Ignite Creation Date:
2025-12-25 @ 4:06 AM
Ignite Modification Date:
2026-01-29 @ 2:55 AM
Study NCT ID:
NCT00399620
Status:
UNKNOWN
Last Update Posted:
2009-01-12
First Post:
2006-11-14
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D010518', 'term': 'Periodontitis'}, {'id': 'D003920', 'term': 'Diabetes Mellitus'}], 'ancestors': [{'id': 'D010510', 'term': 'Periodontal Diseases'}, {'id': 'D009059', 'term': 'Mouth Diseases'}, {'id': 'D009057', 'term': 'Stomatognathic Diseases'}, {'id': 'D044882', 'term': 'Glucose Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'DIAGNOSTIC', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 90}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2008-03'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2009-01', 'lastUpdateSubmitDate': '2009-01-09', 'studyFirstSubmitDate': '2006-11-14', 'studyFirstSubmitQcDate': '2006-11-14', 'lastUpdatePostDateStruct': {'date': '2009-01-12', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2006-11-15', 'type': 'ESTIMATED'}}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Periodontitis', 'Diabetes', 'Gingival crevicular fluid', 'GCF', 'Saliva', 'Chromogranin', 'Electrophorèse', 'Western Blot', 'RT-HPLC'], 'conditions': ['Periodontitis and Diabetitis']}, 'descriptionModule': {'briefSummary': 'Periodontitis is a chronic disease of the supporting tissue of the teeth, characterized by bleeding and inflamed gingival, resorption of alveolar bone. This disease has a significant impact of the quality of life as the teeth become progressively mobile and may fall out spontaneously if no treatment is provided. Periodontal disease has been cited as the sixth complication of diabetes mellitus.Chromogranins / secretogranins are a family of proteins present in nervous endocrine and immune cells, released with catecholamines during stress situations. Chromogranin A (CGA) is the major member of this family.The aim of this study is to determine the level of CGA and its derived peptides in the gingival crevicular fluid (GCF) of health or diabetic patients with and without periodontitis.Then, we want to determine the antimicrobial activity of these peptides.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '80 Years', 'minimumAge': '20 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion criteria:\n\n* Patients from 20 to 80 years old\n* A minimum of 10 teeth\n* Healthy volunteers or diabetic patients with or without periodontitis\n\nExclusion criteria:\n\n* a course of antibiotics\n* a fungicidal therapy\n* a corticotherapy\n* a hormone therapy\n* a pregnancy\n* persons under guardianship'}, 'identificationModule': {'nctId': 'NCT00399620', 'briefTitle': 'Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients', 'organization': {'class': 'OTHER', 'fullName': 'University Hospital, Strasbourg, France'}, 'officialTitle': 'Chromogranin-A-Derived Peptides in the Gingival Crevicular Fluid and the Saliva of Diabetic Patients With or Without Periodontitis', 'orgStudyIdInfo': {'id': '3739'}}, 'armsInterventionsModule': {'interventions': [{'name': 'Gingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up).', 'type': 'PROCEDURE'}]}, 'contactsLocationsModule': {'locations': [{'zip': '67091', 'city': 'Strasbourg', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Martine Soell, MD', 'role': 'CONTACT', 'email': 'martine.soell@chru-strasbourg.fr', 'phone': '33.6.74.86.67.36'}, {'name': 'Martine Soell, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Frédéric Blickle, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Département de Parodontologie - Hôpital Civil', 'geoPoint': {'lat': 48.58392, 'lon': 7.74553}}], 'centralContacts': [{'name': 'Martine Soell, MD', 'role': 'CONTACT', 'email': 'martine.soell@chru-strasbourg.fr', 'phone': '33 6 74 86 67 36'}], 'overallOfficials': [{'name': 'Martine Soell, MD', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Hôpitaux Universitaires de Strasbourg'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University Hospital, Strasbourg, France', 'class': 'OTHER'}}}}