Ignite Creation Date:
2025-12-24 @ 5:32 PM
Ignite Modification Date:
2025-12-24 @ 5:32 PM
Study NCT ID:
NCT00042068
Status:
COMPLETED
Last Update Posted:
2013-11-01
First Post:
2002-07-22
Is Possible Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
A Multi-Center Trial to Compare Three Doses of Meloxicam and Placebo in Patients With Rheumatoid Arthritis
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001172', 'term': 'Arthritis, Rheumatoid'}], 'ancestors': [{'id': 'D001168', 'term': 'Arthritis'}, {'id': 'D007592', 'term': 'Joint Diseases'}, {'id': 'D009140', 'term': 'Musculoskeletal Diseases'}, {'id': 'D012216', 'term': 'Rheumatic Diseases'}, {'id': 'D003240', 'term': 'Connective Tissue Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D001327', 'term': 'Autoimmune Diseases'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000077239', 'term': 'Meloxicam'}], 'ancestors': [{'id': 'D013843', 'term': 'Thiazines'}, {'id': 'D013457', 'term': 'Sulfur Compounds'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D013844', 'term': 'Thiazoles'}, {'id': 'D001393', 'term': 'Azoles'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE'}, 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'count': 1000}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2002-06'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2013-10', 'completionDateStruct': {'date': '2003-07'}, 'lastUpdateSubmitDate': '2013-10-31', 'studyFirstSubmitDate': '2002-07-22', 'studyFirstSubmitQcDate': '2002-07-23', 'lastUpdatePostDateStruct': {'date': '2013-11-01', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2002-07-24', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Response according to American College of Rheumatology 20% (ACR20) classification', 'timeFrame': 'at 12 weeks'}], 'secondaryOutcomes': [{'measure': 'Number of painful or tender joints', 'timeFrame': 'up to 12 weeks'}, {'measure': 'Number of swollen joints', 'timeFrame': 'up to 12 weeks'}, {'measure': "Patient's global (overall) assessment of disease activity", 'timeFrame': 'up to 12 weeks'}, {'measure': "Investigator's global (overall) assessment of disease activity", 'timeFrame': 'up to 12 weeks'}, {'measure': "Patient's assessment of pain", 'timeFrame': 'up to 12 weeks'}, {'measure': "Patient's assessment of physical function (mHAQ)", 'timeFrame': 'up to 12 weeks'}, {'measure': 'C-Reactive Protein (CRP)', 'timeFrame': 'up to 12 weeks'}, {'measure': 'Withdrawal due to lack of efficacy', 'timeFrame': 'up to 12 weeks'}, {'measure': 'Duration of morning stiffness', 'timeFrame': 'up to of 12 weeks'}, {'measure': "Patient's final global (overall) assessment of efficacy", 'timeFrame': 'at end of 12 weeks'}, {'measure': "Investigator's final global (overall) assessment of efficacy", 'timeFrame': 'at end of 12 weeks'}, {'measure': 'Patient status with regard to change in arthritic condition', 'timeFrame': 'at end of 12 weeks'}, {'measure': 'Use of rescue medication', 'timeFrame': 'up to 12 weeks'}, {'measure': 'Incidence and intensity of adverse events', 'timeFrame': 'until 4 weeks post treatment'}, {'measure': "Patient's final global assessment of tolerability", 'timeFrame': 'at end of 12 weeks'}, {'measure': "Investigator's final global assessment of tolerability", 'timeFrame': 'at end of 12 weeks'}, {'measure': 'Withdrawals due to adverse events', 'timeFrame': 'at end of 12 weeks'}]}, 'conditionsModule': {'conditions': ['Arthritis, Rheumatoid']}, 'descriptionModule': {'briefSummary': 'A 12-week trial consisting of 5 visits (6 if follow up is needed) to find out how effective and safe three different doses of meloxicam are compared with placebo in Rheumatoid Arthritis. Patient will take one dose of study medication daily.