Ignite Creation Date:
2025-12-25 @ 3:11 AM
Ignite Modification Date:
2026-02-02 @ 2:46 AM
Study NCT ID:
NCT02135705
Status:
RECRUITING
Last Update Posted:
2024-03-12
First Post:
2014-04-10
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
LOWER: Lomitapide Observational Worldwide Evaluation Registry
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000090542', 'term': 'Homozygous Familial Hypercholesterolemia'}], 'ancestors': [{'id': 'D006938', 'term': 'Hyperlipoproteinemia Type II'}, {'id': 'D008052', 'term': 'Lipid Metabolism, Inborn Errors'}, {'id': 'D008661', 'term': 'Metabolism, Inborn Errors'}, {'id': 'D030342', 'term': 'Genetic Diseases, Inborn'}, {'id': 'D009358', 'term': 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities'}, {'id': 'D006951', 'term': 'Hyperlipoproteinemias'}, {'id': 'D006949', 'term': 'Hyperlipidemias'}, {'id': 'D050171', 'term': 'Dyslipidemias'}, {'id': 'D052439', 'term': 'Lipid Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C473731', 'term': 'BMS201038'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 300}, 'targetDuration': '10 Years', 'patientRegistry': True}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2014-03-18', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-03', 'completionDateStruct': {'date': '2028-09-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-03-11', 'studyFirstSubmitDate': '2014-04-10', 'studyFirstSubmitQcDate': '2014-05-08', 'lastUpdatePostDateStruct': {'date': '2024-03-12', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2014-05-12', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2028-03-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Hepatic Abnormalities', 'timeFrame': 'patients will be followed for 10 years', 'description': 'to evaluate the occurrence of hepatic abnormalities'}], 'secondaryOutcomes': [{'measure': 'Gastrointestinal (GI) Events', 'timeFrame': 'patients will be followed for 10 years', 'description': 'to evaluate the occurrence of GI events'}, {'measure': 'Tumors', 'timeFrame': 'patients will be followed for 10 years', 'description': 'to evaluate any occurrence of tumors (small bowel, hepatic, colorectal or pancreatic)'}, {'measure': 'Events associated with coagulopathy', 'timeFrame': 'patients will be followed for 10 years', 'description': 'to evaluate the occurrence of events associated with coagulopathy (abnormal bleeding, cerebral haemorrhage or GI bleeding)'}, {'measure': 'Major Adverse Cardiovascular Events (MACE) events', 'timeFrame': 'patients will be followed for 10 years', 'description': 'to evaluate the occurrence of MACE events'}, {'measure': 'Death, including cause of death', 'timeFrame': 'patients will be followed for 10 years', 'description': 'to evaluate the occurrence and cause of death'}, {'measure': 'Pregnancy', 'timeFrame': 'patients will be followed for 10 years', 'description': 'to evaluate the occurrence and outcomes of pregnancy in females of reproductive potential treated with lomitapide. Patients who become pregnant will be offered enrolment into a separate Pregnancy Exposure Registry (PER).'}, {'measure': 'Serum lipid levels', 'timeFrame': 'patients will be followed for 10 years', 'description': 'to evaluate the long-term effectiveness of lomitapide in maintaining control of serum lipid levels in a clinical practice setting.'}, {'measure': 'Prescriber behavior', 'timeFrame': 'patients will be followed for 10 years', 'description': 'to evaluate whether prescribers of lomitapide enrolled at registry sites are following the screening and monitoring recommendations as specified in the PI and the prescriber educational materials aimed at risk minimization.'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'conditions': ['Homozygous Familial Hypercholesterolemia']}, 'referencesModule': {'references': [{'pmid': '36520008', 'type': 'DERIVED', 'citation': "Larrey D, D'Erasmo L, O'Brien S, Arca M; Italian Working Group on Lomitapide. Long-term hepatic safety of lomitapide in homozygous familial hypercholesterolaemia. Liver Int. 2023 Feb;43(2):413-423. doi: 10.1111/liv.15497. Epub 2022 Dec 30."}, {'pmid': '30663562', 'type': 'DERIVED', 'citation': 'Giammanco A, Cefalu AB, Noto D, Averna MR. Therapeutic Options for Homozygous Familial Hypercholesterolemia: The Role of Lomitapide. Curr Med Chem. 2020;27(23):3773-3783. doi: 10.2174/0929867326666190121120735.'}]}, 'descriptionModule': {'briefSummary': 'This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.', 'detailedDescription': 'To evaluate the occurrence of adverse events of special interest, long term effectiveness of lomitapide, and to evaluate whether prescribers of lomitapide are following screening and monitoring recommendations as specified in product labeling.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Patients treated with lomitapide who agree to participate in the study.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Patients of all ages, including minors, who have initiated commercial treatment with lomitapide prior to or at time of registry enrolment.