Gene:
tenascin XB
Gene ID:
196823
Symbol:
TNXB
Species:
1000
Description:
This gene encodes a member of the tenascin family of extracellular matrix proteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. The specific function of this protein is unknown, but its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. The gene expresses two transcripts.