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '80 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Age greater than or equal to 18 and less than or equal to 80\n* Diagnosis of Rheumatoid Arthritis for at least six weeks\n* Taking an NSAID\n* If female: using adequate contraception\n* Willingness to stop current NSAID until criteria reached to begin study drug\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Intolerance or hypersensitivity to NSAIDs or ingredients of trial drug\n* Pregnancy, lactating\n* Use of investigational drug within 30 days prior to entering the trial\n* History of peptic ulcer or of gastrointestinal hemorrhage except simple hemorrhoidal bleeding\n* History of cerebrovascular or other bleeding disorder\n* Severe hypertension\n* Other disease that might interfere with safety of the patient or evaluation of trial drug (investigator's opinion)\n* RA of functional class IV\n* Synovectomy in any large joint within the past 6 months prior to entering the trial or planned during trial\n* Concomitant therapy with anticoagulant, therapeutic doses of aspirin, phenothiazines, lithium, chronic GI-medication, analgesic drug (except acetaminophen up to 4 grams/day)\n* DMARDs initiated within past three months or dose changed less than two months before entering the trial\n* Therapy with corticosteroids exceeding 10 mg/day prednisone equivalent or change in dose within 1 month before trial\n* Concomitant therapy with ACTH within past month before entering the trial.\n* History of narcotic or alcohol abuse (past 12 months)\n* Abnormal laboratory values\n* Previous participation in the present trial"}, 'identificationModule': {'nctId': 'NCT00042068', 'briefTitle': 'A Multi-Center Trial to Compare Three Doses of Meloxicam and Placebo in Patients With Rheumatoid Arthritis', 'organization': {'class': 'INDUSTRY', 'fullName': 'Boehringer Ingelheim'}, 'officialTitle': 'A Multi-center, Double-Blind, Randomized, Parallel-Group Trial to Compare the Efficacy and Safety of Three Doses of Meloxicam (7.5, 15, and 22.5 mg) and Placebo in Patients With Rheumatoid Arthritis', 'orgStudyIdInfo': {'id': '107.258'}}, 'armsInterventionsModule': {'interventions': [{'name': 'Meloxicam', 'type': 'DRUG'}]}, 'contactsLocationsModule': {'locations': [{'zip': '35801', 'city': 'Huntsville', 'state': 'Alabama', 'country': 'United States', 'facility': 'Suites 570 (research) & 600 (PI)', 'geoPoint': {'lat': 34.7304, 'lon': -86.58594}}, {'zip': '36106', 'city': 'Montgomery', 'state': 'Alabama', 'country': 'United States', 'facility': 'Suite 200', 'geoPoint': {'lat': 32.36681, 'lon': -86.29997}}, {'zip': '99508', 'city': 'Anchorage', 'state': 'Alaska', 'country': 'United States', 'facility': 'Suite 140', 'geoPoint': {'lat': 61.21806, 'lon': -149.90028}}, {'zip': '85308', 'city': 'Glendale', 'state': 'Arizona', 'country': 'United States', 'facility': '#106', 'geoPoint': {'lat': 33.53865, 'lon': -112.18599}}, {'zip': '85012', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Suite 601', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85015', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Suite 201', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '90048', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '91105', 'city': 'Pasadena', 'state': 'California', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 34.14778, 'lon': -118.14452}}, {'zip': '91730', 'city': 'Rancho Cucamonga', 'state': 'California', 'country': 'United States', 'facility': 'Suite 100', 'geoPoint': {'lat': 34.1064, 'lon': -117.59311}}, {'zip': '92270-4469', 'city': 'Rancho Mirage', 'state': 'California', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 33.73974, 'lon': -116.41279}}, {'zip': '92108', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'Suite 208', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '92120', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'Suite 202', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '94578', 'city': 'San Leandro', 'state': 'California', 'country': 'United States', 'facility': 'Suite 301', 'geoPoint': {'lat': 37.72493, 'lon': -122.15608}}, {'zip': '93454', 