Ignite Creation Date:
2025-12-25 @ 1:20 AM
Ignite Modification Date:
2026-01-07 @ 10:58 AM
Study NCT ID:
NCT02842593
Status:
COMPLETED
Last Update Posted:
2017-01-16
First Post:
2016-07-15
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 60}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2014-09'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2017-01', 'completionDateStruct': {'date': '2016-08', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2017-01-13', 'studyFirstSubmitDate': '2016-07-15', 'studyFirstSubmitQcDate': '2016-07-20', 'lastUpdatePostDateStruct': {'date': '2017-01-16', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2016-07-25', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2016-08', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Carotid-femoral pulse wave velocity', 'timeFrame': '12 weeks post exercise training', 'description': 'Assessed using applanation tonometry'}], 'secondaryOutcomes': [{'measure': 'Common carotid artery distensibility', 'timeFrame': '12 weeks post exercise training', 'description': 'Assessed using vascular ultrasound'}, {'measure': 'Left ventricular mass', 'timeFrame': '12 weeks post exercise training', 'description': 'Assessed using standard echocardiography'}]}, 'conditionsModule': {'conditions': ['Weight-Lifting Exercise Program']}, 'descriptionModule': {'briefSummary': 'This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT'], 'maximumAge': '30 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Male\n* Aged 18-30 years old\n* Non-obese (Body mass index less than 30 kg/m2)\n* Non-smoker\n* Healthy based on questionnaire responses\n* Resistance trained (Resistance training \\> 2 times per week for 2 years, minimum 1 lower body exercise session per week)\n\nExclusion Criteria:\n\n* Allergies to milk proteins (whey or casein)\n* Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires\n* Arthritic conditions\n* Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded\n* A history of neuromuscular problems\n* Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).'}, 'identificationModule': {'nctId': 'NCT02842593', 'briefTitle': 'Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men', 'organization': {'class': 'OTHER', 'fullName': 'McMaster University'}, 'officialTitle': 'Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men', 'orgStudyIdInfo': {'id': 'REB 14-333-1'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Resistance exercise training', 'description': "Whole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention.", 'interventionNames': ['Behavioral: Lower-repetition, heavier-load', 'Behavioral: Higher-repetition, lighter-load']}, {'type': 'NO_INTERVENTION', 'label': 'Non-exercising control', 'description': 'Continue habitual physical activity for 12 weeks.'}], 'interventions': [{'name': 'Lower-repetition, heavier-load', 'type': 'BEHAVIORAL', 'description': '8-12 reps/set at \\~80% 1 repetition maximum', 'armGroupLabels': ['Resistance exercise training']}, {'name': 'Higher-repetition, lighter-load', 'type': 'BEHAVIORAL', 'description': '20-25 reps/set at \\~30% 1 repetition maximum', 'armGroupLabels': ['Resistance exercise training']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'L8S4L8', 'city': 'Hamilton', 'state': 'Ontario', 'country': 'Canada', 'facility': 'McMaster University', 'geoPoint': {'lat': 43.25011, 'lon': -79.84963}}], 'overallOfficials': [{'name': 'Stuart M Phillips, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'McMaster University'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'McMaster University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Professor', 'investigatorFullName': 'Stuart Phillips', 'investigatorAffiliation': 'McMaster University'}}}}