Ignite Creation Date:
2025-12-24 @ 1:00 PM
Ignite Modification Date:
2026-01-14 @ 5:45 PM
Study NCT ID:
NCT02720861
Status:
UNKNOWN
Last Update Posted:
2016-03-28
First Post:
2016-03-15
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Prevalence of Genetic Polymporphism on RNF213 rs112735431 Gene in Non-cardioemboli Ischemic Cerebrovascular Disease
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000083242', 'term': 'Ischemic Stroke'}], 'ancestors': [{'id': 'D020521', 'term': 'Stroke'}, {'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D017422', 'term': 'Sequence Analysis, DNA'}], 'ancestors': [{'id': 'D017421', 'term': 'Sequence Analysis'}, {'id': 'D005821', 'term': 'Genetic Techniques'}, {'id': 'D008919', 'term': 'Investigative Techniques'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Blood sample.'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'CROSS_SECTIONAL', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 200}, 'targetDuration': '1 Year', 'patientRegistry': True}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2015-03'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2016-03', 'completionDateStruct': {'date': '2016-06', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2016-03-25', 'studyFirstSubmitDate': '2016-03-15', 'studyFirstSubmitQcDate': '2016-03-25', 'lastUpdatePostDateStruct': {'date': '2016-03-28', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2016-03-28', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2016-03', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Number of Participants With RNF213 rs112735431 Gene polymorphism', 'timeFrame': '1 year'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['RNF213 rs112735431 Gene', 'Acute Non-embolic ischemic stroke'], 'conditions': ['Ischemic Stroke']}, 'descriptionModule': {'briefSummary': 'To explore the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease in Thai patients.', 'detailedDescription': 'This is an cross-sectional observational study in Chulalongkorn hospital, to determine the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were admitted in Chulalongkorn Hospital for acute ischemic stroke treatment.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Acute ischemic stroke patients of Chulalongkorn hospital', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Nationality in Thailand\n* Age equal or more than 18 years\n* Clinical and imaging diagnosis of acute ischemic stroke\n* Patient consent to participate in the research\n\nExclusion Criteria:\n\n* High risk for cardioembolic stroke by TOAST classification\n* Contraindication for venipuncture\n* Pregnancy or breast feeding patient\n* History of head and neck radiation\n* Down's syndrome\n* Marfan syndrome\n* Autoimmune disease such as SLE\n* Ongoing malignancy or remission of malignancy less than 1year"}, 'identificationModule': {'nctId': 'NCT02720861', 'briefTitle': 'Prevalence of Genetic Polymporphism on RNF213 rs112735431 Gene in Non-cardioemboli Ischemic Cerebrovascular Disease', 'organization': {'class': 'OTHER', 'fullName': 'Chulalongkorn University'}, 'officialTitle': 'Prevalence of Genetic Polymporphism on RNF213 rs112735431 Gene in Non-cardioemboli Ischemic Cerebrovascular Disease: A Cross-sectional Study in Thai Patients', 'orgStudyIdInfo': {'id': 'COA No.282/2015'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'non embolic ischemic stroke', 'description': 'acute ischemic stroke from atherosclerosis or lacunar stroke', 'interventionNames': ['Genetic: DNA sequencing']}], 'interventions': [{'name': 'DNA sequencing', 'type': 'GENETIC', 'description': 'withdraw 3m blood from vein only once during the whole design to analyse on DNA sequencing on RNF213 rs112735431 Gene', 'armGroupLabels': ['non embolic ischemic stroke']}]}, 'contactsLocationsModule': {'locations': [{'zip': '10330', 'city': 'Bangkok', 'state': 'Bangkok', 'status': 'RECRUITING', 'country': 'Thailand', 'contacts': [{'name': 'Suporn Travanichakul, MD', 'role': 'CONTACT', 'email': 'stravanichakul@yahoo.com', 'phone': '0858054513'}, {'name': 'Aurauma Chutinet, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Nijasri Charnnarong, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Thiti Snabboon, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Suporn Travanichakul', 'geoPoint': {'lat': 13.75398, 'lon': 100.50144}}], 'centralContacts': [{'name': 'Suporn Travanichakul, MD', 'role': 'CONTACT', 'email': 'stravanichakul@yahoo.com', 'phone': '0858054513'}], 'overallOfficials': [{'name': 'Suporn Travanichakul, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Chulalongkorn University'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO', 'description': 'Not Share'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Chulalongkorn University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Neurology Division of Chulalongkorn hospital', 'investigatorFullName': 'Suporn Travanichakul, MD.', 'investigatorAffiliation': 'Chulalongkorn University'}}}}