Ignite Creation Date:
2025-12-24 @ 1:12 PM
Ignite Modification Date:
2026-02-02 @ 7:26 AM
Study NCT ID:
NCT05458895
Status:
COMPLETED
Last Update Posted:
2024-11-22
First Post:
2021-09-20
Is Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000072137', 'term': 'Vaping'}], 'ancestors': [{'id': 'D012907', 'term': 'Smoking'}, {'id': 'D001519', 'term': 'Behavior'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'Theodore.Wagener@osumc.edu', 'phone': '614-366-4265', 'title': 'Dr. Theodore L. Wagener', 'organization': 'OhioSUCCC'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'timeFrame': 'Up to 3 months', 'eventGroups': [{'id': 'EG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'otherNumAtRisk': 65, 'deathsNumAtRisk': 65, 'otherNumAffected': 0, 'seriousNumAtRisk': 65, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'otherNumAtRisk': 64, 'deathsNumAtRisk': 64, 'otherNumAffected': 0, 'seriousNumAtRisk': 64, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'otherNumAtRisk': 61, 'deathsNumAtRisk': 61, 'otherNumAffected': 0, 'seriousNumAtRisk': 61, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'otherNumAtRisk': 64, 'deathsNumAtRisk': 64, 'otherNumAffected': 0, 'seriousNumAtRisk': 64, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'otherNumAtRisk': 64, 'deathsNumAtRisk': 64, 'otherNumAffected': 0, 'seriousNumAtRisk': 64, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'otherNumAtRisk': 63, 'deathsNumAtRisk': 63, 'otherNumAffected': 0, 'seriousNumAtRisk': 63, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'otherNumAtRisk': 60, 'deathsNumAtRisk': 60, 'otherNumAffected': 0, 'seriousNumAtRisk': 60, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'otherNumAtRisk': 65, 'deathsNumAtRisk': 65, 'otherNumAffected': 0, 'seriousNumAtRisk': 65, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'otherNumAtRisk': 87, 'deathsNumAtRisk': 87, 'otherNumAffected': 0, 'seriousNumAtRisk': 87, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Plasma Nicotine Concentration', 'denoms': [{'units': 'Participants', 'counts': [{'value': '63', 'groupId': 'OG000'}, {'value': '60', 'groupId': 'OG001'}, {'value': '60', 'groupId': 'OG002'}, {'value': '63', 'groupId': 'OG003'}, {'value': '62', 'groupId': 'OG004'}, {'value': '62', 'groupId': 'OG005'}, {'value': '59', 'groupId': 'OG006'}, {'value': '62', 'groupId': 'OG007'}, {'value': '83', 'groupId': 'OG008'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'title': 'Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '63', 'groupId': 'OG000'}, {'value': '60', 'groupId': 'OG001'}, {'value': '60', 'groupId': 'OG002'}, {'value': '63', 'groupId': 'OG003'}, {'value': '62', 'groupId': 'OG004'}, {'value': '62', 'groupId': 'OG005'}, {'value': '59', 'groupId': 'OG006'}, {'value': '62', 'groupId': 'OG007'}, {'value': '83', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '0.78', 'groupId': 'OG000', 'lowerLimit': '0.32', 'upperLimit': '1.65'}, {'value': '1.08', 'groupId': 'OG001', 'lowerLimit': '0.45', 'upperLimit': '2.34'}, {'value': '0.89', 'groupId': 'OG002', 'lowerLimit': '0.35', 'upperLimit': '1.89'}, {'value': '1.16', 'groupId': 'OG003', 'lowerLimit': '0.49', 'upperLimit': '2.62'}, {'value': '0.80', 'groupId': 'OG004', 'lowerLimit': '0.30', 'upperLimit': '1.92'}, {'value': '0.88', 'groupId': 'OG005', 'lowerLimit': '0.38', 'upperLimit': '2.10'}, {'value': '1.03', 'groupId': 'OG006', 'lowerLimit': '0.48', 'upperLimit': '2.36'}, {'value': '1.01', 'groupId': 'OG007', 'lowerLimit': '0.51', 'upperLimit': '2.21'}, {'value': '0.43', 'groupId': 'OG008', 'lowerLimit': '0.19', 'upperLimit': '0.83'}]}]}, {'title': '5 Minutes', 'denoms': [{'units': 'Participants', 'counts': [{'value': '62', 'groupId': 'OG000'}, {'value': '58', 'groupId': 'OG001'}, {'value': '57', 'groupId': 'OG002'}, {'value': '61', 'groupId': 'OG003'}, {'value': '58', 'groupId': 'OG004'}, {'value': '60', 'groupId': 'OG005'}, {'value': '56', 'groupId': 'OG006'}, {'value': '62', 'groupId': 'OG007'}, {'value': '77', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '3.04', 'groupId': 'OG000', 'lowerLimit': '1.59', 'upperLimit': '5.16'}, {'value': '2.63', 'groupId': 'OG001', 'lowerLimit': '1.32', 'upperLimit': '4.73'}, {'value': '4.47', 'groupId': 'OG002', 'lowerLimit': '2.30', 'upperLimit': '7.61'}, {'value': '4.66', 'groupId': 'OG003', 'lowerLimit': '2.61', 'upperLimit': '8.10'}, {'value': '3.63', 'groupId': 'OG004', 'lowerLimit': '1.72', 'upperLimit': '6.15'}, {'value': '3.29', 'groupId': 'OG005', 'lowerLimit': '1.68', 'upperLimit': '5.80'}, {'value': '7.83', 'groupId': 'OG006', 'lowerLimit': '4.33', 'upperLimit': '16.90'}, {'value': '8.76', 'groupId': 'OG007', 'lowerLimit': '4.13', 'upperLimit': '14.90'}, {'value': '12.50', 'groupId': 'OG008', 'lowerLimit': '7.49', 'upperLimit': '19.30'}]}]}, {'title': '10 Minutes', 'denoms': [{'units': 'Participants', 'counts': [{'value': '61', 'groupId': 'OG000'}, {'value': '57', 'groupId': 'OG001'}, {'value': '56', 'groupId': 'OG002'}, {'value': '60', 'groupId': 'OG003'}, {'value': '58', 'groupId': 'OG004'}, {'value': '58', 'groupId': 'OG005'}, {'value': '55', 'groupId': 'OG006'}, {'value': '59', 'groupId': 'OG007'}, {'value': '77', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '3.12', 'groupId': 'OG000', 'lowerLimit': '2.02', 'upperLimit': '5.76'}, {'value': '3.18', 'groupId': 'OG001', 'lowerLimit': '1.75', 'upperLimit': '5.17'}, {'value': '4.92', 'groupId': 'OG002', 'lowerLimit': '2.35', 'upperLimit': '7.07'}, {'value': '4.66', 'groupId': 'OG003', 'lowerLimit': '2.67', 'upperLimit': '7.27'}, {'value': '4.45', 'groupId': 'OG004', 'lowerLimit': '2.46', 'upperLimit': '7.90'}, {'value': '4.14', 'groupId': 'OG005', 'lowerLimit': '1.81', 'upperLimit': '7.18'}, {'value': '8.10', 'groupId': 'OG006', 'lowerLimit': '4.97', 'upperLimit': '19.10'}, {'value': '7.02', 'groupId': 'OG007', 'lowerLimit': '4.29', 'upperLimit': '16.60'}, {'value': '14.10', 'groupId': 'OG008', 'lowerLimit': '8.11', 'upperLimit': '21.00'}]}]}, {'title': '35 Minutes', 'denoms': [{'units': 'Participants', 'counts': [{'value': '61', 'groupId': 'OG000'}, {'value': '59', 'groupId': 'OG001'}, {'value': '57', 'groupId': 'OG002'}, {'value': '60', 'groupId': 'OG003'}, {'value': '60', 'groupId': 'OG004'}, {'value': '59', 'groupId': 'OG005'}, {'value': '55', 'groupId': 'OG006'}, {'value': '61', 'groupId': 