Ignite Creation Date:
2025-12-25 @ 2:19 AM
Ignite Modification Date:
2026-01-07 @ 8:13 AM
Study NCT ID:
NCT05436834
Status:
COMPLETED
Last Update Posted:
2025-11-26
First Post:
2022-06-27
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study to Evaluate the Safety and Immunogenicity of the mRNA COVID-19 Vaccines in Healthy Children Between 6 Months to Less Than 6 Years of Age
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000086382', 'term': 'COVID-19'}], 'ancestors': [{'id': 'D011024', 'term': 'Pneumonia, Viral'}, {'id': 'D011014', 'term': 'Pneumonia'}, {'id': 'D012141', 'term': 'Respiratory Tract Infections'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D014777', 'term': 'Virus Diseases'}, {'id': 'D018352', 'term': 'Coronavirus Infections'}, {'id': 'D003333', 'term': 'Coronaviridae Infections'}, {'id': 'D030341', 'term': 'Nidovirales Infections'}, {'id': 'D012327', 'term': 'RNA Virus Infections'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000722752', 'term': 'mRNA-1273.214 COVID-19 vaccine'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'SEQUENTIAL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1807}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2022-06-21', 'type': 'ACTUAL'}, 'statusVerifiedDate': '2025-11', 'completionDateStruct': {'date': '2025-10-20', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-11-25', 'studyFirstSubmitDate': '2022-06-27', 'studyFirstSubmitQcDate': '2022-06-27', 'lastUpdatePostDateStruct': {'date': '2025-11-26', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2022-06-29', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2025-10-20', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Number of Participants with Solicited Local and Systemic Adverse Reactions (ARs)', 'timeFrame': 'Up to Day 8 (7 days post-vaccination)'}, {'measure': 'Number of Participants with Unsolicited Adverse Events (AEs)', 'timeFrame': 'Up to Day 29 (28 days after each injection)'}, {'measure': 'Number of Participants with Medically-Attended AEs (MAAEs)', 'timeFrame': 'Up to Day 394 (12 months after last dose)'}, {'measure': 'Number of Participants with Serious AEs (SAEs)', 'timeFrame': 'Up to Day 394 (12 months after last dose)'}, {'measure': 'Number of Participants with Adverse Events of Special Interest (AESI)', 'timeFrame': 'Up to Day 394 (12 months after last dose)'}, {'measure': 'Number of Participants with AEs Leading to Withdrawal', 'timeFrame': 'Up to Day 394 (12 months after last dose)'}, {'measure': 'Geometric Mean (GM) of the Serum Antibody (Ab) Level against Omicron BA.1 and Ancestral SARS-CoV-2 after mRNA-1273.214 Administration at Day 57', 'timeFrame': 'Day 57'}, {'measure': 'GM of the Serum Ab Level against Omicron BA.1 and Ancestral SARS-CoV-2 after mRNA-1273.214 Administration at Day 29', 'timeFrame': 'Day 29'}, {'measure': 'Seroresponse Rate (SRR) against Omicron BA.1 and Ancestral SARS-CoV-2 after mRNA-1273.214 Administration', 'timeFrame': 'Day 29'}, {'measure': 'GM of the Serum Ab Level against Omicron XBB.1.5 after mRNA-1273.815 Administration', 'timeFrame': 'Up to Day 57'}], 'secondaryOutcomes': [{'measure': 'SRR against Omicron BA.1 and Ancestral SARS-CoV-2 after mRNA-1273.214 Administration Regardless of prior SARS-CoV-2 Infection', 'timeFrame': 'Day 57'}, {'measure': 'GM of the Serum Ab Level against Omicron XBB.1.5 after mRNA-1273.815 Administration Regardless of prior SARS-CoV-2 Infection', 'timeFrame': 'Up to Day 57'}, {'measure': 'SRR against Omicron XBB.1.5 after mRNA-1273.815 Administration Regardless of prior SARS-CoV-2 Infection', 'timeFrame': 'Up to Day 57'}]}, 'oversightModule': {'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Coronavirus disease 2019', 'COVID-19'], 'conditions': ['SARS-CoV-2']}, 'referencesModule': {'references': [{'pmid': '38518789', 'type': 'DERIVED', 'citation': 'Dixit A, Bennett R, Ali K, Griffin C, Clifford RA, Turner M, Poston R, Hautzinger K, Yeakey A, Girard B, Zhou W, Deng W, Zhou H, Schnyder Ghamloush S, Kuter BJ, Slobod K, Miller JM, Priddy F, Das R; ROVER Study Investigators. Interim safety and immunogenicity of COVID-19 omicron BA.1 variant-containing vaccine in children in the USA: an open-label non-randomised phase 3 trial. Lancet Infect Dis. 2024 Jul;24(7):687-697. doi: 10.1016/S1473-3099(24)00101-4. Epub 2024 Mar 19.'