Ignite Creation Date:
2025-12-25 @ 12:43 AM
Ignite Modification Date:
2025-12-25 @ 10:55 PM
Study NCT ID:
NCT02180867
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-12-01
First Post:
2014-07-01
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D018234', 'term': 'Sarcoma, Alveolar Soft Part'}, {'id': 'C563181', 'term': 'Histiocytoma, Angiomatoid Fibrous'}, {'id': 'D018227', 'term': 'Sarcoma, Clear Cell'}, {'id': 'D012509', 'term': 'Sarcoma'}, {'id': 'C563195', 'term': 'Chondrosarcoma, Extraskeletal Myxoid'}, {'id': 'D005354', 'term': 'Fibrosarcoma'}, {'id': 'D006104', 'term': 'Granuloma, Plasma Cell'}, {'id': 'D007890', 'term': 'Leiomyosarcoma'}, {'id': 'D008080', 'term': 'Liposarcoma'}, {'id': 'D018319', 'term': 'Neurofibrosarcoma'}, {'id': 'D018211', 'term': 'Chondrosarcoma, Mesenchymal'}, {'id': 'D018223', 'term': 'Dermatofibrosarcoma'}, {'id': 'D018317', 'term': 'Nerve Sheath Neoplasms'}, {'id': 'D054973', 'term': 'Perivascular Epithelioid Cell Neoplasms'}, {'id': 'D013584', 'term': 'Sarcoma, Synovial'}, {'id': 'D051677', 'term': 'Histiocytoma, Malignant Fibrous'}], 'ancestors': [{'id': 'D009379', 'term': 'Neoplasms, Muscle Tissue'}, {'id': 'D018204', 'term': 'Neoplasms, Connective and Soft Tissue'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D009372', 'term': 'Neoplasms, Connective Tissue'}, {'id': 'D018218', 'term': 'Neoplasms, Fibrous Tissue'}, {'id': 'D006099', 'term': 'Granuloma'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D018205', 'term': 'Neoplasms, Adipose Tissue'}, {'id': 'D009455', 'term': 'Neurofibroma'}, {'id': 'D009380', 'term': 'Neoplasms, Nerve Tissue'}, {'id': 'D010524', 'term': 'Peripheral Nervous System Neoplasms'}, {'id': 'D009423', 'term': 'Nervous System Neoplasms'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D010523', 'term': 'Peripheral Nervous System Diseases'}, {'id': 'D009468', 'term': 'Neuromuscular Diseases'}, {'id': 'D002813', 'term': 'Chondrosarcoma'}, {'id': 'D051642', 'term': 'Histiocytoma'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D004317', 'term': 'Doxorubicin'}, {'id': 'D007069', 'term': 'Ifosfamide'}, {'id': 'C516667', 'term': 'pazopanib'}, {'id': 'D011878', 'term': 'Radiotherapy'}, {'id': 'D011827', 'term': 'Radiation'}], 'ancestors': [{'id': 'D003630', 'term': 'Daunorubicin'}, {'id': 'D018943', 'term': 'Anthracyclines'}, {'id': 'D009279', 'term': 'Naphthacenes'}, {'id': 'D011084', 'term': 'Polycyclic Aromatic Hydrocarbons'}, {'id': 'D006841', 'term': 'Hydrocarbons, Aromatic'}, {'id': 'D006844', 'term': 'Hydrocarbons, Cyclic'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D000617', 'term': 'Aminoglycosides'}, {'id': 'D006027', 'term': 'Glycosides'}, {'id': 'D002241', 'term': 'Carbohydrates'}, {'id': 'D003520', 'term': 'Cyclophosphamide'}, {'id': 'D010752', 'term': 'Phosphoramide Mustards'}, {'id': 'D009588', 'term': 'Nitrogen Mustard Compounds'}, {'id': 'D009150', 'term': 'Mustard Compounds'}, {'id': 'D006846', 'term': 'Hydrocarbons, Halogenated'}, {'id': 'D063088', 'term': 'Phosphoramides'}, {'id': 'D009943', 'term': 'Organophosphorus Compounds'}, {'id': 'D010078', 'term': 'Oxazines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D013812', 'term': 'Therapeutics'}, {'id': 'D055585', 'term': 'Physical Phenomena'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'resultsreportingcoordinator@childrensoncologygroup.org', 'phone': '626-447-0064', 'title': 'Results Reporting Coordinator', 'organization': "Children's Oncology Group"}, 'certainAgreement': {'restrictionType': 'LTE60', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': 'Reporting of adverse events was required from the start of protocol therapy and until 30 days from the last administration of study drugs; up to 1 year', 'description': 'Adverse event reporting is collected routinely using case report forms. The SAE table reflects NCI Common Terminology Criteria for Adverse Events (CTCAEs) submitted by the institution via expedited reporting (NCI AdEERs / CAeRs). All remaining CTCAEs collected by means other than expedited reporting are non-serious and are reported in the "AE Other" table. Ineligible patients are excluded from reporting of adverse events. All-Cause Mortality includes all deaths collected on the study.', 'eventGroups': [{'id': 'EG000', 'title': 'Dose-Finding Level 1 CR', 'description': 'Dose-Finding Level 1 CR:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2', 'otherNumAtRisk': 9, 'deathsNumAtRisk': 9, 'otherNumAffected': 4, 'seriousNumAtRisk': 9, 'deathsNumAffected': 1, 'seriousNumAffected': 6}, {'id': 'EG001', 'title': 'Dose-Finding Level 1 RT', 'description': 'Dose-Finding Level 1 RT:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2', 'otherNumAtRisk': 9, 'deathsNumAtRisk': 9, 'otherNumAffected': 2, 'seriousNumAtRisk': 9, 'deathsNumAffected': 4, 'seriousNumAffected': 6}, {'id': 'EG002', 'title': 'Dose-Finding Level 2 RT', 'description': 'Dose-Finding Level 2 RT:\n\nAdult: Pazopanib 800 mg; Pediatric: Pazopanib 450 mg/m2', 'otherNumAtRisk': 10, 'deathsNumAtRisk': 10, 'otherNumAffected': 5, 'seriousNumAtRisk': 10, 'deathsNumAffected': 3, 'seriousNumAffected': 2}, {'id': 'EG003', 'title': 'Regimen A', 'description': 'Regimen A: Chemoradiation plus pazopanib', 'otherNumAtRisk': 46, 'deathsNumAtRisk': 46, 'otherNumAffected': 20, 'seriousNumAtRisk': 46, 'deathsNumAffected': 5, 'seriousNumAffected': 33}, {'id': 'EG004', 'title': 'Regimen B', 'description': 'Regimen B: Chemoradiation alone', 'otherNumAtRisk': 43, 'deathsNumAtRisk': 43, 'otherNumAffected': 10, 'seriousNumAtRisk': 43, 'deathsNumAffected': 9, 'seriousNumAffected': 8}, {'id': 'EG005', 'title': 'Regimen C', 'description': 'Regimen C: Radiation therapy plus pazopanib', 'otherNumAtRisk': 6, 'deathsNumAtRisk': 6, 'otherNumAffected': 1, 'seriousNumAtRisk': 6, 'deathsNumAffected': 0, 'seriousNumAffected': 1}, {'id': 'EG006', 'title': 'Regimen D', 'description': 'Regimen D: Radiation therapy alone', 'otherNumAtRisk': 6, 'deathsNumAtRisk': 6, 'otherNumAffected': 0, 'seriousNumAtRisk': 6, 'deathsNumAffected': 2, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Alanine aminotransferase increased', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Cardiac disorders - Other, specify', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Hypertension', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Vascular disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Lymphocyte count decreased', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 3}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 2}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Neutrophil count decreased', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 4}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 5}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Platelet count decreased', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 3}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 2}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Radiation recall reaction (dermatologic)', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Wound dehiscence', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'White blood cell decreased', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 4}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 3}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Wound complication', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Localized edema', 'notes': 'Pediatric', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 16, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 18, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 0, 'numAffected': 0}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Alanine aminotransferase increased', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Anemia', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Blood and lymphatic system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Aspartate aminotransferase increased', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Fatigue', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Febrile neutropenia', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 2}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Blood and lymphatic system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Hyperkalemia', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Hyperphosphatemia', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Hypertension', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 1}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Vascular disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Hypokalemia', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Hypotension', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Vascular disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Infections and infestations - Other, specify', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Lipase increased', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Lymphocyte count decreased', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 2}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 3}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Neutrophil count decreased', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 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'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Stroke', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Syncope', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Thromboembolic event', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 4}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Vascular disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Upper respiratory infection', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Urinary tract infection', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Uterine hemorrhage', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Reproductive system and breast disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Vomiting', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 2}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Wound dehiscence', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 2}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 4}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Wound infection', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 3}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'White blood cell decreased', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 8}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Ejection fraction decreased', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Wound complication', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 2}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Postoperative hemorrhage', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Dermatitis radiation', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Lung infection', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Soft tissue infection', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Non-cardiac chest pain', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}, {'term': 'Device related infection', 'notes': 'Adult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 30, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 25, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'CTCv5'}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Feasible Dose: Pediatric', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'All Pediatric Dose Finding CR Cohorts', 'description': 'Dose-Finding CR: Chemoradiation plus pazopanib'}, {'id': 'OG001', 'title': 'All Pediatric Dose Finding RT Cohorts', 'description': 'Dose-Finding RT: Radiation therapy plus pazopanib'}], 'classes': [{'categories': [{'measurements': [{'value': '350', 'groupId': 'OG000'}, {'value': '450', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'After the first 6 weeks of Induction', 'description': 'The dose of pazopanib that is feasible when given in combination with radiation or chemoradiation in pediatric unresected intermediate- and high-risk NRSTS patients. Initially, up to 10 patients (minimum of 3 patients ≥ 2 and \\< 18 years of age and 3 patients ≥ 18 years of age) eligible for each of the two study cohorts were non-randomly assigned (to generate 8 patients evaluable for toxicity) to receive treatment with pazopanib at dose level 1. A protocol-defined list of pazopanib-associated adverse events were defined as dose-limiting toxicities. The pazopanib dose determined to be feasible was based on the number of patient-reported dose-limiting toxicities encountered.', 'unitOfMeasure': 'milligram per square meter', 'reportingStatus': 'POSTED', 'populationDescription': 'Pediatric patients, excluding 1 ineligible patient in Dose-Finding CR group and 1 ineligible patient in Dose-Finding RT group'}, {'type': 'PRIMARY', 'title': 'Feasible Dose: Adult', 'denoms': [{'units': 'Participants', 'counts': [{'value': '4', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'All Adult Dose Finding CR Cohorts', 'description': 'Dose-Finding CR: Chemoradiation plus pazopanib'}, {'id': 'OG001', 'title': 'All Adult Dose Finding RT Cohorts', 'description': 'Dose-Finding RT: Radiation therapy plus pazopanib'}], 'classes': [{'categories': [{'measurements': [{'value': '600', 'groupId': 'OG000'}, {'value': '800', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'After the first 6 weeks of Induction', 'description': 'The dose of pazopanib that is feasible when given in combination with radiation or chemoradiation in adult unresected intermediate- and high-risk NRSTS patients. Initially, up to 10 patients (minimum of 3 patients ≥ 2 and \\< 18 years of age and 3 patients ≥ 18 years of age) eligible for each of the two study cohorts were non-randomly assigned (to generate 8 patients evaluable for toxicity) to receive treatment with pazopanib at dose level 1. A protocol-defined list of pazopanib-associated adverse events were defined as dose-limiting toxicities. The pazopanib dose determined to be feasible was based on the number of patient-reported dose-limiting toxicities encountered.', 'unitOfMeasure': 'milligram', 'reportingStatus': 'POSTED', 'populationDescription': 'Adult patients, excluding 1 ineligible patient in Dose-Finding RT group'}, {'type': 'PRIMARY', 'title': 'Percentage of Chemoradiotherapy Patients With Positive Pathologic Response at Week 13', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '30', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Dose-Finding Level 1 CR', 'description': 'Dose-Finding Level 1 CR:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG001', 'title': 'Regimen A', 'description': 'Regimen A: Chemoradiation plus pazopanib'}, {'id': 'OG002', 'title': 'Regimen B', 'description': 'Regimen B: Chemoradiation alone'}], 'classes': [{'categories': [{'measurements': [{'value': '66.67', 'groupId': 'OG000', 'lowerLimit': '28.95', 'upperLimit': '100'}, {'value': '46.67', 'groupId': 'OG001', 'lowerLimit': '28.81', 'upperLimit': '64.52'}, {'value': '24', 'groupId': 'OG002', 'lowerLimit': '7.26', 'upperLimit': '40.74'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Week 13 after induction', 'description': 'A responder is defined by more than (90% tumor necrosis at week 13). A non-responder has less than 90% necrosis or progressive disease before week 13.', 'unitOfMeasure': 'Percentage of patients', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'It was pre-specified to combine adult and pediatric participants for analysis as they received an equivalent dose of Pazopanib. There were no patients enrolled onto Dose-Finding Level 0 CR or Dose-Finding Level 2 CR. 19 Regimen A patients and 23 Regimen B patients were excluded.'}, {'type': 'PRIMARY', 'title': 'Percentage of Radiotherapy Patients With Positive Pathologic Response at Week 10', 'denoms': [{'units': 'Participants', 'counts': [{'value': '3', 'groupId': 'OG000'}, {'value': '5', 'groupId': 'OG001'}, {'value': '3', 'groupId': 'OG002'}, {'value': '2', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Dose-Finding Level 1 RT', 'description': 'Dose-Finding Level 1 RT:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG001', 'title': 'Dose-Finding Level 2 RT', 'description': 'Dose-Finding Level 2 RT:\n\nAdult: Pazopanib 800 mg; Pediatric: Pazopanib 450 mg/m2'}, {'id': 'OG002', 'title': 'Regimen C', 'description': 'Regimen C: Radiation therapy plus pazopanib'}, {'id': 'OG003', 'title': 'Regimen D', 'description': 'Regimen D: Radiation therapy alone'}], 'classes': [{'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000', 'lowerLimit': '0', 'upperLimit': '0'}, {'value': '40', 'groupId': 'OG001', 'lowerLimit': '0', 'upperLimit': '82.94'}, {'value': '0', 'groupId': 'OG002', 'lowerLimit': '0', 'upperLimit': '0'}, {'value': '0', 'groupId': 'OG003', 'lowerLimit': '0', 'upperLimit': '0'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Week 10 after induction', 'description': 'A responder is defined by more than 90% tumor necrosis at week 10. A non-responder has less than 90% necrosis or progressive disease before week 10.', 'unitOfMeasure': 'Percentage of patients', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'It was pre-specified to combine adult and pediatric participants for analysis as they received an equivalent dose of Pazopanib. There were no patients enrolled onto Dose Level 0 RT. 3 Regimen C patients excluded: 1 patient did not receive treatment and 2 missing review; 4 Regimen D patients excluded due to missing review.'}, {'type': 'PRIMARY', 'title': 'Percentage of Radiotherapy Patients Failure Free at 5 Years Following Study Entry', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Regimen C', 'description': 'Regimen C: Radiation therapy plus pazopanib'}, {'id': 'OG001', 'title': 'Regimen D', 'description': 'Regimen D: Radiation therapy alone'}], 'timeFrame': 'From enrollment to up to 60 months', 'description': 'Time to the first occurrence of relapse, progression, secondary cancer or death from any cause.', 'reportingStatus': 'POSTED', 'populationDescription': 'Data for the phase III portion of the study were never collected because the RT arm was closed earlier due to slow accrual.'