'OG007'}, {'value': '80', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '4.46', 'groupId': 'OG000', 'lowerLimit': '2.45', 'upperLimit': '8.35'}, {'value': '3.51', 'groupId': 'OG001', 'lowerLimit': '2.07', 'upperLimit': '7.44'}, {'value': '5.97', 'groupId': 'OG002', 'lowerLimit': '2.91', 'upperLimit': '10.70'}, {'value': '5.28', 'groupId': 'OG003', 'lowerLimit': '2.98', 'upperLimit': '11.45'}, {'value': '6.39', 'groupId': 'OG004', 'lowerLimit': '3.59', 'upperLimit': '13.95'}, {'value': '4.23', 'groupId': 'OG005', 'lowerLimit': '2.19', 'upperLimit': '10.70'}, {'value': '12.90', 'groupId': 'OG006', 'lowerLimit': '6.00', 'upperLimit': '27.30'}, {'value': '10.60', 'groupId': 'OG007', 'lowerLimit': '4.47', 'upperLimit': '21.60'}, {'value': '20.40', 'groupId': 'OG008', 'lowerLimit': '10.25', 'upperLimit': '31.60'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': '0, 5, 10, 35 min.', 'description': 'Plasma nicotine concentration from blood drawn (3mL) 4 times in each session at baseline (0 min), 5 min., 10 min., 35 min.', 'unitOfMeasure': 'ng/ml', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Number analyzed is slightly different at each of the time points due to missing blood draws'}, {'type': 'PRIMARY', 'title': 'Puff Count', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'categories': [{'measurements': [{'value': '16.17', 'spread': '12.04', 'groupId': 'OG000'}, {'value': '16.67', 'spread': '13.84', 'groupId': 'OG001'}, {'value': '17.67', 'spread': '13.54', 'groupId': 'OG002'}, {'value': '17.88', 'spread': '13.90', 'groupId': 'OG003'}, {'value': '12.52', 'spread': '12.13', 'groupId': 'OG004'}, {'value': '11.29', 'spread': '12.64', 'groupId': 'OG005'}, {'value': '14.50', 'spread': '11.80', 'groupId': 'OG006'}, {'value': '13.97', 'spread': '12.07', 'groupId': 'OG007'}, {'value': '12.40', 'spread': '10.69', 'groupId': 'OG008'}]}]}], 'paramType': 'MEAN', 'timeFrame': '30 minutes', 'description': 'E-cig puff topography data collection for abuse liability. Number of puffs taken during the 30 minutes of ad libitum (as desired) vaping session.', 'unitOfMeasure': 'Number of Puffs', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Average Puff Duration', 'denoms': [{'units': 'Participants', 'counts': [{'value': '56', 'groupId': 'OG000'}, {'value': '55', 'groupId': 'OG001'}, {'value': '57', 'groupId': 'OG002'}, {'value': '58', 'groupId': 'OG003'}, {'value': '46', 'groupId': 'OG004'}, {'value': '41', 'groupId': 'OG005'}, {'value': '55', 'groupId': 'OG006'}, {'value': '54', 'groupId': 'OG007'}, {'value': '77', 'groupId': 'OG008'}]}, {'units': 'Puffs', 'counts': [{'value': '1051', 'groupId': 'OG000'}, {'value': '1067', 'groupId': 'OG001'}, {'value': '1078', 'groupId': 'OG002'}, {'value': '1144', 'groupId': 'OG003'}, {'value': '801', 'groupId': 'OG004'}, {'value': '711', 'groupId': 'OG005'}, {'value': '870', 'groupId': 'OG006'}, {'value': '908', 'groupId': 'OG007'}, {'value': '1079', 'groupId': 'OG008'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.20', 'spread': '1.04', 'groupId': 'OG000'}, {'value': '3.04', 'spread': '1.08', 'groupId': 'OG001'}, {'value': '3.16', 'spread': '1.07', 'groupId': 'OG002'}, {'value': '3.15', 'spread': '1.10', 'groupId': 'OG003'}, {'value': '2.65', 'spread': '0.92', 'groupId': 'OG004'}, {'value': '2.57', 'spread': '0.97', 'groupId': 'OG005'}, {'value': '2.77', 'spread': '1.03', 'groupId': 'OG006'}, {'value': '2.75', 'spread': '1.08', 'groupId': 'OG007'}, {'value': '2.70', 'spread': '1.15', 'groupId': 'OG008'}]}]}], 'paramType': 'MEAN', 'timeFrame': '30 minutes', 'description': 'E-cig puff topography data collection for abuse liability. Average puff duration during the 30 minutes of ad libitum (as desired) vaping session, in seconds.', 'unitOfMeasure': 'seconds', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'typeUnitsAnalyzed': 'Puffs', 'denomUnitsSelected': 'Puffs', 'populationDescription': 'Participants who attended the study visit and whose puff duration was able to be recorded.'}, {'type': 'PRIMARY', 'title': 'Average Puff Volume', 'denoms': [{'units': 'Participants', 'counts': [{'value': '64', 'groupId': 'OG000'}, {'value': '62', 'groupId': 'OG001'}, {'value': '59', 'groupId': 'OG002'}, {'value': '61', 'groupId': 'OG003'}, {'value': '53', 'groupId': 'OG004'}, {'value': '54', 'groupId': 'OG005'}, {'value': '57', 'groupId': 'OG006'}, {'value': '58', 'groupId': 'OG007'}, {'value': '82', 'groupId': 'OG008'}]}, {'units': 'Puffs', 'counts': [{'value': '1051', 'groupId': 'OG000'}, {'value': '1067', 'groupId': 'OG001'}, {'value': '1078', 'groupId': 'OG002'}, {'value': '1144', 'groupId': 'OG003'}, {'value': '801', 'groupId': 'OG004'}, {'value': '711', 'groupId': 'OG005'}, {'value': '870', 'groupId': 'OG006'}, {'value': '908', 'groupId': 'OG007'}, {'value': '1079', 'groupId': 'OG008'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'categories': [{'measurements': [{'value': '48.68', 'spread': '17.28', 'groupId': 'OG000'}, {'value': '46.31', 'spread': '18.44', 'groupId': 'OG001'}, {'value': '50.64', 'spread': '22.05', 'groupId': 'OG002'}, {'value': '51.92', 'spread': '30.01', 'groupId': 'OG003'}, {'value': '36.82', 'spread': '12.13', 'groupId': 'OG004'}, {'value': '35.12', 'spread': '13.16', 'groupId': 'OG005'}, {'value': '41.76', 'spread': '15.35', 'groupId': 'OG006'}, {'value': '40.86', 'spread': '17.26', 'groupId': 'OG007'}, {'value': '69.29', 'spread': '40.42', 'groupId': 'OG008'}]}]}], 'paramType': 'MEAN', 'timeFrame': '30 minutes', 'description': 'E-cig puff topography data collection for abuse liability. The total volume of all puffs taken for each participant during the 30 minutes of ad libitum (as desired) vaping session, in ml.', 'unitOfMeasure': 'ml', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'typeUnitsAnalyzed': 'Puffs', 'denomUnitsSelected': 'Puffs', 'populationDescription': 'Participants who attended the study visit and whose puff volume was able to be recorded.'