Ignite Creation Date:
2025-12-24 @ 4:40 PM
Ignite Modification Date:
2025-12-24 @ 4:40 PM
Study NCT ID:
NCT03972566
Status:
UNKNOWN
Last Update Posted:
2019-06-03
First Post:
2019-05-30
Is Possible Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Localized Effects of PBM and Exogenous NO on CREST Patients Calcinosis Cutis & Raynaud Phenomenon
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D017675', 'term': 'CREST Syndrome'}, {'id': 'D000092182', 'term': 'Calcinosis Cutis'}, {'id': 'D011928', 'term': 'Raynaud Disease'}], 'ancestors': [{'id': 'D015154', 'term': 'Esophageal Motility Disorders'}, {'id': 'D003680', 'term': 'Deglutition Disorders'}, {'id': 'D004935', 'term': 'Esophageal Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D000090122', 'term': 'Livedoid Vasculopathy'}, {'id': 'D013927', 'term': 'Thrombosis'}, {'id': 'D016769', 'term': 'Embolism and Thrombosis'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D016491', 'term': 'Peripheral Vascular Diseases'}, {'id': 'D013684', 'term': 'Telangiectasis'}, {'id': 'D045745', 'term': 'Scleroderma, Limited'}, {'id': 'D012595', 'term': 'Scleroderma, Systemic'}, {'id': 'D003240', 'term': 'Connective Tissue Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017445', 'term': 'Skin Diseases, Vascular'}, {'id': 'D002114', 'term': 'Calcinosis'}, {'id': 'D002128', 'term': 'Calcium Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D045462', 'term': 'Endothelium-Dependent Relaxing Factors'}], 'ancestors': [{'id': 'D014665', 'term': 'Vasodilator Agents'}, {'id': 'D002317', 'term': 'Cardiovascular Agents'}, {'id': 'D045506', 'term': 'Therapeutic Uses'}, {'id': 'D020228', 'term': 'Pharmacologic Actions'}, {'id': 'D020164', 'term': 'Chemical Actions and Uses'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITHOUT_DNA', 'description': "Gaseous NO emanating from subject's arms, Digital Thermal Monitoring (DTM) to measure vascular reactivity"}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 5}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2019-06-20', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2019-05', 'completionDateStruct': {'date': '2019-09-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2019-05-31', 'studyFirstSubmitDate': '2019-05-30', 'studyFirstSubmitQcDate': '2019-05-31', 'lastUpdatePostDateStruct': {'date': '2019-06-03', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2019-06-03', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2019-07-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Chemiluminescence detection', 'timeFrame': '15 minutes', 'description': 'Sievers Nitric Oxide Analyzer NOA 280i detects \\[NO\\] in Ambient Air or Solution'}, {'measure': 'Endothelial Measurement', 'timeFrame': '5 minutes', 'description': 'VENDYS II'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Nitric Oxide', 'Photobiomodulation', 'LLLT', 'Photomedicine'], 'conditions': ['CREST Syndrome', 'Calcinosis Cutis', 'Raynaud Phenomenon']}, 'descriptionModule': {'briefSummary': "Background CREST is an acronym for the cardinal clinical features of the syndrome (Calcinosis, Raynaud phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia) and part of the heterogeneous group of sclerodermas.\n\nCalcinosis is the pathologic calcification of soft tissues. When symptomatic, they can be tender and painful, ulcerate, and drain a white chalky substance. With time, heterotopic bone formation may occur. Inflammatory reactions also intermittently occur at the site of calcinosis. It has been suggested that TGF-beta3 plays a major role in the pathogenesis of calcinosis.\n\nA variety of medical therapies have been used to try to alleviate patient symptoms. These include pharmacological approaches (e..g., warfarin), surgical curettage or excision, as well as carbon dioxide laser treatments. No consistently reliable pharmacological treatment seems to be available to prevent or eliminate calcinosis. Curettage and excision and carbon dioxide laser of localized painful large deposits can relieve symptoms but recurrence is common. In addition, aggressive curettage or excision can damage deeper neurovascular structures. While calcinosis is associated with significant morbidity its treatment remains a challenge.