}, {'type': 'SECONDARY', 'title': 'Percentage of Patients Local Failure Free at 5 Years Following Study Entry', 'denoms': [{'units': 'Participants', 'counts': [{'value': '9', 'groupId': 'OG000'}, {'value': '9', 'groupId': 'OG001'}, {'value': '10', 'groupId': 'OG002'}, {'value': '44', 'groupId': 'OG003'}, {'value': '41', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Dose-Finding Level 1 CR', 'description': 'Dose-Finding Level 1 CR:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG001', 'title': 'Dose-Finding Level 1 RT', 'description': 'Dose-Finding Level 1 RT:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG002', 'title': 'Dose-Finding Level 2 RT', 'description': 'Dose-Finding Level 2 RT:\n\nAdult: Pazopanib 800 mg; Pediatric: Pazopanib 450 mg/m2'}, {'id': 'OG003', 'title': 'Regimen A', 'description': 'Regimen A: Chemoradiation plus pazopanib'}, {'id': 'OG004', 'title': 'Regimen B', 'description': 'Regimen B: Chemoradiation alone'}, {'id': 'OG005', 'title': 'Regimen C', 'description': 'Regimen C: Radiation therapy plus pazopanib'}, {'id': 'OG006', 'title': 'Regimen D', 'description': 'Regimen D: Radiation therapy alone'}], 'classes': [{'categories': [{'measurements': [{'value': '100.00', 'groupId': 'OG000', 'lowerLimit': '100.00', 'upperLimit': '100.00'}, {'value': '80.00', 'groupId': 'OG001', 'lowerLimit': '30.42', 'upperLimit': '100.00'}, {'value': '100.00', 'groupId': 'OG002', 'lowerLimit': '100.00', 'upperLimit': '100.00'}, {'value': '91.09', 'groupId': 'OG003', 'lowerLimit': '77.33', 'upperLimit': '100.00'}, {'value': '87.32', 'groupId': 'OG004', 'lowerLimit': '68.05', 'upperLimit': '100.00'}, {'value': '100.00', 'groupId': 'OG005', 'lowerLimit': '100.00', 'upperLimit': '100.00'}, {'value': '83.33', 'groupId': 'OG006', 'lowerLimit': '16.65', 'upperLimit': '100.00'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'From enrollment to up to 60 months', 'description': 'Defined as disease recurrence only at the primary site of disease at diagnosis. The relative risk of specific failure types will be estimated and compared descriptively using the Cox proportional hazard model. Data were obtained from institutional reported data.', 'unitOfMeasure': 'percentage of participants', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients deemed ineligible in the original cohort are excluded. An additional five (5) patients are excluded in this 5-year analysis as they were deemed ineligible post the initial submission and publication.'}, {'type': 'SECONDARY', 'title': 'Percentage of Patients Regional Failure Free at 5 Years Following Study Entry', 'denoms': [{'units': 'Participants', 'counts': [{'value': '9', 'groupId': 'OG000'}, {'value': '9', 'groupId': 'OG001'}, {'value': '10', 'groupId': 'OG002'}, {'value': '44', 'groupId': 'OG003'}, {'value': '41', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Dose-Finding Level 1 CR', 'description': 'Dose-Finding Level 1 CR:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG001', 'title': 'Dose-Finding Level 1 RT', 'description': 'Dose-Finding Level 1 RT:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG002', 'title': 'Dose-Finding Level 2 RT', 'description': 'Dose-Finding Level 2 RT:\n\nAdult: Pazopanib 800 mg; Pediatric: Pazopanib 450 mg/m2'}, {'id': 'OG003', 'title': 'Regimen A', 'description': 'Regimen A: Chemoradiation plus pazopanib'}, {'id': 'OG004', 'title': 'Regimen B', 'description': 'Regimen B: Chemoradiation alone'}, {'id': 'OG005', 'title': 'Regimen C', 'description': 'Regimen C: Radiation therapy plus pazopanib'}, {'id': 'OG006', 'title': 'Regimen D', 'description': 'Regimen D: Radiation therapy alone'}], 'classes': [{'categories': [{'measurements': [{'value': '100.00', 'groupId': 'OG000', 'lowerLimit': '100.00', 'upperLimit': '100.00'}, {'value': '100.00', 'groupId': 'OG001', 'lowerLimit': '100.00', 'upperLimit': '100.00'}, {'value': '100.00', 'groupId': 'OG002', 'lowerLimit': '100.00', 'upperLimit': '100.00'}, {'value': '100.00', 'groupId': 'OG003', 'lowerLimit': '100.00', 'upperLimit': '100.00'}, {'value': '100.00', 'groupId': 'OG004', 'lowerLimit': '100.00', 'upperLimit': '100.00'}, {'value': '100.00', 'groupId': 'OG005', 'lowerLimit': '100.00', 'upperLimit': '100.00'}, {'value': '100.00', 'groupId': 'OG006', 'lowerLimit': '100.00', 'upperLimit': '100.00'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'From enrollment to up to 60 months', 'description': 'Defined as disease recurrence at lymph nodes regional to the primary disease site, with or without local failure but without distant failure. The relative risk of specific failure types will be estimated and compared descriptively using the Cox proportional hazard model. Data were obtained from institutional reported data.', 'unitOfMeasure': 'percentage of participants', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients deemed ineligible in the original cohort are excluded. An additional five (5) patients are excluded in this 5-year analysis as they were deemed ineligible post the initial submission and publication.'}, {'type': 'SECONDARY', 'title': 'Percentage of Patients Distant Failure Free at 5 Years Following Study Entry', 'denoms': [{'units': 'Participants', 'counts': [{'value': '9', 'groupId': 'OG000'}, {'value': '9', 'groupId': 'OG001'}, {'value': '10', 'groupId': 'OG002'}, {'value': '44', 'groupId': 'OG003'}, {'value': '41', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Dose-Finding Level 1 CR', 'description': 'Dose-Finding Level 1 CR:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG001', 'title': 'Dose-Finding Level 1 RT', 'description': 'Dose-Finding Level 1 RT:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG002', 'title': 'Dose-Finding Level 2 RT', 'description': 'Dose-Finding Level 2 RT:\n\nAdult: Pazopanib 800 mg; Pediatric: Pazopanib 450 mg/m2'}, {'id': 'OG003', 'title': 'Regimen A', 'description': 'Regimen A: Chemoradiation plus pazopanib'}, {'id': 'OG004', 'title': 'Regimen B', 'description': 'Regimen B: Chemoradiation alone'}, {'id': 'OG005', 'title': 'Regimen C', 'description': 'Regimen C: Radiation therapy plus pazopanib'}, {'id': 'OG006', 'title': 'Regimen D', 'description': 'Regimen D: Radiation therapy alone'}], 'classes': [{'categories': [{'measurements': [{'value': '77.78', 'groupId': 'OG000', 'lowerLimit': '48.44', 'upperLimit': '100.00'}, {'value': '33.33', 'groupId': 'OG001', 'lowerLimit': '0.00', 'upperLimit': '71.05'}, {'value': '70.00', 'groupId': 'OG002', 'lowerLimit': '32.43', 'upperLimit': '100.00'}, {'value': '59.89', 'groupId': 'OG003', 'lowerLimit': '39.11', 'upperLimit': '78.67'}, {'value': '62.62', 'groupId': 'OG004', 'lowerLimit': '39.99', 'upperLimit': '85.24'}, {'value': '80.00', 'groupId': 'OG005', 'lowerLimit': '39.52', 'upperLimit': '100.00'}, {'value': '66.67', 'groupId': 'OG006', 'lowerLimit': '0.00', 'upperLimit': '100.00'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'From enrollment to up to 60 months', 'description': 'Defined as disease recurrence at sites other than the primary site and diagnosis and nodes regional to that site (metastatic disease, whether or not present at diagnosis), with or without loco-regional failure. The relative risk of specific failure types will be estimated and compared descriptively using the Cox proportional hazard model. Data were obtained from institutional reported data.', 'unitOfMeasure': 'percentage of participants', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients deemed ineligible in the original cohort are excluded. An additional five (5) patients are excluded in this 5-year analysis as they were deemed ineligible post the initial submission and publication.'}, {'type': 'SECONDARY', 'title': 'Percentage of Patients Who Experienced Grade 3 or Higher Toxicity Assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '9', 'groupId': 'OG000'}, {'value': '9', 'groupId': 'OG001'}, {'value': '10', 'groupId': 'OG002'}, {'value': '46', 'groupId': 'OG003'}, {'value': '43', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Dose-Finding Level 1 CR', 'description': 'Dose-Finding Level 1 CR:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG001', 'title': 'Dose-Finding Level 1 RT', 'description': 'Dose-Finding Level 1 RT:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'OG002', 'title': 'Dose-Finding Level 2 RT', 'description': 'Dose-Finding Level 2 RT:\n\nAdult: Pazopanib 800 mg; Pediatric:\n\nPazopanib 450 mg/m2'}, {'id': 'OG003', 'title': 'Regimen A', 'description': 'Regimen A: Chemoradiation plus pazopanib'}, {'id': 'OG004', 'title': 'Regimen B', 'description': 'Regimen B: Chemoradiation alone'}, {'id': 'OG005', 'title': 'Regimen C', 'description': 'Regimen C: Radiation therapy plus pazopanib'}, {'id': 'OG006', 'title': 'Regimen D', 'description': 'Regimen D: Radiation therapy alone'}], 'classes': [{'title': 'Pediatric Patients', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '3', 'groupId': 'OG001'}, {'value': '3', 'groupId': 'OG002'}, {'value': '16', 'groupId': 'OG003'}, {'value': '18', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '60', 'groupId': 'OG000', 'lowerLimit': '17.06', 'upperLimit': '100'}, {'value': '66.67', 'groupId': 'OG001', 'lowerLimit': '13.32', 'upperLimit': '100'}, {'value': '33.33', 'groupId': 'OG002', 'lowerLimit': '0', 'upperLimit': '86.68'}, {'value': '75', 'groupId': 'OG003', 'lowerLimit': '53.78', 'upperLimit': '96.22'}, {'value': '33.33', 'groupId': 'OG004', 'lowerLimit': '11.56', 'upperLimit': '55.11'}, {'value': '0', 'groupId': 'OG005', 'lowerLimit': '0', 'upperLimit': '0'}]}]}, {'title': 'Adult Patients', 'denoms': [{'units': 'Participants', 'counts': [{'value': '4', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '30', 'groupId': 'OG003'}, {'value': '25', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '75', 'groupId': 'OG000', 'lowerLimit': '32.56', 'upperLimit': '100'}, {'value': '66.67', 'groupId': 'OG001', 'lowerLimit': '28.95', 'upperLimit': '100'}, {'value': '57.14', 'groupId': 'OG002', 'lowerLimit': '20.48', 'upperLimit': '93.80'}, {'value': '86.67', 'groupId': 'OG003', 'lowerLimit': '74.50', 'upperLimit': '98.83'}, {'value': '36', 'groupId': 'OG004', 'lowerLimit': '17.18', 'upperLimit': '54.82'}, {'value': '40', 'groupId': 'OG005', 'lowerLimit': '0', 'upperLimit': '82.94'}, {'value': '0', 'groupId': 'OG006', 'lowerLimit': '0', 'upperLimit': '0'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Reporting of adverse events was required from the start of protocol therapy and until 30 days from the last administration of study drugs; up to 1 year', 'description': 'Participants who experienced Grade 3 or higher toxicity was assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE).', 'unitOfMeasure': 'Percentage of patients', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'Ineligible patients are excluded.'