}, {'type': 'PRIMARY', 'title': 'Lung Function Assessment', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'title': 'FEV', 'categories': [{'measurements': [{'value': '-0.03', 'spread': '0.21', 'groupId': 'OG000'}, {'value': '-0.05', 'spread': '0.21', 'groupId': 'OG001'}, {'value': '-0.01', 'spread': '0.19', 'groupId': 'OG002'}, {'value': '0.003', 'spread': '0.24', 'groupId': 'OG003'}, {'value': '-0.08', 'spread': '0.40', 'groupId': 'OG004'}, {'value': '-0.02', 'spread': '0.38', 'groupId': 'OG005'}, {'value': '-0.05', 'spread': '0.24', 'groupId': 'OG006'}, {'value': '-0.04', 'spread': '0.24', 'groupId': 'OG007'}, {'value': '0.09', 'spread': '0.39', 'groupId': 'OG008'}]}]}, {'title': 'FVC', 'categories': [{'measurements': [{'value': '-0.02', 'spread': '0.29', 'groupId': 'OG000'}, {'value': '-0.01', 'spread': '0.25', 'groupId': 'OG001'}, {'value': '-0.0006', 'spread': '0.24', 'groupId': 'OG002'}, {'value': '0.30', 'spread': '2.36', 'groupId': 'OG003'}, {'value': '-0.12', 'spread': '0.53', 'groupId': 'OG004'}, {'value': '-0.02', 'spread': '0.53', 'groupId': 'OG005'}, {'value': '-0.01', 'spread': '0.37', 'groupId': 'OG006'}, {'value': '-0.23', 'spread': '1.68', 'groupId': 'OG007'}, {'value': '0.13', 'spread': '0.42', 'groupId': 'OG008'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline and 35 minutes', 'description': 'Lung function data will be collect using a handheld spirometry device. Physiological effects of pulmonary function collected from inhaled and exhaled breaths. Measures amount inhaled and how quickly exhaled.\n\nChange from baseline in forced expiratory volume (FEV) Change from baseline in forced vital capacity (FVC)', 'unitOfMeasure': 'Liters', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Airway Inflammation (NIOX VERO)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'categories': [{'measurements': [{'value': '18.94', 'spread': '11.52', 'groupId': 'OG000'}, {'value': '19.27', 'spread': '13.38', 'groupId': 'OG001'}, {'value': '18.95', 'spread': '12.14', 'groupId': 'OG002'}, {'value': '19.69', 'spread': '11.86', 'groupId': 'OG003'}, {'value': '18.52', 'spread': '12.76', 'groupId': 'OG004'}, {'value': '21.94', 'spread': '19.51', 'groupId': 'OG005'}, {'value': '19.20', 'spread': '11.43', 'groupId': 'OG006'}, {'value': '20.02', 'spread': '12.55', 'groupId': 'OG007'}, {'value': '18.77', 'spread': '12.70', 'groupId': 'OG008'}]}]}], 'paramType': 'MEAN', 'timeFrame': '35 minutes', 'description': 'Physiological effects of pulmonary function collected from inhaled and exhaled breaths. Airway inflammation will be assessed using exhaled nitric oxide via the NIOX VERO.', 'unitOfMeasure': 'ppb', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Sensory E-Cigarette Expectancies Scale (SEES)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '87', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Overall Population', 'description': 'Full population of participants evaluated at baseline'}], 'classes': [{'title': 'Enjoyment of Taste and Smell', 'categories': [{'measurements': [{'value': '2.69', 'spread': '0.77', 'groupId': 'OG000'}]}]}, {'title': 'Pleasurable Physical Sensations', 'categories': [{'measurements': [{'value': '2.76', 'spread': '0.87', 'groupId': 'OG000'}]}]}, {'title': 'Enjoyment of Vapor Cloud Production', 'categories': [{'measurements': [{'value': '1.66', 'spread': '1.06', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline', 'description': 'Background measures. Comprised of 9 items each of which range 0-4 from "never" to "almost always".\n\nThe 3 subscales (enjoyment of taste and smell, pleasurable physical sensations, enjoyment of vapor cloud production) are the average of 3 items each; scores range from 0 to 4 with higher scores indicating greater enjoyment.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Modified Cigarette Dependence Scale', 'denoms': [{'units': 'Participants', 'counts': [{'value': '83', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Overall Population', 'description': 'Full population of participants evaluated at baseline'}], 'classes': [{'categories': [{'measurements': [{'value': '17.37', 'spread': '4.18', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline', 'description': 'Assess e-cigarette dependence.\n\nScores range from 5 to 25 with higher scores indicating a greater level of dependence.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Participants who responded to all items on the modified cigarette dependence scale at baseline.'}, {'type': 'SECONDARY', 'title': 'Drug Effects/Liking Questionnaire', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'title': 'Want', 'categories': [{'measurements': [{'value': '40.40', 'spread': '23.83', 'groupId': 'OG000'}, {'value': '32.59', 'spread': '23.08', 'groupId': 'OG001'}, {'value': '44.69', 'spread': '26.44', 'groupId': 'OG002'}, {'value': '37.78', 'spread': '22.14', 'groupId': 'OG003'}, {'value': '27.48', 'spread': '25.41', 'groupId': 'OG004'}, {'value': '17.16', 'spread': '21.13', 'groupId': 'OG005'}, {'value': '43.58', 'spread': '24.87', 'groupId': 'OG006'}, {'value': '29.75', 'spread': '24.76', 'groupId': 'OG007'}, {'value': '45.40', 'spread': '20.93', 'groupId': 'OG008'}]}]}, {'title': 'Like', 'categories': [{'measurements': [{'value': '47.54', 'spread': '25.32', 'groupId': 'OG000'}, {'value': '35.36', 'spread': '25.34', 'groupId': 'OG001'}, {'value': '48.82', 'spread': '27.28', 'groupId': 'OG002'}, {'value': '41.94', 'spread': '24.30', 'groupId': 'OG003'}, {'value': '27.44', 'spread': '27.40', 'groupId': 'OG004'}, {'value': '17.08', 'spread': '21.59', 'groupId': 'OG005'}, {'value': '49.67', 'spread': '27.13', 'groupId': 'OG006'}, {'value': '31.51', 'spread': '25.04', 'groupId': 'OG007'}, {'value': '69.05', 'spread': '21.81', 'groupId': 'OG008'}]}]}, {'title': 'Enjoy', 'categories': [{'measurements': [{'value': '46.51', 'spread': '25.12', 'groupId': 'OG000'}, {'value': '36.70', 'spread': '26.42', 'groupId': 'OG001'}, {'value': '49.66', 'spread': '27.01', 'groupId': 'OG002'}, {'value': '43.02', 'spread': '25.03', 'groupId': 'OG003'}, {'value': '27.39', 'spread': '26.77', 'groupId': 'OG004'}, {'value': '18.27', 'spread': '21.24', 'groupId': 'OG005'}, {'value': '50.02', 'spread': '25.74', 'groupId': 'OG006'}, {'value': '31.42', 'spread': '25.05', 'groupId': 'OG007'}, {'value': '72.57', 'spread': '17.73', 'groupId': 'OG008'}]}]}, {'title': 'Pleasurable', 'categories': [{'measurements': [{'value': '46.28', 'spread': '24.26', 'groupId': 'OG000'}, {'value': '36.42', 'spread': '24.96', 'groupId': 'OG001'}, {'value': '50.23', 'spread': '26.53', 'groupId': 'OG002'}, {'value': '44.66', 'spread': '23.63', 'groupId': 'OG003'}, {'value': '29.33', 'spread': '27.92', 'groupId': 'OG004'}, {'value': '18.60', 'spread': '20.17', 'groupId': 'OG005'}, {'value': '52.13', 'spread': '25.00', 'groupId': 