Gene:
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19
Description:
This gene encodes a disintegrin and metalloproteinase with thrombospondin (ADAMTS) motifs-19, which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS16, another family member. The function of this protein has not been determined.share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene shares high sequence similarity with the protein encoded by ADAMTS17, another family member. The function of this protein has not been determined.