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Relative Frequency of Actionable Mutations', 'timeFrame': 'At diagnosis', 'description': 'Descriptive statistical analyses will be provided to estimate the relative frequency of actionable mutations across the whole cohort and within more common histological subtypes, like synovial sarcoma and malignant peripheral nerve sheath tumors.', 'reportingStatus': 'NOT_POSTED', 'denomUnitsSelected': 'Participants'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Prevalence of Circulating Tumor DNA (ctDNA)', 'timeFrame': 'At diagnosis', 'description': 'Descriptive analyses will be performed to summarize the prevalence of ctDNA.', 'reportingStatus': 'NOT_POSTED', 'denomUnitsSelected': 'Participants'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Mean Pharmacokinetic Parameters of Doxorubicin and Pazopanib', 'timeFrame': 'Up to 48 hours after the end of infusion', 'description': 'Pharmacokinetic parameters such as the clearance of doxorubicin and pazopanib will be estimated.', 'reportingStatus': 'NOT_POSTED', 'denomUnitsSelected': 'Participants'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Change in Fludeoxyglucose F 18 (FDG) Positron Emission Tomography (PET) Maximum Standard Uptake Value (SUVmax)', 'timeFrame': 'From enrollment to week 10 or 13 prior to tumor resection', 'description': 'To evaluate change in FDG PET maximum standard uptake value (SUVmax) from baseline to Week 10 or 13 in patients with unresected tumors and to correlate this change with pathologic response and EFS.', 'reportingStatus': 'NOT_POSTED', 'denomUnitsSelected': 'Participants'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Relative Risk of Failure Based on Both Standard Imaging and Pathologic Assessment', 'timeFrame': 'From enrollment up to 60 months', 'description': 'To compare the rate of response by standard imaging and pathologic assessment to determine which correlates better with local tumor control, distant tumor control, event free survival, and overall survival.', 'reportingStatus': 'NOT_POSTED', 'denomUnitsSelected': 'Participants'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Dose-Finding Level 1 CR', 'description': 'Dose-Finding Level 1 CR:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'FG001', 'title': 'Dose-Finding Level 1 RT', 'description': 'Dose-Finding Level 1 RT:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'FG002', 'title': 'Dose-Finding Level 2 RT', 'description': 'Dose-Finding Level 2 RT:\n\nAdult: Pazopanib 800 mg; Pediatric: Pazopanib 450 mg/m2'}, {'id': 'FG003', 'title': 'Regimen A', 'description': 'Regimen A: Chemoradiation plus pazopanib'}, {'id': 'FG004', 'title': 'Regimen B', 'description': 'Regimen B: Chemoradiation alone'}, {'id': 'FG005', 'title': 'Regimen C', 'description': 'Regimen C: Radiation therapy plus pazopanib'}, {'id': 'FG006', 'title': 'Regimen D', 'description': 'Regimen D: Radiation therapy alone'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '10'}, {'groupId': 'FG001', 'numSubjects': '11'}, {'groupId': 'FG002', 'numSubjects': '10'}, {'groupId': 'FG003', 'numSubjects': '49'}, {'groupId': 'FG004', 'numSubjects': '48'}, {'groupId': 'FG005', 'numSubjects': '6'}, {'groupId': 'FG006', 'numSubjects': '6'}]}, {'type': 'Pediatric Patients', 'achievements': [{'groupId': 'FG000', 'numSubjects': '6'}, {'groupId': 'FG001', 'numSubjects': '4'}, {'groupId': 'FG002', 'numSubjects': '3'}, {'groupId': 'FG003', 'numSubjects': '18'}, {'groupId': 'FG004', 'numSubjects': '19'}, {'groupId': 'FG005', 'numSubjects': '1'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'Adult Patients', 'achievements': [{'groupId': 'FG000', 'numSubjects': '4'}, {'groupId': 'FG001', 'numSubjects': '7'}, {'groupId': 'FG002', 'numSubjects': '7'}, {'groupId': 'FG003', 'numSubjects': '31'}, {'groupId': 'FG004', 'numSubjects': '29'}, {'groupId': 'FG005', 'numSubjects': '5'}, {'groupId': 'FG006', 'numSubjects': '6'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '4'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '6'}, {'groupId': 'FG003', 'numSubjects': '23'}, {'groupId': 'FG004', 'numSubjects': '21'}, {'groupId': 'FG005', 'numSubjects': '3'}, {'groupId': 'FG006', 'numSubjects': '1'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '6'}, {'groupId': 'FG001', 'numSubjects': '11'}, {'groupId': 'FG002', 'numSubjects': '4'}, {'groupId': 'FG003', 'numSubjects': '26'}, {'groupId': 'FG004', 'numSubjects': '27'}, {'groupId': 'FG005', 'numSubjects': '3'}, {'groupId': 'FG006', 'numSubjects': '5'}]}], 'dropWithdraws': [{'type': 'Adverse Event', 'reasons': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '4'}, {'groupId': 'FG002', 'numSubjects': '1'}, {'groupId': 'FG003', 'numSubjects': '5'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'Death', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '1'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'Lack of Efficacy', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '2'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '1'}, {'groupId': 'FG004', 'numSubjects': '6'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '1'}]}, {'type': 'Physician Decision', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '1'}, {'groupId': 'FG003', 'numSubjects': '10'}, {'groupId': 'FG004', 'numSubjects': '9'}, {'groupId': 'FG005', 'numSubjects': '3'}, {'groupId': 'FG006', 'numSubjects': '4'}]}, {'type': 'Withdrawal by Subject', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '1'}, {'groupId': 'FG004', 'numSubjects': '1'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'Ineligible', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '2'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '3'}, {'groupId': 'FG004', 'numSubjects': '5'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'Repeat Eligibility Studies', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '1'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'Refusal of further protocol therapy', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '2'}, {'groupId': 'FG003', 'numSubjects': '6'}, {'groupId': 'FG004', 'numSubjects': '4'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}]}], 'preAssignmentDetails': 'All patients began at Dose-Finding Level 1. Dose-Finding Level 0 CR, Dose-Finding Level 2 CR, and Dose-Finding Level 0 RT never enrolled because protocol-defined dose de-escalation and escalation parameters were not met. Cohorts C and D were closed to further patient accrual on October 12, 2017 due to slower than anticipated enrollment.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '10', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '10', 'groupId': 'BG002'}, {'value': '49', 'groupId': 'BG003'}, {'value': '48', 'groupId': 'BG004'}, {'value': '6', 'groupId': 'BG005'}, {'value': '6', 'groupId': 'BG006'}, {'value': '140', 'groupId': 'BG007'}]}], 'groups': [{'id': 'BG000', 'title': 'Dose-Finding Level 1 CR', 'description': 'Dose-Finding Level 1 CR:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'BG001', 'title': 'Dose-Finding Level 1 RT', 'description': 'Dose-Finding Level 1 RT:\n\nAdult: Pazopanib 600 mg; Pediatric: Pazopanib 350 mg/m2'}, {'id': 'BG002', 'title': 'Dose-Finding Level 2 RT', 'description': 'Dose-Finding Level 2 RT:\n\nAdult: Pazopanib 800 mg; Pediatric: Pazopanib 450 mg/m2'}, {'id': 'BG003', 'title': 'Regimen A', 'description': 'Regimen A: Chemoradiation plus pazopanib'}, {'id': 'BG004', 'title': 'Regimen B', 'description': 'Regimen B: Chemoradiation alone'}, {'id': 'BG005', 'title': 'Regimen C', 'description': 'Regimen C: Radiation therapy plus pazopanib'}, {'id': 'BG006', 'title': 'Regimen D', 'description': 'Regimen D: Radiation therapy alone'}, {'id': 'BG007', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '225.1', 'spread': '57.8', 'groupId': 'BG000'}, {'value': '524.3', 'spread': '270.3', 'groupId': 'BG001'}, {'value': '407.3', 'spread': '224.7', 'groupId': 'BG002'}, {'value': '376.3', 'spread': '243.4', 'groupId': 'BG003'}, {'value': '356.2', 'spread': '221.8', 'groupId': 'BG004'}, {'value': '547.2', 'spread': '260.6', 'groupId': 'BG005'}, {'value': '722.8', 'spread': '141.9', 'groupId': 'BG006'}, {'value': '394.6', 'spread': '242.3', 'groupId': 'BG007'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'Months', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '4', 'groupId': 'BG000'}, {'value': '3', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '30', 'groupId': 'BG003'}, {'value': '18', 'groupId': 'BG004'}, {'value': '2', 'groupId': 'BG005'}, {'value': '3', 'groupId': 'BG006'}, {'value': '63', 'groupId': 'BG007'}]}, {'title': 'Male', 'measurements': [{'value': '6', 'groupId': 'BG000'}, {'value': '8', 'groupId': 'BG001'}, {'value': '7', 'groupId': 'BG002'}, {'value': '19', 'groupId': 'BG003'}, {'value': '30', 'groupId': 'BG004'}, {'value': '4', 'groupId': 'BG005'}, {'value': '3', 'groupId': 'BG006'}, {'value': '77', 'groupId': 