Ignite Creation Date:
2025-12-25 @ 4:19 AM
Ignite Modification Date:
2026-01-15 @ 3:51 PM
Study NCT ID:
NCT06475820
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-08-23
First Post:
2024-05-17
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Baricitinib at Children and Young Adults With Hemoblastosis
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D054198', 'term': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma'}, {'id': 'D015470', 'term': 'Leukemia, Myeloid, Acute'}, {'id': 'D015456', 'term': 'Leukemia, Biphenotypic, Acute'}, {'id': 'D008223', 'term': 'Lymphoma'}, {'id': 'D009190', 'term': 'Myelodysplastic Syndromes'}, {'id': 'D006086', 'term': 'Graft vs Host Disease'}], 'ancestors': [{'id': 'D007945', 'term': 'Leukemia, Lymphoid'}, {'id': 'D007938', 'term': 'Leukemia'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D008206', 'term': 'Lymphatic Diseases'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}, {'id': 'D007951', 'term': 'Leukemia, Myeloid'}, {'id': 'D001855', 'term': 'Bone Marrow Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000596027', 'term': 'baricitinib'}, {'id': 'C543529', 'term': 'vedolizumab'}, {'id': 'D000069594', 'term': 'Abatacept'}, {'id': 'D003520', 'term': 'Cyclophosphamide'}], 'ancestors': [{'id': 'D018796', 'term': 'Immunoconjugates'}, {'id': 'D000906', 'term': 'Antibodies'}, {'id': 'D007136', 'term': 'Immunoglobulins'}, {'id': 'D012712', 'term': 'Serum Globulins'}, {'id': 'D001798', 'term': 'Blood Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D005916', 'term': 'Globulins'}, {'id': 'D010752', 'term': 'Phosphoramide Mustards'}, {'id': 'D009588', 'term': 'Nitrogen Mustard Compounds'}, {'id': 'D009150', 'term': 'Mustard Compounds'}, {'id': 'D006846', 'term': 'Hydrocarbons, Halogenated'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D063088', 'term': 'Phosphoramides'}, {'id': 'D009943', 'term': 'Organophosphorus Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 150}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2023-12-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-04', 'completionDateStruct': {'date': '2027-04-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-08-22', 'studyFirstSubmitDate': '2024-05-17', 'studyFirstSubmitQcDate': '2024-06-19', 'lastUpdatePostDateStruct': {'date': '2024-08-23', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2024-06-26', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2024-07-01', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Estimate the probability of developing acute GVHD stage II-IV after HSCT', 'timeFrame': '100 days after HSCT'}, {'measure': 'side effects of conditioning', 'timeFrame': '100 days after HSCT', 'description': 'Explore the safety based on an assessment of the frequency of occurrence of:\n\n\\- severe (3-5 degrees) side effects of conditioning during 1 month'}, {'measure': 'transplant-associated mortality', 'timeFrame': '100 days after HSCT'}], 'secondaryOutcomes': [{'measure': 'cumulative probability of relapse', 'timeFrame': 'after HSCT by day + 100', 'description': 'Probability of developing a relapse of the primary disease, transplantation-associated mortality on the horizon of 100 days'}, {'measure': 'cumulative probability of relapse', 'timeFrame': 'up to 2 years after HSCT', 'description': 'Probability of developing a relapse of the primary disease, transplantation-associated mortality on the horizon up to 2 years'}, {'measure': 'event-free survival', 'timeFrame': 'after HSCT by day + 100'}, {'measure': 'event-free survival', 'timeFrame': 'up to 2 years after HSCT'}, {'measure': 'Probability of engraftment of leukocyte', 'timeFrame': 'after HSCT by day + 100', 'description': 'cumulative Probability of engraftment of leukocyte of donor origin'}, {'measure': 'Probability of engraftment of platelet', 'timeFrame': 'after HSCT by day + 100', 'description': 'cumulative Probability of engraftment of platelet'}, {'measure': 'Probability of reactivation of CMV', 'timeFrame': '12 months after HSCT', 'description': 'cumulative Probability of reactivation CMV'}, {'measure': 'Probability of reactivation of EBV', 'timeFrame': '12 months after HSCT', 'description': 'cumulative Probability of reactivation EBV'}, {'measure': 'Probability of reactivation of AdV', 'timeFrame': '12 months after HSCT', 'description': 'cumulative Probability of reactivation ADV'}, {'measure': 'Probability of reactivation BK', 'timeFrame': '12 months after HSCT', 'description': 'cumulative Probability of reactivation BK'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Hematopoetic stem cell transplantation', 'posttransplant cyclophosphamide', 'vedolizumab', 'hematoblastosis', 'ALL', 'AML', 'children', 'young adults', 'graft versus host disease'], 'conditions': ['Acute Lymphoblastic Leukemia', 'Acute Myeloid Leukemia', 'Biphenotypic Acute Leukemia', 'Malignant Lymphoma', 'Myelodysplastic Syndromes']}, 'descriptionModule': {'briefSummary': 