}]}, 'descriptionModule': {'briefSummary': 'This study will evaluate the safety and immunogenicity of the mRNA-1273.214 vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concerns (VOCs) in participants aged 6 months to \\<6 years, when administered as a primary series in SARS-CoV-2 vaccine-naïve participants (Part 1) and a single booster dose (BD) given to participants who previously received 2 doses of the mRNA-1273 vaccine as a primary series (Part 2); and will evaluate the safety and immunogenicity of the mRNA-1273.815 vaccine, when administered as a BD in participants aged 6 months to \\<6 years (Part 3) and when administered to SARS-CoV-2 vaccine-naïve participants aged 2 years to \\<5 years of age (Part 4).', 'detailedDescription': 'Part 1 will enroll participants aged 6 months to \\<6 years who have not been previously vaccinated against SARS-CoV-2. Participants will receive 2 doses of the mRNA-1273.214 vaccine.\n\nPart 2 will enroll participants aged 6 months to \\<6 years who have previously been vaccinated with a mRNA-1273 primary series in Study mRNA-1273-P204 (NCT04796896). Participants will receive a single BD of the mRNA-1273.214 vaccine, at least 4 months after completion of the mRNA-1273 primary series.\n\nPart 3 will enroll participants aged 6 months to \\<6 years who have previously been vaccinated with an authorized/approved COVID-19 vaccine. Participants will receive a BD of the mRNA-1273.815 vaccine at least 4 months after the last receipt of a COVID-19 vaccine.\n\nPart 4 will evaluate mRNA-1273.815 vaccine administered as a single dose to SARS-CoV-2 vaccine-naïve participants aged 2 years to \\<5 years of age enrolled in Cohort A (Part 4A), compared to 2 doses given to SARS-CoV-2 vaccine-naïve participants aged 6 months to \\<2 years enrolled in Cohort B (Part 4B).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD'], 'maximumAge': '5 Years', 'minimumAge': '6 Months', 'healthyVolunteers': True, 'eligibilityCriteria': "Inclusion Criteria:\n\n* The participant is 6 months to \\<6 years for Parts 1, 2, and 3; 2 years to \\<5 years for Part 4A; and 6 months to \\<2 years for Part 4B at the time of consent (Screening Visit). Note: for Part 1, participant must be at least 6 months old and must not have reached 6 years of age at the time of administration of first dose. For Part 4B, the participant must be at least 6 months old and must not have reached 2 years of age at the time of administration of first dose.\n* If the participant has a chronic disease (that is, asthma, diabetes mellitus, cystic fibrosis, human immunodeficiency virus \\[HIV\\] infection), the disease should be stable, per investigator assessment, so that the participant can be considered eligible for inclusion. Stable diseases are those which have had no change in their status or in the medications required to control them in the 6 months prior to Screening Visit. Note: a change in medication for dose optimization (that is, insulin dose changes, adjustments for age-related weight gain), change within class of medication, or reduction in dose are not considered signs of instability.\n* In the investigator's opinion, the parent(s)/legally authorized representative(s) (LAR\\[s\\]) understand and are willing and physically able to comply with protocol-mandated follow-up, including all procedures and provide written informed consent.