'OG006'}, {'value': '34.48', 'spread': '24.97', 'groupId': 'OG007'}, {'value': '72.57', 'spread': '15.94', 'groupId': 'OG008'}]}]}, {'title': 'Satisfying', 'categories': [{'measurements': [{'value': '44.89', 'spread': '24.35', 'groupId': 'OG000'}, {'value': '37.45', 'spread': '23.26', 'groupId': 'OG001'}, {'value': '48.84', 'spread': '26.06', 'groupId': 'OG002'}, {'value': '41.98', 'spread': '25.56', 'groupId': 'OG003'}, {'value': '33.95', 'spread': '26.97', 'groupId': 'OG004'}, {'value': '25.05', 'spread': '23.64', 'groupId': 'OG005'}, {'value': '52.48', 'spread': '23.69', 'groupId': 'OG006'}, {'value': '39.69', 'spread': '26.24', 'groupId': 'OG007'}, {'value': '74.33', 'spread': '15.34', 'groupId': 'OG008'}]}]}], 'paramType': 'MEAN', 'timeFrame': '35 minutes', 'description': "An adapted version of the Drug Effects/Liking Questionnaire will assess the desire and liking of UBMC and all three study products, positive and negative effects (i.e., side effects), and perceived strength and effectiveness. Five visual analog scale items ranging from 0 ('not at all') to 100 ('extremely') assessed wanting to smoke the product again, liking the product, enjoying the product, finding the product pleasurable and satisfying.", 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Modified Cigarette Evaluation Questionnaire (mCEQ)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'title': 'Satisfaction', 'categories': [{'measurements': [{'value': '3.35', 'spread': '1.32', 'groupId': 'OG000'}, {'value': '2.78', 'spread': '1.04', 'groupId': 'OG001'}, {'value': '3.58', 'spread': '1.31', 'groupId': 'OG002'}, {'value': '2.97', 'spread': '1.07', 'groupId': 'OG003'}, {'value': '2.93', 'spread': '1.33', 'groupId': 'OG004'}, {'value': '2.26', 'spread': '0.97', 'groupId': 'OG005'}, {'value': '3.80', 'spread': '1.39', 'groupId': 'OG006'}, {'value': '2.93', 'spread': '1.22', 'groupId': 'OG007'}]}]}, {'title': 'Reward', 'categories': [{'measurements': [{'value': '2.19', 'spread': '0.99', 'groupId': 'OG000'}, {'value': '2.17', 'spread': '0.81', 'groupId': 'OG001'}, {'value': '2.35', 'spread': '1.10', 'groupId': 'OG002'}, {'value': '2.23', 'spread': '0.98', 'groupId': 'OG003'}, {'value': '2.24', 'spread': '1.13', 'groupId': 'OG004'}, {'value': '2.01', 'spread': '0.94', 'groupId': 'OG005'}, {'value': '2.50', 'spread': '1.18', 'groupId': 'OG006'}, {'value': '2.32', 'spread': '1.16', 'groupId': 'OG007'}]}]}, {'title': 'Aversion', 'categories': [{'measurements': [{'value': '1.18', 'spread': '0.43', 'groupId': 'OG000'}, {'value': '1.31', 'spread': '0.57', 'groupId': 'OG001'}, {'value': '1.29', 'spread': '0.50', 'groupId': 'OG002'}, {'value': '1.35', 'spread': '0.95', 'groupId': 'OG003'}, {'value': '1.63', 'spread': '0.86', 'groupId': 'OG004'}, {'value': '1.63', 'spread': '0.74', 'groupId': 'OG005'}, {'value': '1.73', 'spread': '1.10', 'groupId': 'OG006'}, {'value': '1.78', 'spread': '1.25', 'groupId': 'OG007'}]}]}, {'title': 'Sensation', 'categories': [{'measurements': [{'value': '3.20', 'spread': '1.55', 'groupId': 'OG000'}, {'value': '2.55', 'spread': '1.30', 'groupId': 'OG001'}, {'value': '3.62', 'spread': '1.66', 'groupId': 'OG002'}, {'value': '2.83', 'spread': '1.34', 'groupId': 'OG003'}, {'value': '2.22', 'spread': '1.50', 'groupId': 'OG004'}, {'value': '1.73', 'spread': '1.19', 'groupId': 'OG005'}, {'value': '3.32', 'spread': '1.57', 'groupId': 'OG006'}, {'value': '2.77', 'spread': '1.48', 'groupId': 'OG007'}]}]}, {'title': 'Craving', 'categories': [{'measurements': [{'value': '3.25', 'spread': '1.58', 'groupId': 'OG000'}, {'value': '3.17', 'spread': '1.44', 'groupId': 'OG001'}, {'value': '3.39', 'spread': '1.38', 'groupId': 'OG002'}, {'value': '3.23', 'spread': '1.44', 'groupId': 'OG003'}, {'value': '3.45', 'spread': '1.58', 'groupId': 'OG004'}, {'value': '2.97', 'spread': '1.54', 'groupId': 'OG005'}, {'value': '4.05', 'spread': '1.68', 'groupId': 'OG006'}, {'value': '3.40', 'spread': '1.53', 'groupId': 'OG007'}]}]}], 'paramType': 'MEAN', 'timeFrame': '35 minutes', 'description': 'The modified Cigarette Evaluation Questionnaire (mCEQ) will assess subjective responses to e-cigarettes (e.g., reward, satisfaction). The 12-item mCEQ includes five subscales: Smoking Satisfaction, Psychological Reward, Aversion, Enjoyment of Respiratory Tract Sensations, and Craving Reduction, with items rated from 1 (not at all) to 7 (extremely likely). Items are averaged to create each of the subscales also ranging from 1 to 7 with higher values indicating greater levels of smoking satisfaction, psychological reward, aversion, enjoyment of respiratory tract sensations, an craving reduction.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'E-cigarette Purchase Task - Breakpoint', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '86', 'groupId': 'OG008'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'categories': [{'measurements': [{'value': '0.5', 'groupId': 'OG000', 'lowerLimit': '0.25', 'upperLimit': '2'}, {'value': '0.38', 'groupId': 'OG001', 'lowerLimit': '0.05', 'upperLimit': '2.5'}, {'value': '1', 'groupId': 'OG002', 'lowerLimit': '0.25', 'upperLimit': '3'}, {'value': '0.5', 'groupId': 'OG003', 'lowerLimit': '0.25', 'upperLimit': '3'}, {'value': '0.5', 'groupId': 'OG004', 'lowerLimit': '0.13', 'upperLimit': '4'}, {'value': '0.25', 'groupId': 'OG005', 'lowerLimit': '0', 'upperLimit': '2'}, {'value': '1', 'groupId': 'OG006', 'lowerLimit': '0.25', 'upperLimit': '3.5'}, {'value': '0.5', 'groupId': 'OG007', 'lowerLimit': '0.13', 'upperLimit': '2'}, {'value': '2.0', 'groupId': 'OG008', 'lowerLimit': '0.5', 'upperLimit': '6.0'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': '35 minutes', 'description': 'Behavioral economic demand Asks participants how much they would be willing to pay (ranging from 0¢ to $1,120) for a puff of their study product. Specifically they will be asked, "Thinking about the study product, how many puffs of e-cigarette would you smoke if they were each at the following prices?". Breakpoint is the first price of zero consumption.', 'unitOfMeasure': 'Dollars', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Tiffany-Drobes Questionnaire of Smoking Urges: Brief Form', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'groups': [{'id': 'OG000', 'title': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG001', 'title': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG002', 'title': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG003', 'title': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG004', 'title': 'High Concentration Free-base Nicotine (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG005', 'title': 'High Concentration Free-base Nicotine (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG006', 'title': 'High Concentration Nicotine Salt (5%), Menthol Flavor', 'description': 'Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG007', 'title': 'High Concentration Nicotine Salt (5%), Tobacco Flavor', 'description': 'Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}, {'id': 'OG008', 'title': 'Usual Brand', 'description': 'Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.'