Ignite Creation Date:
2025-12-25 @ 3:08 AM
Ignite Modification Date:
2025-12-26 @ 1:47 AM
Study NCT ID:
NCT05138133
Status:
RECRUITING
Last Update Posted:
2025-12-18
First Post:
2021-11-17
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D008181', 'term': 'Lupus Nephritis'}, {'id': 'D008180', 'term': 'Lupus Erythematosus, Systemic'}], 'ancestors': [{'id': 'D005921', 'term': 'Glomerulonephritis'}, {'id': 'D009393', 'term': 'Nephritis'}, {'id': 'D007674', 'term': 'Kidney Diseases'}, {'id': 'D014570', 'term': 'Urologic Diseases'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}, {'id': 'D003240', 'term': 'Connective Tissue Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D001327', 'term': 'Autoimmune Diseases'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C582345', 'term': 'anifrolumab'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR'], 'maskingDescription': 'Double Blind (Participant, Care Provider and Investigator)'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 360}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2022-02-15', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-12-05', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-16', 'studyFirstSubmitDate': '2021-11-17', 'studyFirstSubmitQcDate': '2021-11-17', 'lastUpdatePostDateStruct': {'date': '2025-12-18', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2021-11-30', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-02-26', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Difference in proportion of participants with CRR (Complete Renal Response) in anifrolumab group compared with placebo group', 'timeFrame': 'Week 52', 'description': 'CRR is defined as:\n\n* UPCR ≤ 0.5 mg/mg\n* eGFR ≥ 60 mL/min/1.73 m2 or no decrease from baseline of ≥ 20%'}], 'secondaryOutcomes': [{'measure': 'Difference in proportion of participants achieving sustained OCS reduction in anifrolumab group compared with placebo group', 'timeFrame': 'from Week 24 through Week 52', 'description': 'Sustained OCS reduction'}, {'measure': 'HR of achieving sustained CRR in anifrolumab compared with placebo group', 'timeFrame': 'baseline through Week 52', 'description': 'The endpoint for deriving the summary measure is time to sustained CRR, defined as time to achieving CRR that is sustained from that time point through week 52'}, {'measure': 'Difference in the mean standardized AUC for UPCR between anifrolumab and placebo participants', 'timeFrame': 'baseline through Week 52', 'description': 'Proteinuria as measured by the cumulative UPCR'}, {'measure': 'Difference in proportion of participants with CRR in anifrolumab group compared with placebo group', 'timeFrame': 'Week 24', 'description': 'CRR at week 24'}, {'measure': 'HR to summarize the difference in the risk of hazard of renal-related event or death at any given time between anifrolumab and placebo participants', 'timeFrame': 'Through Week 52', 'description': 'Onset of renal-related event or death through Week 52'}, {'measure': 'HR to summarize the difference in the risk of hazard of renal-related event or death at any given time between anifrolumab and placebo participants', 'timeFrame': 'Through Week 76', 'description': 'Onset of renal-related event or death through Week 76'}, {'measure': 'Difference between anifrolumab and placebo in proportions of participants who achieve aCRR', 'timeFrame': 'Week 52', 'description': 'aCRR (alternative complete renal response) defined as;\n\n* UPCR ≤ 0.5 mg/mg\n* eGFR ≥ 90 mL/min/1.73 m2 or no decrease from baseline of ≥ 10%'}, {'measure': 'Difference between anifrolumab and placebo in proportions of participants who achieve CRR with sustained OCS reduction', 'timeFrame': 'Week 52', 'description': 'CRR at Week 52 with Sustained OCS Reduction'}, {'measure': 'HR of achieving sustained CRR in anifrolumab compared to placebo group', 'timeFrame': 'Through week 76', 'description': 'Time to sustained CRR through the time frame period'}, {'measure': 'HR of achieving 50% reduction in UPCR in anifrolumab compared to placebo group', 'timeFrame': 'Through Week 52', 'description': 'The endpoint for deriving the summary measure is time from the first dose of study intervention to achieving 50% reduction in UPCR'}, {'measure': 'Difference in mean UPCR between the anifrolumab and placebo group', 'timeFrame': 'Week 52', 'description': 'Proteinuria as measured by UPCR'}, {'measure': 'Difference in proportion of participants achieving PRR (Partial Renal Response) in anifrolumab group compared with placebo group', 'timeFrame': 'Week 52', 'description': 'PRR defined as:\n\nUPCR \\<1.0 mg/mg (for participants with baseline UPCR ≤3 mg/mg) or \\>50% improvement and ≤3 mg/mg (for participants with baseline UPCR \\>3 mg/mg) eGFR\n\n≥ 60 mL/min/1.73 m2 or no confirmed decrease of ≥20% from baseline'}, {'measure': 'Difference in change from baseline in extra-renal SLEDAI-2K total score', 'timeFrame': 'Through Week 76', 'description': 'The extra-renal SLEDAI-2K score is obtained by