Ignite Creation Date:
2025-12-25 @ 4:25 AM
Ignite Modification Date:
2026-01-29 @ 12:21 AM
Study NCT ID:
NCT00094120
Status:
TERMINATED
Last Update Posted:
2008-01-09
First Post:
2004-10-11
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
MSI-1256F (Squalamine Lactate) in Combination With Verteporfin in Patients With "Wet" Age-Related Macular Degeneration (AMD)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D008268', 'term': 'Macular Degeneration'}], 'ancestors': [{'id': 'D012162', 'term': 'Retinal Degeneration'}, {'id': 'D012164', 'term': 'Retinal Diseases'}, {'id': 'D005128', 'term': 'Eye Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C488568', 'term': 'squalamine lactate'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'count': 60}}, 'statusModule': {'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2004-10'}, 'statusVerifiedDate': '2007-11', 'completionDateStruct': {'date': '2007-02', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2008-01-08', 'studyFirstSubmitDate': '2004-10-11', 'studyFirstSubmitQcDate': '2004-10-13', 'lastUpdatePostDateStruct': {'date': '2008-01-09', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2004-10-14', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2007-02', 'type': 'ACTUAL'}}, 'conditionsModule': {'keywords': ['Age-Related Macular Degeneration - Wet Type'], 'conditions': ['Macular Degeneration']}, 'descriptionModule': {'briefSummary': 'Age-Related Macular Degeneration (AMD) is a degenerative disease of the retina that causes a progressive loss of central vision. AMD is the leading cause of legal blindness among adults age 50 or older in the Western world. AMD presents in two different types - "dry" and the more severe "wet" form. Wet AMD is caused by the growth of abnormal blood vessels in the macula.\n\nSqualamine lactate is an investigational drug that may prevent the growth of these abnormal blood vessels. This study will test the safety and efficacy of Squalamine when administered with verteporfin therapy in patients with "wet" AMD.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '50 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Patients with a diagnosis of "wet" age-related macular degeneration\n\nExclusion Criteria:\n\n* Prior treatment for "wet" age-related macular degeneration'}, 'identificationModule': {'nctId': 'NCT00094120', 'briefTitle': 'MSI-1256F (Squalamine Lactate) in Combination With Verteporfin in Patients With "Wet" Age-Related Macular Degeneration (AMD)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Genaera Corporation'}, 'officialTitle': 'Safety and Efficacy of MSI-1256F (Squalamine Lactate) in Combination With Verteporfin in Patients With "Wet" Age-Related Macular Degeneration (AMD)', 'orgStudyIdInfo': {'id': 'MSI-1256F-208'}}, 'armsInterventionsModule': {'interventions': [{'name': 'MSI-1256F (Squalamine Lactate)', 'type': 'DRUG'}]}, 'contactsLocationsModule': {'locations': [{'zip': '19462', 'city': 'Plymouth Meeting', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Genaera Corporation', 'geoPoint': {'lat': 40.10233, 'lon': -75.27435}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Genaera Corporation', 'class': 'INDUSTRY'}}}}