Gene:
thiamin pyrophosphokinase 1
Gene ID:
205063
Symbol:
TPK1
Species:
1000
Description:
Thiamine pyrophosphokinase (TPK; EC 2.7.6.2) is a cellular enzyme involved in the regulation of thiamine metabolism. TPK catalyzes the conversion of thiamine, a form of vitamin B1, to thiamine pyrophosphate (TDP, or TPP). TDP is an active cofactor for enzymes involved in glycolysis and energy production, including transketolase, pyruvate dehydrogenase, and alpha-ketoglutarate dehydrogenase.[supplied by OMIM]