summing the SLEDAI-2K items without including the items within the renal system organ'}, {'measure': 'Difference in mean change from baseline in domains and component scores of Short Form-36 Version 2 (SF-36v2) and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-fatigue) total score', 'timeFrame': 'Week 52', 'description': 'To evaluate patient-reported HRQOL and health status'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Lupus Nephritis, anifrolumab, Systemic Lupus Erythematosus, intravenous'], 'conditions': ['Lupus Nephritis']}, 'referencesModule': {'references': [{'pmid': '37528520', 'type': 'DERIVED', 'citation': 'Avasare R, Drexler Y, Caster DJ, Mitrofanova A, Jefferson JA. Management of Lupus Nephritis: New Treatments and Updated Guidelines. Kidney360. 2023 Oct 1;4(10):1503-1511. doi: 10.34067/KID.0000000000000230.'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to evaluate the efficacy and safety of IV antifrolumab in adult patients with Active Proliferative Lupus Nephritis', 'detailedDescription': 'This Phase 3, multicenter, multinational, randomized, double-blind, placebo-controlled study with OLE is to evaluate the efficacy and safety of anifrolumab versus placebo as added to SOC (MMF and glucocorticoids) in adults with active proliferative Class III or Class IV LN (both with or without concomitant Class V). The total study duration may be up to approximately 142 weeks, including screening and follow-up. Double-blind period will be 76 weeks. Participants who complete double-blind treatment period may enter open-label extension to receive anifrolumab for up 52 weeks. Approximately 360 of the enrolled participants will be randomly assigned to study intervention (anifrolumab or placebo) at a ratio of 1:1 during double-blind treatment period.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '70 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Active proliferative LN Class III or IV either with or without the presence of Class V according to the 2003 ISN/RPS classification\n2. Renal biopsy obtained within 6 months prior to signing the ICF or during Screening Period.\n3. Urine protein to creatinine ratio \\> 1 mg/mg (113.17 mg/mmol)\n4. eGFR ≥ 35 mL/min/1.73 m2 (as calculated by the Chronic Kidney Disease Epidemiology Collaboration formula).\n5. Fulfills updated 2019 EULAR/ACR SLE classification criteria.\n6. No signs of symptoms of active TB prior to or during screening or no treatment for latent TB\n\nExclusion Criteria:\n\n1. A diagnosis of pure Class V LN based on the renal biopsy obtained within 6 months prior to signing the ICF or during Screening.\n2. Known history of a primary immunodeficiency, splenectomy, or any underlying condition that predisposes the participant to infection, or a positive result for HIV confirmed by the central lab at Screening - an HIV test must be performed during Screening, and the result should be available prior to Week 0 (Day 1).\n3. Evidence of hepatitis C or active hepatitis B.\n4. Any history of cancer except sucessfully cured skin squamos or basal skin carcinoma and cervical cancer in situ.\n5. Receipt of the following for the current LN flare (ie, since the qualifying renal biopsy): IV cyclophosphamide \\> 2 pulses of high-dose (≥ 0.5 g/m2) or \\> 4 doses of low dose (500 mg every 2 weeks) or Average MMF \\> 2.5 g/day (or \\> 1800 mg/day of enteric coated mycophenolate sodium) for more than 8 weeks or Tacrolimus \\> 4 mg/day for more than 8 weeks; Cyclosporine for more than 8 weeks or during last 8 weeks prior to signing the ICF; Voclosporin for more than 8 weeks or during last 8 weeks prior to signing the ICF; Belimumab for more than 12 weeks or during last 12 weeks prior the ICF.\n6. Previous receipt of \\>◦2 investigation treatments (other than anifrolumab) for LN or SLE since time of diagnosis and through the ICF.\n7. Known intolerance to ≤ 1.0 g/day of MMF.\n8. Any history of severe COVID-19 infection.'}, 'identificationModule': {'nctId': 'NCT05138133', 'acronym': 'IRIS', 'briefTitle': 'Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis', 'organization': {'class': 'INDUSTRY', 'fullName': 'AstraZeneca'}, 'officialTitle': 'A Multicentre Randomized Double-Blind Placebo Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis', 'orgStudyIdInfo': {'id': 'D3466C00001'}, 'secondaryIdInfos': [{'id': '2021-002862-42', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Anifrolumab', 'description': 'Solution for intravenous infusion', 'interventionNames': ['Drug: Anifrolumab']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Solution for intravenous infusion', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'Anifrolumab', 'type': 'DRUG', 'otherNames': ['Medi-546'], 'description': 'Anifrolumab intravenous infusion (IV)', 'armGroupLabels': ['Anifrolumab']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Placebo intravenous infusion (IV)', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '85306', 'city': 'Glendale', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.53865, 