Ignite Creation Date:
2025-12-24 @ 5:05 PM
Ignite Modification Date:
2026-01-25 @ 4:57 AM
Study NCT ID:
NCT01164150
Status:
TERMINATED
Last Update Posted:
2023-04-06
First Post:
2010-07-15
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Prospective Randomised Phase II Trial Evaluating Adjuvant Pelvic Radiotherapy Using Either IMRT or 3-Dimensional Planning for Endometrial Cancer. ICORG 09-06
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D016889', 'term': 'Endometrial Neoplasms'}, {'id': 'D011832', 'term': 'Radiation Injuries'}], 'ancestors': [{'id': 'D014594', 'term': 'Uterine Neoplasms'}, {'id': 'D005833', 'term': 'Genital Neoplasms, Female'}, {'id': 'D014565', 'term': 'Urogenital Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D014591', 'term': 'Uterine Diseases'}, {'id': 'D005831', 'term': 'Genital Diseases, Female'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D000091662', 'term': 'Genital Diseases'}, {'id': 'D014947', 'term': 'Wounds and Injuries'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 92}}, 'statusModule': {'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2010-03', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2023-04', 'completionDateStruct': {'date': '2020-03-13', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2023-04-05', 'studyFirstSubmitDate': '2010-07-15', 'studyFirstSubmitQcDate': '2010-07-15', 'lastUpdatePostDateStruct': {'date': '2023-04-06', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2010-07-16', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2020-03-13', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Reduction in the incidence of ≥ grade 2 acute genitourinary (GU) and gastrointestinal (GI) toxicity according to NCI CTCAE v.3.0', 'timeFrame': '2015'}], 'secondaryOutcomes': [{'measure': 'Incidence of late GI and GU toxicity according to NCI CTCAE v.3.0', 'timeFrame': '2015'}, {'measure': 'Feasibility of implementing pelvic nodal irradiation using intensity-modulated radiotherapy in gynecological cancer', 'timeFrame': '2015'}, {'measure': 'Establishment of an image-guided pathway for gynecological cancer radiotherapy', 'timeFrame': '2015'}, {'measure': 'Rate of loco-regional control as assessed by CT scan, MRI, and biopsy', 'timeFrame': '2015'}, {'measure': 'Quality of life as assessed using EORTC QLQ-C30 and EORTC QLQ Cervical Cancer Specific Module CX 24 questionnaires', 'timeFrame': '2015'}, {'measure': 'Rate of disease-free survival', 'timeFrame': '2015'}, {'measure': 'Overall survival rate', 'timeFrame': '2015'}]}, 'conditionsModule': {'keywords': ['gastrointestinal complications', 'urinary complications', 'radiation toxicity', 'recurrent endometrial carcinoma', 'endometrial adenocarcinoma', 'stage IA endometrial carcinoma', 'stage IB endometrial carcinoma', 'stage II endometrial carcinoma', 'stage IIIA endometrial carcinoma', 'stage IIIB endometrial carcinoma', 'stage IIIC endometrial carcinoma'], 'conditions': ['Endometrial Cancer', 'Gastrointestinal Complications', 'Radiation Toxicity', 'Urinary Complications']}, 'descriptionModule': {'briefSummary': 'Post-operative radiotherapy is internationally accepted as standard practice in the management of high-risk endometrial cancer1. Whilst it has no proven impact on overall survival it significantly increases local control.\n\nConventional radiotherapy techniques (3-dimensional) utilise a 3 or 4 field beam arrangement to target the pelvis in order to treat those areas at risk of recurrence: the vagina, the parametrium and the pelvic lymph nodes. However, when using such a technique it is not possible to avoid irradiating sensitive normal tissues such as the bowel and bladder.\n\nToxicity data from international randomised control trials in endometrial cancer report significantly more haematological, gastrointestinal, genitourinary and cutaneous toxicites (all grades) in those who received pelvic irradiation compared to those who did not2,3. These trials delivered radiotherapy using 2 or 3-dimensional techniques.\n\nIntensity Modulated Radiation Therapy (IMRT) is a newer but established radiotherapy technique in many tumour sites that allows us to much more tightly conform the radiation. It uses computer-generated beams to produce radiotherapy volumes that can avoid irradiation of normal tissues in the pelvis.\n\nThere are no randomised studies reported in the literature that compare 3-dimensional pelvic irradiation with IMRT in patients who have had surgery for endometrial cancer. However there are several small studies that report considerable sparing of normal tissues using IMRT and when compared retrospectively with conventionally treated patients demonstrate marked reductions in acute gastrointestinal and genitourinary toxicity4.