\n* Patients who have the ability to understand the requirements of the study and provide written informed consent to comply with the study data collection procedures or paediatric patients with the consent of a parent or legal guardian.\n\nPatients ≥7 years of age (or above the age determined by the IRB/EC and in accordance with the local regulations and requirements) must also provide written informed assent forms.\n\nExclusion Criteria:\n\n* Patients who are receiving lomitapide in clinical trials or through compassionate use, where patients are followed under a separate protocol.\n* Patients receiving an investigational agent, defined as any drug or biologic agent other than lomitapide that has not received market authorization in the country of participation, at time of lomitapide initiation and continuing to receive an investigational agent at time of registry enrolment. These patients may be enrolled if receiving lomitapide when the investigational agent is discontinued..'}, 'identificationModule': {'nctId': 'NCT02135705', 'acronym': 'LOWER', 'briefTitle': 'LOWER: Lomitapide Observational Worldwide Evaluation Registry', 'organization': {'class': 'INDUSTRY', 'fullName': 'Amryt Pharma'}, 'officialTitle': 'LOWER: Lomitapide Observational Worldwide Evaluation Registry', 'orgStudyIdInfo': {'id': 'AEGR-733-025'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Lomitapide', 'description': 'Lomitapide as prescribed by Physician.', 'interventionNames': ['Drug: Lomitapide']}], 'interventions': [{'name': 'Lomitapide', 'type': 'DRUG', 'otherNames': ['Juxtapid', 'Lojuxta'], 'description': 'As prescribed by Physician.', 'armGroupLabels': ['Lomitapide']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35209', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Barry McLean, MD', 'role': 'CONTACT', 'email': 'bmclean@centralalabamaresearch.com', 'phone': '205-949-1907'}, {'name': 'Barry McLean, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Brookwood Baptist Medical Center', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '36608', 'city': 'Mobile', 'state': 'Alabama', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Springhill Physician Practices', 'geoPoint': {'lat': 30.69436, 'lon': -88.04305}}, {'zip': '86326', 'city': 'Cottonwood', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kenneth Bescak, MD', 'role': 'CONTACT', 'email': 'Kbescak@gmail.com', 'phone': '928-634-1331'}, {'name': 'Kenneth Bescak, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northern Arizona Healthcare', 'geoPoint': {'lat': 34.73919, 'lon': -112.00988}}, {'zip': '85296', 'city': 'Gilbert', 'state': 'Arizona', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'One Medical', 'geoPoint': {'lat': 33.35283, 'lon': -111.78903}}, {'zip': '85018', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Joseph Lillo, DO', 'role': 'CONTACT', 'email': 'jlillo3@cox.net', 'phone': '480-941-4845'}, {'name': 'Joseph Lillo, DO', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Scottsdale Family Health', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85718', 'city': 'Tucson', 'state': 'Arizona', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Pima Heart', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '72901', 'city': 'Fort Smith', 'state': 'Arkansas', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Arkansas Heart Center', 'geoPoint': {'lat': 35.38592, 'lon': -94.39855}}, {'zip': '90048', 'city': 'Los Angeles', 'state': 'California', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Cedars-Sinai Medical Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'University of Colorado Health', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '19713', 'city': 'Newark', 'state': 'Delaware', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Alfieri Cardiology', 'geoPoint': {'lat': 39.68372, 'lon': -75.74966}}, {'zip': '33434', 'city': 'Boca Raton', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Seth Baum, MD', 'role': 'CONTACT', 'email': 'sjbaum@fpim.org', 'phone': '561-488-5535'}, {'name': 'Seth Baum, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Preventative Cardiology, Inc.', 'geoPoint': {'lat': 26.35869, 'lon': -80.0831}}, {'zip': '32792-2223', 'city': 'Winter Park', 'state': 'Florida', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Florida Lipid Institute', 'geoPoint': {'lat': 28.6, 'lon': -81.33924}}, {'zip': '30309', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Janice McAlister, NP', 'role': 'CONTACT', 'email': 'jan.mcalister@piedmont.org', 'phone': '404-605-2800'}, {'name': 'Janice McAlister, NP', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Piedmont Heart Institute', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30041', 'city': 'Cumming', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Narendra Singh, MD', 'role': 'CONTACT', 'email': 'mnsingh@yahoo.com', 'phone': '404-384-7227'}, {'name': 'Narendra Singh, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Atlanta Heart Specialists', 'geoPoint': {'lat': 34.20732, 'lon': -84.14019}}, {'zip': '30041', 'city': 'Cumming', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'David