Ignite Creation Date:
2025-12-24 @ 10:44 PM
Ignite Modification Date:
2026-01-01 @ 6:19 PM
Study NCT ID:
NCT06628635
Status:
COMPLETED
Last Update Posted:
2024-10-08
First Post:
2024-10-03
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Examining Different Modes of Exercise for Acute Reduction in Blood Pressure
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D006973', 'term': 'Hypertension'}, {'id': 'D009043', 'term': 'Motor Activity'}], 'ancestors': [{'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D001519', 'term': 'Behavior'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D015444', 'term': 'Exercise'}], 'ancestors': [{'id': 'D009043', 'term': 'Motor Activity'}, {'id': 'D009068', 'term': 'Movement'}, {'id': 'D009142', 'term': 'Musculoskeletal Physiological Phenomena'}, {'id': 'D055687', 'term': 'Musculoskeletal and Neural Physiological Phenomena'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'CROSSOVER'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 10}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2024-01-04', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-10', 'completionDateStruct': {'date': '2024-04-15', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2024-10-04', 'studyFirstSubmitDate': '2024-10-03', 'studyFirstSubmitQcDate': '2024-10-04', 'lastUpdatePostDateStruct': {'date': '2024-10-08', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2024-10-08', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2024-04-10', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change in systolic blood pressure (mmHg)', 'timeFrame': 'Baseline to 60 minutes after exercise'}, {'measure': 'Change in diastolic blood pressure (mmHg)', 'timeFrame': 'Baseline to 60 minutes after exercise'}], 'secondaryOutcomes': [{'measure': 'Change in heart rate (beats per minute)', 'timeFrame': 'Baseline to 60 minutes after exercise'}, {'measure': 'Change in rate-pressure product (beats per mintues x systolic blood pressure mmHg)', 'timeFrame': 'Change from baseline to 60 minutes after exercise'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['blood pressure', 'exercise'], 'conditions': ['Hypertension']}, 'referencesModule': {'references': [{'pmid': '39869856', 'type': 'DERIVED', 'citation': 'Keller C, Chilibeck P. Stretching, isometrics, and aerobic exercise for decreasing blood pressure post-exercise: a randomized crossover study. Appl Physiol Nutr Metab. 2025 Jan 1;50:1-6. doi: 10.1139/apnm-2024-0439.'}]}, 'descriptionModule': {'briefSummary': 'The purpose of the study is to compared different modes of exercise for eliciting post-exercise hypotension. The study will randomize 10 healthy participants to 30 minutes of either aerobic exercise, isometric exercise, stretching, or rest (control). Blood pressure and heart rate will be assessed before and for one hour post-exercise.', 'detailedDescription': "The purpose is to compare different modes of exercise (aerobic vs. isometric vs. static stretching) for reducing blood pressure post-exercise. : Using a randomized crossover design, 5 male and 5 female (n=10) normotensive university students will participate in four different exercise sessions for 30 minutes: aerobic (cycle ergometer at 70% of VO2max), isometric (alternating wall-sit for 70% of max, and handgrip dynamometer at 30% of max for 2 minutes), stretching (targeting the larger muscle groups of the body), and control (rest). Participants' blood pressure and heart rate will be measured before each exercise session and monitored for 60 minutes afterwards to analyze the post-exercise hypotensive response."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Able to safely perform exercise according to the Get Active Questionnaire\n\nExclusion Criteria:\n\n* Taking blood pressure medications'}, 'identificationModule': {'nctId': 'NCT06628635', 'briefTitle': 'Examining Different Modes of Exercise for Acute Reduction in Blood Pressure', 'organization': {'class': 'OTHER', 'fullName': 'University of Saskatchewan'}, 'officialTitle': 'Examining the Effects of Aerobic Exercise, Isometrics, and Stretching on Acute (Post-exercise) Blood Pressure Reduction', 'orgStudyIdInfo': {'id': '2023_24_09'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Aerobic exercise', 'description': '30 minutes of moderate-intensity aerobic exercise on a cycle ergometer', 'interventionNames': ['Behavioral: Exercise']}, {'type': 'EXPERIMENTAL', 'label': 'Isometric exercise', 'description': '30 minutes of isometric exercise (alternating hand-grip with wall-sitting)', 'interventionNames': ['Behavioral: Exercise']}, {'type': 'EXPERIMENTAL', 'label': 'Static stretching', 'description': '30 minutes of static stretching of major muscle groups', 'interventionNames': ['Behavioral: Exercise']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Resting control', 'description': '30 minutes of seated rest', 'interventionNames': ['Behavioral: Resting']}], 'interventions': [{'name': 'Exercise', 'type': 'BEHAVIORAL', 'description': 'Exercise involving aerobics, isometrics, and stretching', 'armGroupLabels': ['Aerobic exercise', 'Isometric exercise', 'Static stretching']}, {'name': 'Resting', 'type': 'BEHAVIORAL', 'description': 'Resting', 'armGroupLabels': ['Resting control']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'S7N5B2', 'city': 'Saskatoon', 'state': 'Saskatchewan', 'country': 'Canada', 'facility': 'University of Saskatchewan', 'geoPoint': {'lat': 52.13238, 'lon': -106.66892}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University of Saskatchewan', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Professor', 'investigatorFullName': 'Phil Chilibeck', 'investigatorAffiliation': 'University of Saskatchewan'}}}}