Ignite Creation Date:
2025-12-24 @ 4:38 PM
Ignite Modification Date:
2026-01-27 @ 8:48 PM
Study NCT ID:
NCT00643266
Status:
COMPLETED
Last Update Posted:
2018-11-16
First Post:
2008-02-26
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D000091942', 'term': 'Cognitive Training'}], 'ancestors': [{'id': 'D000066530', 'term': 'Neurological Rehabilitation'}, {'id': 'D012046', 'term': 'Rehabilitation'}, {'id': 'D000359', 'term': 'Aftercare'}, {'id': 'D003266', 'term': 'Continuity of Patient Care'}, {'id': 'D005791', 'term': 'Patient Care'}, {'id': 'D013812', 'term': 'Therapeutics'}, {'id': 'D006296', 'term': 'Health Services'}, {'id': 'D005159', 'term': 'Health Care Facilities Workforce and Services'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['INVESTIGATOR']}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 91}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2008-02'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2018-11', 'completionDateStruct': {'date': '2013-08', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2018-11-15', 'studyFirstSubmitDate': '2008-02-26', 'studyFirstSubmitQcDate': '2008-03-24', 'lastUpdatePostDateStruct': {'date': '2018-11-16', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2008-03-26', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2013-08', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Recollection estimates', 'timeFrame': 'Immediately post-training and three months post-training', 'description': 'Recollection, defined as Correct "yes" responses to "Same" repetitions minus Incorrect "yes" responses to "Different" repetitions, as a function of condition (trained versus control), lag (3, 16) and time (pre-, post-, and 3 month follow-up)'}], 'secondaryOutcomes': [{'measure': 'Brain activation as assessed by functional magnetic resonance imaging', 'timeFrame': 'Immediately post-training', 'description': 'Prefrontal (inferior, middle, and superior frontal gyri) activation for Different Repetitions minus Same Repetitions, as a function of group (trained versus control), lag (3, 16), and time (pre, post). Additional analyses will compare trained versus control older adults with younger adults on these measures at baseline (pre). Analyses will include an exploration of prefrontal laterality of the effects (left minus right), to see whether training induces greater bilaterality of activation.'}, {'measure': 'Transfer to other recollection-dependent task and to subjective memory measures', 'timeFrame': 'Immediately post-training and three months post-training', 'description': 'Source memory, self-ordered pointing, n-back, a Sternberg task, CVLT, an AB-AC test of proactive interference, the Memory Controllability Inventory, Multifactorial Memory Questionnaire (Ability and Contentment subscales), Meta-Memory in Adulthood questionnaire (locus of control, anxiety, and capability subscales), and an in-house measure of the efficacy of the control program'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['recollection training', 'aging', 'amnestic mild cognitive impairment', 'fMRI'], 'conditions': ['Amnestic Mild Cognitive Impairment', 'Aging']}, 'referencesModule': {'references': [{'pmid': '18331160', 'type': 'RESULT', 'citation': 'Anderson ND, Ebert PL, Jennings JM, Grady CL, Cabeza R, Graham SJ. Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. Neuropsychology. 2008 Mar;22(2):177-87. doi: 10.1037/0894-4105.22.2.177.'}, {'pmid': '25175752', 'type': 'RESULT', 'citation': 'Guild EB, Vasquez BP, Maione AM, Mah L, Ween J, Anderson ND. Dynamic working memory performance in individuals with single-domain amnestic mild cognitive impairment. J Clin Exp Neuropsychol. 2014;36(7):751-60. doi: 10.1080/13803395.2014.941790. Epub 2014 Aug 30.'}, {'pmid': '19128531', 'type': 'RESULT', 'citation': 'Ebert PL, Anderson ND. Proactive and retroactive interference in young adults, healthy older adults, and older adults with amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2009 Jan;15(1):83-93. doi: 10.1017/S1355617708090115.'}, {'pmid': '29494181', 'type': 'RESULT', 'citation': 'Anderson ND, Ebert PL, Grady CL, Jennings JM. Repetition lag training eliminates age-related recollection deficits (and gains are maintained after three months) but does not transfer: Implications for the fractionation of recollection. Psychol Aging. 