Ignite Creation Date:
2025-12-24 @ 5:44 PM
Ignite Modification Date:
2025-12-24 @ 5:44 PM
Study NCT ID:
NCT06777368
Status:
RECRUITING
Last Update Posted:
2025-12-23
First Post:
2024-12-17
Is Possible Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001024', 'term': 'Aortic Valve Stenosis'}], 'ancestors': [{'id': 'D000082862', 'term': 'Aortic Valve Disease'}, {'id': 'D006349', 'term': 'Heart Valve Diseases'}, {'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D014694', 'term': 'Ventricular Outflow Obstruction'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 225}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-02-06', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2033-07', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-19', 'studyFirstSubmitDate': '2024-12-17', 'studyFirstSubmitQcDate': '2025-01-10', 'lastUpdatePostDateStruct': {'date': '2025-12-23', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2025-01-15', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2029-03', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Primary Outcome Measure', 'timeFrame': 'Early (30-days)', 'description': '30-day redo TAVR success defined as correct positioning of a single redo prosthetic heart valve into the proper anatomic location, intended performance of the valve (mean gradient \\<20mmHg, peak velocity \\<3 m/s, Doppler velocity index (DVI) ≥0.25, aortic regurgitation (AR) \\< moderate), and freedom from all-cause mortality, coronary obstruction, unplanned coronary revascularization, and surgery or intervention related to the device'}, {'measure': 'Primary Outcome Measure', 'timeFrame': 'Late (1-year)', 'description': 'a composite endpoint of 1-year freedom from all-cause mortality, all stroke, or any re-hospitalization for valve or redo TAVR procedure-related causes'}], 'secondaryOutcomes': [{'measure': 'Valve Academic Research Consortium (VARC) 3 technical success (at exit from procedure room)', 'timeFrame': 'Time of procedure', 'description': '(VARC) 3 technical success (at exit from procedure room)'}, {'measure': 'VARC 3 30-day device success', 'timeFrame': '30-Day', 'description': '30-day device success'}, {'measure': 'VARC 3 30-day early safety', 'timeFrame': '30-Day', 'description': '30-day early safety'}, {'measure': 'Peak and mean invasive gradient post-procedure', 'timeFrame': 'Time of procedure', 'description': 'Peak and mean invasive gradient will be measured in mmHg'}, {'measure': 'In-hospital clinical outcomes', 'timeFrame': 'Treatment up to 7 days (or until patient is discharged from the hospital if later than 7 days)', 'description': 'Percentage of all participants with all-cause mortality, all stroke, Myocardial infarction (MI), Coronary artery obstruction, Unplanned Percutaneous Coronary Intervention (PCI) or Coronary Artery Bypass Grafting (CABG), Bleeding (VARC 3 type 1-4), Major and Minor vascular and access-related complications, Cardiac structural complications, Permanent pacemaker implantation (PPI), Acute Kidney Injury (AKI) stage 1-4, Endocarditis, and Valve Thrombosis.'}, {'measure': 'Clinical outcomes at 30 days, 1-year, and annually thereafter', 'timeFrame': '30 days, at 1 year, at 2 years, at 3 years, at 4 years, and at 5 years.', 'description': 'All-cause mortality, All stroke, Myocardial infarction (MI), Coronary artery obstruction, Bleeding (VARC 3 type 1-4), Major and Minor vascular and access-related complications, Cardiac structural complications, Permanent pacemaker implantation (PPI), Acute Kidney Injury (AKI) stage 1-4, Endocarditis, Valve Thrombosis, Any rehospitalization and re-intervention.'}, {'measure': 'Bioprosthetic Valve Dysfunction (BVD) at the final required follow-up visit', 'timeFrame': '5 year', 'description': 'Intrinsic permanent changes to the prosthetic valve, including wear and tear, leaflet disruption, flail leaflet, leaflet fibrosis and/or calcification, or strut fracture or deformation'}, {'measure': 'Bioprosthetic Valve Failure (BVF) at the final required follow-up visit', 'timeFrame': 'Through study completion or Up to 5-years', 'description': 'Any bioprosthetic valve dysfunction associated with clinically expressive criteria (new-onset or worsening symptoms, left ventricle dilation/hypertrophy/dysfunction, or pulmonary hypertension) or irreversible Stage 3 Hemodynamic Valve Deterioration (HVD) or Aortic valve reoperation or re-intervention, or Valve-related death.'}, {'measure': 'Echocardiographic assessment pre-discharge or at 30 days, 1-year, and annually thereafter', 'timeFrame': 'After the procedure and prior to discharge from the hospital, at 30 days, at 1 year, at 2 years, at 3 years, at 4 years, and at 5 years.', 'description': 'Left ventricular ejection fraction, mean gradient across aortic valve, effective orifice area, effective orifice area index, patient-prosthesis mismatch, Doppler Velocity Index, total aortic regurgitation, paravalvular aortic regurgitation, and transvalvular aortic regurgitation.'