'GVHD prevention using a combination of post-transplantation cyclophosphamide in combination with abatacept, vedolizumab and and Baricitinib in children and young adults with hematoloblastosis after myeloablative conditioning regimen with treosulfan/TBI, cyclophosphamide/etoposide, fludarabine after HSCT from matched unrelated and haploidentical donors', 'detailedDescription': 'Conditioning regimen:\n\nTreosulfan 42 g/m2/course on the days -5, -4, -3 or total body irradiation 12 Gray/course on the days -8, -7, -6 Etoposide 60 mg/kg on the days -6, -5 Fludarabine 150 mg/m2/course on the days -6, -5, -4, -3, -2\n\nPrevention of GVHD:\n\nCyclophosphamide 80 mg/kg/course on the days +3, +4 Abatacept 10 mg/kg/day on the days +5, +14, +28, +60, +90 Vedolizumab 10 mg/kg/day, max. 300 mg on the days 0, +14, +28, +60\n\nBaricitinib 4 mg/day per os (patient age \\> 9 years), 2 mg/day (patient age \\< 9 years), from day -3 to day +90 (after HSCT), orally, once a day.\n\nDonor selection criteria\n\nIn case of detection of two or more suitable donors, the choice is made in favor of:\n\n* CMV Compliance\n* Sex of donor and recipient\n* medical and psychological suitability and desire of the donor\n* Compatibility by blood type\n\nDuration of therapy\n\n* 120 days (for patients with high risk of recurrence: positive minimal residual disease before HSCT, non-remission status after HSCT, patients diagnosed with juvenile myelomonocytic leukemia)\n* 180 days (for the rest) Time of observation\n* follow up during 3 years after HSCT\n\nCriteria for premature stopping of the study\n\n1. The probability of developing acute GVHD II-IV is above 40%, of which III-IV - above 15%\n2. The probability of 100-day transplant-associated mortality is higher than 20%. Goal Evaluation Date Intermediate analysis after 1 year from the beginning. The final analysis is scheduled to take place 100 days after the last patient is included.\n\nData Monitoring and Management\n\n1\\. Plan of initial examination of the patient\n\nAfter signing the informed consent and registration, the patient undergoes an examination in accordance with the standard plan of pre-transplantation examination and additional examinations, including:\n\n* Confirmation of remission status, determination of MRD, chimerism according to the protocol 1. Monitoring of donor chimerism in patients with acute leukemia Point Days Lines\n\n 1 +30 day general, CD34\n* Only if a relapse of the disease is suspected, cm can be sent to study chimerism:\n\n * General\n * Chimerism in the sorted MRD fraction 2. Minimal residual disease (MRD) monitoring in patients with ALL +30, +100 days after HSCT - for all patients: MRD (immunophenotyping), Cytogenetics (if it presence)\n\n \\+ 60, +180 days after HSCT - for patients with MRD + or refractory before HSCT: MRD (immunophenotyping), Cytogenetics (if it presence) 3. Minimal residual disease (MRD) monitoring in patients with AML\n\n +100 days after HSCT - for all patients: MRD (immunophenotyping), Cytogenetics (if it presence)\n\n \\+ 30, +180 days after HSCT - for patients with MRD + or refractory before HSCT: MRD (immunophenotyping), Cytogenetics (if it presence)\n\n 4\\. Biobanking (KM, blood)\n\nIn this protocol, in addition to routine post-transplantation monitoring, the following studies are carried out:\n\n• Study of the subpopulation composition of peripheral blood lymphocytes: B-cells: CD19\n\nT-cells:\n\nCD3/4/8/ TCR/gd CD3/4/8/45RA/CCR7 (CD197) CD3/4/31/45RA CD4/25/127\n\nNK-compartment:\n\nCD3/CD56\n\nTCR repertoire:\n\nAnalysis multiplicity: +30, +60, +100, +180, +360 day The amount of blood for analysis is 5 ml in a test tube with EDTA.\n\n* Pathogen-specific immunoreconstitution research - ELISPOT method for evaluating the production of gamma-interferon by peripheral blood mononuclears after incubation with microbial antigens. The main antigens studied are (CMV pp65, EBV, Adenovirus (AdvHexon), BK virus) Multiplicity of analysis of recipients: +30, +60, +100, +180, +360. The amount of blood for analysis on +30 days is 10 ml, subsequently - 5 ml in a test tube with EDTA.\n* Virological monitoring by PCR weekly:\n\nBlood: CMV, EBV, ADV by PCR method Chair: ADV MONITORING by PCR is carried out up to 100 days after CGSC. The exception is patients with viremia, or receiving immunosuppressive therapy on day 100.\n\nin case of suspected visceral lesion: cerebrospinal fluid / bal / stool / urine / biopsy / other material\n\n* Biobanking Multiplicity: + 30, +60, +100, +180, +360 Blood in a test tube with EDTA, used 2. Toxicity monitoring:\n* Diagnosis and therapy of acute GVHD Clinical diagnosis and staging of acute GVHD is carried out in accordance with standard criteria (Appendix No. 3).\n\nWhen an isolated rash appears, a skin biopsy is mandatory. When a clinic of acute GVHD appears with damage to the upper and lower gastrointestinal tract (nausea, vomiting, enterocolitis), gastroscopy with a biopsy of the gastric mucosa and colonoscopy with a floor biopsy is reokended.