2018 Feb;33(1):93-108. doi: 10.1037/pag0000214.'}, {'pmid': '28161030', 'type': 'RESULT', 'citation': 'Meusel LA, Grady CL, Ebert PE, Anderson ND. Brain-behavior relationships in source memory: Effects of age and memory ability. Cortex. 2017 Jun;91:221-233. doi: 10.1016/j.cortex.2016.12.023. Epub 2017 Jan 12.'}]}, 'descriptionModule': {'briefSummary': "We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related brain activity compared to younger adults, whereas healthy older adults with poorer memory (Lo-Old) do not. We have also shown that individuals with amnestic Mild Cognitive Impairment (aMCI) have impairments of conscious, effortful, Recollection-based memory processes, whereas their automatic, Familiarity-based memory processes are intact. Our primary current goal is to investigate whether our successful memory intervention will improve Recollection and produce induce altered patterns of brain activity in the Lo-Old and aMCI.\n\nYoung, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive the memory intervention, while the other half in each group will receive a control program consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned while performing the two memory tasks. We predict that the memory intervention will improve performance on a number of memory tasks, and will induce altered patterns of brain activity. In the Lo-Old, their brain activity after the memory intervention will look more like the Hi-Old, while brain activity will become more focal in the aMCI."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['OLDER_ADULT'], 'maximumAge': '90 Years', 'minimumAge': '65 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* 65-90 years old\n* English as a first language or learned before kindergarten\n* Right handed\n\nExclusion Criteria:\n\n* Neurologic disorder\n* Major medical disorder affecting cognition\n* Psychiatric disorder\n* Metal in the body that poses a hazard in the MRI scanner'}, 'identificationModule': {'nctId': 'NCT00643266', 'briefTitle': 'Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment', 'organization': {'class': 'OTHER', 'fullName': 'Baycrest'}, 'officialTitle': 'Memory Interventions for Older Adults', 'orgStudyIdInfo': {'id': 'RecollectionTraining'}, 'secondaryIdInfos': [{'id': 'CIHR MOP 67015'}, {'id': 'ASC 08 95'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': '1', 'description': 'Recollection training via graduated increases in task difficulty, carried out over 36 sessions over 9 training days', 'interventionNames': ['Behavioral: Recollection Training']}, {'type': 'ACTIVE_COMPARATOR', 'label': '2', 'description': 'Computer-delivered information sessions about memory and aging with Jeopardy-like games to engage participants', 'interventionNames': ['Behavioral: Control']}], 'interventions': [{'name': 'Recollection Training', 'type': 'BEHAVIORAL', 'otherNames': ['Memory training'], 'description': 'Participants are exposed to long lists of words. Each word is presented either visually or auditorily, and each word is repeated after a variable number of intervening words (the lag), in each the same modality, or the other modality. Participants are instructed to respond "yes" only to words repeated in the same modality. If a performance criterion is met, the lag is increased for the next session; if the performance criterion is not met, the same lag is repeated in the next session.', 'armGroupLabels': ['1']}, {'name': 'Control', 'type': 'BEHAVIORAL', 'otherNames': ['Educational Control'], 'description': 'Participants view PowerPoint presentations on various topics related to memory and aging (e.g., structural brain changes, diet, stress, depression) and how each of these topics affect memory, and after each presentation, play a Jeopardy-like game to test their knowledge gain', 'armGroupLabels': ['2']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'M6A 2E1', 'city': 'Toronto', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Baycrest', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}], 'overallOfficials': [{'name': 'Nicole D Anderson, PhD, CPsych', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Baycrest'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Baycrest', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Senior Scientist', 'investigatorFullName': 'Dr. Nicole D. Anderson', 'investigatorAffiliation': 'Baycrest'}}}}