', 'city': 'Pasadena', 'state': 'California', 'country': 'United States', 'facility': 'Lotus Clinical Research', 'geoPoint': {'lat': 34.14778, 'lon': -118.14452}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Bonti, Inc.', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}