'city': 'Santa Maria', 'state': 'California', 'country': 'United States', 'facility': 'Suite A', 'geoPoint': {'lat': 34.95303, 'lon': -120.43572}}, {'zip': '91361', 'city': 'Westlake Village', 'state': 'California', 'country': 'United States', 'facility': 'Westlake Medical Research', 'geoPoint': {'lat': 34.14584, 'lon': -118.80565}}, {'zip': '80910', 'city': 'Colorado Springs', 'state': 'Colorado', 'country': 'United States', 'facility': 'Suite 200', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '06810', 'city': 'Danbury', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Suites 205 & 206', 'geoPoint': {'lat': 41.39482, 'lon': -73.45401}}, {'zip': '20006', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'Suite 300', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '33484', 'city': 'Delray Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 26.46146, 'lon': -80.07282}}, {'zip': '32607', 'city': 'Gainsville', 'state': 'Florida', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site'}, {'zip': '32204', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33773', 'city': 'Largo', 'state': 'Florida', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 27.90979, 'lon': -82.78842}}, {'zip': '33173', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Suite 202', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '03474', 'city': 'Ocala', 'state': 'Florida', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 29.1872, 'lon': -82.14009}}, {'zip': '34471', 'city': 'Ocala', 'state': 'Florida', 'country': 'United States', 'facility': 'Renstar Medical Research', 'geoPoint': {'lat': 29.1872, 'lon': -82.14009}}, {'zip': '32804', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '32806', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Suite 2', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '34695', 'city': 'Safety Harbor', 'state': 'Florida', 'country': 'United States', 'facility': 'Suite 406', 'geoPoint': {'lat': 27.99085, 'lon': -82.69316}}, {'zip': '34239', 'city': 'Sarasota', 'state': 'Florida', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 27.33643, 'lon': -82.53065}}, {'zip': '33143', 'city': 'South Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 25.7076, 'lon': -80.29338}}, {'zip': '33710', 'city': 'St. Petersburg', 'state': 'Florida', 'country': 'United States', 'facility': 'Suite 101', 'geoPoint': {'lat': 27.77086, 'lon': -82.67927}}, {'zip': '34996', 'city': 'Stuart', 'state': 'Florida', 'country': 'United States', 'facility': 'Radiant Research', 'geoPoint': {'lat': 27.19755, 'lon': -80.25283}}, {'zip': '33614', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'Suite 203', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '33540', 'city': 'Zephyrhills', 'state': 'Florida', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 28.23362, 'lon': -82.18119}}, {'zip': '83814-2644', 'city': "Coeur d'Alene", 'state': 'Idaho', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 47.67768, 'lon': -116.78047}}, {'zip': '83404', 'city': 'Idaho Falls', 'state': 'Idaho', 'country': 'United States', 'facility': 'Suite 202', 'geoPoint': {'lat': 43.46658, 'lon': -112.03414}}, {'zip': '60045', 'city': 'Lake Forest', 'state': 'Illinois', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 42.25863, 'lon': -87.84063}}, {'zip': '61103', 'city': 'Rockford', 'state': 'Illinois', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 42.27113, 'lon': -89.094}}, {'zip': '62704', 'city': 'Springfield', 'state': 'Illinois', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 39.80172, 'lon': -89.64371}}, {'zip': '46202', 'city': 'Indianapolis', 'state': 'Indiana', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '67207', 'city': 'Wichita', 'state': 'Kansas', 'country': 'United States', 'facility': 'Attn: Kathy Stoddard, Director', 'geoPoint': {'lat': 37.69224, 'lon': -97.33754}}, {'zip': '20902', 'city': 'Wheaton', 'state': 'Maryland', 