Ignite Creation Date:
2025-12-24 @ 11:21 PM
Ignite Modification Date:
2026-01-05 @ 5:29 PM
Study NCT ID:
NCT03300856
Status:
COMPLETED
Last Update Posted:
2018-08-01
First Post:
2017-10-03
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Chart Review: Central Motor Conduction Time in Neurological Disorders
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D009422', 'term': 'Nervous System Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'OTHER'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 225}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2017-10-04', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2018-07', 'completionDateStruct': {'date': '2018-07-19', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2018-07-31', 'studyFirstSubmitDate': '2017-10-03', 'studyFirstSubmitQcDate': '2017-10-03', 'lastUpdatePostDateStruct': {'date': '2018-08-01', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2017-10-04', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2018-07-19', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Summary of central motor conduction studies in neurological disorders', 'timeFrame': 'Study completion'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Transcranial Magnetic Stimulation (TMS)', 'Electrophysiology'], 'conditions': ['Neurological Disorder']}, 'descriptionModule': {'briefSummary': 'Background:\n\nTMS stands for transcranial magnetic stimulation. It is a non-invasive way to stimulate the brain. It helps researchers study the nervous system. TMS can assess central motor conduction time (CMCT). That can be used to diagnose some diseases. It can also show how well treatments are working. Researchers want to study the records of people who have already had TMS. They want to see how it relates to the results of diagnostic studies.\n\nObjectives:\n\nTo study the results of transcranial magnetic stimulation in certain neurological disorders. To create a descriptive analysis of the results.\n\nEligibility:\n\nRecords that are already in the NINDS database\n\nDesign:\n\nThe study will not enroll any participants.\n\nResearchers will search the database for certain terms. These include TMS, CMTC, and motor evoked potentials. This will identify records of people who had TMS for diagnosis.\n\nUsing data from the records, researchers will calculate CMCT. They will note other data that relate to CMCT.\n\nResearchers will analyze their findings. They will write a review article.\n\nPersonal data will be removed from all the records before the findings are analyzed.', 'detailedDescription': 'Objective- To retrospectively study the results of transcranial magnetic stimulation (TMS) in various neurological disorders and create a descriptive analysis of the results.\n\nStudy population- Existing records of patients within the NINDS database who have had TMS performed to measure central motor conduction time (CMCT).\n\nDesign-\n\n* Retrospective descriptive analysis.\n* The NINDS EMG Database will be queried using terms such as TMS, CMCT, and MEP (motor evoked potentials) to identify EMG reports on patients who underwent TMS for diagnosis\n* Within these reports peripheral motor conduction time (PMCT), the cortical motor evoked potential (MEP) latency and amplitude will be used to calculate CMCT, clinical patient factors pertinent to estimation of CMCT as well clinically significant physical exam findings will be recorded as well.\n* Clinical diagnoses and neurological exams will be extracted from medical records\n* Patient identifiers will be de-linked after compiling data from medical records\n\nOutcome measures\n\n\\- Results of CMCT using TMS in different diagnoses will be summarized for different neurologic disorders and correlated to clinical exam measures documented in previous records'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '130 Years', 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Existing records of patients within the NINDS database who have had TMS performed to measure central motor conduction time (CMCT).', 'healthyVolunteers': False, 'eligibilityCriteria': '* INCLUSION CRITERIA:\n\n 1. Patients who were seen in the NINDS EMG section for diagnostic TMS studies\n 2. Patients tested between 1998 and 2017\n 3. Greater than or equal to age 18.'}, 'identificationModule': {'nctId': 'NCT03300856', 'briefTitle': 'Chart Review: Central Motor Conduction Time in Neurological Disorders', 'organization': {'class': 'NIH', 'fullName': 'National Institutes of Health Clinical Center (CC)'}, 'officialTitle': 'Chart Review: Central Motor Conduction Time in Neurological Disorders', 'orgStudyIdInfo': {'id': '999917170'}, 'secondaryIdInfos': [{'id': '17-N-N170'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'Chart Review', 'description': 'Existing records of patients within the NINDS database who have had TMS performed to measure central motor conduction time (CMCT).'}]}, 'contactsLocationsModule': {'locations': [{'zip': '20892', 'city': 'Bethesda', 'state': 'Maryland', 'country': 'United States', 'facility': 'National Institute of Neurological Disorders and Stroke (NINDS)', 'geoPoint': {'lat': 38.98067, 'lon': -77.10026}}], 'overallOfficials': [{'name': 'Mary Kay Floeter, M.D.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'National Institute of Neurological Disorders and Stroke (NINDS)'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'National Institute of Neurological Disorders and Stroke (NINDS)', 'class': 'NIH'}, 'responsibleParty': {'type': 'SPONSOR'}}}}