Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
ADAMTS8
Name:
ADAM metallopeptidase with thrombospondin type 1 motif 8
Location:
11q24.3
Locus Group:
protein-coding gene
Gene Type:
Protein Coding
Locus Type:
gene with protein product
DrugMatrix Data: https://cebs.niehs.nih.gov/cebs/paper/15670
DrugMatrix Gene Data For: 1 Matched Gene
Gene Name: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
Symbol:
Description: This gene encodes a disintegrin and metalloproteinase with thrombospondin motifs-8 (ADAMTS8), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains 2 C-terminal TS motifs, and disrupts angiogenesis in vivo and in vitro more efficiently than thrombospondin-1 or endostatin but somewhat less efficiently than ADAMTS1 protein. A number of disorders have been mapped in the vicinity of this gene, most notably, lung neoplasms.