\n* The participant is 2 years or older and has a body mass index (BMI) at or above the second percentile according to World Health Organization (WHO) Child Growth Standards at the Screening Visit.\n\nOR\n\n* The participant is less than 2 years of age and the participant's height and weight are both at or above the second percentile according to WHO Child Growth Standards at the Screening Visit.\n\nSpecial inclusion criteria for participants aged 6 months to \\< 12 months:\n\n* The participant was born at full-term (≥ 37 weeks gestation) with a minimum birth weight of 2.5 kilograms (kg).\n\nInclusion criteria for Part 2:\n\n* The participant must have received 2 doses of mRNA-1273, approximately 28 to 35 days apart, as 25-μg primary series, and second dose was given at least 4 months prior to enrollment.\n\nInclusion criteria for Part 3 only:\n\n\\- The participant must have received an age-appropriate immunization series of an authorized/approved COVID-19 vaccine, with the last dose given at least 4 months prior to enrolment (Previous vaccines NOT allowed are: XBB.1.5-containing formulation).\n\nExclusion Criteria:\n\n* Has a known history of SARS-CoV-2 infection (that is, reported AE of COVID-19 or asymptomatic SARS-CoV-2 infection during Study mRNA-1273-P204 at the time of rollover into mRNA-1273-P306 or during Part 1 at the time of rollover into Part 3) in the 90 days prior to dosing in this study.\n* Is acutely ill or febrile 24 hours prior to or at the Screening Visit. Fever is defined as a body temperature ≥ 38.0°Celsius (C)/≥ 100.4°Fahrenheit (F). Participants who meet this criterion may have visits rescheduled within the relevant study visit windows. Afebrile participants with minor illnesses can be enrolled at the discretion of the investigator.\n* For Parts 1 and 4, participant has previously been administered an investigational or approved CoV (that is, SARS-CoV-2, SARS-CoV, Middle East respiratory syndrome coronavirus \\[MERS-CoV\\]) vaccine. For Part 2, participant who received any approved/investigational CoV vaccine are ineligible to participate except for those who received mRNA-1273 (prototype) vaccine.\n* Has undergone treatment with investigational or approved agents for prophylaxis against COVID-19 (including receipt of SARS-CoV-2 monoclonal antibodies for prophylaxis or treatment) within 90 days prior to enrollment.\n* Has a known hypersensitivity to a component of the vaccine or its excipients. Hypersensitivity includes, but is not limited to, anaphylaxis or immediate allergic reaction of any severity to a previous dose of an mRNA COVID-19 vaccine or any of its components (including polyethylene glycol \\[PEG\\] or immediate allergic reaction of any severity to polysorbate).\n* Has a medical or psychiatric condition that, according to the investigator's judgment, may pose additional risk as a result of participation, interfere with safety assessments, or interfere with interpretation of results.\n* Has a history of diagnosis or condition that, in the judgment of the investigator, may affect study endpoint assessment or compromise participant safety, specifically the following:\n\n * Congenital or acquired immunodeficiency, other than well-controlled HIV infection.\n * Chronic hepatitis or suspected active hepatitis\n * A bleeding disorder that is considered a contraindication to IM injection or phlebotomy\n * Dermatologic conditions that could affect local solicited AR assessments\n * Any prior diagnosis of malignancy (excluding nonmelanoma skin cancer)\n* Has received the following:\n\n * Any routine vaccination with inactivated or live vaccine(s) within 14 days prior to study vaccination or plans to receive such a vaccine through 14 days following study vaccination.