Gene:
angiopoietin-like 3
Gene ID:
206624
Symbol:
ANGPTL3
Species:
1000
Description:
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. Angiopoietin-like 3 is predominantly expressed in the liver, however, its exact function is not known. The ANGPTL3 protein has the characteristic structure of angiopoietins: a signal peptide, an extended helical domain predicted to form dimeric or trimeric coiled-coils, a short linker peptide, and a globular fibrinogen homology domain (FHD). ANGPTL3 also does not contain the characteristic calcium-binding motif found in other angiopoietins.