Ignite Creation Date:
2025-12-24 @ 10:04 PM
Ignite Modification Date:
2026-01-05 @ 5:37 PM
Study NCT ID:
NCT00610935
Status:
TERMINATED
Last Update Posted:
2021-03-17
First Post:
2008-01-25
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Intramuscular Peramivir in Subjects With Uncomplicated Acute Influenza
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D007251', 'term': 'Influenza, Human'}], 'ancestors': [{'id': 'D012141', 'term': 'Respiratory Tract Infections'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D009976', 'term': 'Orthomyxoviridae Infections'}, {'id': 'D012327', 'term': 'RNA Virus Infections'}, {'id': 'D014777', 'term': 'Virus Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C414210', 'term': 'peramivir'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'clinicaltrials@biocryst.com', 'phone': '+1 919-859-1302', 'title': 'Study Director', 'organization': 'BioCryst Pharmaceuticals Inc'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': False}, 'limitationsAndCaveats': {'description': 'The study was terminated at the discretion of the Sponsor after 82 of the planned 600 subjects were enrolled. The reason for study termination was to allow the Sponsor to focus development efforts on a more concentrated formulation which would also allow evaluation of higher doses of peramivir administered intramuscularly.'}}, 'adverseEventsModule': {'timeFrame': 'Reports of TEAEs were collected from the time of study drug administration through to the follow-up period ending on Day 14.', 'eventGroups': [{'id': 'EG000', 'title': 'Placebo', 'description': 'Placebo intramuscular injection', 'otherNumAtRisk': 25, 'deathsNumAtRisk': 25, 'otherNumAffected': 13, 'seriousNumAtRisk': 25, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Peramivir', 'description': 'Single intramuscular injection of 300mg peramivir', 'otherNumAtRisk': 57, 'deathsNumAtRisk': 57, 'otherNumAffected': 26, 'seriousNumAtRisk': 57, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Diarrhea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 4, 'numAffected': 4}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (9.1)'}, {'term': 'Nausea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 4, 'numAffected': 4}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}, {'term': 'Vomiting', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 3, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 4, 'numAffected': 4}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}, {'term': 'Ageusia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 2, 'numAffected': 2}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}, {'term': 'Dizziness', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 4, 'numAffected': 4}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}, {'term': 'Syncope Vasovagal', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 3, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}, {'term': 'Injection Site Pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 4, 'numAffected': 4}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}, {'term': 'Myalgia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 3, 'numAffected': 3}], 'organSystem': 'Musculoskeletal and connective tissue disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}, {'term': 'Muscle Spasms', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Musculoskeletal and connective tissue disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}, {'term': 'Urine Protein Present', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}, {'term': 'Pruritus', 'stats': [{'groupId': 'EG000', 'numAtRisk': 25, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 57, 'numEvents': 2, 'numAffected': 2}], 'organSystem': 'Skin and subcutaneous tissue disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (10.0)'}], 'frequencyThreshold': '2'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'The Time to Alleviation of Clinical Signs and Symptoms of Influenza', 'denoms': [{'units': 'Participants', 'counts': [{'value': '24', 'groupId': 'OG000'}, {'value': '55', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Placebo intramuscular injection'}, {'id': 'OG001', 'title': 'Peramivir', 'description': 'Single intramuscular injection of 300mg peramivir'}], 'classes': [{'categories': [{'measurements': [{'value': '118.3', 'groupId': 'OG000', 'lowerLimit': '81.3', 'upperLimit': '175.5'}, {'value': '103.9', 'groupId': 'OG001', 'lowerLimit': '81.7', 'upperLimit': '126.8'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Up to 14 days', 'description': 'The primary efficacy endpoint was the time to alleviation of symptoms of influenza in subjects diagnosed with influenza, defined as the