\n\nNote: This excludes influenza vaccine that may be given anytime, but ideally at least 7 days before study dose. If a participant receives an influenza vaccine, this should be captured within the concomitant medication electronic case report form (eCRF).\n\n* Systemic immunosuppressants or immune-modifying drugs for \\>14 days in total within 6 months prior to the day of enrollment (for corticosteroids, ≥1 milligrams (mg)/kg/day or ≥ 10 mg/day prednisone equivalent, if participant weighs \\>10 kg). Participants may have visits rescheduled for enrollment if they no longer meet this criterion within the Screening Visit window. Inhaled, nasal, and topical steroids, and palivizumab are allowed.\n* Intravenous (IV) or subcutaneous (SC) blood products (red cells, platelets, immunoglobulins) within 3 months prior to enrollment.\n\nNote: Other inclusion and exclusion criteria may apply."}, 'identificationModule': {'nctId': 'NCT05436834', 'briefTitle': 'A Study to Evaluate the Safety and Immunogenicity of the mRNA COVID-19 Vaccines in Healthy Children Between 6 Months to Less Than 6 Years of Age', 'organization': {'class': 'INDUSTRY', 'fullName': 'ModernaTX, Inc.'}, 'officialTitle': 'An Open-Label, Phase 3 Study to Evaluate the Safety and Immunogenicity of mRNA Vaccines for SARS-CoV-2 Variants in Participants Aged 6 Months to < 6 Years', 'orgStudyIdInfo': {'id': 'mRNA-1273-P306'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'mRNA-1273.214 (Part 1)', 'description': 'Participants who have not been previously vaccinated against SARS-CoV-2, will receive 2 intramuscular (IM) injections of mRNA-1273.214 vaccine on Day 1 and Day 29.', 'interventionNames': ['Biological: mRNA-1273.214']}, {'type': 'EXPERIMENTAL', 'label': 'mRNA-1273.214 (Part 2)', 'description': 'Participants who have previously been vaccinated with a mRNA-1273 primary series, will receive a single IM BD of mRNA-1273.214 vaccine at least 4 months after completion of the mRNA-1273 primary series.', 'interventionNames': ['Biological: mRNA-1273.214']}, {'type': 'EXPERIMENTAL', 'label': 'mRNA-1273.815 (Part 3)', 'description': 'Participants who have previously been vaccinated with an authorized/approved COVID-19 vaccine, will receive a single IM BD of mRNA-1273.815 vaccine on BD Day 1, at least 4 months after the last dose of a COVID-19 vaccine.', 'interventionNames': ['Biological: mRNA-1273.815']}, {'type': 'EXPERIMENTAL', 'label': 'mRNA-1273.815 (Part 4)', 'description': 'Participants in Part 4 Cohort A will receive a single IM injection of mRNA-1273.815 vaccine on Day 1. Participants in Part 4 Cohort B will receive IM injections of mRNA-1273.815 vaccine on Day 1 and Day 29.', 'interventionNames': ['Biological: mRNA-1273.815']}], 'interventions': [{'name': 'mRNA-1273.214', 'type': 'BIOLOGICAL', 'description': 'Sterile liquid for injection', 'armGroupLabels': ['mRNA-1273.214 (Part 1)', 'mRNA-1273.214 (Part 2)']}, {'name': 'mRNA-1273.815', 'type': 'BIOLOGICAL', 'description': 'Sterile liquid for injection', 'armGroupLabels': ['mRNA-1273.815 (Part 3)', 'mRNA-1273.815 (Part 4)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '34020', 'city': 'Bessemer', 'state': 'Alabama', 'country': 'United States', 'facility': 'Trinity Clinical Research, LLC', 'geoPoint': {'lat': 33.40178, 'lon': -86.95444}}, {'zip': '92220', 'city': 'Banning', 'state': 'California', 'country': 'United States', 'facility': 'Velcocity Clinical Research', 'geoPoint': {'lat': 33.92557, 'lon': -116.87641}}, {'zip': '90640', 'city': 'Montebello', 'state': 'California', 'country': 'United States', 'facility': 'Sera Collection Research Services', 'geoPoint': {'lat': 34.00946, 'lon': -118.10535}}, {'zip': '90723', 'city': 'Paramount', 'state': 'California', 'country': 'United States', 'facility': 'Center For Clinical Trials LLC -Paramount', 'geoPoint': {'lat': 33.88946, 