}], 'classes': [{'title': 'QSU Desire: 0min', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '24.85', 'spread': '8.27', 'groupId': 'OG000'}, {'value': '25.44', 'spread': '7.02', 'groupId': 'OG001'}, {'value': '25.51', 'spread': '7.43', 'groupId': 'OG002'}, {'value': '25.56', 'spread': '7.15', 'groupId': 'OG003'}, {'value': '24.52', 'spread': '7.26', 'groupId': 'OG004'}, {'value': '25.25', 'spread': '7.55', 'groupId': 'OG005'}, {'value': '24.03', 'spread': '7.85', 'groupId': 'OG006'}, {'value': '24.09', 'spread': '7.97', 'groupId': 'OG007'}, {'value': '26.18', 'spread': '7.44', 'groupId': 'OG008'}]}]}, {'title': 'QSU Relief: 0min', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '13.78', 'spread': '7.18', 'groupId': 'OG000'}, {'value': '13.88', 'spread': '7.02', 'groupId': 'OG001'}, {'value': '14.28', 'spread': '7.18', 'groupId': 'OG002'}, {'value': '14.08', 'spread': '7.22', 'groupId': 'OG003'}, {'value': '13.69', 'spread': '7.14', 'groupId': 'OG004'}, {'value': '13.68', 'spread': '6.83', 'groupId': 'OG005'}, {'value': '13.25', 'spread': '7.35', 'groupId': 'OG006'}, {'value': '13.80', 'spread': '7.74', 'groupId': 'OG007'}, {'value': '15.64', 'spread': '6.92', 'groupId': 'OG008'}]}]}, {'title': 'QSU Desire: 5 min', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '85', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '18.92', 'spread': '7.63', 'groupId': 'OG000'}, {'value': '18.38', 'spread': '6.78', 'groupId': 'OG001'}, {'value': '19.54', 'spread': '7.43', 'groupId': 'OG002'}, {'value': '19.00', 'spread': '7.50', 'groupId': 'OG003'}, {'value': '16.34', 'spread': '7.47', 'groupId': 'OG004'}, {'value': '17.44', 'spread': '7.74', 'groupId': 'OG005'}, {'value': '16.78', 'spread': '7.02', 'groupId': 'OG006'}, {'value': '16.98', 'spread': '7.13', 'groupId': 'OG007'}, {'value': '14.45', 'spread': '6.85', 'groupId': 'OG008'}]}]}, {'title': 'QSU Relief: 5min', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '10.77', 'spread': '6.14', 'groupId': 'OG000'}, {'value': '10.56', 'spread': '5.40', 'groupId': 'OG001'}, {'value': '10.98', 'spread': '5.82', 'groupId': 'OG002'}, {'value': '10.77', 'spread': '5.39', 'groupId': 'OG003'}, {'value': '10.08', 'spread': '5.58', 'groupId': 'OG004'}, {'value': '10.35', 'spread': '5.91', 'groupId': 'OG005'}, {'value': '9.95', 'spread': '5.40', 'groupId': 'OG006'}, {'value': '10.02', 'spread': '4.97', 'groupId': 'OG007'}, {'value': '9.95', 'spread': '4.84', 'groupId': 'OG008'}]}]}, {'title': 'QSU Desire: 10 min', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '17.49', 'spread': '8.04', 'groupId': 'OG000'}, {'value': '17.22', 'spread': '6.96', 'groupId': 'OG001'}, {'value': '17.64', 'spread': '7.54', 'groupId': 'OG002'}, {'value': '17.73', 'spread': '7.46', 'groupId': 'OG003'}, {'value': '15.29', 'spread': '7.11', 'groupId': 'OG004'}, {'value': '16.56', 'spread': '7.56', 'groupId': 'OG005'}, {'value': '15.15', 'spread': '6.88', 'groupId': 'OG006'}, {'value': '15.74', 'spread': '6.83', 'groupId': 'OG007'}, {'value': '13.76', 'spread': '6.75', 'groupId': 'OG008'}]}]}, {'title': 'QSU Relief: 10 min', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '9.92', 'spread': '5.82', 'groupId': 'OG000'}, {'value': '10.03', 'spread': '4.97', 'groupId': 'OG001'}, {'value': '9.93', 'spread': '5.44', 'groupId': 'OG002'}, {'value': '9.92', 'spread': '5.13', 'groupId': 'OG003'}, {'value': '9.23', 'spread': '4.71', 'groupId': 'OG004'}, {'value': '9.71', 'spread': '5.30', 'groupId': 'OG005'}, {'value': '9.37', 'spread': '4.96', 'groupId': 'OG006'}, {'value': '9.66', 'spread': '4.84', 'groupId': 'OG007'}, {'value': '9.40', 'spread': '5.05', 'groupId': 'OG008'}]}]}, {'title': 'QSU Desire: 35 min', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '16.17', 'spread': '7.94', 'groupId': 'OG000'}, {'value': '16.72', 'spread': '7.68', 'groupId': 'OG001'}, {'value': '16.87', 'spread': '7.02', 'groupId': 'OG002'}, {'value': '16.88', 'spread': '7.79', 'groupId': 'OG003'}, {'value': '15.41', 'spread': '7.15', 'groupId': 'OG004'}, {'value': '16.54', 'spread': '7.65', 'groupId': 'OG005'}, {'value': '14.55', 'spread': '6.45', 'groupId': 'OG006'}, {'value': '14.92', 'spread': '7.48', 'groupId': 'OG007'}, {'value': '12.49', 'spread': '5.83', 'groupId': 'OG008'}]}]}, {'title': 'QSU Relief: 35 min', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '61', 'groupId': 'OG002'}, {'value': '64', 'groupId': 'OG003'}, {'value': '64', 'groupId': 'OG004'}, {'value': '63', 'groupId': 'OG005'}, {'value': '60', 'groupId': 'OG006'}, {'value': '65', 'groupId': 'OG007'}, {'value': '87', 'groupId': 'OG008'}]}], 'categories': [{'measurements': [{'value': '9.57', 'spread': '5.51', 'groupId': 'OG000'}, {'value': '9.58', 'spread': '4.63', 'groupId': 'OG001'}, {'value': '9.41', 'spread': '4.68', 'groupId': 'OG002'}, {'value': '9.28', 'spread': '4.53', 'groupId': 'OG003'}, {'value': '8.94', 'spread': '4.56', 'groupId': 'OG004'}, {'value': '9.38', 'spread': '4.45', 'groupId': 'OG005'}, {'value': '8.40', 'spread': '3.82', 'groupId': 'OG006'}, {'value': '8.95', 'spread': '4.55', 'groupId': 'OG007'}, {'value': '8.09', 'spread': '4.29', 'groupId': 'OG008'}]}]}], 'paramType': 'MEAN', 'timeFrame': '0, 5, 10, 35 min.', 'description': 'E-cig craving/suppression of craving and withdraw will be measured using the Tiffany-Drobes Questionnaire of Smoking Urges (QSU): Brief Form with a modified version (replacing the word "cigarette" with "e-cigarette"). This is a 10-item measure where participants rate smoking/vaping-related items on a 7-point Likert scale ranging from 1 (strongly disagree) to 7 (strongly