'country': 'United States', 'facility': 'Suite 306', 'geoPoint': {'lat': 39.03983, 'lon': -77.05526}}, {'zip': '02720', 'city': 'Fall River', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Truesdale Clinic', 'geoPoint': {'lat': 41.70149, 'lon': -71.15505}}, {'zip': '49009', 'city': 'Kalamazoo', 'state': 'Michigan', 'country': 'United States', 'facility': 'Suite 202', 'geoPoint': {'lat': 42.29171, 'lon': -85.58723}}, {'zip': '63128', 'city': 'St Louis', 'state': 'Missouri', 'country': 'United States', 'facility': 'Suite 101', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '63141', 'city': 'St Louis', 'state': 'Missouri', 'country': 'United States', 'facility': 'Suite 240', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '68506', 'city': 'Lincoln', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 40.8, 'lon': -96.66696}}, {'zip': '89502-1196', 'city': 'Reno', 'state': 'Nevada', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 39.52963, 'lon': -119.8138}}, {'zip': '08055', 'city': 'Medford', 'state': 'New Jersey', 'country': 'United States', 'facility': 'PC, Jackson Commons D-2', 'geoPoint': {'lat': 39.90095, 'lon': -74.8235}}, {'zip': '08619', 'city': 'Mercerville', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Suite 8', 'geoPoint': {'lat': 40.23705, 'lon': -74.68655}}, {'zip': '10021', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '28210', 'city': 'Charlotte', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Suite 100', 'geoPoint': {'lat': 35.22709, 'lon': -80.84313}}, {'zip': '43214', 'city': 'Columbus', 'state': 'Ohio', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '74135', 'city': 'Tulsa', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 36.15398, 'lon': -95.99277}}, {'zip': '17011', 'city': 'Camp Hill', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 40.23981, 'lon': -76.91997}}, {'zip': '16635', 'city': 'Duncansville', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Altoona Center for Clinical Research', 'geoPoint': {'lat': 40.42341, 'lon': -78.4339}}, {'zip': '16508-1256', 'city': 'Erie', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 42.12922, 'lon': -80.08506}}, {'zip': '17055', 'city': 'Mechanicsburg', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Suite D', 'geoPoint': {'lat': 40.21426, 'lon': -77.00859}}, {'zip': '02919', 'city': 'Johnston', 'state': 'Rhode Island', 'country': 'United States', 'facility': 'Suite 331-333', 'geoPoint': {'lat': 41.82186, 'lon': -71.50675}}, {'zip': '29204', 'city': 'Columbia', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 34.00071, 'lon': -81.03481}}, {'zip': '29406', 'city': 'North Charleston', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Suite H', 'geoPoint': {'lat': 32.85462, 'lon': -79.97481}}, {'zip': '29118', 'city': 'Orangeburg', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 33.49182, 'lon': -80.85565}}, {'zip': '78705', 'city': 'Austin', 'state': 'Texas', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 30.26715, 'lon': -97.74306}}, {'zip': '75225', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '75231', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Radiant Research', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '75246-1632', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Suite 200', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '79410', 'city': 'Lubbock', 'state': 'Texas', 'country': 'United States', 'facility': 'Suite 500', 'geoPoint': {'lat': 33.57786, 'lon': -101.85517}}, {'zip': '78217', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'Suites 207', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '22044', 'city': 'Falls Church', 'state': 'Virginia', 'country': 'United States', 'facility': 'Suite 2A', 'geoPoint': {'lat': 38.88233, 'lon': -77.17109}}, {'zip': '98201', 'city': 'Everett', 'state': 'Washington', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 47.97898, 