}, {'measure': 'Evaluate coronary accessibility (e.g., commissural alignment, valve to valve alignment, etc.) based on Computed Tomography (CT) at either pre-discharge or 30 days', 'timeFrame': 'Up to 30 days', 'description': 'Evaluate coronary accessibility'}, {'measure': 'New York Heart Association (NYHA) classification at pre-discharge, 30 days, 1-year, and annually thereafter', 'timeFrame': 'After the procedure and prior to discharge from the hospital, at 30 days, at 1 year, at 2 years, at 3 years, at 4 years, and at 5 years.', 'description': 'New York Heart Association (NYHA) classification'}, {'measure': 'KCCQ Quality of life (QoL) assessments at 30 days, 1-year, and annually thereafter', 'timeFrame': 'At 30 days, at 1 year, at 2 years, at 3 years, at 4 years, and at 5 years.', 'description': 'QoL: KCCQ assessment'}, {'measure': 'EQ5D Quality of life (QoL) assessments at 30 days, 1-year, and annually thereafter', 'timeFrame': 'At 30 days, at 1 year, at 2 years, at 3 years, at 4 years, and at 5 years.', 'description': 'QoL: EQ5D assessment'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': True}, 'conditionsModule': {'conditions': ['Aortic Stenosis']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR).', 'detailedDescription': 'Primary Objectives:\n\n* To determine the acute and long-term outcomes of redo TAVR for the treatment of BVF affecting TAVs\n* To determine the factors which are associated with the acute and long-term outcomes of redo TAVR'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '105 Years', 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'The study population includes patients with symptomatic heart disease due to BVF affecting TAVs and requiring redo TAVR.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* BVF of a TAV (either Medtronic or Edwards) requiring redo TAVR\n\nExclusion Criteria:\n\n* BVF due solely to paravalvular regurgitation\n* Active endocarditis\n* Untreated acute valve thrombosis\n* Life-expectancy less than 1-year\n* Subject is less than legal age of consent, legally incompetent, or otherwise vulnerable\n* Participating in another study that may influence the outcome of this study'}, 'identificationModule': {'nctId': 'NCT06777368', 'acronym': 'RESTORE', 'briefTitle': 'REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE', 'organization': {'class': 'INDUSTRY', 'fullName': 'Medtronic Cardiovascular'}, 'officialTitle': 'REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE', 'orgStudyIdInfo': {'id': 'MDT23040EVR015'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Medtronic Transcatheter Aortic Valves (TAV) or Edwards Transcatheter Aortic Valves (TAV)', 'description': 'Subjects will receive either a Medtronic TAV or Edwards TAV', 'interventionNames': ['Device: Medtronic TAV', 'Device: Edwards TAV']}], 'interventions': [{'name': 'Medtronic TAV', 'type': 'DEVICE', 'description': 'Medtronic TAV where commercially available', 'armGroupLabels': ['Medtronic Transcatheter Aortic Valves (TAV) or Edwards Transcatheter Aortic Valves (TAV)']}, {'name': 'Edwards TAV', 'type': 'DEVICE', 'description': 'Edwards TAV where commercially available.', 'armGroupLabels': ['Medtronic Transcatheter Aortic Valves (TAV) or Edwards Transcatheter Aortic Valves (TAV)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Marissa Waite', 'role': 'CONTACT'}, {'name': 'Mustafa Ahmed, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Alabama at Birmingham', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '85016', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jessica Byrne', 'role': 'CONTACT'}, {'name': 'Timothy Byrne, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Merick Kirshner, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Abrazo Arizona Heart Hospital', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85712', 'city': 'Tucson', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Morgan Torrez', 'role': 'CONTACT'}, {'name': 'Thomas Waggoner, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Tucson Medical Center', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '90027', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jaclyn Cordova', 'role': 'CONTACT'}, {'name': 'Somjot Brar, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente Los Angeles Medical Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '95816', 'city': 'Sacramento', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jessica McCall', 'role': 'CONTACT'}, {'name': 'Pei-Hsiu Huang, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Sutter Heatlh', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '95825', 'city': 'Sacramento', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ann Rose Downing', 'role': 'CONTACT'}, {'name': 'Femi Philip, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente Northern California', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '94305', 'city': 'Stanford', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ayesha Zaina', 'role': 'CONTACT'}, {'name': 'Anushka Marathe', 'role': 'CONTACT'}, {'name': 'William Fearon, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Stanford Hospital & Clinics', 'geoPoint': {'lat': 37.42411, 'lon': -122.16608}}, {'zip': '91360', 'city': 'Thousand Oaks', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mane Arabyan', 'role': 'CONTACT'}, {'name': 'Greg Fontana, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Saibal Kar, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Los Robles Regional Medical Center', 'geoPoint': {'lat': 