agree). Similar to previous studies, we will collapse the items into two previously identified factors (Factor 1: strong desire and intention to smoke/vape; Factor 2: anticipation of relief from withdrawal symptoms). Scores are calculated by summing the items and range from 5 to 35 for each of the factors with higher scores indicating greater craving to smoke/vape.', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Participants who attended the study product visit and fully completed the QSU items'}, {'type': 'SECONDARY', 'title': 'Vascular Reactivity', 'denoms': [{'units': 'Participants', 'counts': [{'value': '86', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Overall Population', 'description': 'All participants included in the study'}], 'classes': [{'categories': [{'measurements': [{'value': '0.47', 'spread': '0.26', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre-Vaping Session at Visit 1', 'description': 'Endothelial function will be collected through EndoPAT device. Specifically, the natural log of RHI, the reactive hyperemia index, will be recorded.\n\nThe RHI (Reactive Hyperemia Index) or LnRHI (natural log of RHI) is the post-to-pre occlusion PAT™ signal ratio in the occluded arm, relative to the same ratio in the control arm, corrected for baseline vascular tone. Values less than 1.67 or higher than 0.51 are considered to be abnormal.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Participants who attended the baseline study visit and whose endothelial function was able to be recorded with the EndoPAT device.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Overall Population', 'description': 'Full population of participants evaluated at baseline'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '88'}]}, {'type': 'Usual Brand e-Cigarette', 'achievements': [{'groupId': 'FG000', 'numSubjects': '87'}]}, {'type': 'Low Concentration Free-base Nicotine (1%), Menthol Flavor', 'achievements': [{'groupId': 'FG000', 'numSubjects': '65'}]}, {'type': 'Low Concentration Free-base Nicotine (1%), Tobacco Flavor', 'achievements': [{'groupId': 'FG000', 'numSubjects': '64'}]}, {'type': 'Low Concentration Nicotine Salt (1%), Menthol Flavor', 'achievements': [{'groupId': 'FG000', 'numSubjects': '61'}]}, {'type': 'Low Concentration Nicotine Salt (1%), Tobacco Flavor', 'achievements': [{'groupId': 'FG000', 'numSubjects': '64'}]}, {'type': 'High Concentration Free-base Nicotine (1%), Menthol Flavor', 'achievements': [{'groupId': 'FG000', 'numSubjects': '64'}]}, {'type': 'High Concentration Free-base Nicotine (1%), Tobacco Flavor', 'achievements': [{'groupId': 'FG000', 'numSubjects': '63'}]}, {'type': 'High Concentration Nicotine Salt (1%), Menthol Flavor', 'achievements': [{'groupId': 'FG000', 'numSubjects': '60'}]}, {'type': 'High Concentration Nicotine Salt (1%), Tobacco Flavor', 'achievements': [{'groupId': 'FG000', 'numSubjects': '65'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '60'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '28'}]}], 'dropWithdraws': [{'type': 'Withdrawal by Subject', 'reasons': [{'groupId': 'FG000', 'numSubjects': '8'}]}, {'type': 'Lost to Follow-up', 'reasons': [{'groupId': 'FG000', 'numSubjects': '17'}]}, {'type': 'Pregnancy', 'reasons': [{'groupId': 'FG000', 'numSubjects': '2'}]}, {'type': 'Withdrawal by Study Team', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '87', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'Overall Population', 'description': 'Full population of participants evaluated at baseline'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '87', 'groupId': 'BG000'}]}], 'categories': [{'measurements': [{'value': '22.36', 'spread': '1.35', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '87', 'groupId': 'BG000'}]}], 'categories': [{'title': 'Female', 'measurements': [{'value': '51', 'groupId': 'BG000'}]}, {'title': 'Male', 'measurements': [{'value': '36', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '87', 'groupId': 'BG000'}]}], 'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}, {'title': 'Asian', 'measurements': [{'value': '8', 'groupId': 'BG000'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}, {'title': 'Black or African American', 'measurements': [{'value': '4', 'groupId': 'BG000'}]}, {'title': 'White', 'measurements': [{'value': '73', 'groupId': 'BG000'}]}, {'title': 'More than one race', 'measurements': [{'value': '1', 'groupId': 'BG000'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '1', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Years of regular e-cigarette use', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '85', 'groupId': 'BG000'}]}], 'categories': [{'measurements': [{'value': '3.29', 'spread': '2.13', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION', 'populationDescription': 'Two participants failed to provide the age at which they began regularly using e-cigarettes'}], 'populationDescription': 'Demographics are presented as a whole for this cross-over study and not by product order due to the large number of product orderings used to randomize the presentation order of the 8 different products.'}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2022-11-21', 'size': 798541, 'label': 'Study Protocol, Statistical Analysis Plan, and Informed Consent Form', 'hasIcf': True, 'hasSap': True, 'filename': 'Prot_SAP_ICF_000.pdf', 'typeAbbrev': 'Prot_SAP_ICF', 'uploadDate': '2024-09-30T14:20', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'FACTORIAL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 88}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2021-12-02', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-09', 'completionDateStruct': {'date': '2023-08-07', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2024-09-30', 'studyFirstSubmitDate': '2021-09-20', 'resultsFirstSubmitDate': '2024-05-21', 'studyFirstSubmitQcDate': '2022-07-13', 'lastUpdatePostDateStruct': {'date': '2024-11-22', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2024-09-30', 'studyFirstPostDateStruct': {'date': '2022-07-14', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2024-11-22', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2023-08-07', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Plasma Nicotine Concentration', 'timeFrame': '0, 5, 10, 35 min.', 'description': 'Plasma nicotine concentration from blood drawn (3mL) 4 times in each session at baseline (0 min), 5 min., 10 min., 35 min.'