'BG007'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Ethnicity (NIH/OMB)', 'classes': [{'categories': [{'title': 'Hispanic or Latino', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '13', 'groupId': 'BG003'}, {'value': '9', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '26', 'groupId': 'BG007'}]}, {'title': 'Not Hispanic or Latino', 'measurements': [{'value': '6', 'groupId': 'BG000'}, {'value': '9', 'groupId': 'BG001'}, {'value': '9', 'groupId': 'BG002'}, {'value': '34', 'groupId': 'BG003'}, {'value': '38', 'groupId': 'BG004'}, {'value': '6', 'groupId': 'BG005'}, {'value': '6', 'groupId': 'BG006'}, {'value': '108', 'groupId': 'BG007'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '2', 'groupId': 'BG003'}, {'value': '1', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '6', 'groupId': 'BG007'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '0', 'groupId': 'BG007'}]}, {'title': 'Asian', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '1', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '1', 'groupId': 'BG007'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '0', 'groupId': 'BG007'}]}, {'title': 'Black or African American', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '3', 'groupId': 'BG003'}, {'value': '6', 'groupId': 'BG004'}, {'value': '1', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '15', 'groupId': 'BG007'}]}, {'title': 'White', 'measurements': [{'value': '7', 'groupId': 'BG000'}, {'value': '8', 'groupId': 'BG001'}, {'value': '8', 'groupId': 'BG002'}, {'value': '39', 'groupId': 'BG003'}, {'value': '38', 'groupId': 'BG004'}, {'value': '5', 'groupId': 'BG005'}, {'value': '5', 'groupId': 'BG006'}, {'value': '110', 'groupId': 'BG007'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}, {'value': '0', 'groupId': 'BG007'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '7', 'groupId': 'BG003'}, {'value': '3', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '1', 'groupId': 'BG006'}, {'value': '14', 'groupId': 'BG007'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}], 'populationDescription': 'It was pre-specified to combine adult and pediatric participants for analysis as they received an equivalent dose of Pazopanib. There were no patients enrolled onto Dose-Finding Level 0 CR and Dose-Finding Level 2 CR or Dose-Finding Level 0 RT.'}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2019-04-08', 'size': 3503932, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_001.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2024-07-01T11:12', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 140}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2014-07-11', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-06', 'completionDateStruct': {'date': '2025-12-23', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-11-14', 'studyFirstSubmitDate': '2014-07-01', 'resultsFirstSubmitDate': '2020-06-24', 'studyFirstSubmitQcDate': '2014-07-01', 'lastUpdatePostDateStruct': {'date': '2025-12-01', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2020-10-08', 'studyFirstPostDateStruct': {'date': '2014-07-03', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2020-10-09', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2019-06-30', 'type': 'ACTUAL'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Relative Frequency of Actionable Mutations', 'timeFrame': 'At diagnosis', 'description': 'Descriptive statistical analyses will be provided to estimate the relative frequency of actionable mutations across the whole cohort and within more common histological subtypes, like synovial sarcoma and malignant peripheral nerve sheath tumors.'}, {'measure': 'Prevalence of Circulating Tumor DNA (ctDNA)', 'timeFrame': 'At diagnosis', 'description': 'Descriptive analyses will be performed to summarize the prevalence of ctDNA.'}, {'measure': 'Mean Pharmacokinetic Parameters of Doxorubicin and Pazopanib', 'timeFrame': 'Up to 48 hours after the end of infusion', 'description': 'Pharmacokinetic parameters such as the clearance of doxorubicin and pazopanib will be estimated.'}, {'measure': 'Change in Fludeoxyglucose F 18 (FDG) Positron Emission Tomography (PET) Maximum Standard Uptake Value (SUVmax)', 'timeFrame': 'From enrollment to week 10 or 13 prior to tumor resection', 'description': 'To evaluate change in FDG PET maximum standard uptake value (SUVmax) from baseline to Week 10 or 13 in patients with unresected tumors and to correlate this change with pathologic response and EFS.'}, {'measure': 'Relative Risk of Failure Based on Both Standard Imaging and Pathologic Assessment', 'timeFrame': 'From enrollment up to 60 months', 'description': 'To compare the rate of response by standard imaging and pathologic assessment to determine which correlates better with local tumor control, distant tumor control, event free survival, and overall survival.'}], 'primaryOutcomes': [{'measure': 'Feasible Dose: Pediatric', 'timeFrame': 'After the first 6 weeks of Induction', 'description': 'The dose of pazopanib that is feasible when given in combination with radiation or chemoradiation in pediatric unresected intermediate- and high-risk NRSTS patients. Initially, up to 10 patients (minimum of 3 patients ≥ 2 and \\< 18 years of age and 3 patients ≥ 18 years of age) eligible for each of the two study cohorts were non-randomly assigned (to generate 8 patients evaluable for toxicity) to receive treatment with pazopanib at dose level 1. A protocol-defined list of pazopanib-associated adverse events were defined as dose-limiting toxicities. The pazopanib dose determined to be feasible was based on the number of patient-reported dose-limiting toxicities encountered.'}, {'measure': 'Feasible Dose: Adult', 'timeFrame': 'After the first 6 weeks of Induction', 'description': 'The dose of pazopanib that is feasible when given in combination with radiation or chemoradiation in adult unresected intermediate- and high-risk NRSTS patients. Initially, up to 10 patients (minimum of 3 patients ≥ 2 and \\< 18 years of age and 3 patients ≥ 18 years of age) eligible for each of the two study cohorts were non-randomly assigned (to generate 8 patients evaluable for toxicity) to receive treatment with pazopanib at dose level 1. A protocol-defined list of pazopanib-associated adverse events were defined as dose-limiting toxicities. The pazopanib dose determined to be feasible was based on the number of patient-reported dose-limiting toxicities encountered.'}, {'measure': 'Percentage of Chemoradiotherapy Patients With Positive Pathologic Response at Week 13', 'timeFrame': 'Week 13 after induction', 'description': 'A responder is defined by more than (90% tumor necrosis at week 13). A non-responder has less than 90% necrosis or progressive disease before week 13.'}, {'measure': 'Percentage of Radiotherapy Patients With Positive Pathologic Response at Week 10', 'timeFrame': 'Week 10 after induction', 'description': 'A responder is defined by more than 90% tumor necrosis at week 10. A non-responder has less than 90% necrosis or progressive disease before week 10.'}, {'measure': 'Percentage of Radiotherapy Patients Failure Free at 5 Years Following Study Entry', 'timeFrame': 'From enrollment to up to 60 months', 'description': 'Time to the first occurrence of relapse, progression, secondary cancer or death from any cause.'}], 'secondaryOutcomes': [{'measure': 'Percentage of Patients Local Failure Free at 5 Years Following Study Entry', 'timeFrame': 'From enrollment to up to 60 months', 'description': 'Defined as disease recurrence only at the primary site of disease at diagnosis. The relative risk of specific failure types will be estimated and compared descriptively using the Cox proportional hazard model. Data were obtained from institutional reported data.'}, {'measure': 'Percentage of Patients Regional Failure Free at 5 Years Following Study Entry', 'timeFrame': 'From enrollment to up to 60 months', 'description': 'Defined as disease recurrence at lymph nodes regional to the primary disease site, with or without local failure but without distant failure. The relative risk of specific failure types will be estimated and compared descriptively using the Cox proportional hazard model. Data were obtained from institutional reported data.'}, {'measure': 'Percentage of Patients Distant Failure Free at 5 Years Following Study Entry', 'timeFrame': 'From enrollment to up to 60 months', 'description': 'Defined as disease recurrence at sites other than the primary site and diagnosis and nodes regional to that site (metastatic disease, whether or not present at diagnosis), with or without loco-regional failure. The relative risk of specific failure types will be estimated and compared descriptively using the Cox proportional hazard model. Data were obtained from institutional reported data.'}, {'measure': 'Percentage of Patients Who Experienced Grade 3 or Higher Toxicity Assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE)', 'timeFrame': 'Reporting of adverse events was required from the start of protocol therapy and until 30 days from the last administration of study drugs; up to 1 year', 'description': 'Participants who experienced Grade 3 or higher toxicity was assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE).'