Song, MD', 'role': 'CONTACT', 'email': 'drsong@ahsmed.com', 'phone': '678-679-1065'}, {'name': 'David Song, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northside Hospital, Inc.', 'geoPoint': {'lat': 34.20732, 'lon': -84.14019}}, {'zip': '60031', 'city': 'Gurnee', 'state': 'Illinois', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Comprehensive Cardiovascular Care', 'geoPoint': {'lat': 42.3703, 'lon': -87.90202}}, {'zip': '46250', 'city': 'Indianapolis', 'state': 'Indiana', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Community Health Network', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '46290', 'city': 'Indianapolis', 'state': 'Indiana', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'James Trippi, MD', 'role': 'CONTACT', 'email': 'jatrippi@stvincent.org', 'phone': '317-924-5444'}, {'name': 'James Trippi, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'St. Vincent Medical Group, Inc.', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '40050', 'city': 'New Castle', 'state': 'Kentucky', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Henry County Medical Center', 'geoPoint': {'lat': 38.4334, 'lon': -85.16968}}, {'zip': '70360', 'city': 'Houma', 'state': 'Louisiana', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Peter Fail, MD', 'role': 'CONTACT', 'email': 'peter.fail@cardio.com', 'phone': '985-876-0300'}, {'name': 'Peter Fail, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cardiovascular Institute of the South', 'geoPoint': {'lat': 29.59577, 'lon': -90.71953}}, {'zip': '21204', 'city': 'Towson', 'state': 'Maryland', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Get Well Immediate Care', 'geoPoint': {'lat': 39.4015, 'lon': -76.60191}}, {'zip': '48109', 'city': 'Ann Arbor', 'state': 'Michigan', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'University of Michigan Health System', 'geoPoint': {'lat': 42.27756, 'lon': -83.74088}}, {'zip': '48314', 'city': 'Sterling Heights', 'state': 'Michigan', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Complete Family Care Cholesterol Treatment Center', 'geoPoint': {'lat': 42.58031, 'lon': -83.0302}}, {'zip': '55407', 'city': 'Minneapolis', 'state': 'Minnesota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Thomas Knickelbine, MD', 'role': 'CONTACT', 'email': 'thomas.knickelbine@allina.com', 'phone': '612-863-4071'}, {'name': 'Thomas Knickelbine, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Minneapolis Heart Institute Foundation', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '55102', 'city': 'Saint Paul', 'state': 'Minnesota', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'HealthEast Care System', 'geoPoint': {'lat': 44.94441, 'lon': -93.09327}}, {'zip': '38671', 'city': 'Southaven', 'state': 'Mississippi', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Dharmesh Patel, MD', 'role': 'CONTACT', 'email': 'drdharmesh@hotmail.com', 'phone': '901-271-5468'}, {'name': 'Dharmesh Patel, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Stern Cardiovascular Foundation', 'geoPoint': {'lat': 34.98898, 'lon': -90.01259}}, {'zip': '68114', 'city': 'Omaha', 'state': 'Nebraska', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'John Henry, MD', 'role': 'CONTACT'}, {'role': 'CONTACT', 'email': 'john.henry@nmhs.org', 'phone': '(402) 384-2705'}, {'name': 'John Henry, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Methodist Physicians Clinic', 'geoPoint': {'lat': 41.25626, 'lon': -95.94043}}, {'zip': '08817', 'city': 'Edison', 'state': 'New Jersey', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Hackensack Meridian Health', 'geoPoint': {'lat': 40.51872, 'lon': -74.4121}}, {'zip': '08701', 'city': 'Lakewood', 'state': 'New Jersey', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Avinash C. Gupta, MD, PC', 'geoPoint': {'lat': 40.09789, 'lon': -74.21764}}, {'zip': '07070', 'city': 'Rutherford', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Michael Schwarz, MD', 'role': 'CONTACT', 'email': 'dar.schwarz201@gmail.com', 'phone': '732-713-2872'}, {'name': 'Michael Schwarz, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': '201 Route 17 North', 'geoPoint': {'lat': 40.82649, 'lon': -74.10681}}, {'zip': '07481', 'city': 'Wyckoff', 'state': 'New Jersey', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Valley Medical Group', 'geoPoint': {'lat': 41.00954, 'lon': -74.17292}}, {'zip': '10016', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'James Underberg, MD', 'role': 'CONTACT', 'email': 'james.underberg@nyumc.org', 'phone': '212-726-7431'}, {'name': 'James Underberg, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Murray Hill Medical Group', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '13210', 'city': 'Syracuse', 'state': 'New York', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'NY Heart Center', 'geoPoint': {'lat': 43.04812, 'lon': -76.14742}}, {'zip': '13210', 'city': 'Syracuse', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Christopher Prendergast, MD', 'role': 'CONTACT', 'email': 'prenderc@pcacny.com', 'phone': '315-214-7700'}, {'name': 