'lon': -112.18599}}, {'zip': '92037', 'city': 'La Jolla', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '90623', 'city': 'La Palma', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.8464, 'lon': -118.04673}}, {'zip': '92354', 'city': 'Loma Linda', 'state': 'California', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.04835, 'lon': -117.26115}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92868', 'city': 'Orange', 'state': 'California', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.78779, 'lon': -117.85311}}, {'zip': '91786', 'city': 'Upland', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.09751, 'lon': -117.64839}}, {'zip': '06519', 'city': 'New Haven', 'state': 'Connecticut', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 41.30815, 'lon': -72.92816}}, {'zip': '19713', 'city': 'Newark', 'state': 'Delaware', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 39.68372, 'lon': -75.74966}}, {'zip': '33009', 'city': 'Hallandale', 'state': 'Florida', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 25.9812, 'lon': -80.14838}}, {'zip': '33324', 'city': 'Plantation', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 26.13421, 'lon': -80.23184}}, {'zip': '33573', 'city': 'Sun City Center', 'state': 'Florida', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 27.71809, 'lon': -82.35176}}, {'zip': '30308', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '40202', 'city': 'Louisville', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '63108', 'city': 'St Louis', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '89128', 'city': 'Las Vegas', 'state': 'Nevada', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 36.17497, 'lon': -115.13722}}, {'zip': '07103', 'city': 'Newark', 'state': 'New Jersey', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.73566, 'lon': -74.17237}}, {'zip': '07901', 'city': 'Summit', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.71562, 'lon': -74.36468}}, {'zip': '88011', 'city': 'Las Cruces', 'state': 'New Mexico', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 32.31232, 'lon': -106.77834}}, {'zip': '11021', 'city': 'Great Neck', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.80066, 'lon': -73.72846}}, {'zip': '11030', 'city': 'Manhasset', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.79788, 'lon': -73.69957}}, {'zip': '10016', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10032', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '27157', 'city': 'Winston-Salem', 'state': 'North Carolina', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 36.09986, 'lon': -80.24422}}, {'zip': '44130', 'city': 'Middleburg Heights', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 41.36144, 'lon': -81.81291}}, {'zip': '17822', 'city': 'Danville', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.96342, 'lon': -76.61273}}, {'zip': '75013', 'city': 'Allen', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.10317, 'lon': -96.67055}}, {'zip': '76034', 'city': 'Colleyville', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 32.88096, 'lon': -97.15501}}, {'zip': '78539', 'city': 'Edinburg', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 26.30174, 'lon': -98.16334}}, {'zip': '79902', 'city': 'El Paso', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 31.75872, 'lon': -106.48693}}, {'zip': '77054', 'city': 'Houston', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': 'C1425EOE', 'city': 'CABA', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Research Site'}, {'zip': 'C1015ABO', 'city': 'Ciudad de Buenos Aires', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Research Site'}, {'zip': 'X5004AUL', 'city': 'Córdoba', 'status': 'WITHDRAWN', 'country': 'Argentina', 'facility': 'Research Site', 'geoPoint': {'lat': -31.40648, 'lon': -64.18853}}, {'zip': '1900', 'city': 'La Plata', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Research Site', 'geoPoint': {'lat': -34.92126, 'lon': -57.95442}}, {'zip': 'S2000PBJ', 'city': 'Rosario', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Research Site', 'geoPoint': {'lat': -32.94682, 'lon': -60.63932}}, {'zip': '5400', 'city': 'San Juan', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Research Site', 'geoPoint': {'lat': -31.53726, 'lon': -68.52568}}, {'zip': 'X4000AXL', 'city': 'San Miguel de Tucumán', 'status': 'WITHDRAWN', 'country': 'Argentina', 'facility': 'Research Site', 'geoPoint': {'lat': -26.81601, 'lon': -65.21051}}, {'zip': '1200', 'city': 'Brussels', 'status': 'RECRUITING', 'country': 'Belgium', 'facility': 'Research Site', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'zip': '3000', 'city': 'Leuven', 'status': 'RECRUITING', 'country': 'Belgium', 'facility': 'Research Site', 'geoPoint': {'lat': 50.87959, 'lon': 4.70093}}, {'zip': '4000', 'city': 'Liège', 'status': 'RECRUITING', 'country': 'Belgium', 'facility': 'Research Site', 'geoPoint': {'lat': 50.63373, 'lon': 5.56749}}, {'zip': '30130 100', 