}, {'measure': 'Puff Count', 'timeFrame': '30 minutes', 'description': 'E-cig puff topography data collection for abuse liability. Number of puffs taken during the 30 minutes of ad libitum (as desired) vaping session.'}, {'measure': 'Average Puff Duration', 'timeFrame': '30 minutes', 'description': 'E-cig puff topography data collection for abuse liability. Average puff duration during the 30 minutes of ad libitum (as desired) vaping session, in seconds.'}, {'measure': 'Average Puff Volume', 'timeFrame': '30 minutes', 'description': 'E-cig puff topography data collection for abuse liability. The total volume of all puffs taken for each participant during the 30 minutes of ad libitum (as desired) vaping session, in ml.'}, {'measure': 'Lung Function Assessment', 'timeFrame': 'Baseline and 35 minutes', 'description': 'Lung function data will be collect using a handheld spirometry device. Physiological effects of pulmonary function collected from inhaled and exhaled breaths. Measures amount inhaled and how quickly exhaled.\n\nChange from baseline in forced expiratory volume (FEV) Change from baseline in forced vital capacity (FVC)'}, {'measure': 'Airway Inflammation (NIOX VERO)', 'timeFrame': '35 minutes', 'description': 'Physiological effects of pulmonary function collected from inhaled and exhaled breaths. Airway inflammation will be assessed using exhaled nitric oxide via the NIOX VERO.'}], 'secondaryOutcomes': [{'measure': 'Sensory E-Cigarette Expectancies Scale (SEES)', 'timeFrame': 'Baseline', 'description': 'Background measures. Comprised of 9 items each of which range 0-4 from "never" to "almost always".\n\nThe 3 subscales (enjoyment of taste and smell, pleasurable physical sensations, enjoyment of vapor cloud production) are the average of 3 items each; scores range from 0 to 4 with higher scores indicating greater enjoyment.'}, {'measure': 'Modified Cigarette Dependence Scale', 'timeFrame': 'Baseline', 'description': 'Assess e-cigarette dependence.\n\nScores range from 5 to 25 with higher scores indicating a greater level of dependence.'}, {'measure': 'Drug Effects/Liking Questionnaire', 'timeFrame': '35 minutes', 'description': "An adapted version of the Drug Effects/Liking Questionnaire will assess the desire and liking of UBMC and all three study products, positive and negative effects (i.e., side effects), and perceived strength and effectiveness. Five visual analog scale items ranging from 0 ('not at all') to 100 ('extremely') assessed wanting to smoke the product again, liking the product, enjoying the product, finding the product pleasurable and satisfying."}, {'measure': 'Modified Cigarette Evaluation Questionnaire (mCEQ)', 'timeFrame': '35 minutes', 'description': 'The modified Cigarette Evaluation Questionnaire (mCEQ) will assess subjective responses to e-cigarettes (e.g., reward, satisfaction). The 12-item mCEQ includes five subscales: Smoking Satisfaction, Psychological Reward, Aversion, Enjoyment of Respiratory Tract Sensations, and Craving Reduction, with items rated from 1 (not at all) to 7 (extremely likely). Items are averaged to create each of the subscales also ranging from 1 to 7 with higher values indicating greater levels of smoking satisfaction, psychological reward, aversion, enjoyment of respiratory tract sensations, an craving reduction.'}, {'measure': 'E-cigarette Purchase Task - Breakpoint', 'timeFrame': '35 minutes', 'description': 'Behavioral economic demand Asks participants how much they would be willing to pay (ranging from 0¢ to $1,120) for a puff of their study product. Specifically they will be asked, "Thinking about the study product, how many puffs of e-cigarette would you smoke if they were each at the following prices?". Breakpoint is the first price of zero consumption.'}, {'measure': 'Tiffany-Drobes Questionnaire of Smoking Urges: Brief Form', 'timeFrame': '0, 5, 10, 35 min.', 'description': 'E-cig craving/suppression of craving and withdraw will be measured using the Tiffany-Drobes Questionnaire of Smoking Urges (QSU): Brief Form with a modified version (replacing the word "cigarette" with "e-cigarette"). This is a 10-item measure where participants rate smoking/vaping-related items on a 7-point Likert scale ranging from 1 (strongly disagree) to 7 (strongly agree). Similar to previous studies, we will collapse the items into two previously identified factors (Factor 1: strong desire and intention to smoke/vape; Factor 2: anticipation of relief from withdrawal symptoms). Scores are calculated by summing the items and range from 5 to 35 for each of the factors with higher scores indicating greater craving to smoke/vape.'}, {'measure': 'Vascular Reactivity', 'timeFrame': 'Pre-Vaping Session at Visit 1', 'description': 'Endothelial function will be collected through EndoPAT device. Specifically, the natural log of RHI, the reactive hyperemia index, will be recorded.\n\nThe RHI (Reactive Hyperemia Index) or LnRHI (natural log of RHI) is the post-to-pre occlusion PAT™ signal ratio in the occluded arm, relative to the same ratio in the control arm, corrected for baseline vascular tone. Values less than 1.67 or higher than 0.51 are considered to be abnormal.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['E-cigarette Use']}, 'referencesModule': {'references': [{'pmid': '39120901', 'type': 'DERIVED', 'citation': 'Cho YJ, Mehta T, Hinton A, Sloan R, Nshimiyimana J, Tackett AP, Roberts ME, Brinkman MC, Wagener TL. E-Cigarette Nicotine Delivery Among Young Adults by Nicotine Form, Concentration, and Flavor: A Crossover Randomized Clinical Trial. JAMA Netw Open. 2024 Aug 1;7(8):e2426702. doi: 10.1001/jamanetworkopen.2024.26702.'}], 'seeAlsoLinks': [{'url': 'http://cancer.osu.edu', 'label': 'The Jamesline'}]}, 'descriptionModule': {'briefSummary': 'This clinical trial examines the influence of nicotine form, concentration, and e-liquid flavor on youth vaping behavior, as well as the heart and lung effects associated with this behavior. Electronic cigarette (e-cig) "vaping", while being promoted as a safer alternative to conventional cigarettes, has disproportionately attracted adolescents and young adults ("youth"). This trial may help researchers understand how nicotine form, concentration, and flavor affects people\'s vaping behaviors and health.', 'detailedDescription': 'We will examine the influence of nicotine form and concentration, and e-liquid flavor on youth vaping behavior, nicotine uptake, abuse liability, toxicant exposure, and acute cardiovascular and pulmonary effects. Participants will complete 9 vaping sessions. Each vaping session will include a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. During the first session, participants will use their own e-cig and e-liquid; for the following 8 sessions, participants will vape a study-provided e-cig and e-liquid.