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'conditions': ['Alveolar Soft Part Sarcoma', 'Angiomatoid Fibrous Histiocytoma', 'Atypical Fibroxanthoma', 'Clear Cell Sarcoma of Soft Tissue', 'Epithelioid Malignant Peripheral Nerve Sheath Tumor', 'Epithelioid Sarcoma', 'Extraskeletal Myxoid Chondrosarcoma', 'Extraskeletal Osteosarcoma', 'Fibrohistiocytic Neoplasm', 'Fibrosarcoma', 'Inflammatory Myofibroblastic Tumor', 'Intimal Sarcoma', 'Leiomyosarcoma', 'Liposarcoma', 'Liver Embryonal Sarcoma', 'Low Grade Fibromyxoid Sarcoma', 'Low Grade Myofibroblastic Sarcoma', 'Malignant Peripheral Nerve Sheath Tumor', 'Malignant Skin Granular Cell Tumor', 'Malignant Triton Tumor', 'Mesenchymal Chondrosarcoma', 'Myxofibrosarcoma', 'Myxoid Chondrosarcoma', 'Myxoinflammatory Fibroblastic Sarcoma', 'Nerve Sheath Neoplasm', 'PEComa', 'Pericytic Neoplasm', 'Plexiform Fibrohistiocytic Tumor', 'Sclerosing Epithelioid Fibrosarcoma', 'Skin Glomus Tumor', 'Stage IB Soft Tissue Sarcoma AJCC v7', 'Stage IIB Soft Tissue Sarcoma AJCC v7', 'Stage III Soft Tissue Sarcoma AJCC v7', 'Stage IV Soft Tissue Sarcoma AJCC v7', 'Synovial Sarcoma', 'Undifferentiated High Grade Pleomorphic Sarcoma of Bone']}, 'referencesModule': {'references': [{'pmid': '37523624', 'type': 'DERIVED', 'citation': "Weiss AR, Chen YL, Scharschmidt TJ, Xue W, Gao Z, Black JO, Choy E, Davis JL, Fanburg-Smith JC, Kao SC, Kayton ML, Kessel S, Lim R, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Shulkin BL, Terezakis S, Venkatramani R, Zambrano E, Wang D, Hawkins DS, Spunt SL. Outcomes After Preoperative Chemoradiation With or Without Pazopanib in Non-Rhabdomyosarcoma Soft Tissue Sarcoma: A Report From Children's Oncology Group and NRG Oncology. J Clin Oncol. 2023 Nov 1;41(31):4842-4848. doi: 10.1200/JCO.23.00045. Epub 2023 Jul 31."}, {'pmid': '34515544', 'type': 'DERIVED', 'citation': "Avutu V, Weiss AR, Reed DR, Ahmed SK, Allen-Rhoades WA, Chen YE, Davis LE, Eaton BR, Hawkins DS, Indelicato DJ, Patel SR, Randall RL, Reinke DK, Riedel RF, Scharschmidt TJ, Thornton KA, Wang D, Janeway KA, Kopp LM. Identified Enrollment Challenges of Adolescent and Young Adult Patients on the Nonchemotherapy Arm of Children's Oncology Group Study ARST1321. J Adolesc Young Adult Oncol. 2022 Jun;11(3):328-332. doi: 10.1089/jayao.2021.0103. Epub 2021 Sep 9."}, {'pmid': '32827353', 'type': 'DERIVED', 'citation': 'Vatner R, James CD, Sathiaseelan V, Bondra KM, Kalapurakal JA, Houghton PJ. Radiation therapy and molecular-targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges. Pediatr Blood Cancer. 2021 May;68 Suppl 2:e28439. doi: 10.1002/pbc.28439. Epub 2020 Aug 22.'}, {'pmid': '32702309', 'type': 'DERIVED', 'citation': 'Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D. Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial. Lancet Oncol. 2020 Aug;21(8):1110-1122. doi: 10.1016/S1470-2045(20)30325-9. Epub 2020 Jul 20.'}]}, 'descriptionModule': {'briefSummary': 'This randomized phase II/III trial studies how well pazopanib, when combined with chemotherapy and radiation therapy or radiation therapy alone, work in the treatment of patients with newly diagnosed non-rhabdomyosarcoma soft tissue sarcomas that can eventually be removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as ifosfamide and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Pazopanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether these therapies can be safely combined and if they work better when given together in treating patients with non-rhabdomyosarcoma soft tissue sarcomas.', 'detailedDescription': 'PRIMARY OBJECTIVES:\n\nI. To identify the dose of pazopanib that is feasible when given in combination with radiation or chemoradiation in pediatric and adult patients newly diagnosed with unresected intermediate- and high-risk non rhabdomyosarcoma soft tissue sarcomas (NRSTS).\n\nII. To compare the rates of near complete pathologic response (\\> 90% necrosis) with the addition of pazopanib to preoperative chemoradiation versus preoperative chemoradiation alone for potentially resectable \\> 5 cm, grade 2 or 3 intermediate to high risk chemotherapy-sensitive NRSTS in the phase II portion of the study for this cohort.\n\nIII. To compare the rates of near complete pathologic response (\\> 90% necrosis) with the addition of pazopanib to preoperative radiotherapy versus preoperative radiotherapy alone for potentially resectable intermediate to high risk adult and pediatric NRSTS in the phase II portion of the study for this cohort (using a phase II decision rule to go onto the phase III portion of the study).\n\nIV. To compare the rates of event-free survival (EFS) with the addition of pazopanib to preoperative radiotherapy versus preoperative radiotherapy alone for localized intermediate to high risk adult and pediatric NRSTS in the phase III portion of the study for this cohort if the phase II decision rule is passed.\n\nSECONDARY OBJECTIVES:\n\nI. To estimate the rates of local failure, regional failure, distant metastasis free survival, disease-free survival, and overall survival with the addition of pazopanib to preoperative chemoradiation or preoperative radiation in intermediate to high risk adult and pediatric NRSTS.\n\nII. To compare the pattern of recurrence (local, regional and distant) between preoperative chemoradiation or radiation with the addition of pazopanib for adult and pediatric NRSTS.\n\nIII. To define the toxicities of ifosfamide and doxorubicin chemotherapy and radiation when used in combination with pazopanib in intermediate to high risk adult and pediatric NRSTS.\n\nIV. To define the toxicities of preoperative radiotherapy when used in combination with pazopanib in intermediate to high risk adult and pediatric NRSTS.\n\nEXPLORATORY OBJECTIVES:\n\nI. To gain insight into the disease biology of childhood and adult NRSTS through analysis of actionable mutations and whole genome sequencing.\n\nII. To determine if microvessel density and circulating tumor deoxyribonucleic acid (DNA) predict response to pazopanib and outcome.\n\nIII. To determine the effect of pazopanib on doxorubicin exposure in children and adults with NRSTS.\n\nIV. To evaluate change in fludeoxyglucose F 18 (FDG) positron emission tomography (PET) maximum standard uptake value (SUVmax) from baseline to week 10 or 13 in patients with unresected tumors and to correlate this change with pathologic response and EFS.\n\nV. To compare the rate of response by standard imaging and pathologic assessment to determine which correlates better with local tumor control, distant tumor control, EFS, and overall survival.\n\nOUTLINE: This study starts as a dose-escalation study of pazopanib.\n\nCHEMOTHERAPY COHORT: Patients eligible for chemotherapy cohort are randomized to 1 of 2 treatment regimens.\n\nREGIMEN A:\n\nINDUCTION PHASE: Patients receive pazopanib orally (PO) once daily (QD) on weeks 1-12, ifosfamide intravenously (IV) over 2-4 hours on days 1-3 on weeks 1, 4, 7, 10, and doxorubicin IV over 1-15 minutes on days 1-2 on weeks 1 and 4. At least 24 hours after the completion of week 4 doxorubicin, patients undergo radiation therapy on weeks 4-10.\n\nSURGERY: Patients undergo surgery on week 13.\n\nCONTINUATION PHASE: Patients receive pazopanib PO QD on weeks 16-25, ifosfamide IV over 2-4 hours on days 1-3 on weeks 16 and 19, and doxorubicin IV over 1-15 minutes on days 1-2 on weeks 16, 19, and 22. If applicable, patients undergo additional radiation therapy at week 16\n\nREGIMEN B:\n\nINDUCTION PHASE: Patients receive ifosfamide IV over 2-4 hours on days 1-3 on weeks 1, 4, 7, 10 and doxorubicin hydrochloride IV over 1-15 minutes on days 1-2 on weeks 1 and 4. At least 24 hours after the completion of week 4 doxorubicin, patients undergo radiation therapy on weeks 4-10.\n\nSURGERY: Patients undergo surgery on week 13.\n\nCONTINUATION PHASE: Patients receive ifosfamide IV over 2-4 hours on days 1-3 on weeks 16 and 19 and doxorubicin IV over 1-15 minutes on days 1-2 on weeks 16, 19, and 22. If applicable, patients undergo additional radiation therapy at week 16.\n\nNON-CHEMOTHERAPY COHORT: Patients eligible for non-chemotherapy cohort are randomized to 1 of 2 treatment regimens.\n\nREGIMEN C:\n\nINDUCTION PHASE: Patients receive pazopanib PO QD on weeks 1-9. Patients undergo radiation therapy on weeks 1-7.\n\nSURGERY: Patients undergo surgery on week 10.\n\nCONTINUATION PHASE: Patients receive pazopanib PO QD on weeks 13-25. If applicable, patients undergo additional radiation therapy at week 13.\n\nREGIMEN D:\n\nINDUCTION PHASE: Patients undergo radiation therapy on weeks 1-7.\n\nSURGERY: Patients undergo surgery on week 10.\n\nCONTINUATION PHASE: If applicable, patients undergo additional radiation therapy at week 13.\n\nAfter completion of study treatment, patients are followed up at 6, 12, 18, 24, 30, 36, 48, and 60 months.