'lon': -122.20208}}, {'zip': '98166-2967', 'city': 'Seattle', 'state': 'Washington', 'country': 'United States', 'facility': 'Suite D-3', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '98902', 'city': 'Yakima', 'state': 'Washington', 'country': 'United States', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 46.60207, 'lon': -120.5059}}, {'zip': '1405', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': '1427', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': '1428', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': '2000', 'city': 'Rosario', 'country': 'Argentina', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': -32.94682, 'lon': -60.63932}}, {'zip': '4558', 'city': 'Cotton Tree', 'state': 'Queensland', 'country': 'Australia', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': -26.65355, 'lon': 153.10116}}, {'zip': '3144', 'city': 'Malvern', 'state': 'Victoria', 'country': 'Australia', 'facility': 'Emeritus Research', 'geoPoint': {'lat': -37.86259, 'lon': 145.02811}}, {'zip': '6004', 'city': 'Perth', 'state': 'Western Australia', 'country': 'Australia', 'facility': 'Department of Rheumatology', 'geoPoint': {'lat': -31.95224, 'lon': 115.8614}}, {'zip': '1040', 'city': 'Brussels', 'country': 'Belgium', 'facility': 'Clinique du Parc Léopold', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'zip': '3000', 'city': 'Leuven', 'country': 'Belgium', 'facility': 'Medisch Centrum van Huisartsen', 'geoPoint': {'lat': 50.87959, 'lon': 4.70093}}, {'zip': '74043-011', 'city': 'Goiânia GO', 'country': 'Brazil', 'facility': 'Av Anhanguera 6479'}, {'zip': '90035-003', 'city': 'Porto Alegre RS', 'country': 'Brazil', 'facility': 'Rua Ramiro Barcelos 2350'}, {'zip': '04040-000', 'city': 'São Paulo - SP', 'country': 'Brazil', 'facility': 'Boehringer Ingelheim Investigational Site'}, {'zip': '04230-000', 'city': 'São Paulo - SP', 'country': 'Brazil', 'facility': 'Clínica de Doenças Parasitárias e Infecciosas-Hospital Dia'}, {'zip': 'V7C 5L9', 'city': 'Richmond', 'state': 'British Columbia', 'country': 'Canada', 'facility': '230-6091', 'geoPoint': {'lat': 49.17003, 'lon': -123.13683}}, {'zip': 'V8P 5P6', 'city': 'Victoria', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 48.4359, 'lon': -123.35155}}, {'zip': 'N0N 1G0', 'city': 'Corunna', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 42.88338, 'lon': -82.43313}}, {'zip': 'L2A 1Z3', 'city': 'Fort Erie', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 42.90012, 'lon': -78.93286}}, {'zip': 'L8N 1Y2', 'city': 'Hamilton', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 43.25011, 'lon': -79.84963}}, {'zip': 'K7L 2V6', 'city': 'Kingston', 'state': 'Ontario', 'country': 'Canada', 'facility': "Dr. Denis O'Donnell", 'geoPoint': {'lat': 44.22976, 'lon': -76.48098}}, {'zip': 'L5B 4A2', 'city': 'Mississauga', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Trillium Health Centre', 'geoPoint': {'lat': 43.5789, 'lon': -79.6583}}, {'zip': 'K2P 1V3', 'city': 'Ottawa', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 45.41117, 'lon': -75.69812}}, {'zip': 'K9J 7H8', 'city': 'Peterborough', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 44.30012, 'lon': -78.31623}}, {'zip': 'N7T 4X3', 'city': 'Sarnia', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 42.97866, 'lon': -82.40407}}, {'zip': 'M1B 4Y9', 'city': 'Scarborough Village', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 43.73899, 'lon': -79.22124}}, {'zip': 'L2N 4H4', 'city': 'St. Catharines', 'state': 'Ontario', 'country': 'Canada', 'facility': '104-532', 'geoPoint': {'lat': 43.17126, 'lon': -79.24267}}, {'zip': 'M3B 2H9', 'city': 'Toronto', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': 'N8W 5L7', 'city': 'Windsor', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 42.30008, 'lon': -83.01654}}, {'zip': 'H3G 1A4', 'city': 'Montreal', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': 'H3Z, 2Z3', 'city': 