Gene:
checkpoint with forkhead and ring finger domains
Gene ID:
193567
Symbol:
CHFR
Species:
1000
Description:
E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when they are exposed to microtubule poisons. Acts in early prophase before chromosome condense, when the centrosome move apart from each other along the periphery of the nucleus. Probably promotes the formation of Lys- 63-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substates that are polyubiquitinated at Lys-63 are usually not targeted for degradation, but are rather involved in signaling cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress caused by microtubule poisons.