time from injection of study drug to the start of the time period when a subject had Alleviation of Symptoms. A subject had Alleviation of Symptoms if each of the seven symptoms of influenza (cough, sore throat, nasal obstruction, myalgia \\[aches and pains\\], headache, feverishness, and fatigue) as self-assessed and recorded in the subject diary were either absent or were present at no more than mild severity level and at this status for at least 21.5 hours (24 hours minus 10%). No statistical testing was performed.', 'unitOfMeasure': 'hours', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'A total of 80 subjects met the criteria for inclusion in the ITTI population as defined by a positive PCR assay for influenza A or B from the nasopharyngeal specimen obtained prior to administration of study treatment. Seventy-nine of these were included in the primary efficacy analysis for whom data for time to symptom alleviation were available; There was insufficient data from one subject in the placebo group to enable determination of the Time to Alleviation of Symptoms.'}, {'type': 'SECONDARY', 'title': 'To Evaluate Changes in Influenza Virus Titer in Nasopharyngeal Samples in Response to Treatment.', 'denoms': [{'units': 'Participants', 'counts': [{'value': '20', 'groupId': 'OG000'}, {'value': '49', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Placebo intramuscular injection'}, {'id': 'OG001', 'title': 'Peramivir', 'description': 'Single intramuscular injection of 300mg peramivir'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '3.75', 'groupId': 'OG000', 'lowerLimit': '1.75', 'upperLimit': '5.00'}, {'value': '3.75', 'groupId': 'OG001', 'lowerLimit': '1.50', 'upperLimit': '5.00'}]}]}, {'title': 'Day 3 - Change from baseline', 'categories': [{'measurements': [{'value': '-2.25', 'groupId': 'OG000', 'lowerLimit': '-4.25', 'upperLimit': '-0.25'}, {'value': '-2.75', 'groupId': 'OG001', 'lowerLimit': '-4.25', 'upperLimit': '1.00'}]}]}, {'title': 'Day 5 - Change from baseline', 'categories': [{'measurements': [{'value': '-3.00', 'groupId': 'OG000', 'lowerLimit': '-4.25', 'upperLimit': '-0.75'}, {'value': '-3.00', 'groupId': 'OG001', 'lowerLimit': '-4.50', 'upperLimit': '-1.00'}]}]}, {'title': 'Day 9 - Change from baseline', 'categories': [{'measurements': [{'value': '-3.00', 'groupId': 'OG000', 'lowerLimit': '-4.50', 'upperLimit': '-1.50'}, {'value': '-3.25', 'groupId': 'OG001', 'lowerLimit': '-4.50', 'upperLimit': '-0.75'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline assessed on days 3, 5 and 9.', 'description': 'The change in influenza viral titers was defined as the time-weighted change from Baseline in log\\_10 tissue culture infective dose\\_50 (TCID50/mL) and was summarized for each treatment group. The differences between the treatment groups were planned to be evaluated using a Wilcoxon Rank Sum Test controlling for current smoking behavior. Specimens for virologic culture and determination of influenza virus TCID50/mL were obtained at interval visits after treatment. As the study was terminated prematurely, no statistical testing was performed on these data.', 'unitOfMeasure': 'influenza viral titer - log10 TCID50/mL', 'dispersionType': 'Full Range', 'reportingStatus': 'POSTED', 'populationDescription': 'The Intent To Treat Infected population (ITTI) population included all subjects who were randomized, received study drug, and had confirmed influenza A and/or B by primary viral culture or PCR.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Placebo', 'description': 'Placebo intramuscular injection'}, {'id': 'FG001', 'title': 'Peramivir', 'description': 'Single intramuscular injection of 300mg peramivir'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '25'}, {'groupId': 'FG001', 'numSubjects': '57'}]}, {'type': 'ITTI Population', 'comment': 'Intent to treat - infected (ITTI) population included all subjects who were randomized, received at least one injection of study drug, and had proven influenza infection by at least one of the following assessments performed on a Screening/Baseline sample: positive PCR assay or positive viral culture for Influenza A or B.', 'achievements': [{'groupId': 'FG000', 'numSubjects': '25'}, {'groupId': 'FG001', 'numSubjects': '55'}]}, {'type': 'ITT Population', 'comment': 'Intent to treat (ITT) population included all randomized subjects for whom data were analyzed in the respective randomized treatment groups. The ITT population = Safety Population', 'achievements': [{'groupId': 'FG000', 'numSubjects': '25'}, {'groupId': 'FG001', 'numSubjects': '57'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '24'}, {'groupId': 'FG001', 'numSubjects': '54'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '3'}]}], 'dropWithdraws': [{'type': 'Lost to Follow-up', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '1'}]}, {'type': 'Withdrawal by Subject', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '2'}]}, {'type': 'Sponsor Discontinuation', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '0'}]}]}], 'preAssignmentDetails': "Subjects were centrally randomized in a ratio of 2:1 to a single dose of IM peramivir 300 mg or placebo, in accordance with a computer-generated randomization schedule prepared by a non-study statistician. Each subject's assignment to treatment was stratified according to smoking status and RAT test for influenza A or B."