Gene:
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Gene ID:
207381
Symbol:
SDHA
Species:
1000
Description:
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The 70 kDa flavoprotein subunit contains a characteristic cysteine triplet. Mutations in the flavoprotein subunit gene have been linked to a form of mitochondrial respiratory chain deficiency known as Leigh syndrome.