34.17056, 'lon': -118.83759}}, {'zip': '80538', 'city': 'Loveland', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Darcee Robeson', 'role': 'CONTACT'}, {'name': 'Justin Strote, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Medical Center of the Rockies', 'geoPoint': {'lat': 40.39776, 'lon': -105.07498}}, {'zip': '06106', 'city': 'Hartford', 'state': 'Connecticut', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jadwiga Jerman', 'role': 'CONTACT'}, {'name': 'Sarfaraz Memon, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Robert Hagberg, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hartford Hospital', 'geoPoint': {'lat': 41.76371, 'lon': -72.68509}}, {'zip': '05610', 'city': 'New Haven', 'state': 'Connecticut', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Scott Ardito', 'role': 'CONTACT'}, {'name': 'John Forrest, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Yale New Haven Hospital', 'geoPoint': {'lat': 41.30815, 'lon': -72.92816}}, {'zip': '20010', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Erin Collins', 'role': 'CONTACT'}, {'name': 'Ron Waksman, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'MedStar Washington Medical Center', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '33756', 'city': 'Clearwater', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sue Fisher', 'role': 'CONTACT'}, {'name': 'Joshua Rovin, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Jayendrakumar Patel, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Morton Plant Hospital', 'geoPoint': {'lat': 27.96585, 'lon': -82.8001}}, {'zip': '33908', 'city': 'Fort Myers', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Michelle Deckard', 'role': 'CONTACT'}, {'name': 'David Cervantes, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'HealthPark Medical Center, Lee Memorial Health', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '32806', 'city': 'Orlando', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'George Ngo', 'role': 'CONTACT'}, {'name': 'Joel Garcia-Fernandez, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Orlando Health/Orlando Regional Medical Center', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '33606', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mia Eifrid', 'role': 'CONTACT'}, {'name': 'Hiram Bezerra, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Tampa General/USF', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '46845', 'city': 'Fort Wayne', 'state': 'Indiana', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Tressa Brunner', 'role': 'CONTACT'}, {'name': 'Roy Robertson, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Parkview Health', 'geoPoint': {'lat': 41.1306, 'lon': -85.12886}}, {'zip': '46290', 'city': 'Indianapolis', 'state': 'Indiana', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Cari Fekete', 'role': 'CONTACT'}, {'name': 'Ezequiel Munoz, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Saint Vincent Heart Center of Indiana', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '50314', 'city': 'Des Moines', 'state': 'Iowa', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kendra Tuttle', 'role': 'CONTACT'}, {'name': 'David McAllister, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'MercyOne Iowa Heart Center', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '66103', 'city': 'Kansas City', 'state': 'Kansas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Amy Gorsuch', 'role': 'CONTACT'}, {'name': 'George (Trip) Zorn, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The University of Kansas', 'geoPoint': {'lat': 39.11417, 'lon': -94.62746}}, {'zip': '67214', 'city': 'Wichita', 'state': 'Kansas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Meredith Thunberg', 'role': 'CONTACT'}, {'name': 'Bassem Chehab, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Brett Grizzell, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Ascension Via Christi St. Francis', 'geoPoint': {'lat': 37.69224, 'lon': -97.33754}}, {'zip': '04102', 'city': 'Portland', 'state': 'Maine', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Joanne Burgess', 'role': 'CONTACT'}, {'name': 'David Butzel, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Maine Medical Center', 'geoPoint': {'lat': 43.65737, 'lon': -70.2589}}, {'zip': '21218', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Keith Moyer', 'role': 'CONTACT'}, {'name': 'John Wang, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Medstar Union Memorial Hospital', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '21287', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Michele Fisher', 'role': 'CONTACT'}, {'name': 'Rani Hasan, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Johns Hopkins Hospital', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Joanna Mandinova', 'role': 'CONTACT'}, {'name': 'Rahul Sakhuja, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Massachusetts General Hospital', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '02135', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sinead Coyle', 'role': 'CONTACT'}, {'name': 'Piotr Sobieszczyk, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Brigham and Women's Hospital", 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '48109', 