'city': 'Belo Horizonte', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -19.92083, 'lon': -43.93778}}, {'zip': '13087-567', 'city': 'Campinas', 'status': 'NOT_YET_RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -22.90556, 'lon': -47.06083}}, {'zip': '78020-500', 'city': 'Cuiabá', 'status': 'NOT_YET_RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -15.59611, 'lon': -56.09667}}, {'zip': '36010-570', 'city': 'Juiz de Fora', 'status': 'NOT_YET_RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -21.76417, 'lon': -43.35028}}, {'zip': '87060-040', 'city': 'Maringá', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -23.42528, 'lon': -51.93861}}, {'zip': '90035-903', 'city': 'Porto Alegre', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'zip': '50740-465', 'city': 'Recife', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -8.05389, 'lon': -34.88111}}, {'zip': '40150-150', 'city': 'Salvador', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -12.97563, 'lon': -38.49096}}, {'zip': '15090-000', 'city': 'São José do Rio Preto', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -20.81972, 'lon': -49.37944}}, {'zip': '04014-002', 'city': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '04036-002', 'city': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '05403-9000', 'city': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '4002', 'city': 'Plovdiv', 'status': 'COMPLETED', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '4002', 'city': 'Plovdiv', 'status': 'WITHDRAWN', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '1336', 'city': 'Sofia', 'status': 'WITHDRAWN', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1431', 'city': 'Sofia', 'status': 'COMPLETED', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1680', 'city': 'Sofia', 'status': 'WITHDRAWN', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '100034', 'city': 'Beijing', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100044', 'city': 'Beijing', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '233004', 'city': 'Bengbu', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 32.94083, 'lon': 117.36083}}, {'zip': '610072', 'city': 'Chengdu', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}, {'zip': '510080', 'city': 'Guangzhou', 'status': 'WITHDRAWN', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510530', 'city': 'Guangzhou', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '570311', 'city': 'Haikou', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 20.03421, 'lon': 110.34651}}, {'zip': '310009', 'city': 'Hangzhou', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'zip': '250021', 'city': 'Jinan', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 36.66833, 'lon': 116.99722}}, {'zip': '272011', 'city': 'Jining', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 35.405, 'lon': 116.58139}}, {'zip': '330006', 'city': 'Nanchang', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 28.68396, 'lon': 115.85306}}, {'zip': '210009', 'city': 'Nanjing', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '210029', 'city': 'Nanjing', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '530021', 'city': 'Nanning', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '200025', 'city': 'Shanghai', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '200040', 'city': 'Shanghai', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '201210', 'city': 'Shanghai', 'status': 'WITHDRAWN', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '110004', 'city': 'Shengyang', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 28.01749, 'lon': 119.37448}}, {'zip': '518036', 'city': 'Shenzhen', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 22.54554, 'lon': 114.0683}}, {'zip': '050001', 'city': 'Shijiazhuang', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'zip': '300201', 'city': 'Tianjin', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '430060', 'city': 'Wuhan', 'status': 'COMPLETED', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '214023', 'city': 'Wuxi', 'status': 'COMPLETED', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 31.56887, 'lon': 120.28857}}, {'zip': '710061', 'city': "Xi'an", 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 34.25833, 'lon': 108.92861}}, {'zip': '450000', 'city': 'Zhengzhou', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '080020', 'city': 'Barranquilla', 'status': 'RECRUITING', 'country': 'Colombia', 'facility': 'Research Site', 'geoPoint': {'lat': 10.96854, 'lon': -74.78132}}, {'zip': '760042', 'city': 'Cali', 'status': 'RECRUITING', 'country': 'Colombia', 'facility': 'Research Site', 'geoPoint': {'lat': 3.43054, 'lon': -76.5199}}, {'zip': '050010', 'city': 'Medellín', 'status': 'WITHDRAWN', 'country': 'Colombia', 'facility': 'Research Site', 'geoPoint': {'lat': 6.245, 'lon': -75.57151}}, {'zip': '050010', 'city': 'Medellín', 'status': 'RECRUITING', 'country': 'Colombia', 'facility': 'Research Site', 'geoPoint': {'lat': 6.245, 