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'minimumAge': '2 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Note: eligible patients must have a body surface area \\>= 0.5 m\\^2 AND be able to swallow whole tablets\n* Newly diagnosed and histopathologically confirmed, potentially resectable NRSTS of the extremity and trunk will be eligible for the chemotherapy or non-chemotherapy cohort based on:\n\n * Evidence of chemotherapy sensitivity of the histologic sarcoma subtype based on existing evidence from prior clinical trials\n * Sufficient risk of metastatic disease to warrant chemotherapy based on size and grade and\n * Medically deemed able or unable to undergo chemotherapy\n * Notes: an incisional biopsy or core biopsy is preferred; fine needle aspiration biopsy is not acceptable to establish the diagnosis\n* ELIGIBLE SITES:\n\n * Extremities: upper (including shoulder) and lower (including hip)\n * Trunk: body wall\n* INELIGIBLE SITES: Head and neck, visceral organs (with the exception of embryonal sarcoma of the liver), retroperitoneum, peritoneum, pelvis within the confines of the bony pelvis\n* ELIGIBILITY FOR CHEMOTHERAPY COHORT:\n* Stage T2a/b (\\> 5 cm) and grade 2 or 3 AND\n* One of the following chemosensitive histologies as defined in the World Health Organization (WHO) classification of soft tissue tumors (with some evidence of good response to chemoradiation and of sufficient high risk of metastases, or clear evidence of metastases):\n\n * Unclassified soft tissue sarcomas that are too undifferentiated to be placed in a specific pathologic category in the WHO classification (often called "undifferentiated soft tissue sarcoma" or "soft tissue sarcoma not otherwise specified \\[NOS\\]")\n * Synovial sarcoma\n * Angiosarcoma of soft tissue\n * Adult fibrosarcoma\n * Mesenchymal (extraskeletal) chondrosarcoma\n * Leiomyosarcoma\n * Liposarcoma (excluding myxoid liposarcoma)\n * Undifferentiated pleomorphic sarcoma\n * Embryonal sarcoma of the liver\n* Patients meeting the above criteria (histology, size, and grade) with the EXCEPTION of histologies noted above may enroll on the chemotherapy cohort or the non-chemotherapy cohort at the discretion of the enrolling investigator; patients meeting these criteria with the EXCEPTION of histologies noted above but medically deemed unable to receive chemotherapy or who elect not to receive chemotherapy are eligible for the non-chemotherapy cohort\n* Patients with the following histologies are only eligible for the chemotherapy cohort and cannot enroll on the non-chemotherapy cohort:\n\n * Unclassified soft tissue sarcomas that are too undifferentiated to be placed in a specific pathologic category in the WHO classification (often called "undifferentiated soft tissue sarcoma" or "soft tissue sarcoma NOS") in patients \\< 30 years of age\n * Synovial sarcoma\n * Embryonal sarcoma of the liver\n* ELIGIBILITY FOR NON-CHEMOTHERAPY COHORT:\n* Patients with any size of grade 2 or 3 of the following "intermediate (rarely metastasizing)" or "malignant" tumors, as defined in the WHO classification of soft tissue tumors for which we have consensus data of chemotherapy-resistance are eligible only for the non-chemotherapy cohort:\n\n * So-called fibrohistiocytic tumors - plexiform fibrohistiocytic tumor, giant cell tumor of soft tissues\n * Fibroblastic/myofibroblastic tumors - solitary fibrous tumor, malignant solitary fibrous tumor, inflammatory myofibroblastic tumor, low grade myofibroblastic sarcoma, myxoinflammatory fibroblastic sarcoma, atypical myxoinflammatory fibroblastic tumor, myxofibrosarcoma, low grade fibromyxoid sarcoma, sclerosing epithelioid fibrosarcoma\n * Tumors of uncertain differentiation - epithelioid sarcoma, alveolar soft part sarcoma, clear cell sarcoma of soft tissue, angiomatoid fibrous histiocytoma, ossifying fibromyxoid tumor, myoepithelioma, myoepithelial carcinoma, extraskeletal myxoid chondrosarcoma, neoplasms with perivascular epithelioid cell differentiation (PEComa), intimal sarcoma, atypical fibroxanthoma, mixed tumor NOS, phosphaturic mesenchymal tumor, malignant ossifying fibromyxoid tumor, malignant mixed tumor, malignant phosphaturic mesenchymal tumor\n * Chondro-osseous tumors - extraskeletal osteosarcoma\n * Pericytic (perivascular) tumors - malignant glomus tumor\n * Nerve sheath tumors - malignant peripheral nerve sheath tumor, malignant granular cell tumor, epithelioid malignant peripheral nerve sheath tumor, malignant Triton tumor\n * Undifferentiated sarcomas (with a specific pathologic category in the WHO classification) - undifferentiated round cell sarcoma, undifferentiated epithelioid sarcoma, undifferentiated spindle cell sarcoma\n* Patients meeting the criteria (histology, size, and grade) with the EXCEPTION of histologies noted above may enroll on the non-chemotherapy cohort at the discretion of the enrolling investigator; patients meeting these criteria with the EXCEPTION of histologies noted above but medically deemed unable to receive chemotherapy or who elect not to receive chemotherapy are eligible for the non-chemotherapy cohort; note that tumors arising in bone are NOT eligible for this study\n* Extent of disease:\n\n * Patients with non-metastatic and metastatic disease are eligible\n * Initially unresectable patients, with or without metastatic disease, are eligible as long as there is a commitment at enrollment to resect the primary tumor\n* Sufficient tissue and blood must be available to submit for required biology studies\n* Lansky performance status score \\>= 70 for patients =\\< 16 years of age\n* Karnofsky performance status score \\>= 70 for patients \\> 16 years of age\n* Absolute neutrophil count \\>= 1500/uL; Note: no transfusions are permitted 7 days prior to laboratory studies to determine eligibility\n* Platelet count \\>= 100,000/uL; Note: no transfusions are permitted 7 days prior to laboratory studies to determine eligibility\n* Hemoglobin \\>= 8 g/dL for patients =\\< 16 years of age; \\>= 9 g/dL for patients \\> 16 years of age; Note: no transfusions are permitted 7 days prior to laboratory studies to determine eligibility\n* Creatinine clearance or radioisotope glomerular filtration rate (GFR) \\>= 70 mL/min/1.73 m\\^2 or normal serum creatinine based on age/gender as follows:\n\n * 2 to \\< 6 years; 0.8 mg/dL male; 0.8 mg/dL female\n * 6 to \\< 10 years; 1 mg/dL male; 1 mg/dL female\n * 10 to \\< 13 years; 1.2 mg/dL male; 1.2 mg/dL female\n * 13 to \\< 16 years; 1.5 mg/dL male; 1.4 mg/dL female\n * \\>= 16 years; 1.5 mg/dL male; 1.4 mg/dL female\n* Total bilirubin =\\< 1.5 x upper limit of normal (ULN) for age\n* Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase \\[AST\\]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \\[ALT\\]) \\< 2.5 x upper limit of normal (ULN) for age\n* Shortening fraction of \\>= 27% by echocardiogram OR ejection fraction of \\>= 50% by radionuclide angiogram\n* Corrected QT interval (QTc) \\< 480 msec\n* No evidence of dyspnea at rest, no exercise intolerance, and a resting pulse oximetry reading \\> 94% on room air if there is clinical indication for determination\n* Patients on low molecular weight heparin or Coumadin (with a stable international normalized ratio \\[INR\\]) are eligible\n* Patient must have a life expectancy of at least 3 months with appropriate therapy\n* All patients and/or their parents or legal guardians must sign a written informed consent\n* All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met\n\nExclusion Criteria:\n\n* Patients with grade 1 NRSTS tumors of any size are not eligible\n* Patients with known central nervous system (CNS) metastases are not eligible; Note: brain imaging is not an eligibility requirement\n* Patients with evidence of active bleeding or bleeding diathesis will be excluded (Note: patients aged \\> 17 years with excess of 2.5 mL of hemoptysis are not eligible)\n* Patients with gross total resection of the primary tumor prior to enrollment on ARST1321 are NOT eligible; patients who have experienced tumor recurrence after a gross total tumor resection are NOT eligible\n* Patients with uncontrolled hypertension are ineligible; uncontrolled hypertension is defined as follows:\n\n * Patients aged =\\< 17 years: greater than 95th percentile systolic and diastolic blood pressure based on age and height which is not controlled by one anti-hypertensive medication\n * Patients aged \\> 17 years: systolic blood pressure \\>= 140 mmHg and/or diastolic blood pressure \\>= 90 mmHg that is not controlled by one anti-hypertensive medication\n* Prior Therapy:\n\n * Patients must have had no prior anthracycline (e.g., doxorubicin, daunorubicin) or ifosfamide chemotherapy\n * Patients must have had no prior use of pazopanib or similar multi-targeted tyrosine kinase inhibitors (TKI)\n * Patients must have had no prior radiotherapy to tumor-involved sites\n * Note: patients previously treated for a non-NRSTS cancer are eligible provided they meet the prior therapy requirements; patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier are excluded\n* Other types of invasive malignancy that are not disease free within 3 years except for non-melanoma skin cancer, lentigo maligna, any carcinoma-in-situ or prostate cancer with low risk factors\n* CYTOCHROME P450 3A4 (CYP3A4) substrates WITH narrow therapeutic indices: patients chronically receiving medications known to be metabolized by CYP3A4 and with narrow therapeutic indices within 7 days prior to study enrollment, including but not limited to pimozide, aripiprazole, triazolam, ergotamine and halofantrine are not eligible; Note: the use of fentanyl is permitted\n* CYP3A4 Inhibitors: patients chronically receiving drugs that are known potent CYP3A4 inhibitors within 7 days prior to study enrollment, including but not limited to itraconazole, clarithromycin, erythromycin many non-nucleoside reverse-transcriptase inhibitors (NNRTIs), diltiazem, verapamil, and grapefruit juice are not eligible\n* CYP3A4 Inducers: patients chronically receiving drugs that are known potent CYP3A4 inducers within 14 days prior to study enrollment, including but not limited to carbamazepine, phenobarbital, phenytoin, rifampin, and St. John\'s wort are not eligible (with the exception of glucocorticoids)\n* Certain medications that are associated with a risk for QTc