'Montreal', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': 'H9R 3J1', 'city': 'Pointe-Claire', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 45.44868, 'lon': -73.81669}}, {'zip': '13008', 'city': 'Marseille', 'country': 'France', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 43.29695, 'lon': 5.38107}}, {'zip': '06000', 'city': 'Nice', 'country': 'France', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 43.70313, 'lon': 7.26608}}, {'zip': '37000', 'city': 'Tours', 'country': 'France', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 47.39484, 'lon': 0.70398}}, {'zip': '37044', 'city': 'Tours', 'country': 'France', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 47.39484, 'lon': 0.70398}}, {'zip': '52064', 'city': 'Aachen', 'country': 'Germany', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 50.77664, 'lon': 6.08342}}, {'zip': '55543', 'city': 'Bad Kreuznach', 'country': 'Germany', 'facility': 'Augusta-Klinik', 'geoPoint': {'lat': 49.8414, 'lon': 7.86713}}, {'zip': '23795', 'city': 'Bad Segeberg', 'country': 'Germany', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 53.93775, 'lon': 10.30745}}, {'zip': '14059', 'city': 'Berlin', 'country': 'Germany', 'facility': 'Rheumatologie und Physikalische Therapie', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'zip': '08236', 'city': 'Ellefeld', 'country': 'Germany', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 50.48367, 'lon': 12.3888}}, {'zip': '45356', 'city': 'Essen', 'country': 'Germany', 'facility': 'Elisabeth-Krankenhaus', 'geoPoint': {'lat': 51.45657, 'lon': 7.01228}}, {'zip': '56818', 'city': 'Klotten', 'country': 'Germany', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 50.16667, 'lon': 7.2}}, {'zip': '04229', 'city': 'Leipzig', 'country': 'Germany', 'facility': 'ClinPharm International GmbH & Co. KG', 'geoPoint': {'lat': 51.33962, 'lon': 12.37129}}, {'zip': '81541', 'city': 'München', 'country': 'Germany', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 51.60698, 'lon': 13.31243}}, {'zip': '90402', 'city': 'Nuremberg', 'country': 'Germany', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 49.45421, 'lon': 11.07752}}, {'zip': '90461', 'city': 'Nuremberg', 'country': 'Germany', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 49.45421, 'lon': 11.07752}}, {'zip': '85643', 'city': 'Steinhöring', 'country': 'Germany', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 48.08679, 'lon': 12.0314}}, {'zip': '72070', 'city': 'Tübingen', 'country': 'Germany', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 48.52266, 'lon': 9.05222}}, {'zip': '65191', 'city': 'Wiesbaden', 'country': 'Germany', 'facility': 'Klinik für Rheumatologie,', 'geoPoint': {'lat': 50.08601, 'lon': 8.24435}}, {'zip': '1027', 'city': 'Budapest', 'country': 'Hungary', 'facility': 'National Institute for Rheumatology and Physiotherapy', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'zip': '4031', 'city': 'Debrecen', 'country': 'Hungary', 'facility': 'DOTE', 'geoPoint': {'lat': 47.53167, 'lon': 21.62444}}, {'zip': '9024', 'city': 'Győr', 'country': 'Hungary', 'facility': 'Aladár Petz County Hospital', 'geoPoint': {'lat': 47.68333, 'lon': 17.63512}}, {'zip': '8380', 'city': 'Hévíz', 'country': 'Hungary', 'facility': 'St. Andrew State Hospital', 'geoPoint': {'lat': 46.79031, 'lon': 17.18408}}, {'zip': '3501', 'city': 'Miskolc', 'country': 'Hungary', 'facility': 'St. Ferenc Hospital', 'geoPoint': {'lat': 48.10327, 'lon': 20.77806}}, {'zip': '3601', 'city': 'Ózd', 'country': 'Hungary', 'facility': 'Pál Almási Balogh Hospital', 'geoPoint': {'lat': 48.21667, 'lon': 20.3}}, {'zip': '7621', 'city': 'Pécs', 'country': 'Hungary', 'facility': 'Hungarian Brothers of St. John of Good', 'geoPoint': {'lat': 46.07617, 'lon': 18.22814}}, {'zip': '6720', 'city': 'Szeged', 'country': 'Hungary', 'facility': 'Szegedi University', 'geoPoint': {'lat': 46.253, 'lon': 20.14824}}, {'zip': '8201', 'city': 