'lon': -75.57151}}, {'zip': '050025', 'city': 'Medellín', 'status': 'RECRUITING', 'country': 'Colombia', 'facility': 'Research Site', 'geoPoint': {'lat': 6.245, 'lon': -75.57151}}, {'zip': '15002', 'city': 'Aurillac', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 44.92539, 'lon': 2.43983}}, {'zip': '33076', 'city': 'Bordeaux', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 44.84124, 'lon': -0.58046}}, {'zip': '13005', 'city': 'Marseille', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 43.29695, 'lon': 5.38107}}, {'zip': '75013', 'city': 'Paris', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'zip': '75018', 'city': 'Paris', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'zip': '75679', 'city': 'Paris', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'zip': '67098', 'city': 'Strasbourg', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 48.58392, 'lon': 7.74553}}, {'zip': '31059', 'city': 'Toulouse', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 43.60426, 'lon': 1.44367}}, {'zip': '50937', 'city': 'Cologne', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 50.93333, 'lon': 6.95}}, {'zip': '1307', 'city': 'Dresden', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 51.05089, 'lon': 13.73832}}, {'zip': '45147', 'city': 'Essen', 'status': 'WITHDRAWN', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 51.45657, 'lon': 7.01228}}, {'zip': '37075', 'city': 'Göttingen', 'status': 'WITHDRAWN', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 51.53443, 'lon': 9.93228}}, {'zip': '30625', 'city': 'Hanover', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 52.37052, 'lon': 9.73322}}, {'zip': '69120', 'city': 'Heidelberg', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 49.40768, 'lon': 8.69079}}, {'zip': '73230', 'city': 'Kirchheim', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 50.83333, 'lon': 9.56667}}, {'zip': '55131', 'city': 'Mainz Am Rhein', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Research Site'}, {'zip': '70376', 'city': 'Stuttgart', 'status': 'WITHDRAWN', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 48.78232, 'lon': 9.17702}}, {'zip': '1027', 'city': 'Budapest', 'status': 'WITHDRAWN', 'country': 'Hungary', 'facility': 'Research Site', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'zip': '1085', 'city': 'Budapest', 'status': 'RECRUITING', 'country': 'Hungary', 'facility': 'Research Site', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'zip': '1097', 'city': 'Budapest', 'status': 'RECRUITING', 'country': 'Hungary', 'facility': 'Research Site', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'zip': '4032', 'city': 'Debrecen', 'status': 'RECRUITING', 'country': 'Hungary', 'facility': 'Research Site', 'geoPoint': {'lat': 47.53167, 'lon': 21.62444}}, {'zip': '7624', 'city': 'Pécs', 'status': 'RECRUITING', 'country': 'Hungary', 'facility': 'Research Site', 'geoPoint': {'lat': 46.07617, 'lon': 18.22814}}, {'zip': '380005', 'city': 'Ahmedabad', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 23.02579, 'lon': 72.58727}}, {'zip': '382421', 'city': 'Ahmedabad', 'status': 'TERMINATED', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 23.02579, 'lon': 72.58727}}, {'zip': '248001', 'city': 'Dehradun', 'status': 'RECRUITING', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 30.32443, 'lon': 78.03392}}, {'zip': '110029', 'city': 'Delhi', 'status': 'WITHDRAWN', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 28.65195, 'lon': 77.23149}}, {'zip': '110029', 'city': 'Delhi', 'status': 'RECRUITING', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 28.65195, 'lon': 77.23149}}, {'zip': '110060', 'city': 'Delhi', 'status': 'WITHDRAWN', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 28.65195, 'lon': 77.23149}}, {'zip': '122001', 'city': 'Gurugram', 'status': 'WITHDRAWN', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 28.4601, 'lon': 77.02635}}, {'zip': '500082', 'city': 'Hyderabad', 'status': 'RECRUITING', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 17.38405, 'lon': 78.45636}}, {'zip': '700020', 'city': 'Kolkata', 'status': 'RECRUITING', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 22.56263, 'lon': 88.36304}}, {'zip': '387001', 'city': 'Nadiād', 'status': 'TERMINATED', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 22.69385, 'lon': 72.86157}}, {'zip': '110017', 'city': 'New Delhi', 'status': 'WITHDRAWN', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 28.62137, 'lon': 77.2148}}, {'zip': '110070', 'city': 'New Delhi', 'status': 'WITHDRAWN', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 28.62137, 'lon': 77.2148}}, {'zip': '110075', 'city': 'New Delhi', 'status': 'WITHDRAWN', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 28.62137, 'lon': 77.2148}}, {'zip': '411001', 'city': 'Pune', 'status': 'TERMINATED', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 18.51957, 'lon': 73.85535}}, {'zip': '500003', 'city': 'Secunderabad', 'status': 'RECRUITING', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 