}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'BG000'}, {'value': '57', 'groupId': 'BG001'}, {'value': '82', 'groupId': 'BG002'}]}], 'groups': [{'id': 'BG000', 'title': 'Placebo', 'description': 'Placebo intramuscular injection'}, {'id': 'BG001', 'title': 'Peramivir', 'description': 'Single intramuscular injection of 300mg peramivir'}, {'id': 'BG002', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '33.9', 'spread': '8.86', 'groupId': 'BG000'}, {'value': '32.6', 'spread': '12.67', 'groupId': 'BG001'}, {'value': '33.0', 'spread': '11.60', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '14', 'groupId': 'BG000'}, {'value': '28', 'groupId': 'BG001'}, {'value': '42', 'groupId': 'BG002'}]}, {'title': 'Male', 'measurements': [{'value': '11', 'groupId': 'BG000'}, {'value': '29', 'groupId': 'BG001'}, {'value': '40', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Asian', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '4', 'groupId': 'BG002'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}, {'title': 'Black or African American', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '6', 'groupId': 'BG002'}]}, {'title': 'White', 'measurements': [{'value': '15', 'groupId': 'BG000'}, {'value': '41', 'groupId': 'BG001'}, {'value': '56', 'groupId': 'BG002'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '6', 'groupId': 'BG000'}, {'value': '9', 'groupId': 'BG001'}, {'value': '15', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Current Smoking Behavior at Randomization', 'classes': [{'title': 'Smoker', 'categories': [{'measurements': [{'value': '4', 'groupId': 'BG000'}, {'value': '14', 'groupId': 'BG001'}, {'value': '18', 'groupId': 'BG002'}]}]}, {'title': 'Non-smoker', 'categories': [{'measurements': [{'value': '21', 'groupId': 'BG000'}, {'value': '43', 'groupId': 'BG001'}, {'value': '64', 'groupId': 'BG002'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}, {'title': 'Influenza PCR Results', 'classes': [{'title': 'Negative', 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}]}]}, {'title': 'Influenza A (H1N1)', 'categories': [{'measurements': [{'value': '5', 'groupId': 'BG000'}, {'value': '16', 'groupId': 'BG001'}, {'value': '21', 'groupId': 'BG002'}]}]}, {'title': 'Influenza A (H3N2)', 'categories': [{'measurements': [{'value': '15', 'groupId': 'BG000'}, {'value': '33', 'groupId': 'BG001'}, {'value': '48', 'groupId': 'BG002'}]}]}, {'title': 'Influenza A (IND)', 'categories': [{'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}]}, {'title': 'Influenza B', 'categories': [{'measurements': [{'value': '4', 'groupId': 'BG000'}, {'value': '6', 'groupId': 'BG001'}, {'value': '10', 'groupId': 'BG002'}]}]}, {'title': 'Influenza A and B', 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}], 'populationDescription': 'The ITT population included all randomized subjects for whom data were analyzed in the respective randomized treatment groups. The ITT population was the primary population for analyses of demography and subject accountability as well as safety.'}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2007-08-24', 'size': 2768495, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2021-02-24T06:42', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 82}}, 'statusModule': {'whyStopped': 'This study was terminated for administrative reasons.', 'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2008-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2021-02', 'dispFirstSubmitDate': '2011-12-21', 'completionDateStruct': {'date': '2008-02', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2021-02-24', 'studyFirstSubmitDate': '2008-01-25', 'dispFirstSubmitQcDate': '2011-12-21', 'resultsFirstSubmitDate': '2021-02-05', 'studyFirstSubmitQcDate': '2008-02-07', 'dispFirstPostDateStruct': {'date': '2011-12-26', 'type': 'ESTIMATED'}, 'lastUpdatePostDateStruct': {'date': '2021-03-17', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2021-02-24', 