'lon': -118.15979}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'country': 'United States', 'facility': 'University of Colorado', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '20016', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'Meridian Clinical Research', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '33166', 'city': 'Doral', 'state': 'Florida', 'country': 'United States', 'facility': 'Prohealth Research Center', 'geoPoint': {'lat': 25.81954, 'lon': -80.35533}}, {'zip': '32209', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'University of Florida Jacksonville', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '34741', 'city': 'Kissimmee', 'state': 'Florida', 'country': 'United States', 'facility': 'Kissimmee Clinical Research', 'geoPoint': {'lat': 28.30468, 'lon': -81.41667}}, {'zip': '33125', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Med-Care Research', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33612', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'University of South Florida', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '30030', 'city': 'Decatur', 'state': 'Georgia', 'country': 'United States', 'facility': 'IResearch', 'geoPoint': {'lat': 33.77483, 'lon': -84.29631}}, {'zip': '31210', 'city': 'Macon', 'state': 'Georgia', 'country': 'United States', 'facility': 'Meridian Clinical Research', 'geoPoint': {'lat': 32.84069, 'lon': -83.6324}}, {'zip': '83642', 'city': 'Meridian', 'state': 'Idaho', 'country': 'United States', 'facility': 'Velcocity Clinical Research', 'geoPoint': {'lat': 43.61211, 'lon': -116.39151}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'Lurie Childrens Hospital', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '66210', 'city': 'Overland Park', 'state': 'Kansas', 'country': 'United States', 'facility': 'Meridian Clinical Research', 'geoPoint': {'lat': 38.98223, 'lon': -94.67079}}, {'zip': '40517', 'city': 'Lexington', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Michael W. Simon MD, PSC', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40536', 'city': 'Lexington', 'state': 'Kentucky', 'country': 'United States', 'facility': 'University of Kentucky', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '70508', 'city': 'Lafayette', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Velocity Clinical Research - Lafayette - PPDS', 'geoPoint': {'lat': 30.22409, 'lon': -92.01984}}, {'zip': '70006', 'city': 'Metairie', 'state': 'Louisiana', 'country': 'United States', 'facility': 'MedPharmics', 'geoPoint': {'lat': 29.98409, 'lon': -90.15285}}, {'zip': '70006', 'city': 'Metairie', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Velocity Clinical Research - Covington - PPDS', 'geoPoint': {'lat': 29.98409, 'lon': -90.15285}}, {'zip': '55402', 'city': 'Minneapolis', 'state': 'Minnesota', 'country': 'United States', 'facility': 'Clinical Research Institute', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '65212', 'city': 'Columbia', 'state': 'Missouri', 'country': 'United States', 'facility': 'University of Missouri Health Care', 'geoPoint': {'lat': 38.95171, 'lon': -92.33407}}, {'zip': '68901', 'city': 'Hastings', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Meridian Clinical Research', 'geoPoint': {'lat': 40.58612, 'lon': -98.38839}}, {'zip': '68510', 'city': 'Lincoln', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Meridian Clinical Research', 'geoPoint': {'lat': 40.8, 'lon': -96.66696}}, {'zip': '68516', 'city': 'Lincoln', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Be Well Clinical Studies, LLC - Lincoln - ERN - PPDS', 'geoPoint': {'lat': 40.8, 'lon': -96.66696}}, {'zip': '68114', 'city': 'Omaha', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Quality Clinical Research', 'geoPoint': {'lat': 41.25626, 'lon': -95.94043}}, {'zip': '87102', 