17.50427, 'lon': 78.54263}}, {'zip': '522002', 'city': 'Vijayawada', 'status': 'TERMINATED', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 16.50745, 'lon': 80.6466}}, {'zip': '530013', 'city': 'Visakapatnam', 'status': 'TERMINATED', 'country': 'India', 'facility': 'Research Site'}, {'zip': '60126', 'city': 'Ancona', 'status': 'RECRUITING', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 43.60717, 'lon': 13.5103}}, {'zip': '40138', 'city': 'Bologna', 'status': 'RECRUITING', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 44.49381, 'lon': 11.33875}}, {'zip': '25123', 'city': 'Brescia', 'status': 'WITHDRAWN', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 45.53558, 'lon': 10.21472}}, {'zip': '44124', 'city': 'Cona', 'status': 'TERMINATED', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 44.80583, 'lon': 11.7069}}, {'zip': '84025', 'city': 'Eboli', 'status': 'RECRUITING', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 40.61747, 'lon': 15.05693}}, {'zip': '20900', 'city': 'Monza', 'status': 'WITHDRAWN', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 45.58005, 'lon': 9.27246}}, {'zip': '35128', 'city': 'Padua', 'status': 'RECRUITING', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 45.40797, 'lon': 11.88586}}, {'zip': '00152', 'city': 'Roma', 'status': 'WITHDRAWN', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'zip': '00161', 'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'zip': '113-8655', 'city': 'Bunkyō City', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 35.5331, 'lon': 139.4217}}, {'zip': '260-8712', 'city': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 35.6, 'lon': 140.11667}}, {'zip': '104-8560', 'city': 'Chūōku', 'status': 'WITHDRAWN', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 33.63867, 'lon': 130.67068}}, {'zip': '810-8563', 'city': 'Fukuoka', 'status': 'WITHDRAWN', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'zip': '500-8513', 'city': 'Gifu', 'status': 'WITHDRAWN', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 35.42291, 'lon': 136.76039}}, {'zip': '734-8551', 'city': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 34.4, 'lon': 132.45}}, {'zip': '693-8501', 'city': 'Izumo-shi', 'status': 'WITHDRAWN', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '761-0793', 'city': 'Kita-gun', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '807-8555', 'city': 'Kitakyushu-shi', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '390-8621', 'city': 'Matsumoto-shi', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '852-8501', 'city': 'Nagasaki', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 32.75, 'lon': 129.88333}}, {'zip': '700-8558', 'city': 'Okayama', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 34.65, 'lon': 133.93333}}, {'zip': '675-1392', 'city': 'Ono', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 34.85, 'lon': 134.93333}}, {'zip': '545-8586', 'city': 'Osaka', 'status': 'WITHDRAWN', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 34.69379, 'lon': 135.50107}}, {'zip': '252-0375', 'city': 'Sagamihara-shi', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '060-8648', 'city': 'Sapporo', 'status': 'WITHDRAWN', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'zip': '980-0872', 'city': 'Sendai', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 38.26667, 'lon': 140.86667}}, {'zip': '142-0054', 'city': 'Shinagawa-ku', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '160-8582', 'city': 'Shinjuku-ku', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '162-8655', 'city': 'Shinjuku-ku', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '162-8666', 'city': 'Shinjuku-ku', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '470-1192', 'city': 'Toyoake-shi', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '68100', 'city': 'Batu Caves', 'status': 'RECRUITING', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 3.238, 'lon': 101.682}}, {'zip': '30450', 'city': 'Ipoh', 'status': 'RECRUITING', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 4.5841, 'lon': 101.0829}}, {'zip': '43000', 'city': 'Kajang', 'status': 'RECRUITING', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 2.99424, 'lon': 101.78875}}, {'zip': '59100', 'city': 'Kuala Lumpur', 'status': 'RECRUITING', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 3.1412, 'lon': 101.68653}}, {'zip': '25100', 'city': 'Kuantan', 'status': 'RECRUITING', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 3.8077, 'lon': 103.326}}, {'zip': '34000', 'city': 'Taiping', 'status': 'RECRUITING', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 4.85, 'lon': 100.73333}}, {'zip': '31000', 'city': 'Chihuahua City', 'status': 'RECRUITING', 'country': 'Mexico', 'facility': 'Research Site', 'geoPoint': {'lat': 28.63528, 'lon': -106.08889}}, {'zip': '44160', 'city': 'Guadalajara', 'status': 'RECRUITING', 'country': 'Mexico', 'facility': 'Research Site', 'geoPoint': {'lat': 20.67738, 'lon': -103.34749}}, {'zip': '44650', 