\n\nThe biopsy material should also be sent for virological examination. Before starting therapy, a consultation is held with the head of the protocol / appointed expert.\n\n• Criteria for prescribing systemic immunosuppressive therapy: Acute GVHD stage I - therapy is not carried out Acute GVHF stage II-IV - methylprednisolone 1-2 mg / kg / day IV The period for assessing the response to first-line therapy: 72 hours, 7 days, 14 days from the start of therapy.\n\n• Criteria for prescribing second-line therapy: progression of manifestations of O.RTPH after 72 hours or no improvement after 7 days or incomplete resolution of clinical and laboratory manifestations after 14 days\n\n• Diagnosis and therapy of chronic GVHD: Diagnosis and staging of chronic GVHD are performed in accordance with THE NIH criteria (Appendix No. 4). Due to the fact that the development of chronic GVHD is one of the main parameters for the evaluation of the study, the diagnosis and staging of chronic GVHD are performed prospectively, monthly from the day +100, using a structured examination in accordance with Appendix No. 2.\n\nTherapy of chronic GVHD is carried out in accordance with the standard adopted in the clinic'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT'], 'maximumAge': '21 Years', 'minimumAge': '1 Day', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\nfollowing diseases:\n\n* acute lymphoblastic,\n* myeloblastic,\n* biphenotypic,\n* bilinear leukemia,\n* malignant lymphoma,\n* myelodysplastic syndrome, 2. Donors:\n* voluntary fully HLA-matched unrelated,\n* related haploidentical donors 3. Clinical center: National Medical Research Center of pediatric haematology, oncology and immunology named after Dmitry Rogachev" of the Ministry of Health of Russia 4. Availability of consent to conduct a study\n\nExclusion Criteria:\n\nAge over 21 years\n\n* Patients with ALL outside clinical and hematological remission\n* Clinical status:\n\n * Lansky/Karnowski index \\<70% (supplement No.1)\n * Heart function: left ventricular ejection fraction \\<40% according to ultrasound of the heart1\n * Kidney function: clearance of endogenous creatinine \\< 70 ml / min\n * Liver function: total bilirubin, ALT, AST, ALP \\> 2 norms\n * Lung function: lung capacity \\<50%, for children who cannot carry out of respiratory function - oxygen saturation during pulse oximetry \\<92%\n* Uncontrolled viral, fungal or bacterial infection.\n* Mental illness of the patient or caregivers, making it impossible to realize the essence of the study and compromising compliance with medical appointments and sanitary and hygienic regime 1 These patients may receive treatment according to the protocol, but the results will be evaluated separately'}, 'identificationModule': {'nctId': 'NCT06475820', 'briefTitle': 'Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Baricitinib at Children and Young Adults With Hemoblastosis', 'organization': {'class': 'OTHER', 'fullName': 'Federal Research Institute of Pediatric Hematology, Oncology and Immunology'}, 'officialTitle': 'Prospective Pilot Study of the Clinical Efficacy and Safety of the Method for Preventing a Graft-versus-host Disease Through the Agency of Using the Combination of Post-transplantation Cyclophosphamide With Abatacept, Vedolizumab and Baricitinib at Children and Young Adults With Hemoblastosis After Hematopoietic Stem Cell Transplantation From an Unrelated or Haploidentic Donor', 'orgStudyIdInfo': {'id': 'NCHPOI-2023-07'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Baricitinib and Cyclophosphamide', 'description': 'Baricitinib 4 mg/day per os (patient age \\> 9 years), 2 mg/day (patient age \\< 9 years), from day -3 to day +90 (after HSCT), orally, once a day.', 'interventionNames': ['Drug: Baricitinib']}], 'interventions': [{'name': 'Baricitinib', 'type': 'DRUG', 'otherNames': ['Vedolizumab', 'Abatacept', 'Cyclophosphamide'], 'description': 'GVHD prevention using a combination of post-transplantation cyclophosphamide\n\nPrevention of GVHD:\n\nCyclophosphamide 80 mg/kg/course on the days +3, +4 Abatacept 10 mg/kg/day on the days +5, +14, +28, +60, +90 Vedolizumab 10 mg/kg/day, max. 300 mg on the days 0, +14, +28, +60 Baricitinib 4 mg/day per os (patient age \\> 9 years), 2 mg/day (patient age \\< 9 years), from day -3 to day +90 (after HSCT), orally, once a day.', 'armGroupLabels': ['Baricitinib and Cyclophosphamide']}]}, 'contactsLocationsModule': {'locations': [{'zip': '11198', 'city': 'Moscow', 'state': 'Samory-Mashela,1', 'country': 'Russia', 'facility': 'Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology', 'geoPoint': {'lat': 55.75204, 'lon': 37.61781}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Federal Research Institute of Pediatric Hematology, Oncology and Immunology', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}