Gene:
iron-responsive element binding protein 2
Gene ID:
195529
Symbol:
IREB2
Species:
1000
Description:
Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.