'studyFirstPostDateStruct': {'date': '2008-02-08', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2021-03-17', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2008-02', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'The Time to Alleviation of Clinical Signs and Symptoms of Influenza', 'timeFrame': 'Up to 14 days', 'description': 'The primary efficacy endpoint was the time to alleviation of symptoms of influenza in subjects diagnosed with influenza, defined as the time from injection of study drug to the start of the time period when a subject had Alleviation of Symptoms. A subject had Alleviation of Symptoms if each of the seven symptoms of influenza (cough, sore throat, nasal obstruction, myalgia \\[aches and pains\\], headache, feverishness, and fatigue) as self-assessed and recorded in the subject diary were either absent or were present at no more than mild severity level and at this status for at least 21.5 hours (24 hours minus 10%). No statistical testing was performed.'}], 'secondaryOutcomes': [{'measure': 'To Evaluate Changes in Influenza Virus Titer in Nasopharyngeal Samples in Response to Treatment.', 'timeFrame': 'Change from baseline assessed on days 3, 5 and 9.', 'description': 'The change in influenza viral titers was defined as the time-weighted change from Baseline in log\\_10 tissue culture infective dose\\_50 (TCID50/mL) and was summarized for each treatment group. The differences between the treatment groups were planned to be evaluated using a Wilcoxon Rank Sum Test controlling for current smoking behavior. Specimens for virologic culture and determination of influenza virus TCID50/mL were obtained at interval visits after treatment. As the study was terminated prematurely, no statistical testing was performed on these data.'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['Influenza', 'Subjects with uncomplicated acute influenza'], 'conditions': ['Influenza']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to determine the safety and effectivess of a single intramuscular injection of peramivir for the treatment of subjects with acute, uncomplicated influenza.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Male and non-pregnant female subjects age ≥18 years.\n* A positive Influenza A and/or B Rapid Antigen Test (RAT) performed with a commercially available test kit on an adequate anterior nasal specimen, in accordance with the manufacturer's instructions. A negative initial RAT should be repeated within one-hour.\n* Presence of fever at time of screening of ≥38.0 ºC (≥100.4 ºF) taken orally, or ≥38.5 ºC (≥101.2 ºF) taken rectally. A subject self-report of a history of fever or feverishness within the 24 hours prior to screening will also qualify for enrollment in the absence of documented fever at the time of screening.\n* Presence of at least one respiratory symptom (cough, sore throat, or nasal symptoms) of at least moderate severity.\n* Presence of at least one constitutional symptom (myalgia \\[aches and pains\\], headache, feverishness, or fatigue) of at least moderate severity.\n* Onset of symptoms no more than 48 hours before presentation for screening.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Women who are pregnant or breast-feeding.\n* Presence of clinically significant signs of acute respiratory distress.\n* History of severe chronic obstructive pulmonary disease (COPD) or severe persistent asthma (See section 15.2).\n* History of congestive heart failure requiring daily pharmacotherapy with symptoms consistent with New York Heart Association Class III or IV functional status within the past 12 months.\n* Screening ECG which suggests acute ischemia or presence of medically significant dysrhythmia.\n* History of chronic renal impairment requiring hemodialysis and/or known or suspected to have moderate or severe renal impairment (actual or estimated creatinine clearance \\<50 mL/min).\n* Clinical evidence of worsening of any chronic medical condition (temporally associated with the onset of symptoms of influenza) which, in the investigator's opinion, indicates that such finding(s) could represent complications of influenza.\n* Current clinical evidence, including clinical signs and/or symptoms consistent with otitis, bronchitis, sinusitis and/or pneumonia, or active bacterial infection at any body site that requires therapy with oral or systemic antibiotics.\n* Presence of immunocompromised status due to chronic illness, previous organ transplant, or use of immunosuppressive medical therapy which would include oral or systemic treatment with \\> 10 mg prednisone or equivalent on a daily basis within 30 days of screening.\n* Currently receiving treatment for viral hepatitis B or viral hepatitis C.