'city': 'Guadalajara', 'status': 'RECRUITING', 'country': 'Mexico', 'facility': 'Research Site', 'geoPoint': {'lat': 20.67738, 'lon': -103.34749}}, {'zip': '06726', 'city': 'México', 'status': 'RECRUITING', 'country': 'Mexico', 'facility': 'Research Site', 'geoPoint': {'lat': 31.00435, 'lon': -108.15213}}, {'zip': '14080', 'city': 'México', 'status': 'RECRUITING', 'country': 'Mexico', 'facility': 'Research Site', 'geoPoint': {'lat': 31.00435, 'lon': -108.15213}}, {'zip': '78290', 'city': 'San Luis Potosí City', 'status': 'COMPLETED', 'country': 'Mexico', 'facility': 'Research Site', 'geoPoint': {'lat': 22.15234, 'lon': -100.97135}}, {'zip': '1105 AZ', 'city': 'Amsterdam', 'status': 'RECRUITING', 'country': 'Netherlands', 'facility': 'Research Site', 'geoPoint': {'lat': 52.37403, 'lon': 4.88969}}, {'zip': 'CALLAO 2', 'city': 'Bellavista', 'status': 'WITHDRAWN', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -7.05614, 'lon': -76.5911}}, {'zip': '15023', 'city': 'Lima', 'status': 'RECRUITING', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -12.04318, 'lon': -77.02824}}, {'zip': '15036', 'city': 'Lima', 'status': 'WITHDRAWN', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -12.04318, 'lon': -77.02824}}, {'zip': '15046', 'city': 'Lima', 'status': 'RECRUITING', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -12.04318, 'lon': -77.02824}}, {'zip': '15082', 'city': 'Lima', 'status': 'WITHDRAWN', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -12.04318, 'lon': -77.02824}}, {'zip': '15102', 'city': 'Lima', 'status': 'RECRUITING', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -12.04318, 'lon': -77.02824}}, {'zip': 'L34', 'city': 'Lima', 'status': 'RECRUITING', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -12.04318, 'lon': -77.02824}}, {'zip': 'LIMA 27', 'city': 'Lima', 'status': 'RECRUITING', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -12.04318, 'lon': -77.02824}}, {'zip': 'LIMA 27', 'city': 'Lima', 'status': 'WITHDRAWN', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -12.04318, 'lon': -77.02824}}, {'zip': 'LIMA 29', 'city': 'Lima', 'status': 'RECRUITING', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -12.04318, 'lon': -77.02824}}, {'zip': '20001', 'city': 'Piura', 'status': 'WITHDRAWN', 'country': 'Peru', 'facility': 'Research Site', 'geoPoint': {'lat': -5.18192, 'lon': -80.65715}}, {'zip': '86-605', 'city': 'Bydgoszcz', 'status': 'WITHDRAWN', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 53.1235, 'lon': 18.00762}}, {'zip': '92-213', 'city': 'Lodz', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 51.77058, 'lon': 19.47395}}, {'zip': '05-830', 'city': 'Nadarzyn', 'status': 'WITHDRAWN', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 52.09438, 'lon': 20.80776}}, {'zip': '10-561', 'city': 'Olsztyn', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 53.78376, 'lon': 20.49272}}, {'zip': '46-020', 'city': 'Opole', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 50.67119, 'lon': 17.92604}}, {'zip': '60-355', 'city': 'Poznan', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 52.40692, 'lon': 16.92993}}, {'zip': '61-545', 'city': 'Poznan', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 52.40692, 'lon': 16.92993}}, {'zip': '35-301', 'city': 'Rzeszów', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 50.04132, 'lon': 21.99901}}, {'zip': '70-111', 'city': 'Szczecin', 'status': 'WITHDRAWN', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 53.42894, 'lon': 14.55302}}, {'zip': '02-006', 'city': 'Warsaw', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '50-556', 'city': 'Wroclaw', 'status': 'WITHDRAWN', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 51.10286, 'lon': 17.03006}}, {'zip': '51-124', 'city': 'Wroclaw', 'status': 'WITHDRAWN', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 51.10286, 'lon': 17.03006}}, {'zip': '00725', 'city': 'Caguas', 'status': 'RECRUITING', 'country': 'Puerto Rico', 'facility': 'Research Site', 'geoPoint': {'lat': 18.23412, 'lon': -66.0485}}, {'zip': '00918', 'city': 'San Juan', 'status': 'RECRUITING', 'country': 'Puerto Rico', 'facility': 'Research Site', 'geoPoint': {'lat': 18.46633, 'lon': -66.10572}}, {'zip': '454048', 'city': 'Chelyabinsk', 'status': 'WITHDRAWN', 'country': 'Russia', 'facility': 'Research Site', 'geoPoint': {'lat': 55.1611, 'lon': 61.42877}}, {'zip': '660022', 'city': 'Krasnoyarsk', 'status': 'WITHDRAWN', 'country': 'Russia', 'facility': 'Research Site', 'geoPoint': {'lat': 56.03742, 'lon': 92.93136}}, {'zip': '115522', 'city': 'Moscow', 'status': 'TERMINATED', 'country': 'Russia', 'facility': 'Research Site', 'geoPoint': {'lat': 55.75204, 'lon': 37.61781}}, {'zip': '123182', 'city': 'Moscow', 'status': 'WITHDRAWN', 'country': 'Russia', 'facility': 'Research Site', 'geoPoint': {'lat': 55.75204, 'lon': 37.61781}}, {'zip': '630090', 'city': 'Novosibirsk', 'status': 'WITHDRAWN', 'country': 'Russia', 'facility': 'Research Site', 'geoPoint': {'lat': 55.02259, 'lon': 