'city': 'Ann Arbor', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jessica Frizzell', 'role': 'CONTACT'}, {'name': 'Stanley Chetcuti, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Shininchi Fukuhara, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Michigan Health', 'geoPoint': {'lat': 42.27756, 'lon': -83.74088}}, {'zip': '48202', 'city': 'Detroit', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Emily Ward', 'role': 'CONTACT'}, {'name': 'Pedro Engel Gonzalez, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Henry Ford Hospital', 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}, {'zip': '49503', 'city': 'Grand Rapids', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Elizabeth Helm', 'role': 'CONTACT'}, {'name': 'William Merhi, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Stephane Leung, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Corewell Health (Spectrum)', 'geoPoint': {'lat': 42.96336, 'lon': -85.66809}}, {'zip': '55407', 'city': 'Minneapolis', 'state': 'Minnesota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Alexa Hunsinger', 'role': 'CONTACT'}, {'name': 'Paul Sorajja, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Vinayak Bapat, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Abbott Northwestern/Minneapolis Heart', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '55905', 'city': 'Rochester', 'state': 'Minnesota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Tricia Conley', 'role': 'CONTACT'}, {'name': 'Mohamad Alkhouli, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mayo Clinic', 'geoPoint': {'lat': 44.02163, 'lon': -92.4699}}, {'zip': '56303', 'city': 'Saint Cloud', 'state': 'Minnesota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jennifer Humbert', 'role': 'CONTACT'}, {'name': 'Thom Dahle, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CentraCare Heart and Vascular Center', 'geoPoint': {'lat': 45.5608, 'lon': -94.16249}}, {'zip': '64111', 'city': 'Kansas City', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Peggy Owen', 'role': 'CONTACT'}, {'name': 'Chetan Huded, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "St. Luke's Hospital of Kansas City", 'geoPoint': {'lat': 39.09973, 'lon': -94.57857}}, {'zip': '59802', 'city': 'Missoula', 'state': 'Montana', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Tara Westlie', 'role': 'CONTACT'}, {'name': 'Michael Reed, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Travis Abicht, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Providence Saint Patrick Hospital', 'geoPoint': {'lat': 46.87215, 'lon': -113.994}}, {'zip': '03756', 'city': 'Lebanon', 'state': 'New Hampshire', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Brian Aldrich', 'role': 'CONTACT'}, {'name': 'Michael Young, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Dartmouth-Hitchcock Medical Center', 'geoPoint': {'lat': 43.64229, 'lon': -72.25176}}, {'zip': '07753', 'city': 'Neptune City', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ann Marie DeToro', 'role': 'CONTACT'}, {'name': 'Matthew Saybolt, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Jersey Shore University Medical Center', 'geoPoint': {'lat': 40.20011, 'lon': -74.02792}}, {'zip': '07652', 'city': 'Paramus', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kimberly Michel', 'role': 'CONTACT'}, {'name': 'Rajiv Tayal, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Valley Hospital', 'geoPoint': {'lat': 40.94454, 'lon': -74.07542}}, {'zip': '14203', 'city': 'Buffalo', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Lindsay Moshides', 'role': 'CONTACT'}, {'name': 'Vijay Iyer, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Buffalo General Medical Center', 'geoPoint': {'lat': 42.88645, 'lon': -78.87837}}, {'zip': '11030', 'city': 'Manhasset', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kristine McGowan', 'role': 'CONTACT'}, {'name': 'Bruce Rutkin, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northwell Health', 'geoPoint': {'lat': 40.79788, 'lon': -73.69957}}, {'zip': '10016', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Patricia Kozikowski', 'role': 'CONTACT'}, {'name': 'Mathew Williams, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'NYU Langone Medical Center', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10029', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mercedes Morales Castro', 'role': 'CONTACT'}, {'name': 'Samin Sharma, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mount Sinai Hospital', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '11576', 'city': 'Roslyn', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Joan Jennings', 'role': 'CONTACT'}, {'name': 'George Petrossian, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Newell Robinson, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Saint Francis Hospital', 'geoPoint': {'lat': 40.79982, 'lon': -73.65096}}, {'zip': '10467', 'city': 'The Bronx', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Tammy Rodriguez Guzman', 'role': 'CONTACT'}, {'name': 'Mohamed Azeem Latib, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Montefiore Medical Center', 'geoPoint': {'lat': 40.84985, 'lon': 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