\n\nPhotobiomodulation (PBM) has been shown to promote wound healing, suppress inflammatory reactions and regulate collagen synthesis in a number of in vitro and in vivo studies.\n\nHuman skin contains photolabile nitric oxide (NO) derivatives which decompose after UVA irradiation and release vasoactive NO. However, aside from blue light, barely nothing has been reported about the effects of red and NIR wavelengths.\n\nMethod A custom-built air tight sleeve which envelopes the forearm of a subject will be used to measure the NO emanating from the skin under photobiomodulation conditions (red \\& NIR) and quantified by chemiluminescence detection.\n\nSimultaneously, CREST patient's hands exhibiting calcinosis and/or Raynaud phenomenon will be exposed to exogenous gaseous nitric oxide (INOMAX) to determine the vascular impact of this approach.\n\nThis case series will assess Light Emitting Diode (LED) based PBM therapy as a treatment alternative for cutaneous calcinosis and the effects of gaseous NO on calcinosis and/or Raynaud phenomenon in CREST patients."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '60 Years', 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': "Patients suffering from CREST that have consulted in Dr. Barolet's Clinic of Dermatology", 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Male or female\n* 18-60 years of age\n* CREST syndrome with calcinosis cutis.\n* CREST syndrome without calcinosis cutis.\n\nExclusion Criteria:\n\n* Diabetes mellitus\n* Acute inflammation\n* Arrhythmia\n* Acute malignancy\n* Renal failure\n* Active CVD\n* Photodermatosis and/or photosensitivity including skin cancer-prone disease/syndrome (XP and Bloom Syndrome)\n* Porphyria and/or hypersensitivity to porphyrins\n* Congenital or acquired immunodeficiency.'}, 'identificationModule': {'nctId': 'NCT03972566', 'briefTitle': 'Localized Effects of PBM and Exogenous NO on CREST Patients Calcinosis Cutis & Raynaud Phenomenon', 'organization': {'class': 'OTHER', 'fullName': 'RoseLab Skin Optics Laboratory'}, 'officialTitle': 'Localized Effects of Photobiomodulation and Exogenous Nitric Oxide on CREST Patients Calcinosis Cutis & Raynaud Phenomenon', 'orgStudyIdInfo': {'id': 'NO-5420'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'CREST with Calcinosis cutis', 'interventionNames': ['Drug: INOMAX']}, {'label': 'CREST without Calcinosis cutis', 'interventionNames': ['Drug: INOMAX']}], 'interventions': [{'name': 'INOMAX', 'type': 'DRUG', 'description': 'INOMAX + PBM', 'armGroupLabels': ['CREST with Calcinosis cutis', 'CREST without Calcinosis cutis']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'H7T0G3', 'city': 'Laval', 'state': 'Quebec', 'country': 'Canada', 'contacts': [{'name': 'Daniel Barolet, MD', 'role': 'CONTACT', 'email': 'daniel.barolet@mcgill.ca', 'phone': '450-686-4744'}, {'name': 'Augustin Barolet, B.Eng', 'role': 'CONTACT', 'email': 'augustin.barolet@mail.mcgill.ca', 'phone': '450-686-4744'}], 'facility': 'Clinique Dr Daniel Barolet', 'geoPoint': {'lat': 45.56995, 'lon': -73.692}}], 'centralContacts': [{'name': 'Daniel Barolet, MD', 'role': 'CONTACT', 'email': 'daniel.barolet@mcgill.ca', 'phone': '450-686-4744'}, {'name': 'Augustin Barolet, B.Eng', 'role': 'CONTACT', 'email': 'augustin.barolet@mail.mcgill.ca', 'phone': '450-686-4744'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'RoseLab Skin Optics Laboratory', 'class': 'OTHER'}, 'collaborators': [{'name': 'Mallinckrodt', 'class': 'INDUSTRY'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Director', 'investigatorFullName': 'Dr Daniel Barolet', 'investigatorAffiliation': 'RoseLab Skin Optics Laboratory'}}}}