'Veszprém', 'country': 'Hungary', 'facility': 'Ferenc Csolnoky County Hospital', 'geoPoint': {'lat': 47.09327, 'lon': 17.91149}}, {'city': 'Genova', 'country': 'Italy', 'facility': 'Università degli Studi', 'geoPoint': {'lat': 45.21604, 'lon': 11.87211}}, {'zip': '60035', 'city': 'Iesi', 'country': 'Italy', 'facility': 'Ospedale Augusto Murri', 'geoPoint': {'lat': 43.52142, 'lon': 13.24368}}, {'zip': '80131', 'city': 'Napoli', 'country': 'Italy', 'facility': 'Università degli Studi di Napoli "Federico II"', 'geoPoint': {'lat': 40.87618, 'lon': 14.5195}}, {'zip': '73016', 'city': 'SAN Cesario (Lecce)', 'country': 'Italy', 'facility': 'Ospedale A. Galateo', 'geoPoint': {'lat': 40.30221, 'lon': 18.16098}}, {'zip': '115522', 'city': 'Moscow', 'country': 'Russia', 'facility': 'Institute of Rheumatology of RAMN', 'geoPoint': {'lat': 55.75204, 'lon': 37.61781}}, {'zip': '117049', 'city': 'Moscow', 'country': 'Russia', 'facility': 'City Clinical Hospital No. 1', 'geoPoint': {'lat': 55.75204, 'lon': 37.61781}}, {'zip': '431-070', 'city': 'Gyeonggi-do', 'country': 'South Korea', 'facility': '896 Pyung Chon-Dong, Dongan-Gu', 'geoPoint': {'lat': 37.58944, 'lon': 126.76917}}, {'zip': '442-721', 'city': 'Gyeonggi-do', 'country': 'South Korea', 'facility': 'San-5, Woncheon-Dong, Paldal-Gu', 'geoPoint': {'lat': 37.58944, 'lon': 126.76917}}, {'zip': '100-032', 'city': 'Seoul', 'country': 'South Korea', 'facility': '85 Jeo-Dong 2Ga', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '110-744', 'city': 'Seoul', 'country': 'South Korea', 'facility': 'Seoul National University Hospital', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '120-752', 'city': 'Seoul', 'country': 'South Korea', 'facility': 'Boehringer Ingelheim Investigational Site', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'city': 'Kaohsiung City', 'country': 'Taiwan', 'facility': 'Kaohsiung Medical University Chung-Ho Memorial Hospital', 'geoPoint': {'lat': 22.61626, 'lon': 120.31333}}, {'city': 'Kaohsiung City', 'country': 'Taiwan', 'facility': 'Rheumatology-Allergy-Immunology', 'geoPoint': {'lat': 22.61626, 'lon': 120.31333}}, {'zip': '105', 'city': 'Taipei', 'country': 'Taiwan', 'facility': 'Chang Gung Memorial Hospital', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'city': 'Taipei', 'country': 'Taiwan', 'facility': 'Taipei Veterans General Hospital', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '49044', 'city': 'Dnyepropetrovsk', 'country': 'Ukraine', 'facility': 'Dnyepropyetrovsk Medical Academy'}, {'zip': '83098', 'city': 'Donetsk', 'country': 'Ukraine', 'facility': 'Central City Hospital', 'geoPoint': {'lat': 48.023, 'lon': 37.80224}}, {'zip': '83114', 'city': 'Donetsk', 'country': 'Ukraine', 'facility': 'State Medical University', 'geoPoint': {'lat': 48.023, 'lon': 37.80224}}, {'zip': '61091', 'city': 'Kharkiv', 'country': 'Ukraine', 'facility': 'Municipal Institute of Health Care', 'geoPoint': {'lat': 49.98177, 'lon': 36.25475}}, {'zip': '61115', 'city': 'Kharkiv', 'country': 'Ukraine', 'facility': 'City Multitype Clinical Hospital No. 25', 'geoPoint': {'lat': 49.98177, 'lon': 36.25475}}, {'zip': '01023', 'city': 'Kiev', 'country': 'Ukraine', 'facility': 'Central Clinical Hospital', 'geoPoint': {'lat': 50.45466, 'lon': 30.5238}}, {'zip': '03151', 'city': 'Kiev', 'country': 'Ukraine', 'facility': 'Institute of Cardiology', 'geoPoint': {'lat': 50.45466, 'lon': 30.5238}}, {'zip': '04107', 'city': 'Kiev', 'country': 'Ukraine', 'facility': 'Regional Hospital No. 1', 'geoPoint': {'lat': 50.45466, 'lon': 30.5238}}, {'zip': '04114', 'city': 'Kyiv', 'country': 'Ukraine', 'facility': 'Institute of Gerontology', 'geoPoint': {'lat': 50.45466, 'lon': 30.5238}}], 'overallOfficials': [{'name': 'Boehringer Ingelheim Study Coordinator', 'role': 'STUDY_CHAIR', 'affiliation': 'Boehringer Ingelheim Ltd./Bracknell'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Boehringer Ingelheim', 'class': 'INDUSTRY'}}}}