\n* Presence of known HIV infection with a CD4 count \\<350 cell/mm3.\n* Current therapy with oral warfarin or other systemic anticoagulant.\n* Receipt of any doses of rimantadine, amantadine, zanamivir, or oseltamivir in the 7 days prior to screening.\n* Immunized against influenza with live attenuated virus vaccine (FluMist®) in the previous 21 days.\n* Immunized against influenza with inactivated virus vaccine within the previous 14 days.\n* Receipt of any intramuscular injection within the previous 14 days.\n* History of alcohol abuse or drug addiction within 1 year prior to admission in the study.\n* Participation in a previous study of intramuscular or intravenous peramivir or previous participation in this study.\n* Participation in a study of any investigational drug or device within the last 30 days."}, 'identificationModule': {'nctId': 'NCT00610935', 'briefTitle': 'Intramuscular Peramivir in Subjects With Uncomplicated Acute Influenza', 'organization': {'class': 'INDUSTRY', 'fullName': 'BioCryst Pharmaceuticals'}, 'officialTitle': 'A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Intramuscular Peramivir in Subjects With Uncomplicated Acute Influenza.', 'orgStudyIdInfo': {'id': 'BCX1812 311'}, 'secondaryIdInfos': [{'id': 'HHS # O100200700032C', 'type': 'REGISTRY', 'domain': 'U.S. Department of Health & Human Services'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Placebo intramuscular injection', 'interventionNames': ['Drug: Placebo']}, {'type': 'EXPERIMENTAL', 'label': 'Peramivir', 'description': 'Single intramuscular injection of 300mg peramivir', 'interventionNames': ['Drug: Peramivir']}], 'interventions': [{'name': 'Peramivir', 'type': 'DRUG', 'description': 'To evaluate the efficacy of peramivir administered intramuscularly compared to placebo on the time to alleviation of clinical symptoms in adult subjects with uncomplicated acute influenza.', 'armGroupLabels': ['Peramivir']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Single intramuscular injection', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '36054', 'city': 'Millbrook', 'state': 'Alabama', 'country': 'United States', 'facility': 'Physical Express', 'geoPoint': {'lat': 32.47986, 'lon': -86.36192}}, {'zip': '35404', 'city': 'Tuscaloosa', 'state': 'Alabama', 'country': 'United States', 'facility': 'Alabama Family Medical Center', 'geoPoint': {'lat': 33.20984, 'lon': -87.56917}}, {'zip': '85050', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'HOPE Research Institute', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '72401', 'city': 'Jonesboro', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Clopton Clinic', 'geoPoint': {'lat': 35.8423, 'lon': -90.70428}}, {'zip': '72401', 'city': 'Jonesboro', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Research Solutions, LLC', 'geoPoint': {'lat': 35.8423, 'lon': -90.70428}}, {'zip': '72653', 'city': 'Mountain Home', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Kevin Adkins, MD', 'geoPoint': {'lat': 36.33534, 'lon': -92.38516}}, {'zip': '92805', 'city': 'Anaheim', 'state': 'California', 'country': 'United States', 'facility': 'NuLife Clinical Research, Inc.', 'geoPoint': {'lat': 33.83529, 'lon': -117.9145}}, {'zip': '90211', 'city': 'Beverly Hills', 'state': 'California', 'country': 'United States', 'facility': 'Impact Clinical Trials', 'geoPoint': {'lat': 34.07362, 'lon': -118.40036}}, {'zip': '90620', 'city': 'Buena Park', 'state': 'California', 'country': 'United States', 'facility': 'Associated Pharmaceutical Research Center, Inc.', 'geoPoint': {'lat': 33.86751, 'lon': -117.99812}}, {'zip': '95628', 'city': 'Fair Oaks', 'state': 'California', 'country': 'United States', 'facility': 'Med Investigations Incorporated', 'geoPoint': {'lat': 38.64463, 'lon': -121.27217}}, {'zip': '93703', 'city': 'Fresno', 'state': 'California', 'country': 'United States', 'facility': 'Universal Biopharma Research Institute Inc.', 'geoPoint': {'lat': 36.74773, 'lon': -119.77237}}, {'zip': '93726', 'city': 'Fresno', 'state': 'California', 'country': 'United States', 'facility': 'Research Center of Fresno, Inc', 'geoPoint': {'lat': 36.74773, 'lon': -119.77237}}, {'zip': '92843', 'city': 'Garden Grove', 'state': 'California', 'country': 'United States', 'facility': 'Harmony Clinical, Inc.', 'geoPoint': {'lat': 33.77391, 'lon': -117.94145}}, {'zip': '90806', 'city': 'Long Beach', 'state': 'California', 'country': 'United States', 'facility': 'Allergy, Asthma, and Respiratory Care Medical Center', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90017', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'National Institute of Clinical Research', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90723', 'city': 'Paramount', 'state': 'California', 'country': 'United States', 'facility': 'Center for Clinical Trials, LLC', 'geoPoint': {'lat': 33.88946, 'lon': -118.15979}}, {'zip': '92120', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'San Diego Sports Medicine and Family Health Center', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '93405', 'city': 'San Luis Obispo', 'state': 'California', 'country': 'United States', 'facility': 'Coastal Medical Research Group, Inc.', 'geoPoint': {'lat': 35.28275, 'lon': -120.65962}}, {'zip': '80304', 'city': 'Boulder', 'state': 'Colorado', 'country': 'United States', 'facility': 'Alpine Clinical Research Center', 'geoPoint': {'lat': 40.01499, 'lon': -105.27055}}, {'zip': '80904', 'city': 'Colorado Springs', 'state': 'Colorado', 'country': 'United States', 'facility': 'Clinicos, LLC', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '80501', 'city': 'Longmont', 'state': 'Colorado', 'country': 'United States', 'facility': 'Longmont Clinic, P.C.', 'geoPoint': {'lat': 40.16721, 'lon': -105.10193}}, {'zip': '32605', 'city': 'Gainesville', 'state': 'Florida', 'country': 'United States', 'facility': 'Florida Research Network, LLC', 'geoPoint': {'lat': 29.65163, 'lon': -82.32483}}, {'zip': '33012', 'city': 'Hialeah', 'state': 'Florida', 'country': 'United States', 'facility': 'AGA Clinical Trials', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '33013', 'city': 'Hialeah', 'state': 'Florida', 'country': 'United States', 'facility': 'Eastern Research', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '32117', 'city': 'Holly Hill', 'state': 'Florida', 'country': 'United States', 'facility': 'Century Clinical Research Inc', 'geoPoint': {'lat': 29.24359, 'lon': -81.03756}}, {'zip': '32205', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Jacksonville Center for Clinical Research', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '32216', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Jacksonville Center for Clinical Research', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '32257', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Office of Roger J. Miller, Jr., MD', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33463', 'city': 'Lake Worth', 'state': 'Florida', 'country': 'United States', 'facility': 'MD Now Medical Center', 'geoPoint': {'lat': 26.61708, 'lon': -80.07231}}, {'zip': '33773', 'city': 'Largo', 'state': 'Florida', 'country': 'United States', 'facility': 'DMI Healthcare Group', 'geoPoint': {'lat': 27.90979, 'lon': -82.78842}}, {'zip': '33143', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Well Pharma Medical Research, Corp.', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '32806', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Compass Research LLC', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '33028', 'city': 'Pembroke Pines', 'state': 'Florida', 'country': 'United States', 'facility': 'Pines Research, LLC', 'geoPoint': {'lat': 26.00315, 'lon': -80.22394}}, {'zip': '34769', 'city': 'Saint Cloud', 'state': 'Florida', 'country': 'United States', 'facility': 'Wilker/Powers Center for Clinical Studies', 'geoPoint': {'lat': 28.2489, 'lon': -81.28118}}, {'zip': '33409', 'city': 'West Palm Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Palm Beach Research Center', 'geoPoint': {'lat': 26.71534, 'lon': -80.05337}}, {'zip': '31082', 'city': 'Sandersville', 'state': 'Georgia', 'country': 'United States', 'facility': 'Sandersville Family Practice Center', 'geoPoint': {'lat': 32.98154, 'lon': -82.81014}}, {'zip': '62301', 'city': 'Quincy', 'state': 'Illinois', 'country': 'United States', 'facility': 'Quincy Medical Group', 'geoPoint': {'lat': 39.9356, 'lon': -91.40987}}, {'zip': '46268', 'city': 'Indianapolis', 'state': 'Indiana', 'country': 'United States', 'facility': 'Investigators Research Group, LLC', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '47630', 'city': 'Newburgh', 'state': 'Indiana', 'country': 'United States', 'facility': 'Welborn Clinic Gateway', 'geoPoint': {'lat': 37.94449, 'lon': -87.40529}}, {'zip': '52001', 'city': 'Dubuque', 'state': 'Iowa', 'country': 'United States', 'facility': 'Medical Associates Clinic PC', 'geoPoint': {'lat': 42.50056, 'lon': -90.66457}}, {'zip': '66216', 'city': 'Shawnee Mission', 'state': 'Kansas', 'country': 'United States', 'facility': 'Heart of America Research Institute', 'geoPoint': {'lat': 39.02, 'lon': -94.66583}}, {'zip': '66608', 'city': 'Topeka', 'state': 'Kansas', 'country': 'United States', 'facility': 'American Medical Exams, P.A.', 'geoPoint': {'lat': 39.04833, 'lon': -95.67804}}, {'zip': '67212', 'city': 'Wichita', 'state': 'Kansas', 'country': 'United States', 'facility': 'Heartland Research Associates, LLC', 'geoPoint': {'lat': 37.69224, 'lon': -97.33754}}, {'zip': '41701', 'city': 'Hazard', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Kentucky Lung Clinic', 'geoPoint': {'lat': 37.24954, 'lon': -83.19323}}, {'zip': '42653-0099', 'city': 'Whitley City', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Winchester, Patton, Burgess, PSC', 'geoPoint': {'lat': 36.72341, 'lon': -84.47049}}, {'zip': '70808', 'city': 'Baton Rouge', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Gulf Coast Research, LLC', 'geoPoint': {'lat': 30.44332, 'lon': -91.18747}}, {'zip': '70503', 'city': 'Lafayette', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Gulf Coast Research LLC', 'geoPoint': {'lat': 30.22409, 'lon': -92.01984}}, {'zip': '71104', 'city': 'Shreveport', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Byron Jackson', 'geoPoint': {'lat': 32.52515, 'lon': -93.75018}}, {'zip': '49616', 'city': 'Benzonia', 'state': 'Michigan', 'country': 'United States', 'facility': 'Professional Clinical Research-Benzonia', 'geoPoint': {'lat': 44.62139, 'lon': -86.09926}}, {'zip': '49601', 'city': 'Cadillac', 'state': 'Michigan', 'country': 'United States', 'facility': 'Professional Clinical Research, Inc.', 'geoPoint': {'lat': 44.25195, 'lon': -85.40116}}, {'zip': '49643', 'city': 'Interlochen', 'state': 'Michigan', 'country': 'United States', 'facility': 'Professional Clinical Research-Interlochen', 'geoPoint': {'lat': 44.64472, 'lon': -85.7673}}, {'zip': '48081', 'city': 'Saint Clair Shores', 'state': 'Michigan', 'country': 'United States', 'facility': 'KMED Research', 'geoPoint': {'lat': 42.49698, 'lon': -82.88881}}, {'zip': '38654', 'city': 'Olive Branch', 'state': 'Mississippi', 'country': 'United States', 'facility': 'Olive Branch Family Medical Center', 'geoPoint': {'lat': 34.96176, 'lon': -89.82953}}, {'zip': '65807', 'city': 'Springfield', 'state': 'Missouri', 'country': 'United States', 'facility': 'Clinvest', 'geoPoint': {'lat': 37.21533, 'lon': -93.29824}}, {'zip': '59715', 'city': 'Bozeman', 'state': 'Montana', 'country': 'United States', 'facility': 'Clinical Research Department', 'geoPoint': {'lat': 45.67965, 'lon': -111.03856}}, {'zip': '59701', 'city': 'Butte', 'state': 'Montana', 'country': 'United States', 'facility': 'Mercury Street Medical Group, PLLC', 'geoPoint': {'lat': 46.00382, 'lon': -112.53474}}, {'zip': '68025', 'city': 'Fremont', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Prarie Fields Family Medicine, P.C', 'geoPoint': {'lat': 41.43333, 'lon': -96.49808}}, {'zip': '08690', 'city': 'Hamilton', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Quick Care Medical', 'geoPoint': {'lat': 40.20706, 'lon': -74.08125}}, {'zip': '14901', 'city': 'Elmira', 'state': 'New York', 'country': 'United States', 'facility': 'Health Sciences Research Center at Asthma & Allergy Associates P.C.', 'geoPoint': {'lat': 42.0898, 'lon': -76.80773}}, {'zip': '14850', 'city': 'Ithaca', 'state': 'New York', 'country': 'United States', 'facility': 'Health Sciences Research Center', 'geoPoint': {'lat': 42.44063, 'lon': -76.49661}}, {'zip': '27605', 'city': 'Raleigh', 'state': 'North Carolina', 'country': 'United States', 'facility': 'American Institute of Healthcare & Fitness', 'geoPoint': {'lat': 35.7721, 'lon': -78.63861}}, {'zip': '44406', 'city': 'Canfield', 'state': 'Ohio', 'country': 'United States', 'facility': 'Community Medical Partners', 'geoPoint': {'lat': 41.02506, 'lon': -80.76091}}, {'zip': '43207', 'city': 'Columbus', 'state': 'Ohio', 'country': 'United States', 'facility': 'Parsons Avenue Medical Clinic', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '44124', 'city': 'Lyndhurst', 'state': 'Ohio', 'country': 'United States', 'facility': 'Ohio Clinical Research LLC', 'geoPoint': {'lat': 41.52005, 'lon': -81.48873}}, {'zip': '73013', 'city': 'Edmond', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Physician Care PM', 'geoPoint': {'lat': 35.65283, 'lon': -97.4781}}, {'zip': '74055', 'city': 'Owasso', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Urgent Care of Green County', 'geoPoint': {'lat': 36.26954, 'lon': -95.85471}}, {'zip': '97520', 'city': 'Ashland', 'state': 'Oregon', 'country': 'United States', 'facility': 'Integrated Medical Research PC', 'geoPoint': {'lat': 42.19458, 'lon': -122.70948}}, {'zip': '15241', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Primary Physicians Research Inc.', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '18974', 'city': 'Warminster', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Warminster Medical Associates, PC', 'geoPoint': {'lat': 40.20678, 'lon': -75.09962}}, {'zip': '02920', 'city': 'Cranston', 'state': 'Rhode