Ignite Creation Date:
2025-12-25 @ 12:03 AM
Ignite Modification Date:
2026-01-02 @ 12:52 AM
Study NCT ID:
NCT03059758
Status:
COMPLETED
Last Update Posted:
2025-09-10
First Post:
2017-02-16
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Deductive Reasoning and Math Learning Difficulty
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 137}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2015-04-15', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-09', 'completionDateStruct': {'date': '2018-12-05', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-09-03', 'studyFirstSubmitDate': '2017-02-16', 'studyFirstSubmitQcDate': '2017-02-20', 'lastUpdatePostDateStruct': {'date': '2025-09-10', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2017-02-23', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2018-11-19', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Correlation between brain activity during deductive reasoning and math skill 18 to 24 months later', 'timeFrame': '18 to 24 months after scanning', 'description': 'Brain activity measured using fMRI and math skill measured using a standardized test 18 to 24 months after scanning'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Healthy']}, 'referencesModule': {'references': [{'pmid': '32097661', 'type': 'BACKGROUND', 'citation': 'Schwartz F, Epinat-Duclos J, Leone J, Poisson A, Prado J. Neural representations of transitive relations predict current and future math calculation skills in children. Neuropsychologia. 2020 Apr;141:107410. doi: 10.1016/j.neuropsychologia.2020.107410. Epub 2020 Feb 22.'}]}, 'descriptionModule': {'briefSummary': 'Most studies to date that have examined the factors underlying math achievement in children have focused on basic numerical knowledge. Yet, math skills are clearly not limited to basic numerical knowledge and recent behavioral studies suggest a relationship between math and deductive reasoning skills. The goal of this study is to determine the neural mediators of this relationship using functional magnetic resonance imaging. The investigators will ask children from 8 to 14 to complete a standardized math achievement test, and measure their brain activity while they process deductive arguments. The investigators will then correlate brain activity during reasoning to individual math skills to identify the brain regions in which activity during reasoning is modulated by math skill.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD'], 'maximumAge': '14 Years', 'minimumAge': '8 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Girl or boy between 8 and 14\n* Right-handed\n* Affiliated to the French social security\n* Whose parents gave informed consent\n\nExclusion Criteria:\n\n* Neurological disorders\n* Psychiatric disorders\n* Birth complications requiring admission into neonatal intensive care unit\n* Medication affecting central nervous system processing\n* Significant hearing impairment\n* Uncorrected visual impairment\n* Non-native French speaker\n* Contraindications for MRI'}, 'identificationModule': {'nctId': 'NCT03059758', 'briefTitle': 'Deductive Reasoning and Math Learning Difficulty', 'organization': {'class': 'OTHER', 'fullName': 'Hospices Civils de Lyon'}, 'officialTitle': 'Deductive Reasoning and Math Learning Difficulty: an fMRI Study in Children', 'orgStudyIdInfo': {'id': '69HCL16_0686'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Brain activity during reasoning and measure of math skill', 'description': 'Brain activity during reasoning and measure of math skill', 'interventionNames': ['Other: fMRI']}], 'interventions': [{'name': 'fMRI', 'type': 'OTHER', 'otherNames': ['fMRI scanning'], 'description': 'All participants are scanned while evaluating deductive reasoning problems. Their math skill is also assessed.', 'armGroupLabels': ['Brain activity during reasoning and measure of math skill']}]}, 'contactsLocationsModule': {'locations': [{'zip': '69678', 'city': 'Bron', 'country': 'France', 'facility': 'CH le Vinatier', 'geoPoint': {'lat': 45.73865, 'lon': 4.91303}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Hospices Civils de Lyon', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}