Ignite Creation Date:
2026-03-26 @ 3:16 PM
Ignite Modification Date:
2026-06-14 @ 3:38 AM
Study NCT ID:
NCT07322068
Status:
NOT_YET_RECRUITING
Last Update Posted:
2026-01-07
First Post:
2026-01-05
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Perennial Malaria Chemoprevention in the Malaria Vaccine Era
Sponsor:
Stanford University
Organization:
Study Overview
Official Title:
Perennial Malaria Chemoprevention in the Malaria Vaccine Era
Status:
NOT_YET_RECRUITING
Status Verified Date:
2026-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PMC-VAC
Brief Summary:
Malaria remains a major cause of pediatric deaths and morbidity in Africa. An affordable malaria vaccine, R21, is being deployed in Uganda and other African countries with high malaria transmission, but efficacy is incomplete and wanes rapidly, and R21 does not provide protection until infants complete the primary vaccination series, or \~9 months of age. The goal of this study is to see whether combining R21 vaccination with two novel perennial malaria chemoprevention regimens can enhance protection against malaria compared with R21 alone. This study will take place at Masafu General Hospital (MGH) in Busia District, a rural area in Southeastern Uganda bordering Lake Victoria.
Detailed Description:
None
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: