Ignite Creation Date:
2025-12-24 @ 5:08 PM
Ignite Modification Date:
2025-12-28 @ 9:48 AM
Study NCT ID:
NCT04385550
Status:
UNKNOWN
Last Update Posted:
2020-05-13
First Post:
2020-05-09
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study of Anlotinib Hydrochloride Capsule Combined With AK105 Injection in Subject With Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D017239', 'term': 'Paclitaxel'}, {'id': 'D000077143', 'term': 'Docetaxel'}], 'ancestors': [{'id': 'D043823', 'term': 'Taxoids'}, {'id': 'D043822', 'term': 'Cyclodecanes'}, {'id': 'D003516', 'term': 'Cycloparaffins'}, {'id': 'D006840', 'term': 'Hydrocarbons, Alicyclic'}, {'id': 'D006844', 'term': 'Hydrocarbons, Cyclic'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D004224', 'term': 'Diterpenes'}, {'id': 'D013729', 'term': 'Terpenes'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 528}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2020-05-20', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2020-01', 'completionDateStruct': {'date': '2023-12-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2020-05-09', 'studyFirstSubmitDate': '2020-05-09', 'studyFirstSubmitQcDate': '2020-05-09', 'lastUpdatePostDateStruct': {'date': '2020-05-13', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2020-05-13', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2023-10-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Overall survival (OS)', 'timeFrame': 'up to 45 weeks', 'description': 'OS defined as the time from randomization to death from any cause. Subjects who do not die at the end of the extended follow-up period, or were lost to follow-up during the study, were censored at the last date they were known to be alive.'}], 'secondaryOutcomes': [{'measure': 'Progression-free survival (PFS)', 'timeFrame': 'up to 45 weeks', 'description': 'PFS defined as the time from randomization until the first documented progressive disease (PD) or death from any cause.'}, {'measure': 'Overall response rate (ORR)', 'timeFrame': 'up to 45 weeks', 'description': 'Percentage of subjects achieving complete response (CR) and partial response (PR).'}, {'measure': 'Disease control rate (DCR)', 'timeFrame': 'up to 45 weeks', 'description': 'Percentage of subjects achieving complete response (CR) and partial response (PR) and stable disease (SD).'}, {'measure': 'Duration of response (DOR)', 'timeFrame': 'up to 45 weeks', 'description': 'DOR defined as time from earliest date of disease response to earliest date of disease progression based on radiographic assessment.'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma']}, 'descriptionModule': {'briefSummary': 'This is a randomized, controlled, open-label, multicenter study to evaluate efficacy of AK105 injection combined with Anlotinib Hydrochloride Capsules versus standard second-line chemotherapy. Patients are treated with AK105 injection combined with Anlotinib Hydrochloride Capsules or standard second-line chemotherapy, with 1:1 random ratio.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* 1\\. Understood and signed an informed consent form; 2.Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1; Life expectancy ≥ 3 months; 3. Histopathology or cytology confirmed as metastatic or local advanced gastric and gastro-oesophageal junction adenocarcinoma; 4. First-line standard chemotherapy regimen in patients with advanced gastric or gastroesophageal junction adenocarcinoma after treatment failure; 5. Has at least one measurable lesion; 6. Weight ≥40 kg or BMI ≥18.5; 7. Adequate organ function; 8. Male or female subjects should agree to use an adequate method of contraception starting with the first dose of study therapy through 6 months after the last dose of study (such as intrauterine devices , contraceptives or condoms) ;No pregnant or breastfeeding women, and a negative pregnancy test are received within 7 days before the randomization.\n\nExclusion Criteria:\n\n* 1\\. Histopathology confirmed as squamous cell carcinoma, carcinoid, undifferentiated carcinoma, or other gastric cancer; 2. HER2 positive; 3. Has received paclitaxel or docetaxel in the first-line treatment; 4. Has received paclitaxel or docetaxel in the neoadjuvant or adjuvant treatment regimen and have relapsed or metastasized within 6 months after the last dose; 5. Has other malignant tumors within 5 years; 6. Has used anti-angiogenic drugs such as anlotinib, apatinib, lenvatinib, sorafenib, sunitinib, bevacizumab, or related immunotherapy drugs for PD-1, PD-L1, etc; 7. Severe hypersensitivity after administration of other monoclonal antibodies; 8. Has spinal cord compression, cancerous meningitis and symptomatic brain metastasis； 9. Has adverse events caused by previous therapy except alopecia that did not recover to ≤grade 1; 10. Has received radiotherapy, chemotherapy and surgery within 4 weeks before the first dose; 11. Has gastrointestinal bleeding tendency within 4 weeks before the first dose; 12. The tumor has invaded important blood vessels and will cause fatal bleeding; 13. Has multiple factors affecting oral medication; 14. Has uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage; 15. Has any active autoimmune disease or history of autoimmune disease; 16. Immunosuppressant or systemic or absorbable local hormone therapy is required to achieve the aim of immunosuppression (dose \\> 10mg/ day prednisone or other therapeutic hormones) and is still used within 2 weeks after the first administration; 17. Has any serious and / or uncontrolled disease; 18. Has active viral infection; 19. Has participated in other anticancer drug clinical trials within 4 weeks; 20. According to the judgement of the investigators, there are other factors that may lead to the termination of the study.'}, 'identificationModule': {'nctId': 'NCT04385550', 'briefTitle': 'A Study of Anlotinib Hydrochloride Capsule Combined With AK105 Injection in Subject With Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma', 'organization': {'class': 'INDUSTRY', 'fullName': 'Chia Tai Tianqing Pharmaceutical Group Co., Ltd.'}, 'officialTitle': 'A Randomized, Open-label, Controlled, Multicenter Phase III Study of Hydrochloride Capsule Combined With AK105 Injection Versus Standard Second-line Chemotherapy for Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma', 'orgStudyIdInfo': {'id': 'ALTN-AK05-III-01'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Anlotinib hydrochloride capsule + AK105 injection', 'description': 'Anlotinib hydrochloride capsule 12mg given orally in fasting conditions, once daily in 21-day cycle (14 days on treatment from Day 1-14, 7 days off treatment from Day 15-21) plus AK105 200mg intravenously (IV) on Day 1 of each 21-day cycle.', 'interventionNames': ['Drug: Anlotinib hydrochloride capsule', 'Drug: AK105 injection']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Standard Second-line Chemotherapy', 'description': 'Participants receive 80 mg/m² IV paclitaxel on Days 1, 8 and 15 of each 28-day cycle, or 75mg/m² docetaxel every 3 weeks of each 21-day cycle until disease progression or unacceptable toxicity.', 'interventionNames': ['Drug: Paclitaxel injection', 'Drug: Docetaxel injection']}], 'interventions': [{'name': 'Anlotinib hydrochloride capsule', 'type': 'DRUG', 'description': 'Anlotinib hydrochloride capsule 12mg given orally in fasting conditions, once daily in 21-day cycle (14 days on treatment from Day 1-14, 7 days off treatment from Day 15-21).', 'armGroupLabels': ['Anlotinib hydrochloride capsule + AK105 injection']}, {'name': 'AK105 injection', 'type': 'DRUG', 'description': 'AK105 200mg intravenously (IV) on Day 1 of each 21-day cycle.', 'armGroupLabels': ['Anlotinib hydrochloride capsule + AK105 injection']}, {'name': 'Paclitaxel injection', 'type': 'DRUG', 'description': 'Paclitaxel injection 80mg / m² IV on Days 1, 8 and 15 of each 28-day cycle.', 'armGroupLabels': ['Standard Second-line Chemotherapy']}, {'name': 'Docetaxel injection', 'type': 'DRUG', 'description': 'Docetaxel injection 75mg / m² IV every 3 weeks of each 21-day cycle.', 'armGroupLabels': ['Standard Second-line Chemotherapy']}]}, 'contactsLocationsModule': {'locations': [{'zip': '230022', 'city': 'Hefei', 'state': 'Anhui', 'country': 'China', 'contacts': [{'name': 'Kangsheng Gu, Doctor', 'role': 'CONTACT'}, {'name': 'Kangsheng Gu, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The First Affiliated Hospital of Anhui Medical University', 'geoPoint': {'lat': 31.86389, 'lon': 117.28083}}, {'zip': '100038', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'contacts': [{'name': 'Jirun Peng, Doctor', 'role': 'CONTACT', 'email': '1446316766@qq.com'}, {'name': 'Jirun Peng, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Beijing Shijitan Hospital Affiliated to Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100048', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'contacts': [{'name': 'Xinhong Zhang, Doctor', 'role': 'CONTACT', 'email': 'zhangxh1970@sina.com'}, {'name': 'Xinhong Zhang, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Sixth Medical Center of PLA General Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100144', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'contacts': [{'name': 'Delin Wang', 'role': 'CONTACT', 'email': 'dlwang163@sohu.com'}, {'name': 'Delin Wang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Peking University Shougang Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '101100', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'contacts': [{'name': 'Dong Yan, Doctor', 'role': 'CONTACT', 'email': 'yd15yt88@163.com'}, {'name': 'Dong Yan, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Beijing Luhe Hospital Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '102218', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'contacts': [{'name': 'Zhuo Yu, Doctor', 'role': 'CONTACT', 'email': 'yuzhuo@vip.sina.com'}, {'name': 'Zhuo Yu, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Beijing Tsinghua Changgung Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '350011', 'city': 'Fuzhou', 'state': 'Fujian', 'country': 'China', 'contacts': [{'name': 'Zengqing Guo', 'role': 'CONTACT'}, {'name': 'Zengqing Guo', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Fujian Provincial Cancer Hospital', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '362000', 'city': 'Quanzhou', 'state': 'Fujian', 'country': 'China', 'contacts': [{'name': 'Peiling Xin', 'role': 'CONTACT', 'email': 'xinpeiling62@126.com'}, {'name': 'Peiling Xin', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Quanzhou First Hospital', 'geoPoint': {'lat': 24.91389, 'lon': 118.58583}}, {'zip': '362000', 'city': 'Quanzhou', 'state': 'Fujian', 'country': 'China', 'contacts': [{'name': 'Tianwen Xu, Doctor', 'role': 'CONTACT', 'email': 'xutianwen53@163.com'}, {'name': 'Tianwen Xu, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Second Affiliated Hospital of Fujian Medical University', 'geoPoint': {'lat': 24.91389, 'lon': 118.58583}}, {'zip': '361003', 'city': 'Xiamen', 'state': 'Fujian', 'country': 'China', 'contacts': [{'name': 'Jiayi Li', 'role': 'CONTACT', 'email': 'ljy778848@qq.com'}, {'name': 'Jiayi Li', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The First Affiliated Hospital of Xiamen University', 'geoPoint': {'lat': 24.47979, 'lon': 118.08187}}, {'zip': '361004', 'city': 'Xiamen', 'state': 'Fujian', 'country': 'China', 'contacts': [{'name': 'Zhijie Ding, Doctor', 'role': 'CONTACT', 'email': 'zhijieding@sina.com'}, {'name': 'Zhijie Ding, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Zhongshan Hospital Xiamen University', 'geoPoint': {'lat': 24.47979, 'lon': 118.08187}}, {'zip': '730000', 'city': 'Lanzhou', 'state': 'Gansu', 'country': 'China', 'contacts': [{'name': 'Xiaoming Hou, Doctor', 'role': 'CONTACT', 'email': '1795950416@qq.com'}, {'name': 'Xiaoming Hou, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The First Hospital of Lanzhou University', 'geoPoint': {'lat': 36.05701, 'lon': 103.83987}}, {'zip': '733000', 'city': 'Wuwei', 'state': 'Gansu', 'country': 'China', 'contacts': [{'name': 'Linzhi Lu', 'role': 'CONTACT', 'email': 'lulinzh12006@163.com'}, {'name': 'Linzhi Lu', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Gansu Wuwei Tumour Hospital', 'geoPoint': {'lat': 37.92672, 'lon': 102.63202}}, {'zip': '510000', 'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'contacts': [{'name': 'Ruihua Xu, Doctor', 'role': 'CONTACT', 'email': 'ruihxu@163.com'}, {'name': 'Ruihua Xu, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Sun Yat-Sen University Cancer Center', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510610', 'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'contacts': [{'name': 'Yanhong Deng, Doctor', 'role': 'CONTACT'}, {'name': 'Yanhong Deng, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Sixth Affiliated Hospital of Sun Yat-sen University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '524000', 'city': 'Zhanjiang', 'state': 'Guangdong', 'country': 'China', 'contacts': [{'name': 'Zhong Xie', 'role': 'CONTACT', 'email': 'xiexieg@126.com'}, {'name': 'Zhong Xie', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Affiliated Hospital of Guangdong Medical University', 'geoPoint': {'lat': 21.23391, 'lon': 110.38749}}, {'zip': '530021', 'city': 'Nanning', 'state': 'Guangxi', 'country': 'China', 'contacts': [{'name': 'Jiansi Chen', 'role': 'CONTACT', 'email': 'wcwk0771@126.com'}, {'name': 'Jiansi Chen', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Guangxi Medical University Affiliated Tumor Hospital', 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '050010', 'city': 'Shijiazhuang', 'state': 'Hebei', 'country': 'China', 'contacts': [{'name': 'Da Jiang', 'role': 'CONTACT', 'email': 'jiangda139@163.com'}, {'name': 'Da Jiang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Fourth Hospital of Hebei Medical University', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'zip': '150040', 'city': 'Harbin', 'state': 'Heilongjiang', 'country': 'China', 'contacts': [{'name': 'Yanqiao Zhang, Doctor', 'role': 'CONTACT', 'email': 'yanqiaozhang@126.com'}, {'name': 'Yanqiao Zhang, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Harbin Medical University Cancer Hospital', 'geoPoint': {'lat': 45.75, 'lon': 126.65}}, {'zip': '455000', 'city': 'Anyang', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Tao Wu', 'role': 'CONTACT', 'email': 'wuren909@163.com'}, {'name': 'Tao Wu', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'AnYang Tumor Hospital', 'geoPoint': {'lat': 36.096, 'lon': 114.38278}}, {'zip': '453000', 'city': 'Xinxiang', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Guifang Zhang', 'role': 'CONTACT', 'email': 'xxchzhangguifang@126.com'}, {'name': 'Guifang Zhang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Xinxiang Central Hospital', 'geoPoint': {'lat': 35.19033, 'lon': 113.80151}}, {'zip': '450003', 'city': 'Zhengzhou', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Yanru Qin, Doctor', 'role': 'CONTACT', 'email': 'yanruqin@163.com'}, {'name': 'Yanru Qin, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The First Affiliated Hospital of Zhengzhou University', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '450008', 'city': 'Zhengzhou', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Huijuan Wu', 'role': 'CONTACT'}, {'name': 'Huijuan Wu', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Henan Cancer Hospital', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '430022', 'city': 'Wuhan', 'state': 'Hubei', 'country': 'China', 'contacts': [{'name': 'Tao Zhang, Doctor', 'role': 'CONTACT', 'email': '1277577866@qq.com'}, {'name': 'Tao Zhang, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Union Hospital,Tongji Medical College,Huazhong University of Science and Technology', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '430030', 'city': 'Wuhan', 'state': 'Hubei', 'country': 'China', 'contacts': [{'name': 'Xianglin Yuan, Doctor', 'role': 'CONTACT', 'email': 'xlyuan1020@163.com'}, {'name': 'Xianglin Yuan, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '430079', 'city': 'Wuhan', 'state': 'Hubei', 'country': 'China', 'contacts': [{'name': 'Xinjun Liang, Doctor', 'role': 'CONTACT', 'email': 'doctorlxj@163.com'}, {'name': 'Xinjun Liang, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hubei Cancer Hospital', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '410008', 'city': 'Changsha', 'state': 'Hunan', 'country': 'China', 'contacts': [{'name': 'Shan Zeng, Doctor', 'role': 'CONTACT', 'email': 'Shanzeng2012@163.com'}, {'name': 'Shan Zeng, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Xiangya Hospital Central South University', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '410011', 'city': 'Changsha', 'state': 'Hunan', 'country': 'China', 'contacts': [{'name': 'Hongliang Yao, Doctor', 'role': 'CONTACT', 'email': 'yaohl0326@163.com'}, {'name': 'Hongliang Yao, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Second Xiangya Hospital of Central South University', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '410013', 'city': 'Changsha', 'state': 'Hunan', 'country': 'China', 'contacts': [{'name': 'Shanzhi Gu', 'role': 'CONTACT', 'email': '105575191@qq.com'}, {'name': 'Shanzhi Gu', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hunan Cancer Hospital', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '210009', 'city': 'Nanjing', 'state': 'Jiangsu', 'country': 'China', 'contacts': [{'name': 'Jianwei Lu, Doctor', 'role': 'CONTACT', 'email': 'lujw@medmail.com.cn'}, {'name': 'Jianwei Lu, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Jiangsu Cancer Hospital', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '210029', 'city': 'Nanjing', 'state': 'Jiangsu', 'country': 'China', 'contacts': [{'name': 'Lingjun Zhu, Doctor', 'role': 'CONTACT'}, {'name': 'Lingjun Zhu, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Jiangsu Province Hospital', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '226361', 'city': 'Nantong', 'state': 'Jiangsu', 'country': 'China', 'contacts': [{'name': 'Jianhong Wang', 'role': 'CONTACT', 'email': 'ywk_wjh@163.com'}, {'name': 'Jianhong Wang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Nantong Cancer Hospital', 'geoPoint': {'lat': 32.03028, 'lon': 120.87472}}, {'zip': '214023', 'city': 'Wuxi', 'state': 'Jiangsu', 'country': 'China', 'contacts': [{'name': 'Chaoying Liu', 'role': 'CONTACT', 'email': 'chyliu666@163.com'}, {'name': 'Chaoying Liu', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Wuxi People's Hospital", 'geoPoint': {'lat': 31.56887, 'lon': 120.28857}}, {'zip': '214062', 'city': 'Wuxi', 'state': 'Jiangsu', 'country': 'China', 'contacts': [{'name': 'Yong Mao, Doctor', 'role': 'CONTACT', 'email': 'mydoctorwx@aliyun.com'}, {'name': 'Yong Mao, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital of Jiangnan University', 'geoPoint': {'lat': 31.56887, 'lon': 120.28857}}, {'zip': '330006', 'city': 'Nanchang', 'state': 'Jiangxi', 'country': 'China', 'contacts': [{'name': 'Junhe Li, Doctor', 'role': 'CONTACT', 'email': 'mailto:lijunhe88@163.com'}, {'name': 'Junhe Li, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The First Affiliated Hospital of Nanchang University', 'geoPoint': {'lat': 28.68396, 'lon': 115.85306}}, {'zip': '110042', 'city': 'Shenyang', 'state': 'Liaoning', 'country': 'China', 'contacts': [{'name': 'Baoli Qin, Doctor', 'role': 'CONTACT', 'email': 'poryqin@126.com'}, {'name': 'Baoli Qin, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Liaoning Cancar Hospital', 'geoPoint': {'lat': 41.79222, 'lon': 123.43278}}, {'zip': '750021', 'city': 'Yinchuan', 'state': 'Ningxia', 'country': 'China', 'contacts': [{'name': 'Qingxin Zhuang', 'role': 'CONTACT', 'email': 'zhuangtse@163.com'}, {'name': 'Qingxin Zhuang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "People's Hospital of 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'Shanxi Provincial Cancer Hospital', 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '710004', 'city': 'Xi’an', 'state': 'Shanxi', 'country': 'China', 'contacts': [{'name': 'Xi Chen, Doctor', 'role': 'CONTACT', 'email': '2002chenxi@163.com'}, {'name': 'Xi Chen, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "The Second Affiliated Hospital of Xi'an Jiaotong University", 'geoPoint': {'lat': 35.99785, 'lon': 113.52486}}, {'zip': '710061', 'city': 'Xi’an', 'state': 'Shanxi', 'country': 'China', 'contacts': [{'name': 'Enxiao Li, Doctor', 'role': 'CONTACT', 'email': 'doclienxiao@sina.com'}, {'name': 'Enxiao Li, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "First Affiliated Hospital of Xi'an Jiaotong University", 'geoPoint': {'lat': 35.99785, 'lon': 113.52486}}, {'zip': '300050', 'city': 'Tianjing', 'state': 'Tianjing', 'country': 'China', 'contacts': [{'name': 'Diansheng Zhong, Doctor', 'role': 'CONTACT', 'email': 'zhongdsh@hotmail.com'}, {'name': 'Diansheng 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