Gene:
tubulin tyrosine ligase
Gene ID:
200700
Symbol:
TTL
Species:
1000
Description:
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination.[supplied by OMIM]