'city': 'Albuquerque', 'state': 'New Mexico', 'country': 'United States', 'facility': 'Velocity Clinical Research', 'geoPoint': {'lat': 35.08449, 'lon': -106.65114}}, {'zip': '13901', 'city': 'Binghamton', 'state': 'New York', 'country': 'United States', 'facility': 'Meridian Clinical Research', 'geoPoint': {'lat': 42.09869, 'lon': -75.91797}}, {'zip': '14051', 'city': 'East Amherst', 'state': 'New York', 'country': 'United States', 'facility': 'WellNow Urgent Care Clinical Research', 'geoPoint': {'lat': 43.01839, 'lon': -78.6967}}, {'zip': '13057', 'city': 'East Syracuse', 'state': 'New York', 'country': 'United States', 'facility': 'Child Healthcare Associates - East Syracuse', 'geoPoint': {'lat': 43.06534, 'lon': -76.07853}}, {'zip': '73112', 'city': 'Oklahoma City', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Lynn Health Science Institute', 'geoPoint': {'lat': 35.46756, 'lon': -97.51643}}, {'zip': '02818', 'city': 'East Greenwich', 'state': 'Rhode Island', 'country': 'United States', 'facility': 'Velcocity Clinical Research', 'geoPoint': {'lat': 41.66038, 'lon': -71.45589}}, {'zip': '29414', 'city': 'Charleston', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Coastal Pediatric Associates', 'geoPoint': {'lat': 32.77632, 'lon': -79.93275}}, {'zip': '29414', 'city': 'Charleston', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Meridian Clinical Research', 'geoPoint': {'lat': 32.77632, 'lon': -79.93275}}, {'zip': '29425', 'city': 'Charleston', 'state': 'South Carolina', 'country': 'United States', 'facility': 'MUSC', 'geoPoint': {'lat': 32.77632, 'lon': -79.93275}}, {'zip': '38105', 'city': 'Memphis', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Le Bonheur Childrens Hospital', 'geoPoint': {'lat': 35.14953, 'lon': -90.04898}}, {'zip': '78759', 'city': 'Austin', 'state': 'Texas', 'country': 'United States', 'facility': 'Velocity Clinical Research Austin', 'geoPoint': {'lat': 30.26715, 'lon': -97.74306}}, {'zip': '77701-3739', 'city': 'Beaumont', 'state': 'Texas', 'country': 'United States', 'facility': 'REX Clinical Trials, LLC Beaumont', 'geoPoint': {'lat': 30.08605, 'lon': -94.10185}}, {'zip': '78613', 'city': 'Cedar Park', 'state': 'Texas', 'country': 'United States', 'facility': 'Velcocity Clinical Research', 'geoPoint': {'lat': 30.5052, 'lon': -97.82029}}, {'zip': '78539', 'city': 'Edinburg', 'state': 'Texas', 'country': 'United States', 'facility': 'BRCR Global Texas', 'geoPoint': {'lat': 26.30174, 'lon': -98.16334}}, {'zip': '75033', 'city': 'Frisco', 'state': 'Texas', 'country': 'United States', 'facility': 'Village Health Partners - Frisco Medical Village', 'geoPoint': {'lat': 33.15067, 'lon': -96.82361}}, {'zip': '77008', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Ventavia Research Group', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77065', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Cyfair Clinical Reseach Center', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77081', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Texas Center for Drug Development', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77901', 'city': 'Victoria', 'state': 'Texas', 'country': 'United States', 'facility': 'Victoria Clinical Research Group', 'geoPoint': {'lat': 28.80527, 'lon': -97.0036}}, {'zip': '22015', 'city': 'Burke', 'state': 'Virginia', 'country': 'United States', 'facility': 'PI Coor Clinical Research LLC', 'geoPoint': {'lat': 38.79345, 'lon': -77.27165}}, {'zip': '23226', 'city': 'Richmond', 'state': 'Virginia', 'country': 'United States', 'facility': 'Clinical Research Partners', 'geoPoint': {'lat': 37.55376, 'lon': -77.46026}}, {'zip': 'C1430CKE', 'city': 'CABA', 'state': 'Buenos Aires F.D.', 'country': 'Argentina', 'facility': 'AES - AS - Glenny Corp. 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