82.93175}}, {'zip': '460018', 'city': 'Orenburg', 'status': 'WITHDRAWN', 'country': 'Russia', 'facility': 'Research Site', 'geoPoint': {'lat': 51.76712, 'lon': 55.09883}}, {'zip': '196066', 'city': 'Saint Petersburg', 'status': 'WITHDRAWN', 'country': 'Russia', 'facility': 'Research Site', 'geoPoint': {'lat': 59.93863, 'lon': 30.31413}}, {'zip': '833', 'city': 'Kaohsiung City', 'status': 'RECRUITING', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 22.61626, 'lon': 120.31333}}, {'zip': '220', 'city': 'New Taipei City', 'status': 'RECRUITING', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 25.06199, 'lon': 121.45703}}, {'zip': '40447', 'city': 'Taichung', 'status': 'RECRUITING', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 24.1469, 'lon': 120.6839}}, {'zip': '40705', 'city': 'Taichung', 'status': 'RECRUITING', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 24.1469, 'lon': 120.6839}}, {'zip': '11217', 'city': 'Taipei', 'status': 'RECRUITING', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '114', 'city': 'Taipei', 'status': 'RECRUITING', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '235', 'city': 'Taipei', 'status': 'RECRUITING', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '333', 'city': 'Taoyuan District', 'status': 'WITHDRAWN', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 24.9896, 'lon': 121.3187}}, {'zip': '10220', 'city': 'Bangkok', 'status': 'RECRUITING', 'country': 'Thailand', 'facility': 'Research Site', 'geoPoint': {'lat': 13.75398, 'lon': 100.50144}}, {'zip': '10330', 'city': 'Bangkok', 'status': 'RECRUITING', 'country': 'Thailand', 'facility': 'Research Site', 'geoPoint': {'lat': 13.75398, 'lon': 100.50144}}, {'zip': '90110', 'city': 'Hat Yai', 'status': 'RECRUITING', 'country': 'Thailand', 'facility': 'Research Site', 'geoPoint': {'lat': 7.00836, 'lon': 100.47668}}, {'zip': '50200', 'city': 'Muang', 'status': 'RECRUITING', 'country': 'Thailand', 'facility': 'Research Site'}, {'zip': '10400', 'city': 'Ratchathewi', 'status': 'RECRUITING', 'country': 'Thailand', 'facility': 'Research Site', 'geoPoint': {'lat': 13.759, 'lon': 100.53358}}, {'zip': '54290', 'city': 'Adapazarı', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 40.78056, 'lon': 30.40333}}, {'zip': '06100', 'city': 'Ankara', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'zip': '6500', 'city': 'Ankara', 'status': 'WITHDRAWN', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'city': 'Ankara', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'zip': '34865', 'city': 'Istanbul', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 41.01384, 'lon': 28.94966}}, {'city': 'Istanbul', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 41.01384, 'lon': 28.94966}}, {'zip': '35965', 'city': 'Izmir', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 38.41273, 'lon': 27.13838}}, {'zip': '46100', 'city': 'Kahramanmaraş', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 37.5847, 'lon': 36.92641}}, {'zip': '38039', 'city': 'Kayseri', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 38.73222, 'lon': 35.48528}}, {'zip': '41380', 'city': 'Kocaeli', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 39.62497, 'lon': 27.51145}}, {'zip': '100000', 'city': 'Hanoi', 'status': 'TERMINATED', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 21.0245, 'lon': 105.84117}}, {'zip': '10000', 'city': 'Hanoi', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 21.0245, 'lon': 105.84117}}, {'zip': '100000', 'city': 'Hà Nội', 'status': 'COMPLETED', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 20.47366, 'lon': 106.02292}}, {'zip': '100000', 'city': 'Hà Nội', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 20.47366, 'lon': 106.02292}}, {'zip': '700000', 'city': 'Ho Chi Minh City', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 10.82302, 'lon': 106.62965}}, {'zip': '700000', 'city': 'Ho Chi Minh City', 'status': 'RECRUITING', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 10.82302, 'lon': 106.62965}}, {'zip': '70000', 'city': 'Hochiminh', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'Vietnam', 'facility': 'Research Site'}], 'centralContacts': [{'name': 'AstraZeneca Clinical Study Information Center', 'role': 'CONTACT', 'email': 'information.center@astrazeneca.com', 'phone': '1-877-240-9479'}]}, 'ipdSharingStatementModule': {'url': 'https://astrazenecagroup-dt.pharmacm.com/DT/Home', 'infoTypes': ['STUDY_PROTOCOL', 'SAP'], 'timeFrame': 'AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.', 'ipdSharing': 'YES', 'description': 'Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.\n\nYes, indicates that AZ are accepting requests for IPD, but this does not mean that all requests will be shared.', 'accessCriteria': 'When a request has been approved AstraZeneca will provide access to the de-identified individual patient-level data in an approved sponsored tool. Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'AstraZeneca', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}