prolongation and/or Torsades de Pointes, although not prohibited, should be avoided or replaced with medications that do not carry these risks, if possible\n* Subjects with any condition that may impair the ability to swallow or absorb oral medications/investigational product including:\n\n * Any lesion, whether induced by tumor, radiation or other conditions, which makes it difficult to swallow capsules or pills\n * Prior surgical procedures affecting absorption including, but not limited to major resection of stomach or small bowel\n * Active peptic ulcer disease\n * Malabsorption syndrome\n* Subjects with any condition that may increase the risk of gastrointestinal bleeding or gastrointestinal perforation, including:\n\n * Active peptic ulcer disease\n * Known intraluminal metastatic lesions\n * Inflammatory bowel disease (e.g., ulcerative colitis, Crohn\'s disease) or other gastrointestinal conditions which increase the risk of perforation\n * History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 28 days prior to beginning study treatment\n* Subjects with any of the following cardiovascular conditions within the past 6 months\n\n * Cerebrovascular accident (CVA) or transient ischemic attack (TIA)\n * Cardiac arrhythmia\n * Admission for unstable angina\n * Cardiac angioplasty or stenting\n * Coronary artery bypass graft surgery\n * Pulmonary embolism, untreated deep venous thrombosis (DVT) or DVT which has been treated with therapeutic anticoagulation for less than 6 weeks\n * Arterial thrombosis\n * Symptomatic peripheral vascular disease\n * Class III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system; a subject who has a history of class II heart failure and is asymptomatic on treatment may be considered eligible\n* History of serious or non-healing wound, ulcer, or bone fracture\n* Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements\n* Patients who are unable to swallow whole tablets are not eligible\n* Patients with a body surface area \\< 0.5 m\\^2 are not eligible\n* Human immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with pazopanib; in addition, these subjects are at increased risk of lethal infections when treated with marrow-suppressive therapy\n* Patients who are receiving any other investigational agent(s)\n* Pregnancy and breast feeding:\n\n * Female patients who are pregnant are ineligible due to risks of fetal and teratogenic adverse events as seen in animal/human studies\n * Lactating females are not eligible unless they have agreed not to breastfeed their infants during treatment and for a period of 1 month following completion of treatment\n * Female patients of childbearing potential are not eligible unless a negative pregnancy test result has been obtained\n* Unwillingness to use an effective contraceptive method for the duration of their study participation and for at least 1 month after treatment is completed if sexually active with reproductive potential'}, 'identificationModule': {'nctId': 'NCT02180867', 'briefTitle': 'Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery', 'organization': {'class': 'NIH', 'fullName': 'National Cancer Institute (NCI)'}, 'officialTitle': 'Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754)', 'orgStudyIdInfo': {'id': 'NCI-2014-01340'}, 'secondaryIdInfos': [{'id': 'NCI-2014-01340', 'type': 'REGISTRY', 'domain': 'CTRP (Clinical Trial Reporting Program)'}, {'id': 'ARST1321'}, {'id': 's14-02023'}, {'id': 'ARST1321', 'type': 'OTHER', 'domain': "Children's Oncology Group"}, {'id': 'ARST1321', 'type': 'OTHER', 'domain': 'CTEP'}, {'id': 'U10CA098543', 'link': 'https://reporter.nih.gov/quickSearch/U10CA098543', 'type': 'NIH'}, {'id': 'U10CA180830', 'link': 'https://reporter.nih.gov/quickSearch/U10CA180830', 'type': 'NIH'}, {'id': 'U10CA180886', 'link': 'https://reporter.nih.gov/quickSearch/U10CA180886', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Regimen A (pazopanib, chemoradiation)', 'description': 'See Regimen A Detailed Description.', 'interventionNames': ['Drug: Doxorubicin', 'Drug: Doxorubicin Hydrochloride', 'Drug: Ifosfamide', 'Drug: Pazopanib', 'Drug: Pazopanib Hydrochloride', 'Radiation: Radiation Therapy', 'Procedure: Therapeutic Conventional Surgery']}, {'type': 'EXPERIMENTAL', 'label': 'Regimen B (chemoradiation)', 'description': 'See Regimen B Detailed Description.', 'interventionNames': ['Drug: Doxorubicin', 'Drug: Doxorubicin Hydrochloride', 'Drug: Ifosfamide', 'Radiation: Radiation Therapy', 'Procedure: Therapeutic Conventional Surgery']}, {'type': 'EXPERIMENTAL', 'label': 'Regimen C (pazopanib, radiation therapy)', 'description': 'INDUCTION PHASE: Patients receive pazopanib PO QD on weeks 1-9. Patients undergo radiation therapy on weeks 1-7.\n\nSURGERY: Patients undergo surgery on week 10.\n\nCONTINUATION PHASE: Patients receive pazopanib PO QD on weeks 13-25. If applicable, patients undergo additional radiation therapy at week 13.', 'interventionNames': ['Drug: Pazopanib', 'Drug: Pazopanib Hydrochloride', 'Radiation: Radiation Therapy', 'Procedure: Therapeutic Conventional Surgery']}, {'type': 'EXPERIMENTAL', 'label': 'Regimen D (radiation therapy)', 'description': 'INDUCTION PHASE: Patients undergo radiation therapy on weeks 1-7.\n\nSURGERY: Patients undergo surgery on week 10.\n\nCONTINUATION PHASE: If applicable, patients undergo additional radiation therapy at week 13.', 'interventionNames': ['Radiation: Radiation Therapy', 'Procedure: Therapeutic Conventional Surgery']}], 'interventions': [{'name': 'Doxorubicin', 'type': 'DRUG', 'otherNames': ['Adriablastin', 'Hydroxydaunomycin', 'Hydroxyl Daunorubicin', 'Hydroxyldaunorubicin'], 'description': 'Given IV', 'armGroupLabels': ['Regimen A (pazopanib, chemoradiation)', 'Regimen B (chemoradiation)']}, {'name': 'Doxorubicin Hydrochloride', 'type': 'DRUG', 'otherNames': ['5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)', 'ADM', 'Adriacin', 'Adriamycin', 'Adriamycin Hydrochloride', 'Adriamycin PFS', 'Adriamycin RDF', 'ADRIAMYCIN, HYDROCHLORIDE', 'Adriamycine', 'Adriblastina', 'Adriblastine', 'Adrimedac', 'Chloridrato de Doxorrubicina', 'DOX', 'DOXO-CELL', 'Doxolem', 'Doxorubicin HCl', 'Doxorubicin.HCl', 'Doxorubin', 'Farmiblastina', 'FI 106', 'FI-106', 'FI106', 'hydroxydaunorubicin', 'Rubex'], 'description': 'Given IV', 'armGroupLabels': ['Regimen A (pazopanib, chemoradiation)', 'Regimen B (chemoradiation)']}, {'name': 'Ifosfamide', 'type': 'DRUG', 'otherNames': ['Asta Z 4942', 'Asta Z-4942', 'Cyfos', 'Holoxan', 'Holoxane', 'Ifex', 'IFO', 'IFO-Cell', 'Ifolem', 'Ifomida', 'Ifomide', 'Ifosfamidum', 'Ifoxan', 'IFX', 'Iphosphamid', 'Iphosphamide', 'Iso-Endoxan', 'Isoendoxan', 'Isophosphamide', 'Mitoxana', 'MJF 9325', 'MJF-9325', 'Naxamide', 'Seromida', 'Tronoxal', 'Z 4942', 'Z-4942'], 'description': 'Given IV', 'armGroupLabels': ['Regimen A (pazopanib, chemoradiation)', 'Regimen B (chemoradiation)']}, {'name': 'Pazopanib', 'type': 'DRUG', 'otherNames': ['GW786034'], 'description': 'Given PO', 'armGroupLabels': ['Regimen A (pazopanib, chemoradiation)', 'Regimen C (pazopanib, radiation therapy)']}, {'name': 'Pazopanib Hydrochloride', 'type': 'DRUG', 'otherNames': ['GW 786034B', 'GW-786034B', 'GW786034B', 'Pazopater', 'Votrient'], 'description': 'Given PO', 'armGroupLabels': ['Regimen A (pazopanib, chemoradiation)', 'Regimen C (pazopanib, radiation therapy)']}, {'name': 'Radiation Therapy', 'type': 'RADIATION', 'otherNames': ['Cancer Radiotherapy', 'Energy Type', 'ENERGY_TYPE', 'Irradiate', 'Irradiated', 'Irradiation', 'Radiation', 'Radiation Therapy, NOS', 'Radiotherapeutics', 'Radiotherapy', 'RT', 'Therapy, Radiation'], 'description': 'Undergo radiation therapy', 'armGroupLabels': ['Regimen A (pazopanib, chemoradiation)', 'Regimen B (chemoradiation)', 'Regimen C (pazopanib, radiation therapy)', 'Regimen D (radiation therapy)']}, {'name': 'Therapeutic Conventional Surgery', 'type': 'PROCEDURE', 'description': 'Undergo surgery', 'armGroupLabels': ['Regimen A (pazopanib, chemoradiation)', 'Regimen B (chemoradiation)', 'Regimen C (pazopanib, radiation therapy)', 'Regimen D (radiation therapy)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': "Children's Hospital of Alabama", 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'University of Alabama at Birmingham Cancer Center', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '35243', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'The Kirklin Clinic at Acton Road', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '98508', 'city': 'Anchorage', 'state': 'Alaska', 'country': 'United States', 'facility': 'Anchorage Associates in Radiation Medicine', 'geoPoint': {'lat': 61.21806, 'lon': -149.90028}}, {'zip': '99508', 'city': 'Anchorage', 'state': 'Alaska', 'country': 'United States', 'facility': 'Alaska Breast Care and Surgery LLC', 'geoPoint': {'lat': 61.21806, 'lon': -149.90028}}, {'zip': '99508', 'city': 'Anchorage', 'state': 'Alaska', 'country': 'United States', 'facility': 'Alaska Oncology and Hematology LLC', 'geoPoint': {'lat': 61.21806, 'lon': -149.90028}}, {'zip': '99508', 'city': 'Anchorage', 'state': 'Alaska', 'country': 'United States', 'facility': "Alaska Women's Cancer Care", 'geoPoint': {'lat': 61.21806, 'lon': -149.90028}}, {'zip': '99508', 'city': 'Anchorage', 'state': 'Alaska', 'country': 'United States', 'facility': 'Anchorage Oncology Centre', 'geoPoint': {'lat': 61.21806, 'lon': -149.90028}}, {'zip': '99508', 'city': 'Anchorage', 'state': 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