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '25 Years', 'minimumAge': '21 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* A current exclusive e-cigarette user (\\>= 1 vaping bout per day) for at least the past 3 months (confirmed in lab by salivary cotinine)\n* 21-25 years old\n* Willing to abstain from all tobacco and nicotine for at least 12 hours prior to lab sessions\n* Willing to complete five, 6 hour lab visits\n* Able to read and speak English\n* Willing to provide informed consent\n\nExclusion Criteria:\n\n* Self-reported diagnosis of lung disease including asthma, cystic fibrosis, or chronic obstructive pulmonary disease\n* Unstable or significant psychiatric conditions (past and stable conditions will be allowed)\n* History of cardiac event or distress within the past 3 months\n* Currently pregnant (determined using urine pregnancy test), planning to become pregnant, or breastfeeding\n* Use of other tobacco products \\> 5 days in the past month\n* Current marijuana use \\> 5 times per month\n* Currently engaging in a vaping cessation attempt\n* Ohio State University (OSU) verifies study project 2 current membership/past participation'}, 'identificationModule': {'nctId': 'NCT05458895', 'briefTitle': 'Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth', 'organization': {'class': 'OTHER', 'fullName': 'Ohio State University Comprehensive Cancer Center'}, 'officialTitle': 'Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth', 'orgStudyIdInfo': {'id': 'OSU-20313'}, 'secondaryIdInfos': [{'id': 'NCI-2021-06437', 'type': 'REGISTRY', 'domain': 'CTRP (Clinical Trial Reporting Program)'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'High concentration free-base nicotine (5%), Tobacco flavor', 'description': 'Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'interventionNames': ['Other: ECIG lab session 1']}, {'type': 'EXPERIMENTAL', 'label': 'High concentration nicotine salt (5%), Tobacco flavor', 'description': 'Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'interventionNames': ['Other: ECIG lab session 2']}, {'type': 'EXPERIMENTAL', 'label': 'High concentration free-base nicotine (5%), Menthol flavor', 'description': 'Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'interventionNames': ['Other: ECIG lab session 3']}, {'type': 'EXPERIMENTAL', 'label': 'High concentration nicotine salt (5%), Menthol flavor', 'description': 'Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'interventionNames': ['Other: ECIG lab session 4']}, {'type': 'EXPERIMENTAL', 'label': 'Low concentration free-base nicotine (1%), Tobacco flavor', 'description': 'Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'interventionNames': ['Other: ECIG lab session 5']}, {'type': 'EXPERIMENTAL', 'label': 'Low concentration nicotine salt (1%), Tobacco flavor', 'description': 'Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'interventionNames': ['Other: ECIG lab session 6']}, {'type': 'EXPERIMENTAL', 'label': 'Low concentration free-base nicotine (1%), Menthol flavor', 'description': 'Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'interventionNames': ['Other: ECIG lab session 7']}, {'type': 'EXPERIMENTAL', 'label': 'Low concentration nicotine salt (1%), Menthol flavor', 'description': 'Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'interventionNames': ['Other: ECIG lab session 8']}], 'interventions': [{'name': 'ECIG lab session 1', 'type': 'OTHER', 'description': 'vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'armGroupLabels': ['High concentration free-base nicotine (5%), Tobacco flavor']}, {'name': 'ECIG lab session 2', 'type': 'OTHER', 'description': 'vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'armGroupLabels': ['High concentration nicotine salt (5%), Tobacco flavor']}, {'name': 'ECIG lab session 3', 'type': 'OTHER', 'description': 'vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'armGroupLabels': ['High concentration free-base nicotine (5%), Menthol flavor']}, {'name': 'ECIG lab session 4', 'type': 'OTHER', 'description': 'vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'armGroupLabels': ['High concentration nicotine salt (5%), Menthol flavor']}, {'name': 'ECIG lab session 5', 'type': 'OTHER', 'description': 'vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'armGroupLabels': ['Low concentration free-base nicotine (1%), Tobacco flavor']}, {'name': 'ECIG lab session 6', 'type': 'OTHER', 'description': 'vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'armGroupLabels': ['Low concentration nicotine salt (1%), Tobacco flavor']}, {'name': 'ECIG lab session 7', 'type': 'OTHER', 'description': 'vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'armGroupLabels': ['Low concentration free-base nicotine (1%), Menthol flavor']}, {'name': 'ECIG lab session 8', 'type': 'OTHER', 'description': 'vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping.', 'armGroupLabels': ['Low concentration nicotine salt (1%), Menthol flavor']}]}, 'contactsLocationsModule': {'locations': [{'zip': '43210', 'city': 'Columbus', 'state': 'Ohio', 'country': 'United States', 'facility': 'Ohio State University Comprehensive Cancer Center', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}], 'overallOfficials': [{'name': 'Theodore L Wagener, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Ohio State University Comprehensive Cancer Center'}, {'name': 'Marielle Brinkman, BS', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Ohio State University'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Ohio State University Comprehensive Cancer Center', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Principal Investigator', 'investigatorFullName': 'Theodore Wagener', 'investigatorAffiliation': 'Ohio State University Comprehensive Cancer Center'}}}}