'Christopher Prendergast, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Pediatric Cardiology Associates', 'geoPoint': {'lat': 43.04812, 'lon': -76.14742}}, {'zip': '28204', 'city': 'Charlotte', 'state': 'North Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'John Pasquini, MD', 'role': 'CONTACT', 'email': 'japasquini@novanthealth.org', 'phone': '704-343-9800'}, {'name': 'John Pasquini, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cardiology Specialists of the Carolinas PA', 'geoPoint': {'lat': 35.22709, 'lon': -80.84313}}, {'zip': '28211', 'city': 'Charlotte', 'state': 'North Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Daniel Wise, MD', 'role': 'CONTACT', 'email': 'toowiseguys@me.com', 'phone': '704-369-8080'}, {'name': 'Daniel Wise, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cardiology Specialists Of Carolina', 'geoPoint': {'lat': 35.22709, 'lon': -80.84313}}, {'zip': '18103', 'city': 'Allentown', 'state': 'Pennsylvania', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'The Heart Care Group, PC', 'geoPoint': {'lat': 40.60843, 'lon': -75.49018}}, {'zip': '18015', 'city': 'Bethlehem', 'state': 'Pennsylvania', 'status': 'TERMINATED', 'country': 'United States', 'facility': "St. Luke's University Health Network - Pennsylvania", 'geoPoint': {'lat': 40.62593, 'lon': -75.37046}}, {'zip': '18301', 'city': 'East Stroudsburg', 'state': 'Pennsylvania', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Lehigh Valley Hospital And Health Network', 'geoPoint': {'lat': 40.99954, 'lon': -75.18129}}, {'zip': '19107', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Cardiology Consultants of Philadelphia', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '19148', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'David Whellan, MD', 'role': 'CONTACT', 'email': 'Melissa.McCarey@jefferson.edu', 'phone': '215-503-4282'}, {'name': 'David Whellan, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Thomas Jefferson University Health System', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '29203', 'city': 'Columbia', 'state': 'South Carolina', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Palmetto Health', 'geoPoint': {'lat': 34.00071, 'lon': -81.03481}}, {'zip': '29601', 'city': 'Greenville', 'state': 'South Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jeffrey Siegel, MD', 'role': 'CONTACT', 'email': 'siegeljsjsjs@aol.com', 'phone': '864-232-8296'}, {'name': 'Jeffrey Siegel, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': '317 Saint Francis Dr.', 'geoPoint': {'lat': 34.85262, 'lon': -82.39401}}, {'zip': '78758', 'city': 'Austin', 'state': 'Texas', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Cardiovascular Specialists of Texas', 'geoPoint': {'lat': 30.26715, 'lon': -97.74306}}, {'zip': '75226', 'city': 'Dallas', 'state': 'Texas', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Baylor Scott & White Health', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '05401-1473', 'city': 'Burlington', 'state': 'Vermont', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'David Schneider, MD', 'role': 'CONTACT', 'email': 'david.schneider@uvm.edu', 'phone': '802-847-3734'}, {'name': 'David Schneider, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The University of Vermont Health Network', 'geoPoint': {'lat': 44.47588, 'lon': -73.21207}}, {'zip': '26506', 'city': 'Morgantown', 'state': 'West Virginia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Anthony Morise, MD', 'role': 'CONTACT', 'email': 'tmorise@hsc.wvu.edu', 'phone': '304-598-4651'}, {'name': 'Anthony Morise, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'West Virginia University Medicine', 'geoPoint': {'lat': 39.62953, 'lon': -79.9559}}, {'zip': '53211', 'city': 'Milwaukee', 'state': 'Wisconsin', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Ascension', 'geoPoint': {'lat': 43.0389, 'lon': -87.90647}}, {'zip': '53226', 'city': 'Milwaukee', 'state': 'Wisconsin', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Medical College of Wisconsin', 'geoPoint': {'lat': 43.0389, 'lon': -87.90647}}, {'zip': '54401', 'city': 'Wausau', 'state': 'Wisconsin', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Aspirus Research Institute', 'geoPoint': {'lat': 44.95914, 'lon': -89.63012}}, {'zip': 'H3500BJS', 'city': 'Reconquista', 'state': 'Chaco CPA', 'status': 'RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Dario Gomez, MD', 'role': 'CONTACT', 'email': 'dariogomez@ciudad.com.ar', 'phone': '(54)(9362) 453-6261'}, {'name': 'Dario Gomez, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Clinica de Salud de Chaco', 'geoPoint': {'lat': -29.15, 'lon': -59.65}}, {'zip': 'B3H2Y9', 'city': 'Halifax', 'state': 'Nova Scotia', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Thomas Ransom, MD', 'role': 'CONTACT', 'email': 'thomas.ransom@nshealth.ca', 'phone': '(902) 473-3712'}, {'name': 'Thomas Ransom, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Nova Scotia Health Authority', 'geoPoint': {'lat': 44.64269, 'lon': 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