Island', 'country': 'United States', 'facility': 'New England Center for Clinical Research, Inc.', 'geoPoint': {'lat': 41.77982, 'lon': -71.43728}}, {'zip': '02919', 'city': 'Johnston', 'state': 'Rhode Island', 'country': 'United States', 'facility': 'Clinical Partners, LLC', 'geoPoint': {'lat': 41.82186, 'lon': -71.50675}}, {'zip': '29601', 'city': 'Greenville', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Paris View Family Practice', 'geoPoint': {'lat': 34.85262, 'lon': -82.39401}}, {'zip': '29615', 'city': 'Greenville', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Andras Koser', 'geoPoint': {'lat': 34.85262, 'lon': -82.39401}}, {'zip': '29681', 'city': 'Simpsonville', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Hillcrest Clinical Research, LLC', 'geoPoint': {'lat': 34.73706, 'lon': -82.25428}}, {'zip': '29303', 'city': 'Spartanburg', 'state': 'South Carolina', 'country': 'United States', 'facility': 'S. Carolina Pharmaceutical Research', 'geoPoint': {'lat': 34.94957, 'lon': -81.93205}}, {'zip': '37620', 'city': 'Bristol', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Holston Medical Group, PC', 'geoPoint': {'lat': 36.59511, 'lon': -82.18874}}, {'zip': '37660', 'city': 'Kingsport', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Holston Medical Group, P.C.', 'geoPoint': {'lat': 36.54843, 'lon': -82.56182}}, {'zip': '77701', 'city': 'Beaumont', 'state': 'Texas', 'country': 'United States', 'facility': 'DiscoveResearch Inc.', 'geoPoint': {'lat': 30.08605, 'lon': -94.10185}}, {'zip': '77802', 'city': 'Bryan', 'state': 'Texas', 'country': 'United States', 'facility': 'DiscoveResearch, Inc.', 'geoPoint': {'lat': 30.67436, 'lon': -96.36996}}, {'zip': '78411', 'city': 'Corpus Christi', 'state': 'Texas', 'country': 'United States', 'facility': 'Intrinsic Research Data, Inc.', 'geoPoint': {'lat': 27.80058, 'lon': -97.39638}}, {'zip': '75230', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Allergy/Immunology Research Center of North Texas', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '75234', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Across America', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '77055', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'West Houston Clinical Research Service', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77070', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Dynamed Clinical Research, L.P.', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '78205', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'Sun Research Institute', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '78213', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'GSA Research', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '78229', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'San Antonio Preventive and Diagnostic Medicine', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '84102', 'city': 'Salt Lake City', 'state': 'Utah', 'country': 'United States', 'facility': 'Optimum Clinical Research', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '84109', 'city': 'Salt Lake City', 'state': 'Utah', 'country': 'United States', 'facility': 'J. Lewis Research Inc', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '84121', 'city': 'Salt Lake City', 'state': 'Utah', 'country': 'United States', 'facility': 'J. Lewis Research Inc. Foothill Family Clinic South', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '84121', 'city': 'Salt Lake City', 'state': 'Utah', 'country': 'United States', 'facility': 'J. Lewis Research, Inc.', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '84045', 'city': 'Saratoga Springs', 'state': 'Utah', 'country': 'United States', 'facility': 'Physicians Research Options, LLC', 'geoPoint': {'lat': 40.34912, 'lon': -111.90466}}, {'zip': '84088', 'city': 'West Jordan', 'state': 'Utah', 'country': 'United States', 'facility': 'J. Lewis Research Inc. FirstMed', 'geoPoint': {'lat': 40.60967, 'lon': -111.9391}}, {'zip': '23229', 'city': 'Richmond', 'state': 'Virginia', 'country': 'United States', 'facility': 'Virginia Adult & Pediatric Allergy & Asthma, P.C Department of Clinical Research', 'geoPoint': {'lat': 37.55376, 'lon': -77.46026}}, {'zip': '24290', 'city': 'Weber City', 'state': 'Virginia', 'country': 'United States', 'facility': 'Holston Medical Group', 'geoPoint': {'lat': 37.75514, 'lon': -78.28389}}, {'zip': '98004', 'city': 'Bellevue', 'state': 'Washington', 'country': 'United States', 'facility': 'Northwest Clinical Research Center', 'geoPoint': {'lat': 47.61038, 'lon': -122.20068}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'BioCryst Pharmaceuticals', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}