\n\nBy delivering post-operative radiotherapy to the pelvis using IMRT (as opposed to the standard 3-dimensional technique) it is anticipated that whilst local control and survival will be unaffected acute and late toxicity will be reduced.', 'detailedDescription': 'Primary Objective:\n\n• To compare the incidence of acute grade \\>2 GU and GI toxicity\n\nSecondary Objectives:\n\n* To establish in the context of a clinical research study the feasibility of implementing pelvic nodal irradiation using IMRT in gynaecological cancer\n* To establish an Image-Guided pathway for gynaecological cancer radiotherapy incorporating\n\n * Set-up errors and optimal margins for set-up uncertainty\n * Investigation of effects of bladder filling and rectal preparation protocols on the planning target volume\n* To estimate the rate of loco-regional control\n* To evaluate Quality of Life\n* To estimate the rate of disease-free survival\n* To estimate the overall survival rate\n* To compare the incidence of late GU and GI toxicity'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Patients undergoing adjuvant pelvic radiotherapy for histologically confirmed endometrial adenocarcinoma / serous carcinoma / papillary serous carcinoma / mixed histology (adenocarcinoma and serous) and following AJCC 2009 grade/stage:\n\n * Grade 2: stage IB (LVSI +/or \\>60yrs)\n * Grade 3: stage IA and IB\n * Grade 1-3: Stage II and IIIA, IIIB and IIIC1\n* Surgery consisting of total hysterectomy, +/- bilateral salpingo-oophorectomy, +/- lymph node sampling\n* Staging with imaging of pelvis and abdomen (either MRI or CT)\n* ECOG PS 0-2\n* Age ≥ 18 years\n* Provision of written informed consent in line with ICH-GCP guidelines\n\nExclusion Criteria:\n\n* Previous radiotherapy to the pelvic region\n* Patients in whom concurrent chemotherapy in planned\n* Patients with macroscopic disease in situ\n* History of inflammatory bowel disease\n* Previous hip replacement\n* Previous bowel surgery (excluding appendectomy)\n* Patients with other syndromes/conditions associated with increased radiosensitivity\n* The patient has or had other co-existing malignancies within the past 5 years other than non-melanoma skin cancer\n* Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study or if it is felt by the research / medical team that the patient may not be able to comply with the protocol'}, 'identificationModule': {'nctId': 'NCT01164150', 'briefTitle': 'Prospective Randomised Phase II Trial Evaluating Adjuvant Pelvic Radiotherapy Using Either IMRT or 3-Dimensional Planning for Endometrial Cancer. ICORG 09-06', 'organization': {'class': 'NETWORK', 'fullName': 'Cancer Trials Ireland'}, 'officialTitle': 'Prospective Randomised Phase II Trial Evaluating Adjuvant Pelvic Radiotherapy Using Either IMRT or 3-Dimensional Planning for Endometrial Cancer', 'orgStudyIdInfo': {'id': 'CTRIAL-IE (ICORG) 09-06'}, 'secondaryIdInfos': [{'id': 'CTRIAL-IE (ICORG) 09-06'}, {'id': 'EU-21048'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Arm B', 'description': 'Radiation: 45 Gy / 25 fractions pelvic radiotherapy using intensity modulated radiotherapy (IMRT) followed by 11 Gy / 2 fractions vaginal vault brachytherapy', 'interventionNames': ['Radiation: 45 Gy/25 fractions']}, {'type': 'OTHER', 'label': 'Arm A Control', 'description': 'Radiation: 45 Gy/25 fraction external beam pelvic radiotherapy delivered using a 3-dimensional planned technique followed by 11 Gy / 2 fractions vaginal vault brachytherapy', 'interventionNames': ['Radiation: 45 Gy/25 fractions']}], 'interventions': [{'name': '45 Gy/25 fractions', 'type': 'RADIATION', 'description': 'Arm A 45 Gy/25 fractions pelvic radiotherapy using 3D planned technique followed by 11Gy/2 fractions vaginal vault brachytherapy', 'armGroupLabels': ['Arm A Control', 'Arm B']}]}, 'contactsLocationsModule': {'locations': [{'zip': '6', 'city': 'Dublin', 'country': 'Ireland', 'facility': "St Luke's Radiation Oncology Network (SLRON) Centres", 'geoPoint': {'lat': 53.33306, 'lon': -6.24889}}, {'city': 'Dublin', 'country': 'Ireland', 'facility': "St Luke's Centre for Radiation Oncology at Beaumont Hospital", 'geoPoint': {'lat': 53.33306, 'lon': -6.24889}}, {'city': 'Dublin', 'country': 'Ireland', 'facility': "St Luke's Centre for Radiation Oncology at St James Hospital", 'geoPoint': {'lat': 53.33306, 'lon': -6.24889}}, {'city': 'Dublin', 'country': 'Ireland', 'facility': "St Luke's Centre for Radiation Oncology at St Lukes Hospital", 'geoPoint': {'lat': 53.33306, 'lon': -6.24889}}, {'city': 'Limerick', 'country': 'Ireland', 'facility': 'Mid-Western Radiation Oncology Centre', 'geoPoint': {'lat': 52.66472, 'lon': -8.62306}}], 'overallOfficials': [{'name': 'Charles Gillham, Dr', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': "Saint Luke's Hospital"}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Cancer Trials Ireland', 'class': 'NETWORK'}, 'responsibleParty': {'type': 'SPONSOR'}}}}