Ignite Creation Date:
2025-12-24 @ 10:33 PM
Ignite Modification Date:
2025-12-24 @ 10:33 PM
Study NCT ID:
NCT05628935
Status:
COMPLETED
Last Update Posted:
2022-11-29
First Post:
2022-11-17
Is Possible Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D007249', 'term': 'Inflammation'}], 'ancestors': [{'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2018-01-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2022-11', 'completionDateStruct': {'date': '2021-11-01', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2022-11-28', 'studyFirstSubmitDate': '2022-11-17', 'studyFirstSubmitQcDate': '2022-11-28', 'lastUpdatePostDateStruct': {'date': '2022-11-29', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2022-11-29', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2020-11-01', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Neutrophil/lymphocyte ratio', 'timeFrame': 'up to 24 hours after surgery', 'description': 'Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block'}], 'secondaryOutcomes': [{'measure': 'Platelet/lymphocyte ratio', 'timeFrame': 'up to 24 hours after surgery', 'description': 'Differences in Platelet/lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block'}, {'measure': 'Mean Platelet Volume', 'timeFrame': 'up to 24 hours after surgery', 'description': 'Differences in Mean Platelet Volume between patients who underwent general anesthesia and peripheral nerve block'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['General Anesthesia', 'Neutrophil Lymphocyte Ratio', 'Peripheral Nerve Block'], 'conditions': ['Inflammation', 'Anesthesia']}, 'descriptionModule': {'briefSummary': 'The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '70 Years', 'minimumAge': '18 Years', 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'Patients aged 18-65 years who have underwent forearm surgery', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Underwent forearm surgery\n* Between aged 18-70\n* Under general anesthesia or peripheral nerve block\n\nExclusion Criteria:\n\n* acute infection\n* morbid obesity\n* chronic treatment with steroids or immunosuppressants\n* recently received chemotherapy\n* hepatic and renal dysfunction;\n* chronic alcohol abusers\n* Multiple trauma\n* Patients with missing data in their files'}, 'identificationModule': {'nctId': 'NCT05628935', 'briefTitle': 'Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio', 'organization': {'class': 'OTHER', 'fullName': 'Zonguldak Bulent Ecevit University'}, 'officialTitle': 'The Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio in Patients Undergoing Forearm Surgery', 'orgStudyIdInfo': {'id': '2020-22/17'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Group G', 'description': 'Patients Undergoing Forearm Surgery under general anesthesia'}, {'label': 'Group P', 'description': 'Patients Undergoing Forearm Surgery under peripheral nerve block', 'interventionNames': ['Procedure: peripheral nerve block']}], 'interventions': [{'name': 'peripheral nerve block', 'type': 'PROCEDURE', 'description': 'local anesthetic application to the brachial plexus', 'armGroupLabels': ['Group P']}]}, 'contactsLocationsModule': {'locations': [{'zip': '67600', 'city': 'Zonguldak', 'state': 'Kozlu', 'country': 'Turkey (Türkiye)', 'facility': 'Zonguldak Bülent Ecevit University Medicine Faculty', 'geoPoint': {'lat': 41.45139, 'lon': 31.79305}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Zonguldak Bulent Ecevit University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'medical doctor', 'investigatorFullName': 'Bengü Gülhan Köksal', 'investigatorAffiliation': 'Zonguldak Bulent Ecevit University'}}}}